16 research outputs found
Primeras experiencias españolas con el uso de los ANTIVEGF intravítreos en la retinopatía del prematuro. Estudio multicéntrico
Objetivo: Evaluar el pronóstico anatómico de los niños con retinopatía del prematuro (ROP) tratados con
inyecciones intraoculares de antiVEGF y laser.
Metodo: Estudio multicéntrico, intervencional y retrospectivo. En el estudio se incluyeron 15 ojos de 12 prematuros
con ROP de alto riesgo de 6 hospitales diferentes. De ellos, 17 recibieron fotocoagulación e inyección
intraocular de dos formas diferentes:
Grupo 1.Tratamiento combinado. Siete ojos. Ambas técnicas se aplicaron en un intervalo menor de 10 días.
Grupo 2. Tratamiento postlaser. Siete ojos. Pacientes en los que seguía progresando la retinopatía después de
la fotocoagulación (la inyección se efectuó, de media, 37,4 días después).
El pronóstico se estableció por la necesidad de vitrectomía y por el resultado anatómica retiniano final. Se efectuó
un estudio estadístico comparativo entre ambos grupos con test no paramétricos (U Mann-Withney y Chi2).
Resultados: Grupo 1. Se dio laser y se puso la inyección intraocular a los 83,2 y 84,7 días de media, respectivamente.
(37,8 y 38,7 semanas postmenstruales-PM-). Grupo 2. Se fotocoaguló a los 70,1 días (36,4 semanas
PM) y la inyección intraocular se inyectó a los 107,5 días (41,8 semanas PM).
Sólo 4 ojos necesitaron vitrectomía, todos pertenecientes al grupo 1 (57,1 %) y por tanto ninguno del grupo 2
(p=0,07). Evolucionaron a pliegue macular o desprendimiento de retina el 14,3 % del grupo 1 y el 71,4 % del
grupo 2 (p=0,1).
Conclusiones: La inyección intravítrea de antiVEGF con fotocoagulación fue más efectiva que cuando se
administra en casos de ojos no respondedores a la fotocoagulaciónObjective: To assess the anatomical outcome of babies with retinopathy of prematurity (ROP) treated with
laser and intravitreal injection of antiVEGF.
Methods: Retrospective, interventional, multicenter trial. The study included 15 eyes of twelve preterm infants
with high risk ROP (from 6 hospitals). Fourteen eyes received intravitreal injections of antiVEGF (bevacizumab
or pegaptanib sodium) and laser photocoagulation in two different regimes:
Group 1 - combined treatment - (7 eyes). Laser and antiVEGF injections were performed in less than 10 days.
Group 2 - postlaser treatment - (7 eyes). Patients with progressive ROP despite peripheral laser ablation (injection
antiVEGF, -mean- 37.4 days after).
The results were evaluated for the need of more surgery and the final retinal anatomical status. Outcomes for
the 2 treatment groups were compared using parametric tests (U Mann-Whitney and Chi2).
Results: Group 1. Retinal photocoagulation and intraocular injection were performed at 83.2 and 84.7 days
(mean values) or 37.8 and 38.7 weeks (mean values) (postmenstrual age -PMA-). Group 2. Babies underwent
photocoagulation at 70.1 days (mean) [36.4 weeks PMA] and injection at 107.5 days [41.8 w. PMA].
Four eyes of group 2 needed vitrectomy (57.1 %) but none in group1 (p=0,07). Macular fold or retinal detachment
developed in 14.3 % of group 1 and 71.4 % of group 2 (p=0,1).
Conclusion: Intravitreal injection of antiVEGF with photocoagulation was more effective than intravitreal
injection in eyes unresponsive to photocoagulatio
Comparison Between Two Warm Ischemic Models in Experimental Liver Transplantation in Pigs
Experimental models of warm ischemia in liver transplantation have
been employed to study the mechanisms and treatment of ischemia reperfusion
injury. METHODS: We compared a control group without (group A, n = 10) versus two
models of warm ischemia of liver transplants in pigs: namely, occlusion of the
hepatic artery and portal vein for 30 minutes (group B, n = 23) and extraction of
the liver 60 minutes after cardiac arrest (group C, n = 5). Liver function tests,
coagulation studies, and liver biopsies were performed during the first 24 hours
post-liver transplant. RESULTS: Clamping of the hepatic vasculature in group B
produced a significant liver injury compared with the control group: elevation of
the ALT and an abnormal 1-hour post-revascularization biopsy similar to that
observed in the cardiac arrest group C. The transaminase levels were lower among
group A animals (P <.05). But the hepatic synthetic functions as reflected in the
protrombin time (PT) were not affected in group B versus group A. The alteration
in PT with respect to the initial value was similar among group A and group B
animals, which were significantly less than that in group C (P <.05).
