Anti-Collision Adaptations of BLE Active Scanning for Dense IoT Tracking Applications

Bluetooth low energy (BLE) is one of most promising technologies to enable the Internet-of-Things (IoT) paradigm. The BLE neighbor discovery process (NDP) based on active scanning may be the core of multiple IoT applications in which a large and varying number of users/devices/tags must be detected in a short period of time. Minimizing the discovery latency and maximizing the number of devices that can be discovered in a limited time are challenging issues due to collisions between frames sent by advertisers and scanners. The mechanism for resolution of collisions between scanners has a great impact on the achieved performance, but backoff in NDP has been poorly studied so far. This paper includes a detailed analysis of backoff in NDP, identifies and studies the factors involved in the process, reveals the limitations and problems presented by the algorithm suggested by the specifications and proposes simple and practical adaptations on scanner functionality. They are easily compatible with the current definitions of the standard, which together with a new proposal for the backoff scheme, may significantly improve the discovery latencies and, thus, the probability of discovering a large number of devices in high density scenarios

A low-cost tracking system for running race applications based on bluetooth low energy technology

Timing points used in running races and other competition events are generally based on radio-frequency identification (RFID) technology. Athletes’ times are calculated via passive RFID tags and reader kits. Specifically, the reader infrastructure needed is complex and requires the deployment of a mat or ramps which hide the receiver antennae under them. Moreover, with the employed tags, it is not possible to transmit additional and dynamic information such as pulse or oximetry monitoring, alarms, etc. In this paper we present a system based on two low complex schemes allowed in Bluetooth Low Energy (BLE): the non-connectable undirected advertisement process and a modified version of scannable undirected advertisement process using the new capabilities present in Bluetooth 5. After fully describing the system architecture, which allows full real-time position monitoring of the runners using mobile phones on the organizer side and BLE sensors on the participants’ side, we derive the mobility patterns of runners and capacity requirements, which are determinant for evaluating the performance of the proposed system. They have been obtained from the analysis of the real data measured in the last Barcelona Marathon. By means of simulations, we demonstrate that, even under disadvantageous conditions (50% error ratio), both schemes perform reliably and are able to detect the 100% of the participants in all the cases. The cell coverage of the system needs to be adjusted when non-connectable process is considered. Nevertheless, through simulation and experimental, we show that the proposed scheme based on the new events available in Bluetooth 5 is clearly the best implementation alternative for all the cases, no matter the coverage area and the runner speed. The proposal widely exceeds the detection requirements of the real scenario, surpassing the measured peaks of 20 sensors per second incoming in the coverage area, moving at speeds that range from 1.5 m/s to 6.25 m/s. The designed real test-bed shows that the scheme is able to detect 72 sensors below 600 ms, fulfilling comfortably the requirements determined for the intended application. The main disadvantage of this system would be that the sensors are active, but we have proved that its consumption can be so low (9.5 µA) that, with a typical button cell, the sensor battery life would be over 10, 000 h of use

Low-cost test measurement setup for real IoT BLE sensor device characterization

The methodology presented in this paper aims to characterize impairments shown by real devices which are usually neglected on standardized tests but that become very important in massive IoT scenarios. For instance, we have measured that real BLE scanners are not able to scan continuously even though they are configured to do so. Besides, we have also found and demonstrated that some manufacturers seem not to apply any backoff mechanism although it is mandatory. These two unexpected behaviors have a significant impact on the performance of massive wireless sensor networks based on BLE. So, it becomes necessary to characterize these and other impairments. The proposed tests are based on device current consumption measurements and their association with the information obtained from upper layers. We describe a new low-cost generic measurement setup and provide all the necessary data (configuration parameters, scripts, etc.) for applying the proposed methodology. As an example, we use it to profile the behavior of Bluetooth Low Energy devices. Furthermore, the proposed setup can also inspire researchers to characterize other wireless technology devices, like Wi-Fi, Zigbee, LoRa, etc

