Serum 25-hydroxyvitamin D, parathyroid hormone, calcium intake, and bone mineral density in Spanish adults

Summary Vitamin D insufficiency is very common among Spanish community-dwelling adult subjects. A threshold of serum 25(OH)D around 30 ng/ml would be necessary for the prevention of secondary hyperparathyroidism and hip bone loss in our population, regardless of the dairy calcium ingestion. Introduction This study aims to assess 25-hydroxyvitamin D?25(OH)D?status in Spanish adult subjects and to analyze its relationships with serum PTH levels, calcium intake, and bone mineral density (BMD). Methods A total of 1811 individuals (1154 postmenopausal women and 657 men) aged 44?93 years participated in the study. Serum 25(OH)D, intact parathyroid hormone (PTH), aminoterminal propeptide of type I collagen (P1NP), and Cterminal telopeptide of type I collagen (?-CTX) levels were measured by electrochemiluminescence. BMD was determined by dual x-ray absorptiometry (DXA) at lumbar spine, femoral neck, and total hip. Results Serum 25(OH)D levels were below 10, 20, and 30 ng/ml in 5, 40, and 83%of participants, respectively. There was a significant seasonal difference in mean serum 25(OH)D, with higher levels in summer?autumn. In multivariate analysis, 25(OH)D levels were negatively correlated with age, serum PTH and creatinine, body mass index, smoking, alcohol intake, and a number of chronic diseases, but positively with dairy calcium intake. The magnitude of the difference in serum PTH according to 25(OH)D quartiles was not influenced by calcium intake. A threshold of serum 25(OH)D around 30 ng/ml was observed for serum PTH and hip BMD. Conclusions Vitamin D insufficiency is very common among Spanish community-dwelling adult subjects. A threshold of serum 25(OH)D around 30 ng/ml would be necessary for the prevention of secondary hyperparathyroidism and hip bone loss in our population, regardless of the dairy calcium ingestion. Programs to improve vitamin D status may be required in our country

Evaluation of Analytical Methods to Study Aquifer Properties with Pumping Tests in Coastal Aquifers with Numerical Modelling (Motril-Salobreña Aquifer)

Two pumping tests were performed in the unconfined Motril-Salobreña detrital aquifer in a 250 m-deep well 300 m from the coastline containing both freshwater and saltwater. It is an artesian well as it is in the discharge zone of this coastal aquifer. The two observation wells where the drawdowns are measured record the influence of tidal fluctuations, and the well lithological columns reveal high vertical heterogeneity in the aquifer. The Theis and Cooper-Jacob approaches give average transmissivity (T) and storage coefficient (S) values of 1460 m2 /d and 0.027, respectively. Other analytical solutions, modified to be more accurate in the boundary conditions found in coastal aquifers, provide similar T values to those found with the Theis and Cooper-Jacob methods, but give very different S values or could not estimate them. Numerical modelling in a synthetic model was applied to analyse the sensitivity of the Theis and Cooper-Jacob approaches to the usual boundary conditions in coastal aquifers. The T and S values calculated from the numerical modelling drawdowns indicate that the regional flow, variable pumping flows, and tidal effect produce an error of under 10 % compared to results obtained with classic methods. Fluids of different density (freshwater and saltwater) cause an error of 20 % in estimating T and of over 100 % in calculating S. The factor most affecting T and S results in the pumping test interpretation is vertical heterogeneity in sediments, which can produce errors of over 100 % in both parameters.This research has been financed by Project CGL2012-32892 (Ministerio de Economía y Competitividad of Spain) and by the Research Group Sedimentary Geology and Groundwater (RNM-369) of the Junta de Andalucía

Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study

Background: The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. Methods: We did a prospective cohort study across 23 hospitals in Spain. We included patients aged 18 years or older with laboratory-confirmed SARS-CoV-2 infection who were admitted to an intensive care unit between March 16, 2020, and Feb 27, 2021. RNA of the SARS-CoV-2 nucleocapsid region 1 (N1) was quantified in plasma samples collected from patients in the first 48 h following admission, using digital PCR. Patients were grouped on the basis of N1 quantity: VIR-N1-Zero ([removed]2747 N1 copies per mL). The primary outcome was all-cause death within 90 days after admission. We evaluated odds ratios (ORs) for the primary outcome between groups using a logistic regression analysis. Findings: 1068 patients met the inclusion criteria, of whom 117 had insufficient plasma samples and 115 had key information missing. 836 patients were included in the analysis, of whom 403 (48%) were in the VIR-N1-Low group, 283 (34%) were in the VIR-N1-Storm group, and 150 (18%) were in the VIR-N1-Zero group. Overall, patients in the VIR-N1-Storm group had the most severe disease: 266 (94%) of 283 patients received invasive mechanical ventilation (IMV), 116 (41%) developed acute kidney injury, 180 (65%) had secondary infections, and 148 (52%) died within 90 days. Patients in the VIR-N1-Zero group had the least severe disease: 81 (54%) of 150 received IMV, 34 (23%) developed acute kidney injury, 47 (32%) had secondary infections, and 26 (17%) died within 90 days (OR for death 0·30, 95% CI 0·16–0·55; p<0·0001, compared with the VIR-N1-Storm group). 106 (26%) of 403 patients in the VIR-N1-Low group died within 90 days (OR for death 0·39, 95% CI 0·26–0·57; p[removed]11 página

