Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2)

BACKGROUND: Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control. METHODS: Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25·7 million adults (age 15-99 years) and 75,000 children (age 0-14 years) diagnosed with cancer during 1995-2009 and followed up to Dec 31, 2009, or later. We looked at cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, and adult and childhood leukaemia. Standardised quality control procedures were applied; errors were corrected by the registry concerned. We estimated 5-year net survival, adjusted for background mortality in every country or region by age (single year), sex, and calendar year, and by race or ethnic origin in some countries. Estimates were age-standardised with the International Cancer Survival Standard weights. FINDINGS: 5-year survival from colon, rectal, and breast cancers has increased steadily in most developed countries. For patients diagnosed during 2005-09, survival for colon and rectal cancer reached 60% or more in 22 countries around the world; for breast cancer, 5-year survival rose to 85% or higher in 17 countries worldwide. Liver and lung cancer remain lethal in all nations: for both cancers, 5-year survival is below 20% everywhere in Europe, in the range 15-19% in North America, and as low as 7-9% in Mongolia and Thailand. Striking rises in 5-year survival from prostate cancer have occurred in many countries: survival rose by 10-20% between 1995-99 and 2005-09 in 22 countries in South America, Asia, and Europe, but survival still varies widely around the world, from less than 60% in Bulgaria and Thailand to 95% or more in Brazil, Puerto Rico, and the USA. For cervical cancer, national estimates of 5-year survival range from less than 50% to more than 70%; regional variations are much wider, and improvements between 1995-99 and 2005-09 have generally been slight. For women diagnosed with ovarian cancer in 2005-09, 5-year survival was 40% or higher only in Ecuador, the USA, and 17 countries in Asia and Europe. 5-year survival for stomach cancer in 2005-09 was high (54-58%) in Japan and South Korea, compared with less than 40% in other countries. By contrast, 5-year survival from adult leukaemia in Japan and South Korea (18-23%) is lower than in most other countries. 5-year survival from childhood acute lymphoblastic leukaemia is less than 60% in several countries, but as high as 90% in Canada and four European countries, which suggests major deficiencies in the management of a largely curable disease. INTERPRETATION: International comparison of survival trends reveals very wide differences that are likely to be attributable to differences in access to early diagnosis and optimum treatment. Continuous worldwide surveillance of cancer survival should become an indispensable source of information for cancer patients and researchers and a stimulus for politicians to improve health policy and health-care systems

Formation of polyacrylate brushes on silica surfaces

cited By 52International audienceWe report the formation of polyacrylate (molten state polymers: Tg <room temperature) monolayers attached onto silica surfaces using covalently bonded initiators for radical-chain polymerisation. In a first reaction step, the initiator is self-assembled on the surface. In a subsequent reaction, the initiator is activated and the polymer formed in situ at the surface of the substrate with high grafting density ('grafting from' procedure). Moreover, the use of a living free radical process permits the molecular weight and polydispersity of the polymer chains to be controlled, and thus the polymer monolayer thickness also. We have also made a preliminary qualitative characterisation by X-ray spectroscopy (XPS) and Fourier transformed infrared (FTIR) measurements. © 2002 Society of Chemical Industry

Palaeobiogeography of the genus Latochara (fossil Charophyta) in the Upper Jurassic of Souther Europe. New data from Oléron Island (France)

International audienc

A novel 1,3-β-glucan synthase from the comycete <i>Saprolegnia monoica</i>

International audienc

Exploitation des plaques photographiques en spectrometrie de masse a etincelles par analyse d'images

SIGLEAvailable from CEN Saclay, Service de Documentation, 91191 - Gif-sur-Yvette Cedex (France) / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Chimie et environnement

Cet article présente un tour d’horizon de quelques-unes des thématiques de recherche développées en région Hauts-de-France dans les domaines de la chimie durable et de la chimie de l’environnement

A comprehensive methodology for the assessment of the health status of estuarine ecosystems.

Conseil International pour l'Exploration de la Mer. e−paper ICES CM 2007/I:09, http://www.ices.dk/products/CMdocs/CM-2007/I/I0907.pdf

Trame verte et bleue et espèces volantes. Note d’enjeux et de problématique

Ce rapport dresse un état des lieux des enjeux liés aux déplacements des espèces volantes, en particulier des oiseaux et des chauves-souris, confrontés à des obstacles spécifiques situés dans la strate aérienne. Il décrit ces principaux obstacles (éoliennes, lignes électriques, bâti, aéronefs), en présentant les potentiels problèmes rencontrés (dérangement, collisions, électrocutions, barotraumatisme, etc.) et en synthétisant les mesures de gestion préconisées pour les limiter. Il termine par un bilan de la prise en compte actuelle de cette problématique dans la Trame verte et bleue, en particulier aux échelles nationale (ON TVB) et régionale (SRCE) et conclut par une mise en perspective sur la nécessité de développer une trame aérienne en France