H^+ -> W^+ l_i^- l_j^+$ decay in the two Higgs doublet model

We study the lepton flavor violating H^+ -> W^+ l_i^- l_j^+ and the lepton flavor conserving $H^+ -> W^+ l_i^- l_i^+ (l_i=\tau, l_j=\mu) decays in the general 2HDM, so called model III. We estimate the decay width \Gamma for LFV (LFC) at the order of the magnitude of (10^{-11}-10^{-5}) GeV ((10^{-9}-10^{-4}) GeV), for 200 GeV\leq m_{H^\pm}\leq 400 GeV, and the intermediate values of the coupling \bar{\xi}^{E}_{N,\tau \mu}\sim 5 GeV (\bar{\xi}^{E}_{N,\tau \tau}\sim 30 GeV). We observe that the experimental result of the process under consideration can give comprehensive information about the physics beyond the standard model and the existing free parameters.Comment: 8 pages, 7 Figure

Bluetooth Mesh Analysis, Issues, and Challenges

BLE is a widely used short-range technology which has gained a relevant position inside the Internet-of-Things (IoT) paradigm development thanks to its simplicity, low-power consumption, low-cost and robustness. New enhancements over BLE have focused on supporting mesh network topology. Compared to other mesh networks, BLE mesh has only considered a managed flooding protocol in its first version. Managed flooding may generally seem inefficient in many contexts, but it is a high desirable option when data transmission is urgent, the network is small or its configuration changes in a very dynamic way. Knowing the interest to many application contexts, this paper analyses the impact of tweaking several features over the reliability and efficiency of the mesh network. These features are configured and controlled in different layers: message repetition schemes, the transmission randomization, the election of a scheme based on an acknowledged or unacknowledged transmission, etc. In order to estimate the real performance of a mesh network deployment, this paper evaluates the effects of the interaction of the chosen parameters, their appropriate adjustment in relation with the characteristics of real implementations and the true overhead related to the whole protocol stack. The paper identifies configuration challenges, proposes network tuning criteria and outlines possible standard improvements. For this purpose, a detailed assessment on the implementation and execution of real devices has been performed with their chipset limitations

A randomized phase II clinical trial of dendritic cell vaccination following complete resection of colon cancer liver metastasis

Surgically resectable synchronic and metachronic liver metastases of colon cancer have high risk of relapse in spite of standard-of-care neoadjuvant and adjuvant chemotherapy regimens. Dendritic cell vaccines loaded with autologous tumor lysates were tested for their potential to avoid or delay disease relapses (NCT01348256). Patients with surgically amenable liver metastasis of colon adenocarcinoma (n = 19) were included and underwent neoadjuvant chemotherapy, surgery and adjuvant chemotherapy. Fifteen patients with disease-free resection margins were randomized 1:1 to receive two courses of four daily doses of dendritic cell intradermal vaccinations versus observation. The trial had been originally designed to include 56 patients but was curtailed due to budgetary restrictions. Follow-up of the patients indicates a clear tendency to fewer and later relapses in the vaccine arm (median disease free survival –DFS-) 25.26 months, 95% CI 8. 74-n.r) versus observation arm (median DFS 9.53 months, 95% CI 5.32–18.88)

Flavor changing Z-decays from scalar interactions at a Giga-Z Linear Collider

The flavor changing decay Z -> d_I \bar{d}_J is investigated with special emphasis on the b \bar{s} final state. Various models for flavor violation are considered: two Higgs doublet models (2HDM's), supersymmetry (SUSY) with flavor violation in the up and down-type squark mass matrices and SUSY with flavor violation mediated by R-parity-violating interaction. We find that, within the SUSY scenarios for flavor violation, the branching ratio for the decay Z -> b \bar{s} can reach 10^{-6} for large \tan\beta values, while the typical size for this branching ratio in the 2HDM's considered is about two orders of magnitudes smaller at best. Thus, flavor changing SUSY signatures in radiative Z decays such as Z -> b \bar{s} may be accessible to future ``Z factories'' such as a Giga-Z version of the TESLA design.Comment: 27 pages, 15 figures, REVTeX4. A new section added and a few minor corrections were made in the tex

