On deriving p-mode parameters for inclined solar-like stars

Thanks to their high quality, new and upcoming asteroseismic observations - with CoRoT, Kepler, and from the ground... - can benefit from the experience gained with helioseismology. We focus in this paper on solar-like oscillations, for which the inclination of the rotation axis is unknown. We present a theoretical study of the errors of p-mode parameters determined by means of a maximum-likelihood estimator, and we also analyze correlations and biases. We have used different, complementary approaches: we have performed either semi-analytical computation of the Hessian matrix, fitting of single mean profiles, or Monte Carlo simulations. We give first analytical approximations for the errors of frequency, inclination and rotational splitting. The determination of the inclination is very challenging for the common case of slow rotators (like the Sun), making difficult the determination of a reliable rotational splitting. Moreover, due to the numerous correlations, biases - more or less significant - can appear in the determination of various parameters in the case of bad inclination fittings, especially when a locking at 90 degrees occurs. This issue concerning inclination locking is also discussed. Nevertheless, the central frequency and some derived parameters such as the total power of the mode are free of such biases.Comment: 9 pages, 6 figures, to appear in A&

Comparison of standardised versus non-standardised methods for testing the in vitro potency of oxytetracycline against mannheimia haemolytica and pasteurella multocida

The in vitro pharmacodynamics of oxytetracycline was established for six isolates of each of the calf pneumonia pathogens Mannheimia haemolytica and Pasteurella multocida. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and bacterial time-kill curves were determined in two matrices, Mueller Hinton broth (MHB) and calf serum. Geometric mean MIC ratios, serum:MHB, were 25.2:1 (M. haemolytica) and 27.4:1 (P. multocida). The degree of binding of oxytetracycline to serum protein was 52.4%. Differences between serum and broth MICs could not be accounted for by oxytetracycline binding to serum protein. In vitro time-kill data suggested a co-dependent killing action of oxytetracycline. The in vitro data indicate inhibition of the killing action of oxytetracycline by serum factor(s). The nature of the inhibition requires further study. The outcome of treatment with oxytetracycline of respiratory tract infections in calves caused by M. haemolytica and P. multocida may not be related solely to a direct killing action

Mercury emissions and stable isotopic compositions at Vulcano Island (Italy)

Sampling and analyses methods for determining the stable isotopic compositions of Hg in an active volcanic system were tested and optimized at the volcanic complex of Vulcano (Aeolian Islands, Italy). Condensed gaseous fumarole Hg(fum) T , plume gaseous elemental Hg(g) 0 and plume particulate Hg(p) II were obtained at fumaroles F0, F5, F11, and FA. The average total Hg emissions, based on HgT/SO2 in condensed fumarolic gases and plumes, range from 2.5 to 10.1 kg y−1, in agreement with published values [Ferrara, R., Mazzolai, B., Lanzillotta, E., Nucaro, E., Pirrone, N., 2000. Volcanoes as emission sources of atmospheric mercury in the Mediterranean Basin. Sci. Total Environ. 259(1–3), 115–121; Aiuppa, A., Bagnato, E., Witt, M.L.I., Mather, T.A., Parello, F., Pyle, D.M., Martin, R.S., 2007. Real-time simultaneous detection of volcanic Hg and SO2 at La Fossa Crater, Vulcano (Aeolian Islands, Sicily). Geophys. Res. Lett. 34(L21307).]. Plume Hg(p) II increases with distance from the fumarole vent, at the expense of Hg(g) 0 and indicates significant in-plume oxidation and condensation of fumarole Hg(fum) T . Relative to the NIST SRM3133 Hg standard, the stable isotopic compositions of Hg are δ202Hg(fum) T =−0.74‰±0.18 (2SD, n=4) for condensed gaseous fumarole Hg(fum) T , δ202Hg(g) 0 =−1.74‰±0.36 (2SD, n=1) for plume gaseous elemental Hg(g) 0 at the F0 fumarole, and δ202Hg(p) II =−0.11‰±0.18 (2SD, n=4) for plume particulate Hg(p) II . The enrichment of Hg(p) II in the heavy isotopes and Hg(g) 0 in the light isotopes relative to the total condensed fumarolic Hg(fum) T gas complements the speciation data and demonstrates a gas-particle fractionation occurring after the gas expulsion inambient T° atmosphere. A first order Rayleigh equilibriumcondensation isotope fractionation model yields a fractionation factor αcond-gas of 1.00135±0.00058

Mission agropastoralisme et production fourragère dans le Sud-Ouest de Madagascar du 15 novembre eu 6 décembre 1996

