A rare manifestation of neonatal alloimmune thrombocytopaenia

Neonatal alloimmune thrombocytopaenia (NAIT) results from a fetomaternal incompatibility with maternal sensitisation against a fetal human platelet antigen (HPA) and antibodies transfer to the fetal circulation, leading to platelet destruction. The clinical presentation is variable and isolated intraocular haemorrhage is rare. We present the case of a male newborn, with intrauterine growth restriction, born at 29 weeks due to pre-eclampsia. He presented proptosis of the left eye, hyphaema and elevated intraocular pressure, with no other signs of haemorrhage. Severe thrombocytopaenia was found (27×10(9)/L). Perinatal infection and maternal thrombocytopaenia were excluded. Positive anti-HPA-1a and antihuman leucocyte antigen class I alloantibodies were found in the mother. Platelet crossmatch between the father's platelets and mother's plasma was positive. Platelet transfusions and intravenous immunoglobulin were given with favourable response. This case highlights an unusual presentation of NAIT, which should be suspected in the presence of severe thrombocytopaenia in the first 24-72 h of life

Quantum Gowdy T3T^3 Model: Schrodinger Representation with Unitary Dynamics

The linearly polarized Gowdy $T^3$ model is paradigmatic for studying technical and conceptual issues in the quest for a quantum theory of gravity since, after a suitable and almost complete gauge fixing, it becomes an exactly soluble midisuperspace model. Recently, a new quantization of the model, possessing desired features such as a unitary implementation of the gauge group and of the time evolution, has been put forward and proven to be essentially unique. An appropriate setting for making contact with other approaches to canonical quantum gravity is provided by the Schr\"odinger representation, where states are functionals on the configuration space of the theory. Here we construct this functional description, analyze the time evolution in this context and show that it is also unitary when restricted to physical states, i.e. states which are solutions to the remaining constraint of the theory.Comment: 21 pages, version accepted for publication in Physical Review

A unique Fock quantization for fields in non-stationary spacetimes

In curved spacetimes, the lack of criteria for the construction of a unique quantization is a fundamental problem undermining the significance of the predictions of quantum field theory. Inequivalent quantizations lead to different physics. Recently, however, some uniqueness results have been obtained for fields in non-stationary settings. In particular, for vacua that are invariant under the background symmetries, a unitary implementation of the classical evolution suffices to pick up a unique Fock quantization in the case of Klein-Gordon fields with time-dependent mass, propagating in a static spacetime whose spatial sections are three-spheres. In fact, the field equation can be reinterpreted as describing the propagation in a Friedmann-Robertson-Walker spacetime after a suitable scaling of the field by a function of time. For this class of fields, we prove here an even stronger result about the Fock quantization: the uniqueness persists when one allows for linear time-dependent transformations of the field in order to account for a scaling by background functions. In total, paying attention to the dynamics, there exists a preferred choice of quantum field, and only one $SO(4)$-invariant Fock representation for it that respects the standard probabilistic interpretation along the evolution. The result has relevant implications e.g. in cosmology.Comment: Typos correcte

Uniqueness of the Fock representation of the Gowdy S1×S2S^1\times S^2 and S3S^3 models

After a suitable gauge fixing, the local gravitational degrees of freedom of the Gowdy $S^1\times S^2$ and $S^3$ cosmologies are encoded in an axisymmetric field on the sphere $S^2$. Recently, it has been shown that a standard field parametrization of these reduced models admits no Fock quantization with a unitary dynamics. This lack of unitarity is surpassed by a convenient redefinition of the field and the choice of an adequate complex structure. The result is a Fock quantization where both the dynamics and the SO(3)-symmetries of the field equations are unitarily implemented. The present work proves that this Fock representation is in fact unique inasmuch as, up to equivalence, there exists no other possible choice of SO(3)-invariant complex structure leading to a unitary implementation of the time evolution.Comment: 10 pages, minor changes, version accepted for publication in Classical and Quantum Gravit