Patient-reported outcomes in a phase III, randomized study of sunitinib versus interferon-{alpha} as first-line systemic therapy for patients with metastatic renal cell carcinoma in a European population

BACKGROUND: The purpose of this study is to evaluate the impact on the health-related quality of life (HRQoL) of sunitinib versus interferon-alpha (IFN-alpha) treatment in patients with metastatic renal cell carcinoma (mRCC). PATIENTS AND METHODS: In all, 304 mRCC patients (European cohort) were randomized 1 : 1 to receive sunitinib (50 mg/day for 4 weeks, followed by 2 weeks off) or IFN-alpha (9 million units s.c. injection three times/week). The following questionnaires were completed (days 1 and 28 per cycle): Functional Assessment of Cancer Therapy-General (FACT-G), the FACT-Kidney Symptom Index and the EuroQol Group's EQ-5D self-report questionnaire (EQ-5D). Results correspond to an ongoing trial with progression-free survival time as primary end point, and patients were still being followed up. Data were analyzed using repeated measures mixed effects models (MEMs) that allow the inclusion of initial differences and uncompleted repeated measures, with the assumption of data missing at random. Six-cycle results were included. RESULTS: Results consistently showed that patients in sunitinib group experienced statistically significantly milder kidney-related symptoms, better cancer-specific HRQoL and general health status (in social utility scores) during the study period as measured by these patient-reported outcome end points. No statistical differences between groups were found on the FACT-G physical well-being subscale or the EQ-5D VAS values. CONCLUSIONS: Results from MEM showed the sunitinib's benefit on HRQoL compared with IFN-alpha

Surgical treatment for colorectal cancer: Analysis of the influence of an enhanced recovery programme on long-term oncological outcomes-a study protocol for a prospective, multicentre, observational cohort study

Introduction The evidence currently available from enhanced recovery after surgery (ERAS) programmes concerns their benefits in the immediate postoperative period, but there is still very little evidence as to whether their correct implementation benefits patients in the long term. The working hypothesis here is that, due to the lower response to surgical aggression and lower rates of postoperative complications, ERAS protocols can reduce colorectal cancer-related mortality. The main objective of this study is to analyse the impact of an ERAS programme for colorectal cancer on 5-year survival. As secondary objectives, we propose to analyse the weight of each of the predefined items in the oncological results as well as the quality of life. Methods and analysis A multicentre prospective cohort study was conducted in patients older than 18 years of age who are scheduled to undergo surgery for colorectal cancer. The study involved 12 hospitals with an implemented enhanced recovery protocol according to the guidelines published by the Spanish National Health Service. The intervention group includes patients with a minimum implementation level of 70%, and the control group includes those who fail to reach this level. Compliance will be studied using 18 key performance indicators, and the results will be analysed using cancer survival indicators, including overall survival, cancer-specific survival and relapse-free survival. The time to recurrence, perioperative morbidity and mortality, hospital stay and quality of life will also be studied, the latter using the validated EuroQol Five questionnaire. The propensity index method will be used to create comparable treatment and control groups, and a multivariate regression will be used to study each variable. The Kaplan-Meier estimator will be used to estimate survival and the log-rank test to make comparisons. A p value of less than 0.05 (two-tailed) will be considered to be significant. Ethics and dissemination Ethical approval for this study was obtained from the Aragon Ethical Committee (C.P.-C.I. PI20/086) on 4 March 2020. The findings of this study will be submitted to peer-reviewed journals (BMJ Open, JAMA Surgery, Annals of Surgery, British Journal of Surgery). Abstracts will be submitted to relevant national and international meetings. Trial registration number NCT04305314

HPM Approximations for Trajectories: From a Golf Ball Path to Mercury’s Orbit

In this work, we propose the approximated analytical solutions for two highly nonlinear problems using the homotopy perturbation method (HPM). We obtained approximations for a golf ball trajectory model and a Mercury orbit’s model. In addition, to enlarge the domain of convergence of the first case study, we apply the Laplace-Padé resummation method to the HPM series solution. For both case studies, we were able to obtain approximations in good agreement with numerical methods, depicting the basic nature of the trajectories of the phenomena