La mission a rencontré des éleveurs des régions de Morondava, Tuléar, Sakaraha, Ampanihy, Ambovombe et Fort-Dauphin. L'élevage extensif des bovins est traditionnellement très développé dans cette région de Madagascar. Dans la moitié nord, les ressources fourragères sont suffisamment abondantes en quantité, même si la qualité est insuffisante une partie de l'année. Dans la moitié sud, la plus aride, les pâturages sont insuffisants. Dans ce contexte du sud, les élevages de petits ruminants peuvent trouver leur place et se développer. Sur l'ensemble de la région, l'abreuvement des animaux pose des questions. Dans le nord, l'eau ne manque pas mais des aménagements de mares seraient nécessaires. Dans le sud, les travaux d'hydraulique pastorale entrepris dans la région d'Ampanihy répondent à un besoin exprimé par les éleveurs et sont entrepris dans le cadre d'une approche participative intéressante. La gestion des ressources naturelles en pâturages passe par une meilleure utilisation des feux. L'appui du projet aux élevages laitiers concerne seulement les animaux croisés et devraient s'intéresser aussi aux troupeaux de zébus. Une grande attention doit être portée à la façon dont ces femelles laitières sont alimentée

Modulation of sodium-coupled uptake and membrane fluidity by cisplatin in renal proximal tubular cells in primary culture and brush-border membrane vesicles

Modulation of sodium-coupled uptake and membrane fluidity by cisplatin in renal proximal tubular cells in primary culture and brush-border membrane vesicles. The proximal tubule appears to be the main target for the adverse effects of cis-diamminedichloroplatinum (II) (cDDP). We evaluated the early effects of cDDP at concentrations (3 to 67 µM) lower that those which alter cell viability, on three apical transport systems and on the physical state of the brush border membrane (BBM) in rabbit proximal tubule (RPT) cells in primary culture. The maximal effect, corresponding to a 30% decrease in Na+-coupled uptake of phosphate (Pi) and α-methylglucopyranoside (MGP) and a twofold increase in Na+-coupled alanine uptake, was obtained at 17 µM (5 µg/ml) cDDP and occurred through a modification of their affinity. At this concentration, cDDP increased BBM fluidity and decreased the BBM cholesterol content by 28%, without increasing the permeability of tight junctions. To clarify the role of cDDP-induced increase in BBM fluidity on alterations of Na+-coupled uptake, these parameters were also investigated in BBM vesicles isolated from rabbit renal cortex directly exposed to cDDP. cDDP induced a concentration-dependent inhibition of Na+-coupled uptake of MGP, Pi and alanine in BBM vesicles from the renal cortex, associated with a decrease in protein sulfhydryl content, without modifying BBM fluidity. Our findings strongly suggest that the cDDP-induced increase in BBM fluidity in RPT cells results from an indirect mechanism, possibly an alteration of cholesterol metabolism, and did not play a major role in the cDDP-induced inhibition of Na+/Pi and Na+/ glucose cotransport systems that may be mainly mediated through a direct chemical interaction with essential sulfhydryl groups of the transporters

Exoplanets or Dynamic Atmospheres? The Radial Velocity and Line Shape Variations of 51 Pegasi and Tau Bootis

Because of our relatively low spectral resolution, we compare our observations with Gray's line bisector data by fitting observed line profiles to an expansion in terms of orthogonal (Hermite) functions. To obtain an accurate comparison, we model the emergent line profiles from rotating and pulsating stars, taking the instrumental point spread function into account. We describe this modeling process in detail. We find no evidence for line profile or strength variations at the radial velocity period in either 51 Peg or in Tau Boo. For 51 Peg, our upper limit for line shape variations with 4.23-day periodicity is small enough to exclude with 10 sigma confidence the bisector curvature signal reported by Gray & Hatzes; the bisector span and relative line depth signals reported by Gray (1997) are also not seen, but in this case with marginal (2 sigma) confidence. We cannot, however, exclude pulsations as the source of 51 Peg's radial velocity variation, because our models imply that line shape variations associated with pulsations should be much smaller than those computed by Gray & Hatzes; these smaller signals are below the detection limits both for Gray & Hatzes' data and for our own. Tau Boo's large radial velocity amplitude and v*sin(i) make it easier to test for pulsations in this star. Again we find no evidence for periodic line-shape changes, at a level that rules out pulsations as the source of the radial velocity variability. We conclude that the planet hypothesis remains the most likely explanation for the existing data.Comment: 44 pages, 19 figures, plain TeX, accepted to ApJS (companion to letter astro-ph/9712279

