Regional Income Inequalities in Europe: An Updated Measurement and Some Decomposition Results

In this paper well-known summary inequality indexes are used to explore interregional income inequalities in Europe. In particular, we mainly employ Theils’population-weighted index because of its appealing properties. Two decomposition analysis are applied. First, regional inequalities are decomposed by regional subgroups (countries). Second, intertemporal inequality changes are separated into income and population changes. The main results can be summarized as follows. First, data confirm a reduction in crossregional inequality during 1982-97. Second, this reduction is basically due to real convergence among countries. Third, currently the greater part of European interregional disparities is within-country by nature, which introduce an important challenge for the European policy. Fourth, inequality changes are due mainly to income variations, population changes playing a minor role.regional inequality, inequality decomposition

Timing the decision support for real-world many-objective optimization problems

Lately, there is growing emphasis on improving the scalability of multi-objective evolutionary algorithms (MOEAs) so that many-objective problems (characterized by more than three objectives) can be effectively dealt with. Alternatively, the utility of integrating decision maker’s (DM’s) preferences into the optimization process so as to target some most preferred solutions by the DM (instead of the whole Pareto-optimal front), is also being increasingly recognized. The authors here, have earlier argued that despite the promises in the latter approach, its practical utility may be impaired by the lack of—objectivity, repeatability, consistency, and coherence in the DM’s preferences. To counter this, the authors have also earlier proposed a machine learning based decision support framework to reveal the preference-structure of objectives. Notably, the revealed preference-structure may be sensitive to the timing of application of this framework along an MOEA run. In this paper the authors counter this limitation, by integrating a termination criterion with an MOEA run, towards determining the appropriate timing for application of the machine learning based framework. Results based on three real-world many-objective problems considered in this paper, highlight the utility of the proposed integration towards an objective, repeatable, consistent, and coherent decision support for many-objective problems

Can social norms explain long-term trends in alcohol use? Insights from inverse generative social science

Social psychological theory posits entities and mechanisms that attempt to explain observable differences in behavior. For example, dual process theory suggests that an agent's behavior is influenced by intentional (arising from reasoning involving attitudes and perceived norms) and unintentional (i.e., habitual) processes. In order to pass the generative sufficiency test as an explanation of alcohol use, we argue that the theory should be able to explain notable patterns in alcohol use that exist in the population, e.g., the distinct differences in drinking prevalence and average quantities consumed by males and females. In this study, we further develop and apply inverse generative social science (iGSS) methods to an existing agent-based model of dual process theory of alcohol use. Using iGSS, implemented within a multi-objective grammar-based genetic program, we search through the space of model structures to identify whether a single parsimonious model can best explain both male and female drinking, or whether separate and more complex models are needed. Focusing on alcohol use trends in New York State, we identify an interpretable model structure that achieves high goodness-of-fit for both male and female drinking patterns simultaneously, and which also validates successfully against reserved trend data. This structure offers a novel interpretation of the role of norms in formulating drinking intentions, but the structure's theoretical validity is questioned by its suggestion that individuals with low autonomy would act against perceived descriptive norms. Improved evidence on the distribution of autonomy in the population is needed to understand whether this finding is substantive or is a modeling artefact

Component-based design of multi-objective evolutionary algorithms using the Tigon optimization library

Multi-objective optimization problems involve several conflicting objectives that have to be optimized simultaneously. Generating a complete Pareto-optimal front (POF) can be computationally expensive or even infeasible, and for that reason there has been an enormous interest in using multi-objective evolutionary algorithms (MOEAs), which are known to generate a good approximation of the POF. MOEAs can be difficult to implement, and even for experienced optimization experts it can be a very time consuming task. For this reason several optimization libraries exist in the literature, providing off-the-shelf access to the most popular MOEAs. Some optimization libraries also provide a framework to design MOEAs. However, existing frameworks can be too stringent and do not provide sufficient flexibility for the design of more sophisticated MOEAs. To address this, a recently proposed optimization library, known as Tigon, features a component-based framework for the design of MOEAs with a focus on flexibility and re-usability. This paper demonstrates the generality of this new framework by showing how to implement different types of MOEAs, covering several paradigms in evolutionary computation. The work in this paper serves as a guide for researchers, and others alike, to build their own MOEAs by using the Tigon optimization library

