Measuring the Hubble Constant with the Hubble Space Telescope

Ten years ago our team completed the Hubble Space Telescope Key Project on the extragalactic distance scale. Cepheids were detected in some 25 galaxies and used to calibrate four secondary distance indicators that reach out into the expansion field beyond the noise of galaxy peculiar velocities. The result was H_0 = 72 +/- 8 km/sec/Mpc and put an end to galaxy distances uncertain by a factor of two. This work has been awarded the Gruber Prize in Cosmology for 2009.Comment: Gruber Prize Lecture to be published in Transactions of the IA

Technology applications

A summary of NASA Technology Utilization programs for the period of 1 December 1971 through 31 May 1972 is presented. An abbreviated description of the overall Technology Utilization Applications Program is provided as a background for the specific applications examples. Subjects discussed are in the broad headings of: (1) cancer, (2) cardiovascular disease, (2) medical instrumentation, (4) urinary system disorders, (5) rehabilitation medicine, (6) air and water pollution, (7) housing and urban construction, (8) fire safety, (9) law enforcement and criminalistics, (10) transportation, and (11) mine safety

Hybrid-learning for social design

Underlying causes of conflict, inequity, and injustice remain deeply entrenched in the lives of people ranging from impoverished villages to overpopulated megalopolises. To help address these complex issues, social design brings together designers from varying disciplines to address the needs of the community. While universities across the world recognize the need to introduce social design pedagogy into their curriculum, many programs remain confined within Western post-graduate education. In response, two multidisciplinary professors initiated a team-taught \u27Design for Social Change\u27 course in an undergraduate design program in Dubai, UAE. Open to students across disciplines, the course followed a hybrid-learning approach to planning, conducting, and evaluating learning activities. The methodology empowered students to determine their project interest, cooperatively build research, and value their diverse skills. This paper introduces the notion of hybrid-learning, collabor-active team-teaching in an interdisciplinary classroom, and applies the methodology to a social design course in the MENA region. This paper has been presented as part of the Tasmeem Exploration Platform during Tasmeem Conference, Doha, 2013

Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer.

Progenitor cells are considered an important cell of origin of human malignancies. However, there has not been any single gene that can define mammary bipotential progenitor cells, and as such it has not been possible to use genetic methods to introduce oncogenic alterations into these cells in vivo to study tumorigenesis from them. Keratin 6a is expressed in a subset of mammary luminal epithelial cells and body cells of terminal end buds. By generating transgenic mice using the Keratin 6a (K6a) gene promoter to express tumor virus A (tva), which encodes the receptor for avian leukosis virus subgroup A (ALV/A), we provide direct evidence that K6a(+) cells are bipotential progenitor cells, and the first demonstration of a non-basal location for some biopotential progenitor cells. These K6a(+) cells were readily induced to form mammary tumors by intraductal injection of RCAS (an ALV/A-derived vector) carrying the gene encoding the polyoma middle T antigen. Tumors in this K6a-tva line were papillary and resembled the normal breast-like subtype of human breast cancer. This is the first model of this subtype of human tumors and thus may be useful for preclinical testing of targeted therapy for patients with normal-like breast cancer. These observations also provide direct in vivo evidence for the hypothesis that the cell of origin affects mammary tumor phenotypes

Inelastic Diffraction and Spectroscopy of Very Weakly Bound Clusters

We study the coherent inelastic diffraction of very weakly bound two body clusters from a material transmission grating. We show that internal transitions of the clusters can lead to new separate peaks in the diffraction pattern whose angular positions determine the excitation energies. Using a quantum mechanical approach to few body scattering theory we determine the relative peak intensities for the diffraction of the van der Waals dimers (D_2)_2 and H_2-D_2. Based on the results for these realistic examples we discuss the possible applications and experimental challenges of this coherent inelastic diffraction technique.Comment: 15 pages + 5 figures. J. Phys. B (in press

Using Tree Rings to Predict the Response of Tree Growth to Climate Change in the Continental United States during the Twenty-First Century

In the early 1900s, tree-ring scientists began analyzing the relative widths of annual growth rings preserved in the cross sections of trees to infer past climate variations. Now, many ring-width index (RWI) chronologies, each representing a specific site and species, are archived online within the International Tree-Ring Data Bank (ITRDB). Comparing annual tree-ring-width data from 1097 sites in the continental United States to climate data, the authors quantitatively evaluated how trees at each site have historically responded to interannual climate variations. For each site, they developed a climate-driven statistical growth equation that uses regional climate variables to model RWI values. The authors applied these growth models to predict how tree growth will respond to twenty-first-century climate change, considering four climate projections. Although caution should be taken when extrapolating past relationships with climate into the future, the authors observed several clear and interesting patterns in the growth projections that seem likely if warming continues. Most notably, the models project that productivity of dominant tree species in the southwestern United States will decrease substantially during this century, especially in warmer and drier areas. In the northwest, nonlinear growth relationships with temperature may lead to warming-induced declines in growth for many trees that historically responded positively to warmer temperatures. This work takes advantage of the unmatched temporal length and spatial breath of annual growth data available within the ITRDB and exemplifies the potential of this ever-growing archive of tree-ring data to serve in meta-analyses of large-scale forest ecology

Influence of retardation effects on 2D magnetoplasmon spectrum

Within dissipationless limit the magnetic field dependence of magnetoplasmon spectrum for unbounded 2DEG system found to intersect the cyclotron resonance line, and, then approaches the frequency given by light dispersion relation. Recent experiments done for macroscopic disc-shape 2DEG systems confirm theory expectations.Comment: 2 pages,2 figure

Tracking system analytic calibration activities for the Mariner Mars 1971 mission

Data covering various planning aspects of Mariner Mars 1971 mission are summarized. Data cover calibrating procedures for tracking stations, radio signal propagation in the troposphere, effects of charged particles on radio transmission, orbit calculation, and data smoothing

Systems, interactions and macrotheory

A significant proportion of early HCI research was guided by one very clear vision: that the existing theory base in psychology and cognitive science could be developed to yield engineering tools for use in the interdisciplinary context of HCI design. While interface technologies and heuristic methods for behavioral evaluation have rapidly advanced in both capability and breadth of application, progress toward deeper theory has been modest, and some now believe it to be unnecessary. A case is presented for developing new forms of theory, based around generic “systems of interactors.” An overlapping, layered structure of macro- and microtheories could then serve an explanatory role, and could also bind together contributions from the different disciplines. Novel routes to formalizing and applying such theories provide a host of interesting and tractable problems for future basic research in HCI