Lagrangian Curves in a 4-dimensional affine symplectic space

Lagrangian curves in R4 entertain intriguing relationships with second order deformation of plane curves under the special affine group and null curves in a 3-dimensional Lorentzian space form. We provide a natural affine symplectic frame for Lagrangian curves. It allows us to classify La- grangrian curves with constant symplectic curvatures, to construct a class of Lagrangian tori in R4 and determine Lagrangian geodesic

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Capacidade de suprimento de potássio em solos de Minas Gerais-Brasil

O potássio está presente em diferentes formas no solo, diferindo na acessibilidade para as plantas e com reversibilidade entre essas formas. A capacidade dos solos no suprimento de K para as plantas é diferenciada e determinante na sustentabilidade da produção agrícola e no manejo da fertilização com este nutriente. Assim, neste trabalho objetivou-se avaliar a capacidade de suprimento de K por solos do Estado de Minas Gerais (Brasil) de diferentes mineralogias, em cultivo sucessivo de milho. O experimento foi conduzido em casa de vegetação, num esquema fatorial 7 x 6 (sete solos e seis doses de K), sendo as unidades experimentais distribuídas em blocos casualizados, com quatro repetições, por sete cultivos sucessivos. As plantas eram colhidas após 45 d para cada cultivo. A disponibilidade de K para as plantas foi avaliada no início e no intervalo de cada cultivo, usando os extratores Mehlich-1 e Mehlich-3. Veri!cou-se expressiva redução dos teores de K no solo, comprometendo a produção de matéria seca do milho em todos os solos estudados. A reserva de K foi maior nos Argissolos, seguido dos Cambissolos e Latossolos. Houve participação de formas não trocáveis de K na nutrição do milho. A disponibilidade de K no solo avaliada pelo extrator Mehlich-1 representou 40% do K absorvido pelas plantas e, 61% do K absorvido quando utilizou-se o extrator Mehlich-3

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. © 2022. The Author(s)

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. © 2022, The Author(s)