Methods for constrained optimization of expensive mixed-integer multi-objective problems, with application to an internal combustion engine design problem

Engineering design optimization problems increasingly require computationally expensive high-fidelity simulation models to evaluate candidate designs. The evaluation budget may be small, limiting the effectiveness of conventional multi-objective evolutionary algorithms. Bayesian optimization algorithms (BOAs) are an alternative approach for expensive problems but are underdeveloped in terms of support for constraints and non-continuous design variables—both of which are prevalent features of real-world design problems. This study investigates two constraint handling strategies for BOAs and introduces the first BOA for mixed-integer problems, intended for use on a real-world engine design problem. The new BOAs are empirically compared to their closest competitor for this problem—the multi-objective evolutionary algorithm NSGA-II, itself equipped with constraint handling and mixed-integer components. Performance is also analysed on two benchmark problems which have similar features to the engine design problem, but are computationally cheaper to evaluate. The BOAs offer statistically significant convergence improvements of between 5.9% and 31.9% over NSGA-II across the problems on a budget of 500 design evaluations. Of the two constraint handling methods, constrained expected improvement offers better convergence than the penalty function approach. For the engine problem, the BOAs identify improved feasible designs offering 36.4% reductions in nitrogen oxide emissions and 2.0% reductions in fuel consumption when compared to a notional baseline design. The use of constrained mixed-integer BOAs is recommended for expensive engineering design optimization problems

Liger : a cross-platform open-source integrated optimization and decision-making environment

Real-world optimization problems involving multiple conflicting objectives are commonly best solved using multi-objective optimization as this provides decision-makers with a family of trade-off solutions. However, the complexity of using multi-objective optimization algorithms often impedes the optimization process. Knowing which optimization algorithm is the most suitable for the given problem, or even which setup parameters to pick, requires someone to be an optimization specialist. The lack of supporting software that is readily available, easy to use and transparent can lead to increased design times and increased cost. To address these challenges, Liger is presented. Liger has been designed for ease of use in industry by non-specialists in optimization. The user interacts with Liger via a visual programming language to create an optimization workflow, enabling the user to solve an optimization problem. Liger contains a novel optimization library known as Tigon. The library utilizes the concept of design patterns to enable the composition of optimization algorithms by making use of simple reusable operator nodes. The library offers a varied range of multi-objective evolutionary algorithms which cover different paradigms in evolutionary computation; and supports a wide variety of problem types, including support for using more than one programming language at a time to implement the optimization model. Additionally, Liger functionality can be easily extended by plugins that provide access to state-of-the-art visualization tools and are responsible for managing the graphical user interface. Lastly, new user-driven interactive capabilities are shown to facilitate the decision-making process and are demonstrated on a control engineering optimization problem

Efeito da adição de sulfato de amônio sobre a produção de ácido succínico durante a fermentação alcoólica

Succinic acid production by yeasts during alcoholic fermentation of cane molasse supplemented with 25, 50 and 100 ppm of nitrogen in the form of ammonium sulfate was determined by gas-liquid chromatography. Ethanol production was not effected by the different levels of nitrogen, but there was a significant reduction in the content of succinic acid which was inversely related with the ammonium sulfate concentration in the medium.A produção de ácido succínico por leveduras durante a fermentação alcoólica de mosto de melaço suplementado com 25, 50 e 100 ppm de nitrogênio na forma de sulfato de amônio foi determinada por cromatografia em fase gasosa. A adição de nitrogênio amoniacal não afetou significativamente a produção de álcool etílico. Houve redução significativa no teor de ácido succínico com o aumento da quantidade de nitrogênio adicionada

