Complexes of stationary domain walls in the resonantly forced Ginsburg-Landau equation

The parametrically driven Ginsburg-Landau equation has well-known stationary solutions -- the so-called Bloch and Neel, or Ising, walls. In this paper, we construct an explicit stationary solution describing a bound state of two walls. We also demonstrate that stationary complexes of more than two walls do not exist.Comment: 10 pages, 2 figures, to appear in Physical Review

KANDUNGAN ESCHERICHIA COLI DAN KONDISI FISIK SUMUR GALI DI KELURAHAN KAKASKASEN III LINGKUNGAN III KECAMATAN TOMOHON UTARA KOTA TOMOHON

Sumber air bersih yang digunakan penduduk di Indonesia umumnya yaitu sumur gali terlindung (29%), sumur pompa (24%), dan air ledeng/PDAM (19%). Air sumur gali beresiko tercemar E.coli bila lokasi sumur terletak dekat dengan sumber pencemar dan /atau memiliki kondisi fisik yang tidak sesuai dengan syarat kesehatan. Tujuan dari penelitian ini untuk mengetahui kandungan E.coli air sumur gali dan kondisi fisik sumur gali di Kelurahan Kakaskasen III Lingkungan III Kecamatan Tomohon Utara Kota Tomohon. Penelitian ini merupakan survey deskriptif berbasis laboratorium. Populasi berjumlah 68 sumur. Sampel berjumlah 20 sampel sumur yang diperoleh secara purposive sampling. Kandungan E.coli ditentukan melalui pemeriksaan laboratorium. Kondisi fisik sumur gali ditentukan menggunakan instrumen check list. Data dianalisis secara deskriptif berpatokan pada distribusi frekuensi dan persentase. Hasil penelitian menunjukkan bahwa dari 20 sampel air sumur gali terdapat 1 sampel (5%) yang positif mengandung E.coli dan 19 sampel (95%) tidak mengandung E.coli. terdapat 15 sumur gali (75%) yang kondisi fisiknya tidak memenuhi syarat dan 5 lainnya (25%) memenuhi syarat. Kesimpulan penelitian ini yaitu 1 sumur galli (5%) mengandung E.coli sehingga tidak memenuhi syarat kesehatan. Terdapat 15 sumur gali (75%) memiliki kondisi fisik yang tidak sesuai degan persyaratan kesehatan dengan demikian beresiko tercemar.Kata Kunci: Sumur Gali, Kandungan EscherichiaColi, Kondisi FisikABSTRACTSource of clean water that generally used by public in Indonesia was protected dug wells (29 %), pump well (24 %), tap water/PDAM (19%). Dug well water has risk of being contaminated by E.coli if the well is located near the polluter source and/or has inappropriate physical condition with health requirement. The objective of this research is to find out about E.coli's content of dug well water and physical condition of dug well water in Kakaskasen III Ward III Subdistrict North Tomohon Subdistrict, Tomohon City. This research is descriptive survey laboratory-based. Total population 68 wells. Total sample 20 wells obtained by purposive sampling. E.coli content determined by laboratory- test. Physical condition of dug well determined by using check list instrument. Descriptive data analysis based on frequency distribution and percentage.The result of the research showed that from 20 samples of dug wells water there was 1 sample (5 %) positively contain E.coli and 19 samples (95 %) does not contain E.coli. There was 15 dug wells (75%) that the physical condition inappropriate with the requirement and the other 5 (25%) is appropriate. The conclusion of this research was 1 (5%) dug well contain E.coli so that it was inappropriate with health requirements. There was 15 (75 %) dug wells has physical condition that inapproriate with health requirements so that has a risk of being contaminated.Keywords:Well Dug, Escherichia coli Content, Physic Conditio

Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity

The molecular chaperone Heat shock protein 90 (Hsp90) is essential for the folding, stability, and activity of several drivers of oncogenesis. Hsp90 inhibitors are currently under clinical evaluation for cancer treatment, however their efficacy is limited by lack of biomarkers to optimize patient selection. We have recently identified the tumor suppressor tuberous sclerosis complex 1 (Tsc1) as a new co-chaperone of Hsp90 that affects Hsp90 binding to its inhibitors. Highly variable mutations of TSC1 have been previously identified in bladder cancer and correlate with sensitivity to the Hsp90 inhibitors. Here we showed loss of TSC1 leads to hypoacetylation of Hsp90-K407/K419 and subsequent decreased binding to the Hsp90 inhibitor ganetespib. Pharmacologic inhibition of histone deacetylases (HDACs) restores acetylation of Hsp90 and sensitizes Tsc1-mutant bladder cancer cells to ganetespib, resulting in apoptosis. Our findings suggest that TSC1 status may predict response to Hsp90 inhibitors in patients with bladder cancer, and co-targeting HDACs can sensitize tumors with Tsc1 mutations to Hsp90 inhibitors

Initial experience in treating lung cancer with helical tomotherapy

Helical tomotherapy is a new form of image-guided radiation therapy that combines features of a linear accelerator and a helical computed tomography (CT) scanner. Megavoltage CT (MVCT) data allow the verification and correction of patient setup on the couch by comparison and image registration with the kilovoltage CT multi-slice images used for treatment planning. An 84-year-old male patient with Stage III bulky non-small cell lung cancer was treated on a Hi-ART II tomotherapy unit. Daily MVCT imaging was useful for setup corrections and signaled the need to adapt the delivery plan when the patient’s anatomy changed significantly

