1,897 research outputs found
Questing for Algebraic Mass Dimension One Spinor Fields
This work deals with new classes of spinors of mass dimension one in
Minkowski spacetime. In order to accomplish it, the Lounesto classification
scheme and the inversion theorem are going to be used. The algebraic framework
shall be revisited by explicating the central point performed by the Fierz
aggregate. Then the spinor classification is generalized in order to encompass
the new mass dimension one spinors. The spinor operator is shown to play a
prominent role to engender the new mass dimension one spinors, accordingly.Comment: 7 pages, final version to appear in Eur. Phys. J.
On the bilinear covariants associated to mass dimension one spinors
In this paper we approach the issue of Clifford algebra basis deformation,
allowing for bilinear covariants associated to Elko spinors which satisfy the
Fierz-Pauli-Kofink identities. We present a complete analysis of covariance,
taking into account the involved dual structure associated to Elko. Moreover,
the possible generalizations to the recently presented new dual structure are
performed.Comment: 9 pages, 0 figure
On the Spinor Representation
A systematic study of the spinor representation by means of the fermionic
physical space is accomplished and implemented. The spinor representation space
is shown to be constrained by the Fierz-Pauli-Kofink identities among the
spinor bilinear covariants. A robust geometric and topological structure can be
manifested from the spinor space, wherein, for instance, the first and second
homotopy groups play prominent roles on the underlying physical properties,
associated to the fermionic fields.Comment: 16 page
Pre-pregnancy maternal obesity associates with endoplasmic reticulum stress in human umbilical vein endothelium
Obesity associates with the endoplasmic reticulum (ER) stress-induced endothelial dysfunction. Pregnant women with pre-pregnancy maternal obesity (PGMO) may transfer this potential risk to their offspring; however, whether ER stress occurs and associates with foetoplacental endothelial dysfunction in PGMO is unknown. We studied the l-arginine transport and nitric oxide (NO) synthesis in human umbilical vein endothelial cells (HUVECs) from women with PGMO or with a normal pre-pregnancy weight. We analysed the expression and activation of the ER stress sensors protein kinase RNA-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1α (IRE1α), and activating transcription factor 6 (ATF6). PGMO associated with lower endothelial NO synthase activity due to increased Thr-inhibitor and decreased Ser-stimulator phosphorylation. However, higher expression and activity of the human cationic amino acid transporter 1 was found. PGMO caused activation of PERK and its downstream targets eukaryotic initiation factor 2 (eIF2α), C/EBP homologous protein 10 (CHOP), and tribbles-like protein 3 (TRB3). Increased IRE1α protein abundance (but not its phosphorylation or X-box binding protein 1-mRNA splicing) and increased c-Jun N-terminal kinase 1 phosphorylation was seen in PGMO. A preferential nuclear location of the activating transcription factor 6 (ATF6) was found in HUVECs from PGMO. All the changes seen in PGMO were blocked by TUDCA but unaltered by tunicamycin. Thus, PGMO may determine a state of ER stress via upregulation of the PERK-eIF2α-CHOP-TRB3 axis signalling in HUVECs. This phenomenon results in foetoplacental vascular endothelial dysfunction at birth
Hailstorm events in the Central Andes of Peru: insights from historical data and radar microphysics
Hailstorms, while fascinating from a meteorological perspective, pose significant risks to communities, agriculture, and infrastructure. In regions such as the Central Andes of Peru, the characteristics and frequency of these extreme weather events remain largely uncharted. This study fills this gap by investigating the historical frequency and vertical structure of hailstorms in this region. We analyzed historical hailstorm records dating back to 1958 alongside 4 years of observations (2017â2021) from the Parsivel2 disdrometer and a cloud-profiling radar MIRA35c. Our findings indicate a trend of decreasing hail frequency (â0.5 events per decade). However, the p value of 0.07 suggests the need for further investigation, particularly in relation to environmental changes and reporting methods. The results show that hailstorms predominantly occur during the austral summer months, with peak frequency in December, and are most common during the afternoon and early evening hours. The analysis of radar variables such as reflectivity, radial velocity, spectral width, and linear depolarization ratio (LDR) reveals distinct vertical profiles for hail events. Two case studies highlight the diversity in the radar measurements of hailstorms, underscoring the complexity of accurate hail detection. This study suggests the need for refining the Parsivel2 algorithm and further understanding its classification of hydrometeors. Additionally, the limitations of conventional radar variables for hail detection are discussed, recommending the use of LDR and Doppler spectrum analysis for future research. Our findings lay the groundwork for the development of more efficient hail detection algorithms and improved understanding of hailstorms in the Central Andes of Peru.</p
Thin disc, Thick Disc and Halo in a Simulated Galaxy
Within a cosmological hydrodynamical simulation, we form a disc galaxy with
sub- components which can be assigned to a thin stellar disc, thick disk, and a
low mass stellar halo via a chemical decomposition. The thin and thick disc
populations so selected are distinct in their ages, kinematics, and
metallicities. Thin disc stars are young (<6.6 Gyr), possess low velocity
dispersion ({\sigma}U,V,W = 41, 31, 25 km/s), high [Fe/H], and low [O/Fe]. The
thick disc stars are old (6.6<age<9.8 Gyrs), lag the thin disc by \sim21 km/s,
possess higher velocity dispersion ({\sigma}U,V,W = 49, 44, 35 km/s),
relatively low [Fe/H] and high [O/Fe]. The halo component comprises less than
4% of stars in the "solar annulus" of the simulation, has low metallicity, a
velocity ellipsoid defined by ({\sigma}U,V,W = 62, 46, 45 km/s) and is formed
primarily in-situ during an early merger epoch. Gas-rich mergers during this
epoch play a major role in fuelling the formation of the old disc stars (the
thick disc). This is consistent with studies which show that cold accretion is
the main source of a disc galaxy's baryons. Our simulation initially forms a
relatively short (scalelength \sim1.7 kpc at z=1) and kinematically hot disc,
primarily from gas accreted during the galaxy's merger epoch. Far from being a
competing formation scenario, migration is crucial for reconciling the short,
hot, discs which form at high redshift in {\Lambda}CDM, with the properties of
the thick disc at z=0. The thick disc, as defined by its abundances maintains
its relatively short scale-length at z = 0 (2.31 kpc) compared with the total
disc scale-length of 2.73 kpc. The inside-out nature of disc growth is
imprinted the evolution of abundances such that the metal poor {\alpha}-young
population has a larger scale-length (4.07 kpc) than the more chemically
evolved metal rich {\alpha}-young population (2.74 kpc).Comment: Submitted to MNRAS. This version after helpful referee comments.
