Copeptin Levels Remain Unchanged during the Menstrual Cycle.

BACKGROUND: Copeptin, a surrogate marker for arginin vasopressin production, is evaluated as an osmo-dependent stress and inflammatory biomarker in different diseases. We investigated copeptin during the menstrual cycle and its relationship to sex hormones, markers of subclinical inflammation and estimates of body fluid. METHODS: In 15 healthy women with regular menstrual cycles, blood was drawn on fifteen defined days of their menstrual cycle and was assayed for copeptin, progesterone, estradiol, luteinizing hormone, high-sensitive C-reactive protein, tumor necrosis factor-alpha and procalcitonin. Symptoms of fluid retention were assessed on each visit, and bio impedance analysis was measured thrice to estimate body fluid changes. Mixed linear model analysis was performed to assess the changes of copeptin across the menstrual cycle and the relationship of sex hormones, markers of subclinical inflammation and estimates of body fluid with copeptin. RESULTS: Copeptin levels did not significantly change during the menstrual cycle (p = 0.16). Throughout the menstrual cycle, changes in estradiol (p = 0.002) and in the physical premenstrual symptom score (p = 0.01) were positively related to copeptin, but changes in other sex hormones, in markers of subclinical inflammation or in bio impedance analysis-estimated body fluid were not (all p = ns). CONCLUSION: Although changes in estradiol and the physical premenstrual symptom score appear to be related to copeptin changes, copeptin does not significantly change during the menstrual cycle

Characterization of microbulk detectors in argon- and neon-based mixtures

A recent Micromegas manufacturing technique, so called Microbulk, has been developed, improving the uniformity and stability of this kind of detectors. Excellent energy resolutions have been obtained, reaching values as low as 11% FWHM at 5.9 keV in Ar+5%iC4H10. This detector has other advantages like its flexible structure, low material budget and high radio-purity. Two microbulk detectors with gaps of 50 and 25 um have been characterized in argon- and neon-based mixtures with ethane, isobutane and cyclohexane. The results will be presented and discussed. The gain curves have been fitted to the Rose-Korff gain model and dependences of the electron mean free path and the threshold energy for ionization have been obtained. The possible relation between these two parameters and the energy resolution will be also discussed.Comment: Submitted to the Journal of Instrumentatio

Dynamical model of sequential spatial memory: winnerless competition of patterns

We introduce a new biologically-motivated model of sequential spatial memory which is based on the principle of winnerless competition (WLC). We implement this mechanism in a two-layer neural network structure and present the learning dynamics which leads to the formation of a WLC network. After learning, the system is capable of associative retrieval of pre-recorded sequences of spatial patterns.Comment: 4 pages, submitted to PR

Physics Opportunities with the 12 GeV Upgrade at Jefferson Lab

This white paper summarizes the scientific opportunities for utilization of the upgraded 12 GeV Continuous Electron Beam Accelerator Facility (CEBAF) and associated experimental equipment at Jefferson Lab. It is based on the 52 proposals recommended for approval by the Jefferson Lab Program Advisory Committee.The upgraded facility will enable a new experimental program with substantial discovery potential to address important topics in nuclear, hadronic, and electroweak physics.Comment: 64 page

PROFIT: a new alternative for emission-line PROfile FITting

I briefly describe a simple routine for emission-line profiles fitting by Gaussian curves or Gauss-Hermite series. The PROFIT (line-PROfile FITting) routine represent a new alternative for use in fits data cubes, as those from Integral Field Spectroscopy or Fabry-Perot Interferometry, and may be useful to better study the emission-line flux distributions and gas kinematics in distinct astrophysical objects, such as the central regions of galaxies and star forming regions. The PROFIT routine is written in IDL language and is available at http://www.ufsm.br/rogemar/software.html. The PROFIT routine was used to fit the [Fe II]1.257um emission-line profiles for about 1800 spectra of the inner 350 pc of the Seyfert galaxy Mrk1066 obtained with Gemini NIFS and shows that the line profiles are better reproduced by Gauss-Hermite series than by the commonly used Gaussian curves. The two-dimensional map of the h_3 Gauss-Hermite moment shows its highest absolute values in regions close to the edge of the radio structure. These high values may be originated in an biconical outflowing gas associated with the radio jet - previously observed in the optical [O III] emission. The analysis of this kinematic component indicates that the radio jet leaves the center of the galaxy with the north-west side slightly oriented towards us and the south-east side away from us, being partially hidden by the disc of the galaxy.Comment: Accepted for publication Astrophysics & Space Science - 7 pges; 4 Fig