Developing music teacher identities: an international multi-site study

This study investigates pre-service music teacher’s (PSMT) perceptions of their professional identities. University-level education students in the United States America (USA), Spain and Australia were all asked interview questions based on general themes relevant to teacher identity development, and their responses were subjected to content analysis. Similarities were found in their perceptions of the role of ‘music teacher’ and their pre-university experiences/influences. Across the sites it seems that there was a dynamic and shifting relationship between PSMTs’ understandings of themselves as ‘musicians’ or as ‘teachers’ during their university years. This study confirms previous research in the area and contributes to the field in its discovery that these themes are found across three international sites. Implications of the findings are discussed and recommendations made for future research and practice

Activity of different desoximetasone preparations compared to other topical corticosteroids in the vasoconstriction assay

Introduction: We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical bioavailability of different topical corticosteroid formulations in healthy human beings focussing on desoximetasone (DM). Materials and Methods: Two DM 0.25% formulations {[}ointment (DM-o) and fatty ointment (DM-fo, water-free); class III corticosteroids], the corresponding active ingredient-free vehicles and three comparators of different strength {[}clobetasol propionate 0.05% (CP 0.05%), fatty ointment, class IV; hydrocortisone (HC) 1%, fatty ointment, class I, and betamethasone (BM) 0.05%, fatty ointment, class III] were tested using the vasoconstriction assay. The degree of vasoconstriction (blanching) in the treatment field was compared to the one found in untreated control fields using chromametric measurements and clinical assessment. Results/Conclusion: DM-o 0.25%, DM-fo 0.25% and BM 0.05% showed similar vasoconstrictive potential, i.e., clear blanching. In fact, both DM preparations were proven to be non-inferior to BM 0.05%, while CP 0.05% was found a little less active. HC 1.0% and the DM vehicles showed no clear-cut vasoconstrictive effect. No adverse events related to the study medications were observed. Good topical bioavailability of both DM formulations was detected by chromametric measurement and clinical assessment. Copyright (C) 2008 S. Karger AG, Basel

Behavioural activation written self-help to improve mood, wellbeing and quality of life in people with dementia supported by informal carers (PROMOTE): study protocol for a single-arm feasibility study.

Background: Increases in life expectancy have resulted in a global rise in dementia prevalence. Dementia is associated with poor wellbeing, low quality of life and increased incidence of mental health difficulties such as, low mood or depression. However, currently there is limited access to evidence-based psychological interventions for people with dementia experiencing low mood and poor wellbeing. Behavioural activation-based self-help, supported by informal carers and guided by mental health professionals, may represent an effective and acceptable solution. Methods/design: The present study is a Phase II (feasibility) single-arm trial informed by the MRC Complex Interventions Research Methods Framework. Up to fifty dementia participant/informal carer dyads will be recruited from a variety of settings including primary care, dementia-specific health settings, and community outreach. People living with dementia will receive behavioural activation based self-help and be supported by their informal carer who has received training in the skills required to support the self-help approach. In turn, during the use of the intervention the informal carer will be guided by mental health professionals to help them work through the materials and problem solve any difficulties. Consistent with the objectives of feasibility studies, outcomes relating to recruitment from different settings, employment of different recruitment methods, attrition, data collection procedures, clinical delivery and acceptability of the intervention will be examined. Clinical outcomes for people with dementia (symptoms of depression and quality of life) and informal carers (symptoms of depression and anxiety, carer burden and quality of life) will be measured pretreatment and at 3 months post-treatment allocation. Discussion: This study will examine the feasibility and acceptability of a novel behavioural activation-based self-help intervention designed to promote wellbeing and improve low mood in people living with dementia, alongside methodological and procedural uncertainties associated with research-related procedures. As determined by pre-specified progression criteria, if research procedures and the new intervention demonstrate feasibility and acceptability, results will then be used to inform the design of a pilot randomised controlled trial (RCT) to specifically examine remaining methodological uncertainties associated with recruitment into a randomised controlled design.This study is collaboratively funded by Cornwall Foundation Partnership Trust, South West Peninsula Academic Health Sciences Network and the University of Exeter

Exact solutions to the four Goldstone modes around a dark soliton of the nonlinear Schroedinger equation

This article is concerned with the linearisation around a dark soliton solution of the nonlinear Schr\"odinger equation. Crucially, we present analytic expressions for the four linearly-independent zero eigenvalue solutions (also known as Goldstone modes) to the linearised problem. These solutions are then used to construct a Greens matrix which gives the first-order spatial response due to some perturbation. Finally we apply this Greens matrix to find the correction to the dark-soliton wavefunction of a Bose-Einstein condensate in the presence of fluctuations.Comment: 14 pages, 3 figures, submitted to Journal of Physics

Can plastic pollution drive the emergence and dissemination of novel zoonotic diseases?

As the volume of plastic in the environment increases, so too does human interactions with plastic pollution. Similarly, domestic, feral, and wild animals are increasingly interacting with plastic pollution, highlighting the potential for contamination of plastic wastes with animal faeces, urine, saliva, and blood. Substantial evidence indicates that once in the environment, plastics rapidly become colonised by microbial biofilm (the so-called ‘plastisphere), which often includes potentially harmful microbial pathogens (including pathogens that are zoonotic in nature). Climate change, increased urbanisation, and the intensification of agriculture, mean that the three-way interactions between humans, animals, and plastic pollution are becoming more frequent, which is significant as almost 60% of emerging human infectious diseases during the last century have been zoonotic. Here, we critically review the potential for contaminated environmental plastics to facilitate the evolution of novel pathogenic strains of microorganisms, and the subsequent role of plastic pollution in the cyclical dissemination of zoonotic pathogens. As the interactions between humans, animals, and plastic pollution continues to grow, and the volume of plastics entering the environment increases, there is clearly an urgent need to better understand the role of plastic waste in facilitating zoonotic pathogen evolution and dissemination, and the effect this can have on environmental and human health