Comments welcome to [email protected]
Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations - a study protocol from the clinical and applied research in Chikungunya (REPLICK network)
BACKGROUND: Chikungunya is associated with high morbidity and the natural history of symptomatic infection has been divided into three phases (acute, post-acute, and chronic) according to the duration of musculoskeletal symptoms. Although this classification has been designed to help guide therapeutic decisions, it does not encompass the complexity of the clinical expression of the disease and does not assist in the evaluation of the prognosis of severity nor chronic disease. Thus, the current challenge is to identify and diagnose musculoskeletal disorders and to provide the optimal treatment in order to prevent perpetuation or progression to a potentially destructive disease course. METHODS: The study is the first product of the Clinical and Applied Research Network in Chikungunya (REPLICK). This is a prospective, outpatient department-based, multicenter cohort study in Brazil. Four work packages were defined: i. Clinical research; ii) Translational Science - comprising immunology and virology streams; iii) Epidemiology and Economics; iv) Therapeutic Response and clinical trials design. Scheduled appointments on days 21 (D21)â±â7 after enrollment, D90â±â15, D120â±â30, D180â±â30; D360â±â30; D720â±â60, and D1080â±â60 days. On these visits a panel of blood tests are collected in addition to the clinical report forms to obtain data on socio-demographic, medical history, physical examination and questionnaires devoted to the evaluation of musculoskeletal manifestations and overall health are performed. Participants are asked to consent for their specimens to be maintained in a biobank. Aliquots of blood, serum, saliva, PAXgene, and when clinically indicated to be examined, synovial fluid, are stored at -80° C. The study protocol was submitted and approved to the National IRB and local IRB at each study site. DISCUSSION: Standardized and harmonized patient cohorts are needed to provide better estimates of chronic arthralgia development, the clinical spectra of acute and chronic disease and investigation of associated risk factors. This study is the largest evaluation of the long-term sequelae of individuals infected with CHIKV in the Brazilian population focusing on musculoskeletal manifestations, mental health, quality of life, and chronic pain. This information will both define disease burden and costs associated with CHIKV infection, and better inform therapeutic guidelines
Is the Milky Way ringing? The hunt for high velocity streams
We perform numerical simulations of a stellar galactic disk with initial
conditions chosen to represent an unrelaxed population which might have been
left following a merger. Stars are unevenly distributed in radial action angle,
though the disk is axisymmetric. The velocity distribution in the simulated
Solar neighborhood exhibits waves traveling in the direction of positive v,
where u,v are the radial and tangential velocity components. As the system
relaxes and structure wraps in phase space, the features seen in the uv-plane
move closer together. We show that these results can be obtained also by a
semi-analytical method. We propose that this model could provide an explanation
for the high velocity streams seen in the Solar neighborhood at approximate v
in km/s, of -60 (HR 1614), -80 (Arifyanto and Fuchs 2006), -100 (Arcturus), and
-160 (Klement et al. 2008). In addition, we predict four new features at v ~
-140, -120, 40 and 60 km/s. By matching the number and positions of the
observed streams, we estimate that the Milky Way disk was strongly perturbed
~1.9 Gyr ago. This event could have been associated with Galactic bar
formation.Comment: 5 pages, 4 figures, Accepted to MNRAS Letters, added reference
Multiplicity dependence of jet-like two-particle correlations in p-Pb collisions at = 5.02 TeV
Two-particle angular correlations between unidentified charged trigger and
associated particles are measured by the ALICE detector in p-Pb collisions at a
nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum
range 0.7 5.0 GeV/ is examined,
to include correlations induced by jets originating from low
momen\-tum-transfer scatterings (minijets). The correlations expressed as
associated yield per trigger particle are obtained in the pseudorapidity range
. The near-side long-range pseudorapidity correlations observed in
high-multiplicity p-Pb collisions are subtracted from both near-side
short-range and away-side correlations in order to remove the non-jet-like
components. The yields in the jet-like peaks are found to be invariant with
event multiplicity with the exception of events with low multiplicity. This
invariance is consistent with the particles being produced via the incoherent
fragmentation of multiple parton--parton scatterings, while the yield related
to the previously observed ridge structures is not jet-related. The number of
uncorrelated sources of particle production is found to increase linearly with
multiplicity, suggesting no saturation of the number of multi-parton
interactions even in the highest multiplicity p-Pb collisions. Further, the
number scales in the intermediate multiplicity region with the number of binary
nucleon-nucleon collisions estimated with a Glauber Monte-Carlo simulation.Comment: 23 pages, 6 captioned figures, 1 table, authors from page 17,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/161
- âŠ