Oscillation frequencies and mode lifetimes in alpha Centauri A

We analyse our recently-published velocity measurements of alpha Cen A (Butler et al. 2004). After adjusting the weights on a night-by-night basis in order to optimize the window function to minimize sidelobes, we extract 42 oscillation frequencies with l=0 to 3 and measure the large and small frequency separations. We give fitted relations to these frequencies that can be compared with theoretical models and conclude that the observed scatter about these fits is due to the finite lifetimes of the oscillation modes. We estimate the mode lifetimes to be 1-2 d, substantially shorter than in the Sun.Comment: Accepted by Ap

Calculation of Spectral Darkening and Visibility Functions for Solar Oscillations

Calculations of spectral darkening and visibility functions for the brightness oscillations of the Sun resulting from global solar oscillations are presented. This has been done for a broad range of the visible and infrared continuum spectrum. The procedure for the calculations of these functions includes the numerical computation of depth-dependent derivatives of the opacity caused by p modes in the photosphere. A radiative-transport code was used for this purpose to get the disturbances of the opacities from temperature and density fluctuations. The visibility and darkening functions are obtained for adiabatic oscillations under the assumption that the temperature disturbances are proportional to the undisturbed temperature of the photosphere. The latter assumption is the only way to explore any opacity effects since the eigenfunctions of p-mode oscillations have not been obtained so far. This investigation reveals that opacity effects have to be taken into account because they dominate the violet and infrared part of the spectrum. Because of this dominance, the visibility functions are negative for those parts of the spectrum. Furthermore, the darkening functions show a wavelength-dependent change of sign for some wavelengths owing to these opacity effects. However, the visibility and darkening functions under the assumptions used contradict the observations of global p-mode oscillations, but it is beyond doubt that the opacity effects influence the brightness fluctuations of the Sun resulting from global oscillations

Quantitative kinetics and enthalpy measurements of biphasic underflow chemical reactions by InfraRed Thermography

Abstract The scope of this paper is to present the experimental study of a well known chemical reaction in a biphasic millifluidic droplet flow by using InfraRed Thermography. This simple thermal evaluation enables the characterization of kinetics and enthalpy of exothermic chemical reactions. The originality of this work is the application of a very simple thermal model based on an homogenized thin body approximation to perform calorimetric estimations. This novel calorimeter needs a thermal calibration step to estimate the heat losses (W). Then, a correlation method is applied for the simultaneous estimation of the heat source (φ) and the characteristic coefficient due the convective effects (H). Here the estimation of the characteristic coefficient H (s −1 ) is done at each flow rate ratio (R). This procedure is applied for several chemical reaction performed at different flow rate ratios. Then, the enthalpy is estimated with an error lower than 2%. In addition, the methodology to estimate the mixing kinetics of the reaction can be pointed out by the integrated flux over the time. Finally, a non contact thermal calorimeter based on millifluidic and IR thermography was developed. It is a convenient and powerful tool for the characterization of chemical reaction performed in a droplet flow

Pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida

Pharmacokinetic-pharmacodynamic (PK/PD) integration and modelling were used to predict dosage schedules for florfenicol for two pig pneumonia pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida. Pharmacokinetic data were pooled for two bioequivalent products, pioneer and generic formulations, administered intramuscularly to pigs at a dose rate of 15 mg/kg. Antibacterial potency was determined in vitro as minimum inhibitory concentration (MIC) and Mutant Prevention Concentration in broth and pig serum, for six isolates of each organism. For both organisms and for both serum and broth MICs, average concentration:MIC ratios over 48 h were similar and exceeded 2.5:1 and times greater than MIC exceeded 35 h. From in vitro time-kill curves, PK/PD modelling established serum breakpoint values for the index AUC24h/MIC for three levels of inhibition of growth, bacteriostasis and 3 and 4log10 reductions in bacterial count; means were 25.7, 40.2 and 47.0 h, respectively, for P. multocida and 24.6, 43.8 and 58.6 h for A. pleuropneumoniae. Using these PK and PD data, together with literature MIC distributions, doses for each pathogen were predicted for: (1) bacteriostatic and bactericidal levels of kill; (2) for 50 and 90% target attainment rates (TAR); and (3) for single dosing and daily dosing at steady state. Monte Carlo simulations for 90% TAR predicted single doses to achieve bacteriostatic and bactericidal actions over 48 h of 14.4 and 22.2 mg/kg (P. multocida) and 44.7 and 86.6 mg/kg (A. pleuropneumoniae). For daily doses at steady state, and 90% TAR bacteriostatic and bactericidal actions, dosages of 6.2 and 9.6 mg/kg (P. multocida) and 18.2 and 35.2 mg/kg (A. pleuropneumoniae) were required. PK/PD integration and modelling approaches to dose determination indicate the possibility of tailoring dose to a range of end-points