An Agent-Based Approach to Self-Organized Production

The chapter describes the modeling of a material handling system with the production of individual units in a scheduled order. The units represent the agents in the model and are transported in the system which is abstracted as a directed graph. Since the hindrances of units on their path to the destination can lead to inefficiencies in the production, the blockages of units are to be reduced. Therefore, the units operate in the system by means of local interactions in the conveying elements and indirect interactions based on a measure of possible hindrances. If most of the units behave cooperatively ("socially"), the blockings in the system are reduced. A simulation based on the model shows the collective behavior of the units in the system. The transport processes in the simulation can be compared with the processes in a real plant, which gives conclusions about the consequencies for the production based on the superordinate planning.Comment: For related work see http://www.soms.ethz.c

Fulminant hyperpyrexia induced by bleomycin

Mild and self-limiting fever following bleomycin use is common, and a fatal hyperpyrexial response occurs rarely. In previously reported cases, such hyperpyrexia occurred either after the initial administration of the drug or during subsequent therapy following an initial pyrexial response. We describe a fatal hyperpyrexial reaction after bleomycin in a patient with T-cell lymphoma who had had no febrile response when she received her initial injection 3 weeks earlier. Since the occurrence of this hyperpyrexial response is unpredictable, health care workers as well as patients and relatives should always be alert to this potentially lethal complication and prompt measures should be taken in any patient who develops fever after bleomycin use.published_or_final_versio

Quantization and Compressive Sensing

Quantization is an essential step in digitizing signals, and, therefore, an indispensable component of any modern acquisition system. This book chapter explores the interaction of quantization and compressive sensing and examines practical quantization strategies for compressive acquisition systems. Specifically, we first provide a brief overview of quantization and examine fundamental performance bounds applicable to any quantization approach. Next, we consider several forms of scalar quantizers, namely uniform, non-uniform, and 1-bit. We provide performance bounds and fundamental analysis, as well as practical quantizer designs and reconstruction algorithms that account for quantization. Furthermore, we provide an overview of Sigma-Delta ($\Sigma\Delta$) quantization in the compressed sensing context, and also discuss implementation issues, recovery algorithms and performance bounds. As we demonstrate, proper accounting for quantization and careful quantizer design has significant impact in the performance of a compressive acquisition system.Comment: 35 pages, 20 figures, to appear in Springer book "Compressed Sensing and Its Applications", 201

Open strings, 2D gravity and AdS/CFT correspondence

We present a detailed discussion of the duality between dilaton gravity on AdS_2 and open strings. The correspondence between the two theories is established using their symmetries and field theoretical, thermodynamic, and statistical arguments. We use the dual conformal field theory to describe two-dimensional black holes. In particular, all the semiclassical features of the black holes, including the entropy, have a natural interpretation in terms of the dual microscopic conformal dynamics. The previous results are discussed in the general framework of the Anti-de Sitter/Conformal Field Theory dualities.Comment: 22 pages, Typeset using REVTE

The long-time dynamics of two hydrodynamically-coupled swimming cells

Swimming micro-organisms such as bacteria or spermatozoa are typically found in dense suspensions, and exhibit collective modes of locomotion qualitatively different from that displayed by isolated cells. In the dilute limit where fluid-mediated interactions can be treated rigorously, the long-time hydrodynamics of a collection of cells result from interactions with many other cells, and as such typically eludes an analytical approach. Here we consider the only case where such problem can be treated rigorously analytically, namely when the cells have spatially confined trajectories, such as the spermatozoa of some marine invertebrates. We consider two spherical cells swimming, when isolated, with arbitrary circular trajectories, and derive the long-time kinematics of their relative locomotion. We show that in the dilute limit where the cells are much further away than their size, and the size of their circular motion, a separation of time scale occurs between a fast (intrinsic) swimming time, and a slow time where hydrodynamic interactions lead to change in the relative position and orientation of the swimmers. We perform a multiple-scale analysis and derive the effective dynamical system - of dimension two - describing the long-time behavior of the pair of cells. We show that the system displays one type of equilibrium, and two types of rotational equilibrium, all of which are found to be unstable. A detailed mathematical analysis of the dynamical systems further allows us to show that only two cell-cell behaviors are possible in the limit of $t\to\infty$, either the cells are attracted to each other (possibly monotonically), or they are repelled (possibly monotonically as well), which we confirm with numerical computations