655 research outputs found
Operation of Faddeev-Kernel in Configuration Space
We present a practical method to solve Faddeev three-body equations at
energies above three-body breakup threshold as integral equations in coordinate
space. This is an extension of previously used method for bound states and
scattering states below three-body breakup threshold energy. We show that
breakup components in three-body reactions produce long-range effects on
Faddeev integral kernels in coordinate space, and propose numerical procedures
to treat these effects. Using these techniques, we solve Faddeev equations for
neutron-deuteron scattering to compare with benchmark solutions.Comment: 20 pages, 8 figures, to be published in Few-Body System
Characterization of Intrinsic Properties of Promoters.
Accurate characterization of promoter behavior is essential for the rational design of functional synthetic transcription networks such as logic gates and oscillators. However, transcription rates observed from promoters can vary significantly depending on the growth rate of host cells and the experimental and genetic contexts of the measurement. Furthermore, in vivo measurement methods must accommodate variation in translation, protein folding, and maturation rates of reporter proteins, as well as metabolic load. The external factors affecting transcription activity may be considered to be extrinsic, and the goal of characterization should be to obtain quantitative measures of the intrinsic characteristics of promoters. We have developed a promoter characterization method that is based on a mathematical model for cell growth and reporter gene expression and exploits multiple in vivo measurements to compensate for variation due to extrinsic factors. First, we used optical density and fluorescent reporter gene measurements to account for the effect of differing cell growth rates. Second, we compared the output of reporter genes to that of a control promoter using concurrent dual-channel fluorescence measurements. This allowed us to derive a quantitative promoter characteristic (ρ) that provides a robust measure of the intrinsic properties of a promoter, relative to the control. We imposed different extrinsic factors on growing cells, altering carbon source and adding bacteriostatic agents, and demonstrated that the use of ρ values reduced the fraction of variance due to extrinsic factors from 78% to less than 4%. This is a simple and reliable method to quantitatively describe promoter properties.TJR was supported by a Microsoft Research studentship and EC FP7 Project No. 612146 (PLASWIRES) awarded to JH, JRB by a Microsoft Research studentship and internship, and FF by CONICYT-PAI/Concurso Nacional de Apoyo al Retorno de Investigadores/as desde el Extranjero Folio 8213002 7, and EPSRC grant EP/H019162/1 awarded to JH. JWA acknowledges the EPSRC and the Wellcome Trust for support.This is the author accepted manuscript. The final version is available from ACS via http://dx.doi.org/10.1021/acssynbio.5b0011
Progress in Development of the Analogue Read-out Chip for Silicon Strip Detector Modules for LHC Experiments
Ethics, space, and somatic sensibilities: comparing relationships between scientific researchers and their human and animal experimental subjects
Drawing on geographies of affect and nature-society relations, we propose a radical rethinking of how scientists, social scientists, and regulatory agencies conceptualise human and animal participants in scientif ic research. The scientific rationale for using animal bodies to simulate what could be done in human bodies emphasises shared somatic capacities that generate comparable responses to clinical interventions. At the same time, regulatory guidelines and care practices stress the differences between human and animal subjects. In this paper we consider the implications of this differentiation between human and animal bodies in ethical and welfare protocols and practices. We show how the bioethical debates around the use of human subjects tend to focus on issues of consent and language, while recent work in animal welfare reflects an increasing focus on the affectual dimensions of ethical practice. We argue that this attention to the more-than-representational dimensions of ethics and welfare might be equally important for human subjects. We assert that paying attention to these somatic sensibilities can offer insights into how experimental environments can both facilitate and restrict the development of more care-full and response-able relations between researchers and their experimental subjects. <br/
S-, P- and D-wave resonances in positronium-sodium and positronium-potassium scattering
Scattering of positronium (Ps) by sodium and potassium atoms has been
investigated employing a three-Ps-state coupled-channel model with Ps(1s,2s,2p)
states using a time-reversal-symmetric regularized electron-exchange model
potential fitted to reproduce accurate theoretical results for PsNa and PsK
binding energies. We find a narrow S-wave singlet resonance at 4.58 eV of width
0.002 eV in the Ps-Na system and at 4.77 eV of width 0.003 eV in the Ps-K
system. Singlet P-wave resonances in both systems are found at 5.07 eV of width
0.3 eV. Singlet D-wave structures are found at 5.3 eV in both systems. We also
report results for elastic and Ps-excitation cross sections for Ps scattering
by Na and K.Comment: 9 pages, 5 figures, Accepted in Journal of Physics
Analogue read-out chip for Si strip detector modules for LHC experiments
We present a 128-channel analogue front-end chip SCTA128 for readout of silicon strip detectors employed in the inner tracking detectors of LHC experiments. The architecture of the chip and critical design issues are discussed. The performance of the chip has been evaluated in detail in bench tests and is presented in the paper. The chip is used to read out prototype analogue modules compatible in size, functionality and performance with the ATLAS SCT base line modules. Several full size detector modules equipped with SCTA128 chips have been built and tested successfully in the lab with E particles as well as in beam tests
An Instrument For Investigation of the Cosmic Microwave Background Radiation at Intermediate Angular Scales
We describe an off-axis microwave telescope for observations of the
anisotropy in the cosmic microwave background (CMB) radiation on angular scales
between 0.5 deg and 3 deg. The receiver utilizes cryogenic
high-electron-mobility transistor (HEMT) amplifiers and detects the total power
in multiple 3 GHz wide channels. Both frequency and polarization information
are recorded allowing discrimination between CMB radiation and potential
foreground sources and allowing checks for systematic effects. The instrumental
radiometric offset is small (~1 mK). Data are taken by rapidly sampling while
sweeping the beam many beamwidths across the sky. After detection, a
spatio-temporal filter is formed in software which optimizes the sensitivity in
a multipole band in the presence of atmospheric fluctuations. Observations were
made from Saskatoon, Saskatchewan (SK), Canada during the winter of 1993 with
six channels between 27.6 and 34.0 GHz, in 1994 with twelve channels between
27.6 and 44.1 GHz, and in 1995 with six channels between 38.2 and 44.1 GHz. The
performance of the instrument and assessment of the atmospheric noise at this
site are discussed.Comment: latex file is called inst.tex. 30 pages with 14 Postscript figures.
Uses aas2pp4.sty (included). Submitted to Ap
Electron exchange model potential: Application to positronium-helium scattering
The formulation of a suitable nonlocal model potential for electron exchange
is presented, checked with electron-hydrogen and electron-helium scattering,
and applied to the study of elastic and inelastic scattering and ionization of
ortho positronium (Ps) by helium. The elastic scattering and the
excitations of Ps are investigated using a three-Ps-state close-coupling
approximation. The higher () excitations and ionization of Ps atom are
treated in the framework of Born approximation with present exchange.
Calculations are reported of phase shifts, and elastic, Ps-excitation, and
total cross sections. The present target elastic total cross section agrees
well with experimental results at thermal to medium energies.Comment: 16 latex pages, 7 postscript figure
Single-sex schistosome infections of definitive hosts: Implications for epidemiology and disease control in a changing world
Measurement of spin-exchange effects in electron-hydrogen collisions: Further studies of impact ionization
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