965 research outputs found
Feeling of knowing and restudy choices
Feeling-of-knowing judgments (FOK-Js) reflect peopleâs confidence that they would be able to recognize a currently unrecallable item. Although much research has been devoted to the factors determining the magnitude and accuracy of FOK-Js, much less work has addressed the issue of whether FOK-Js are related to any form of metacognitive control over memory processes. In the present study, we tested the hypothesis that FOK-Js are related to participantsâ choices of which unrecallable items should be restudied. In three experiments, we showed that participants tend to choose for restudy items with high FOK-Js, both when they are explicitly asked to choose for restudy items that can be mastered in the restudy session (Exps. 1a and 2) and when such specific instructions are omitted (Exp. 1b). The study further demonstrated that increasing FOK-Js via priming cues affects restudy choices, even though it does not affect recall directly. Finally, Experiment 2 showed the strategy of restudying unrecalled items with high FOK-Js to be adaptive, because the efficacy of restudy is greater for these items than for items with low FOK-Js. Altogether, the present findings underscore an important role of FOK-Js for the metacognitive control of study operations
The origin of very wide binary systems
The majority of stars in the Galactic field and halo are part of binary or
multiple systems. A significant fraction of these systems have orbital
separations in excess of thousands of astronomical units, and systems wider
than a parsec have been identified in the Galactic halo. These binary systems
cannot have formed through the 'normal' star-formation process, nor by capture
processes in the Galactic field. We propose that these wide systems were formed
during the dissolution phase of young star clusters. We test this hypothesis
using N-body simulations of evolving star clusters and find wide binary
fractions of 1-30%, depending on initial conditions. Moreover, given that most
stars form as part of a binary system, our theory predicts that a large
fraction of the known wide 'binaries' are, in fact, multiple systems.Comment: 4 pages, 1 figure, to appear in the proceedings of IAU Symposium 266,
eds. R. de Grijs & J.R.D. Lepin
Is our Sun a Singleton?
Most stars are formed in a cluster or association, where the number density
of stars can be high. This means that a large fraction of initially-single
stars will undergo close encounters with other stars and/or exchange into
binaries. We describe how such close encounters and exchange encounters can
affect the properties of a planetary system around a single star. We define a
singleton as a single star which has never suffered close encounters with other
stars or spent time within a binary system. It may be that planetary systems
similar to our own solar system can only survive around singletons. Close
encounters or the presence of a stellar companion will perturb the planetary
system, often leaving planets on tighter and more eccentric orbits. Thus
planetary systems which initially resembled our own solar system may later more
closely resemble some of the observed exoplanet systems.Comment: 2 pages, 1 figure. To be published in the proceedings of IAUS246
"Dynamical Evolution of Dense Stellar Systems". Editors: E. Vesperini (Chief
Editor), M. Giersz, A. Sill
Linear and nonlinear waveguides induced by optical vortex solitons
We study, numerically and analytically, linear and nonlinear waveguides
induced by optical vortex solitons in a Kerr medium. Both fundamental and
first-order guided modes are analyzed, as well as the cases of effectively
defocusing and focusing nonlinearity.Comment: 3 pages, 3 figures, changed conten
RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer
BackgroundMultigene expression assays for molecular subtypes and biomarkers can aid clinical management of early invasive breast cancer. Based on RNA-sequencing we aimed to develop single-sample predictor (SSP) models for conventional clinical markers, molecular intrinsic subtype and risk of recurrence (ROR).MethodsA uniformly accrued breast cancer cohort of 7743 patients with RNA-sequencing data from fresh tissue was divided into a training set and a reserved test set. We trained SSPs for PAM50 molecular subtypes and ROR assigned by nearest-centroid (NC) and SSPs for conventional clinical markers from histopathology data. Additionally, SSP classifications were compared with ProsignaÂź in two external cohorts. Prognostic value was assessed using distant recurrence-free interval.ResultsIn the test set, agreement between SSP and NC classifications for PAM50 (five subtypes) and Subtype (four subtypes) was high (85%, Kappa=0.78) and very high (90%, Kappa=0.84) respectively. Accuracy for ROR risk category was high (84%, Kappa=0.75, weighted Kappa=0.90). The prognostic value for SSP and NC was assessed as equivalent. Agreement for SSP and histopathology was very high or high for receptor status, while moderate and poor for Ki67 status and Nottingham histological grade, respectively. SSP concordance with ProsignaÂź was high for subtype and moderate and high for ROR risk category. In pooled analysis, concordance between SSP and ProsignaÂź for emulated treatment recommendation for chemotherapy (yes vs. no) was high (85%, Kappa=0.66). In postmenopausal ER+/HER2-/N0 patients SSP application suggested changed treatment recommendations for up to 17% of patients, with nearly balanced escalation and de-escalation of chemotherapy.ConclusionsSSP models for histopathological variables, PAM50, and ROR classifications can be derived from RNA-sequencing that closely matches clinical tests. Agreement and outcome analyses suggest that NC and SSP models are interchangeable on a group-level and nearly so on a patient level. Retrospective evaluation in postmenopausal ER+/HER2-/N0 patients suggested that molecular testing could lead to a changed therapy recommendation for almost one-fifth of patients
Dipole-Mode Vector Solitons
We find a new type of optical vector soliton that originates from trapping of
a dipole mode by a soliton-induced waveguide. These solitons, which appear as a
consequence of the vector nature of the two component system, are more stable
than the previously found optical vortex-mode solitons and represent a new type
of extremely robust nonlinear vector structure.Comment: Four pages with five eps figure
Observation of dipole-mode vector solitons
We report on the first experimental observation of a novel type of optical
vector soliton, a {\em dipole-mode soliton}, recently predicted theoretically.
We show that these vector solitons can be generated in a photorefractive medium
employing two different processes: a phase imprinting, and a symmetry-breaking
instability of a vortex-mode vector soliton. The experimental results display
remarkable agreement with the theory, and confirm the robust nature of these
radially asymmetric two-component solitary waves.Comment: 4 pages, 8 figures; pictures in the PRL version are better qualit
Mas-related G-proteinâcoupled receptors inhibit pathological pain in mice
An important objective of pain research is to identify novel drug targets for the treatment of pathological persistent pain states, such as inflammatory and neuropathic pain. Mas-related G-proteinâcoupled receptors (Mrgprs) represent a large family of orphan receptors specifically expressed in small-diameter nociceptive primary sensory neurons. To determine the roles of Mrgprs in persistent pathological pain states, we exploited a mouse line in which a chromosomal locus spanning 12 Mrgpr genes was deleted (KO). Initial studies indicated that these KO mice show prolonged mechanical- and thermal-pain hypersensitivity after hind-paw inflammation compared with wild-type littermates. Here, we show that this mutation also enhances the windup response of dorsal-horn wide dynamic-range neurons, an electrophysiological model for the triggering of central pain sensitization. Deletion of the Mrgpr cluster also blocked the analgesic effect of intrathecally applied bovine adrenal medulla peptide 8â22 (BAM 8â22), an MrgprC11 agonist, on both inflammatory heat hyperalgesia and neuropathic mechanical allodynia. Spinal application of bovine adrenal medulla peptide 8â22 also significantly attenuated windup in wild-type mice, an effect eliminated in KO mice. These data suggest that members of the Mrgpr family, in particular MrgprC11, may constitute an endogenous inhibitory mechanism for regulating persistent pain in mice. Agonists for these receptors may, therefore, represent a class of antihyperalgesics for treating persistent pain with minimal side effects because of the highly specific expression of their targets
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