The Demise Of Silicon Graphics Explicated By A Structural Functionalist

It has been asserted that positivism is the philosophical basis of research in the field of Information Systems by Goles and Hirschheim. This is seen as problematic in an area that undergoes swift and constant change because of its technological nature. The rise and fall of Silicon Graphics Incorporated (SGI) is the focus of this paper. The mechanism for explaining change is the action theory of Talcott Parsons, a structural functionalist, whose theory, in turn, is attacked for the inability to account facilely for change.

Google Glass FOR THE Educator: A Postmortem Separating the Reality From the Hype and Some Thoughts for Google

The article offers information on the wearable technology Google Glass and its potential for the education market. Topics include the history of Project Glass when it was announced in April 2012 to its end in January 2015, the flaws of first Glass version from Wi-Fi access requirements to poor quality video and audio capture, and the use of Glass from video tours to interviews

So, You Want to Be an Adjunct Professor?: The Processes, Perils, and Potential

The American Bar Association’s “50 Simple Ways to Market Your Practice” includes as No. 43 “do adjunct professor work.” In addition, law school economics and restructurings are creating new opportunities for adjunct professor work. If you are intrigued by the possibility of adjunct teaching, now may be just the time to explore such an opportunity with a law school. Law students routinely report high interest and satisfaction with courses taught by practicing attorneys. Yet these successful teaching experiences don’t just happen! There are a number of things to consider before sending your resume to the Dean of your local law school. This article describes best practices to help ensure a successful outcome for an attorney interested in adjunct professor work. Incorporating the best practices in this article into your adjunct teaching will create the learning environment students are seeking, enhance your teaching experience, and leverage this networking and career development opportunity. A decision tree/flow chart is included as an Appendix to the article to assist in determining whether to “do adjunct professor work.

Temperature-Dependent Effects of Cutaneous Bacteria on a Frog’s Tolerance of Fungal Infection

Defense against pathogens is one of many benefits that bacteria provide to animal hosts. A clearer understanding of how changes in the environment affect the interactions between animals and their microbial benefactors is needed in order to predict the impact and dynamics of emerging animal diseases. Due to its dramatic effects on the physiology of animals and their pathogens, temperature may be a key variable modulating the level of protection that beneficial bacteria provide to their animal hosts. Here we investigate how temperature and the makeup of the skin microbial community affect the susceptibility of amphibian hosts to infection by Batrachochytrium dendrobatidis (Bd), one of two fungal pathogens known to cause the disease chytridiomycosis. To do this, we manipulated the skin bacterial communities of susceptible hosts, northern cricket frogs (Acris crepitans), prior to exposing these animals to Bd under two different ecologically relevant temperatures. Our manipulations included one treatment where antibiotics were used to reduce the skin bacterial community, one where the bacterial community was augmented with the antifungal bacterium, Stenotrophomonas maltophilia, and one in which the frog’s skin bacterial community was left intact. We predicted that frogs with reduced skin bacterial communities would be more susceptible (i.e., less resistant to and/or tolerant of Bd infection), and frogs with skin bacterial communities augmented with the known antifungal bacterium would be less susceptible to Bd infection and chytridiomycosis. However, we also predicted that this interaction would be temperature dependent. We found a strong effect of temperature but not of skin microbial treatment on the probability and intensity of infection in Bd-exposed frogs. Whether temperature affected survival; however, it differed among our skin microbial treatment groups, with animals having more S. maltophilia on their skin surviving longer at 14 but not at 26°C. Our results suggest that temperature was the predominant factor influencing Bd’s ability to colonize the host (i.e., resistance) but that the composition of the cutaneous bacterial community was important in modulating the host’s ability to survive (i.e., tolerate) a heavy Bd infection

The influence of 2- chlorodeoxyadenosine in combination with tumour necrosis factor-α or its mutein on murine leukaemias L1210 and P388

We investigated the influence of 2-chlorodeoxyadenosine (2-CdA) in combination with tumour necrosis factor-α (TNFα) or its mutein VI, which differs from the native molecule by N-terminal amino acid composition, on the survival time of mice inoculated with leukaemia L1210 or P388. Groups of mice with leukaemia L1210 and P388 receiving 2-CdA combined with TNFα had shorter survival times than animals treated with these agents separately. In contrast, the administration of 2-CdA in conjunction with mutein VI, prolonged the survival of mice inoculated with these leukaemias as compared with animals receiving these agents separately. The results of the present study emphasize the importance of the biological activity of the TNFα molecule N-terminus

Let\u27s Teach Our Students Legal Technology... But What Should We Include?

A renaissance” is often described as a cultural rebirth, a movement ushering in a modern age and leaving behind the old ways of doing things. There is every indication that we are entering a technology-driven renaissance in the legal profession. Artificial intelligence (AI), “big data,” document automation, e-discovery tools, cloud-based case management systems, and communication and collaboration tools are just a few of the ways that technology is transforming the practice of law in the twenty-first century

A comparison of the Antileukaemic Effects of Recombinant Human Tumour Necrosis Factor-α and its Muteins on Leukaemia L1210 and Leukaemia P388 in Mice

We investigated the influence of recombinant human tumour necrosis factor alpha (TNF-α) and its derivatives termed muteins III, V, VI—in which the first 3 to 7 amino acids of native TNF-α have been replaced—on the survival time of mice inoculated with leukaemia L1210 or leukaemia P338. TNF-α prolonged the survival of mice with leukaemia L1210 but did not have any therapeutic activity in leukaemia P388-bearing mice. Muteins-treated mice with leukaemia P388 lived longer than animals receiving TNF-α, while those inoculated with leukaemia L1210 did not show any significant prolongation of life compared with the TNF-α treated group. The results presented in this report indicate that the antileukaemic activity of TNF-α is governed at least in part by the nature of the N-terminal amino acids