Characterization of the functioning of the Motril-Salobrena coastal aquifer (SE Spain) through the use of environmental tracers

Environmental tracers were used to characterize the origin and determine the age of the groundwater in the Motril–Salobreña aquifer (south-eastern Spain). The stable isotope concentrations (δ18O/δ2H), compared to the results obtained in previous studies, indicate that most of the recharge during the sampling period was from irrigation return flow and the carbonate Escalate aquifer. The combined dating of 3H, 3He, 4He, 85Kr, and 39Ar allowed establishing the presence of modern water throughout the aquifer, although with different mixing percentages. Thus, there is a large zone characterized by a fluvial domain with 100% young waters ( 170 years), and the percentage of young water is reduced (22.5%). This is explained by the greater distance that groundwater travels (aquifer thicknesses is over 250 m) and the lower permeability of the aquifer in the deeper sectors

Groundwater age dating in Motril-Salobreña Coastal aquifer with environmental tracers (δ18O/δ2H, 3H/3He, 4He, 85Kr, and 39Ar)

Congress on Groundwater and Global Change in the Western Mediterranean (2017. Granada)The Motril-Salobreña coastal aquifer (SE Spain) is under high anthropogenic pressure due to the changes in river infiltration, irrigation and pumping. There are several uncertainties regarding how groundwater flows from the recharge areas to the discharge areas, and how long groundwater circulates in the aquifer due to the presence of layers with different hydraulic conductivity. This study constrains the age distribution in the aquifer by dating water samples taken at three different locations (recharge sector, intermediate sector and discharge sector) and at variable depths. The environmental tracers used were δ18O/δ2H, 4He, 3H/3He, 85Kr, and 39Ar. The groundwater dating allows to define the flow distri bution and preferential flowpaths, to determine the mean groundwater residence times in the system and to establish the connection between age distribution and saltwater intrusion processes. Mean groundwater residence times range from recent to ~170 years, with the presence of young water in almost all the areas of the aquifer at a shallow depth and an age gradient at deeper locations in the discharge zone. The presence of the salt wedge increases the age mixing processes. The groundwater flow in the shallow part of the aquifer (0-50 m depth) turns out to be fast, with a residence time lower than 5 years, while the flow in the deeper parts (50-150 m depth) is slower and groundwater has at least 170 years.Departamento de Geodinámica, Universidad de Granada, EspañaClimate and Environmental Physics, University of Bern, SuizaDepartment of Geosciences and Natural Resources Management, University of Copenhagen, DinamarcaUnidad de Granada, Instituto Geológico y Minero de España, EspañaInstitute of Environmental Physics, University of Bremen, AlemaniaDepartment of Geological Sciences, University of Delaware, Estados UnidosPeer reviewe

Benchmark analysis of forecasted seasonal temperature over different climatic areas

From a long-term perspective, an improvement of seasonal forecasting, which is often exclusively based on climatology, could provide a new capability for the management of energy resources in a time scale of just a few months. This paper regards a benchmark analysis in relation to long-term temperature forecasts over Italy in the year 2010, comparing the eni-kassandra meteo forecast (e-kmf®) model, the Climate Forecast System–National Centers for Environmental Prediction (CFS-NCEP) model, and the climatological reference (based on 25-year data) with observations. Statistical indexes are used to understand the reliability of the prediction of 2-m monthly air temperatures with a perspective of 12&nbsp;weeks ahead. The results show how the best performance is achieved by the e-kmf® system which improves the reliability for long-term forecasts compared to climatology and the CFS-NCEP model. By using the reliable high-performance forecast system, it is possible to optimize the natural gas portfolio and management operations, thereby obtaining a competitive advantage in the European energy market