Age at symptom onset and death and disease duration in genetic frontotemporal dementia : an international retrospective cohort study

Background: Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a third of cases being genetic. Most of this genetic component is accounted for by mutations in GRN, MAPT, and C9orf72. In this study, we aimed to complement previous phenotypic studies by doing an international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72. Methods: In this international, retrospective cohort study, we collected data on age at symptom onset, age at death, and disease duration for patients with pathogenic mutations in the GRN and MAPT genes and pathological expansions in the C9orf72 gene through the Frontotemporal Dementia Prevention Initiative and from published papers. We used mixed effects models to explore differences in age at onset, age at death, and disease duration between genetic groups and individual mutations. We also assessed correlations between the age at onset and at death of each individual and the age at onset and at death of their parents and the mean age at onset and at death of their family members. Lastly, we used mixed effects models to investigate the extent to which variability in age at onset and at death could be accounted for by family membership and the specific mutation carried. Findings: Data were available from 3403 individuals from 1492 families: 1433 with C9orf72 expansions (755 families), 1179 with GRN mutations (483 families, 130 different mutations), and 791 with MAPT mutations (254 families, 67 different mutations). Mean age at symptom onset and at death was 49\ub75 years (SD 10\ub70; onset) and 58\ub75 years (11\ub73; death) in the MAPT group, 58\ub72 years (9\ub78; onset) and 65\ub73 years (10\ub79; death) in the C9orf72 group, and 61\ub73 years (8\ub78; onset) and 68\ub78 years (9\ub77; death) in the GRN group. Mean disease duration was 6\ub74 years (SD 4\ub79) in the C9orf72 group, 7\ub71 years (3\ub79) in the GRN group, and 9\ub73 years (6\ub74) in the MAPT group. Individual age at onset and at death was significantly correlated with both parental age at onset and at death and with mean family age at onset and at death in all three groups, with a stronger correlation observed in the MAPT group (r=0\ub745 between individual and parental age at onset, r=0\ub763 between individual and mean family age at onset, r=0\ub758 between individual and parental age at death, and r=0\ub769 between individual and mean family age at death) than in either the C9orf72 group (r=0\ub732 individual and parental age at onset, r=0\ub736 individual and mean family age at onset, r=0\ub738 individual and parental age at death, and r=0\ub740 individual and mean family age at death) or the GRN group (r=0\ub722 individual and parental age at onset, r=0\ub718 individual and mean family age at onset, r=0\ub722 individual and parental age at death, and r=0\ub732 individual and mean family age at death). Modelling showed that the variability in age at onset and at death in the MAPT group was explained partly by the specific mutation (48%, 95% CI 35\u201362, for age at onset; 61%, 47\u201373, for age at death), and even more by family membership (66%, 56\u201375, for age at onset; 74%, 65\u201382, for age at death). In the GRN group, only 2% (0\u201310) of the variability of age at onset and 9% (3\u201321) of that of age of death was explained by the specific mutation, whereas 14% (9\u201322) of the variability of age at onset and 20% (12\u201330) of that of age at death was explained by family membership. In the C9orf72 group, family membership explained 17% (11\u201326) of the variability of age at onset and 19% (12\u201329) of that of age at death. Interpretation: Our study showed that age at symptom onset and at death of people with genetic frontotemporal dementia is influenced by genetic group and, particularly for MAPT mutations, by the specific mutation carried and by family membership. Although estimation of age at onset will be an important factor in future pre-symptomatic therapeutic trials for all three genetic groups, our study suggests that data from other members of the family will be particularly helpful only for individuals with MAPT mutations. Further work in identifying both genetic and environmental factors that modify phenotype in all groups will be important to improve such estimates. Funding: UK Medical Research Council, National Institute for Health Research, and Alzheimer's Society

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries