PPROC, an ontology for transparency in'public procurement

Public procurement or tendering refers to the process followed by public authorities for the procurement of goods and services. In most developed countries, the law requires public authorities to provide online information to ensure competitive tendering as far as possible, for which the adequate announcement of tenders is an essential requirement. In addition, transparency laws being proposed in such countries are making the monitoring of public contracts by citizens a fundamental right. This paper describes the PPROC ontology, which has been developed to give support to both processes, publication and accountability, by semantically describing public procurement processes and contracts. The PPROC ontology is extensive, since it covers not only the usual data about the tender, its objectives, deadlines and awardees, but also details of the whole process, from the initial contract publication to its termination. This makes it possible to use the ontology for both open data publication purposes and for the overall management of the public contract procurement process

Intermittent hypoxic training and cycling performance in triathletes

Athletes include altitude training as a complement to their conventional training to improve performance. The aim of the study was to analyze the effects on anaerobic threshold (AT) produced by an IHT program in triathletes. 18 male trained triathletes were divided into intermittent hypoxic training group (GIHT: n=9; age: 26±6.73 years, height 173.33±5.94 cm, weight: 66.38±5.91 kg) and control group (GC: n=9; age: 29.27±6.84 years, height 174.89±4.59 cm, weight: 71.59±6.81 kg). The IHT program consisted of two 60-min sessions per week at intensities over the AT and atmospheric conditions between 14.5 and 15% FiO2. Before and after the program, cycling performance in a lactate thresholds test was determined. The treatment caused an improvement in the power output and perceived exertion in AT and enhanced cardiac performance in the aerobic threshold and AT.Actividad Física y Deport

Gender variability in electromyographic activity, in vivo behaviour of the human gastrocnemius and mechanical capacity during the take-off phase of a countermovement jump

PURPOSE: The purpose of this study was to analyse gender differences in neuromuscular behaviour of the gastrocnemius and vastus lateralis during the take-off phase of a countermovement jump (CMJ), using direct measures (ground reaction forces, muscle activity and dynamic ultrasound). METHODS: Sixty-four young adults (aged 18-25 years) participated voluntarily in this study, 35 men and 29 women. The firing of the trigger allowed obtainment of data collection vertical ground reaction forces (GRF), surface electromyography activity (sEMG) and dynamic ultrasound gastrocnemius of both legs. RESULTS: Statistically significant gender differences were observed in the jump performance, which appear to be based on differences in muscle architecture and the electrical activation of the gastrocnemius muscles and vastus lateralis. So while men developed greater peak power, velocity take-offs and jump heights, jump kinetics compared to women, women also required a higher electrical activity to develop lower power values. Additionally, the men had higher values pennation angles and muscle thickness than women. CONCLUSION: Men show higher performance of the jump test than women, due to significant statistical differences in the values of muscle architecture (pennation angle and thickness muscle), lower Neural Efficiency Index and a higher amount of sEMG activity per second during the take-off phase of a CMJ.Actividad Física y Deport

Measurements of the LHC longitudinal resistive impedance with beam

The resistive part of the longitudinal impedance contributes to the heat deposition on different elements in the LHC ring including the beam screens, where it has to be absorbed by the cryogenic system and can be a practical limitation for the maximum beam intensity. In this paper, we present the first measurements of the LHC longitudinal resistive impedance with beam, done through synchronous phase shift measurements duringMachine Development sessions in 2012. Synchronous phase shift is measured for different bunch intensities and lengths using the high-precision LHC Beam Phase Module and then data are post-processed to further increase the accuracy. The dependence of the energy loss per particle on bunch length is then obtained and compared with the expected values found using the LHC impedance model

The Spalt Transcription Factors Generate the Transcriptional Landscape of the Drosophila melanogaster Wing Pouch Central Region

The Drosophila genes spalt major (salm) and spalt-related (salr) encode Zn-finger transcription factors regulated by the Decapentaplegic (Dpp) signalling pathway in the wing imaginal disc. The function of these genes is required for cell survival and proliferation in the central region of the wing disc, and also for vein patterning in the lateral regions. The identification of direct Salm and Salr target genes, and the analysis of their functions, are critical steps towards understanding the genetic control of growth and patterning of the Drosophila wing imaginal disc by the Dpp pathway. To identify candidate Salm/Salr target genes, we have compared the expression profile of salm/salr knockdown wing discs with control discs in microarray experiments. We studied by in situ hybridization the expression pattern of the genes whose mRNA levels varied significantly, and uncovered a complex transcription landscape regulated by the Spalt proteins in the wing disc. Interestingly, candidate Salm/Salr targets include genes which expression is turned off and genes which expression is positively regulated by Salm/Salr. Furthermore, loss-of-function phenotypic analysis of these genes indicates, for a fraction of them, a requirement for wing growth and patterning. The identification and analysis of candidate Salm/Salr target genes opens a new avenue to reconstruct the genetic structure of the wing, linking the activity of the Dpp pathway to the development of this epithelial tissueThis work was supported by institutional grants from Fundación Ramón Areces and Banco de Santander to the Centro de Biología Molecular Severo Ochoa. BFU2009-09403, BFU2012-33994, CSD2007-00008 (http://www.mineco.gob.es/portal/site/mineco/). We acknowledge support of the publication fee by the CSIC Open Access Publication Support Initiative through its Unit of Information Resources for Research (URICI). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscrip

Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence

Understanding how distinct cell types arise from multipotent progenitor cells is a major quest in stem cell biology. The liver and pancreas share many aspects of their early development and possibly originate from a common progenitor. However, how liver and pancreas cells diverge from a common endoderm progenitor population and adopt specific fates remains elusive. Using RNA sequencing (RNA-seq), we defined the molecular identity of liver and pancreas progenitors that were isolated from the mouse embryo at two time points, spanning the period when the lineage decision is made. The integration of temporal and spatial gene expression profiles unveiled mutually exclusive signaling signatures in hepatic and pancreatic progenitors. Importantly, we identified the noncanonical Wnt pathway as a potential developmental regulator of this fate decision and capable of inducing the pancreas program in endoderm and liver cells. Our study offers an unprecedented view of gene expression programs in liver and pancreas progenitors and forms the basis for formulating lineage-reprogramming strategies to convert adult hepatic cells into pancreatic cells

Planarian regeneration: achievements and future directions after 20 years of research.

Planarians can undergo dramatic changes in body size and regenerate their entire body plan from small pieces after cutting. This remarkable morphological plasticity has made them an excellent model in which to analyze phenomena such as morphogenesis, restoration of pattern and polarity, control of tissue proportions and tissue homeostasis. They have a unique population of pluripotent stem cells in the adult that can give rise to all differentiated cell types, including the germ cells. These cellular characteristics provide an excellent opportunity to study the mechanisms involved in the maintenance and differentiation of cell populations in intact and regenerating animals. Until recently, the planarian model system lacked opportunities for genetic analysis; however, this handicap was overcome in the last decade through the development of new molecular methods which have been successfully applied to planarians. These techniques have allowed analysis of the temporal and spatial expression of genes, as well as interference with gene function, generating the first phenotypes by loss or gain of function. Finally, the sequencing of the planarian genome has provided the essential tools for an in-depth analysis of the genomic regulation of this model system. In this review, we provide an overview of planarians as a model system for research into development and regeneration and describe new lines of investigation in this area

The sintering, sintered microstructure and mechanical properties of Ti-Fe-Si Alloys

A systematic study has been conducted of the sintering, sintered microstructure and tensile properties of a range of lower cost Ti-Fe-Si alloys, including Ti-3Fe-(0-4)Si, Ti-(3-6)Fe-0.5Si, and Ti-(3-6)Fe-1Si (in wt pct throughout). Small additions of Si (≤1 pct) noticeably improve the as-sintered tensile properties of Ti-3Fe alloy, including the ductility, with fine titanium silicides (TiSi) being dispersed in both the α and β phases. Conversely, additions of >1 pct Si produce coarse and/or networked TiSi silicides along the grain boundaries leading to predominantly intergranular fracture and, hence, poor ductility, although the tensile strength continues to increase because of the reinforcement by TiSi. Increasing the Fe content in the Ti-xFe-0.5/ 1.0Si alloys above 3 pct markedly increases the average grain size and changes the morphology of the α-phase phase to much thinner and more acicular laths. Consequently, the ductility drops t

Recensiones [Revista de Historia Económica Año VII Otoño 1989 n. 3 pp. 727-757]

Antoni Segura i Mas (coord.). El Catastro en España, vol. I (1714-1906) (Por Francisco Comín).-- Antonia Heredia Herrera. Sevilla y los hombres del Comercio (1700-1800) (Por Andrés J. Moreno Mengíbar).-- Pedro Tedde de Lorca. El Banco de San Carlos (1782-1829 (Por Javier Cuenca Esteban).-- José Ramón García López. El Banco de Oviedo, 1864-1874 (Por José Luis García Ruiz).-- Enrique Prieto. Agricultura y atraso en la España contemporánea. Estudio sobre el desarrollo del Capitalismo (Por Carlos Barciela López).-- Mª Asunción Sivera Tejerina. Los cambios técnicos de la agricultura en el término rural de Málaga: siglos XVIII-XX (Por Juan Francisco Zambrana Pineda).-- Pablo Martín Aceña. La política monetaria en España, 1919-1935 (Por M. Cruz Manzano Frias).-- Carles Sudria i Triay. Una societat plenament industrial, vol. 4 de Historia Económica de la Catalunya Contemporánia (Por Gabriel Tortella).-- CH. S. Maier. La refundación de la Europa burguesa. Estabilización en Francia, Alemania e Italia en la década posterior a la Primera Guerra Mundial y In Search of Stability Explorations in Historical Political Economy (Por Mercedes Cabrera).-- Michael Sandersona. Eductttional Opportunity and Social Change in England (Por Clara Eugenia Núñez)Publicad

Guía de la excursión al Triásico de la Sierra de Prades

Peer reviewe