CONCLUSIONS: Occlusion of the hepatic artery and portal vein, a simple surgical
maneuver, causes moderate damage to a liver graft but less alteration of hepatic
synthetic function. Clamping of the hepatic vasculture obtains more long-term
survivors after OLT than cardiac arrest
Thermodynamics of Black Holes in Two (and Higher) Dimensions
A comprehensive treatment of black hole thermodynamics in two-dimensional
dilaton gravity is presented. We derive an improved action for these theories
and construct the Euclidean path integral. An essentially unique boundary
counterterm renders the improved action finite on-shell, and its variational
properties guarantee that the path integral has a well-defined semi-classical
limit. We give a detailed discussion of the canonical ensemble described by the
Euclidean partition function, and examine various issues related to stability.
Numerous examples are provided, including black hole backgrounds that appear in
two dimensional solutions of string theory. We show that the Exact String Black
Hole is one of the rare cases that admits a consistent thermodynamics without
the need for an external thermal reservoir. Our approach can also be applied to
certain higher-dimensional black holes, such as Schwarzschild-AdS,
Reissner-Nordstrom, and BTZ.Comment: 63 pages, 3 pdf figures, v2: added reference
Revista de Vertebrados de la Estación Biológica de Doñana
Materiales para una «Herpetofauna Balearica 5. Las salamanquesas y tortugas del archipiélago de CabreraEcología de una población insular mediterránea del Eslizón ibérico, Chalcides bedriagai (Sauria Scincidae).Ecología alimenticia del águila imperial ibérica (Aquila adalberti) en el Coto Doñana durante la crianza de los pollosDatos sobre la dieta invernal del colirrojo tizón (Phoenicurus ochruros) en encinares de Andalucía occidentalSobre infecciones estafilocócicas en el Aguila imperial ibérica (Aquila adalberti Brehm)Breves notas sobre el Sapo partero ibérico (Alytes cisternasii Boscá)Sobre la presencia de Hyla arborea en la provincia de BadajozAlgunas presas de Elaphe scalaris.Observaciones de Tarentola maurítanica en nido de Hirundo dauricaObservación de una culebra viperina Natrix maura en agua marinaPrimera cita de la CollaIba yebélica (Oenanthe leucopyga) en la Península ibéricaObservaciones de Phoenicopterus ruber en la Ría de Vigo (PontevedraDatos sobre el Myotis emarginatus en la Península ibérica.Peer reviewe
Papel de la cirugía en el tratamiento del linfoma gástrico primario
Primary gastric lymphoma's optimum management remains controversial. We reviewed our series of 23 patients with primary gastric lymphoma treated in our hospital between 1976 and 1998 with surgery as main therapy. Ten patients underwent surgical resection alone, whereas 13 also received postoperative adjuvant therapy, depending on the oncologist-haematologist's recommendations. No differences were found between treatments regarding mortality and morbidity. Clinical-histological features and patients, follow-up are analyzed. No patient died because of lymphoma and there wasn't either local or distant recurrence. We consider that surgery remains a valid option for the primary gastric lymphoma treatment. The introduction of combined modalities of radiation therapy and chemotherapy will depend on the final stage, the tumor histological features, and the feasibility of getting a radical resection
Ensayo clínico, controlado con placebo, triple ciego, para evaluar la eficacia de una heparina de bajo peso molecular (bemiparina) en el tratamiento de las úlceras tórpidas del pie diabético, en atención primaria
Comparison Between Two Warm Ischemic Models in Experimental Liver Transplantation in Pigs
Experimental models of warm ischemia in liver transplantation have
been employed to study the mechanisms and treatment of ischemia reperfusion
injury. METHODS: We compared a control group without (group A, n = 10) versus two
models of warm ischemia of liver transplants in pigs: namely, occlusion of the
hepatic artery and portal vein for 30 minutes (group B, n = 23) and extraction of
the liver 60 minutes after cardiac arrest (group C, n = 5). Liver function tests,
coagulation studies, and liver biopsies were performed during the first 24 hours
post-liver transplant. RESULTS: Clamping of the hepatic vasculature in group B
produced a significant liver injury compared with the control group: elevation of
the ALT and an abnormal 1-hour post-revascularization biopsy similar to that
observed in the cardiac arrest group C. The transaminase levels were lower among
group A animals (P <.05). But the hepatic synthetic functions as reflected in the
protrombin time (PT) were not affected in group B versus group A. The alteration
in PT with respect to the initial value was similar among group A and group B
animals, which were significantly less than that in group C (P <.05).
CONCLUSIONS: Occlusion of the hepatic artery and portal vein, a simple surgical
maneuver, causes moderate damage to a liver graft but less alteration of hepatic
synthetic function. Clamping of the hepatic vasculture obtains more long-term
survivors after OLT than cardiac arrest