Quantum Gowdy T3T^3 model: A unitary description

The quantization of the family of linearly polarized Gowdy $T^3$ spacetimes is discussed in detail, starting with a canonical analysis in which the true degrees of freedom are described by a scalar field that satisfies a Klein-Gordon type equation in a fiducial time dependent background. A time dependent canonical transformation, which amounts to a change of the basic (scalar) field of the model, brings the system to a description in terms of a Klein-Gordon equation on a background that is now static, although subject to a time dependent potential. The system is quantized by means of a natural choice of annihilation and creation operators. The quantum time evolution is considered and shown to be unitary, allowing both the Schr\"odinger and Heisenberg pictures to be consistently constructed. This has to be contrasted with previous treatments for which time evolution failed to be implementable as a unitary transformation. Possible implications for both canonical quantum gravity and quantum field theory in curved spacetime are commented

[The Importance of Early Referral in Pediatric Acute Liver Failure]

INTRODUCTION: Acute liver failure is a rare disorder associated to high morbidity and mortality despite survival improvement through liver transplantation. The importance of a multidisciplinary approach and early referral to a pediatric liver transplantation center were important conclusions of a national meeting in 2008, from which resulted an actuation consensus. OBJECTIVES: To characterize acute liver failure admissions in a Pediatric Intensive Care Unit of the portuguese pediatric livertransplantation center. To compare results before (A) and after (B) 2008. MATERIAL AND METHODS: Observational, retrospective study during a 20 year period (1994-2014). INCLUSION CRITERIA: age < 18 years old and acute liver failure (INR ≥ 2 without vitamin K response and hepatocellular necrosis). Children with previous liver disease were excluded. RESULTS: Fifty children were included, with median age of 24.5 months. The most common etiology under 2 years old was metabolic (34.6%) and above that age was infectious (29.2%). Forty six percent were submitted to liver transplantation and 78% of them survived. Overall mortality was 34%. Median referral time was 7 days in period A (n = 35) and 2 days in period B (n = 15; p = 0.006). Pediatric risk of mortality's median was 14.7 in period A and 6.5 in B (p = 0.019). Mortality was 37% vs 26% in periods A and B, respectively (p = 0.474). DISCUSSION AND CONCLUSIONS: Overall mortality was similar to the observed in other European centers. Liver transplantation is in fact the most effective therapeutic option. After 2008, there was a reduction in referral time and cases severity on admission; however, mortality has not reduced so far.info:eu-repo/semantics/publishedVersio

On the Schroedinger Representation for a Scalar Field on Curved Spacetime

It is generally known that linear (free) field theories are one of the few QFT that are exactly soluble. In the Schroedinger functional description of a scalar field on flat Minkowski spacetime and for flat embeddings, it is known that the usual Fock representation is described by a Gaussian measure. In this paper, arbitrary globally hyperbolic space-times and embeddings of the Cauchy surface are considered. The classical structures relevant for quantization are used for constructing the Schroedinger representation in the general case. It is shown that in this case, the measure is also Gaussian. Possible implications for the program of canonical quantization of midisuperspace models are pointed out.Comment: 11 pages, Revtex, no figure

Monitoring the thermal efficiency of fouled heat exchangers: A simplified method

Fouling is a problem whether we are aware of it or not. In an industrial plant, it is important not only to be able to measure the buildup of unwanted deposits, but also to do it in the simplest and most economically possible way. This paper addresses the question of monitoring fouling in an oil refinery plant, where the high number of heat exchanger units and the variability of the feedstock charge pose additional problems in terms of the practicability of following the energetic performance of such equipment. In this case, the flow rates and quality of the fluids flowing through the heat exchangers do not usually correspond to the design conditions, because they change with time. Therefore, to assess the fouling level of the exchangers, the day-to-day measured thermal efficiency should not be compared with the efficiency predicted in the design calculations. The latter should be recalculated by introducing whenever necessary new values of flow rates, physical properties, and so forth, and by evaluating new heat transfer coefficients. However, the procedures are too time consuming to be applied frequently. The present work describes a simplified method for following heat exchanger performances, based on the assessment of the number of transfer units and thermal efficiencies, where the effects of changing the feedstock charge, particularly the flow rates of the fluids, are taken into account. The only data that need to be collected are the four inlet/outlet temperatures of the heat exchanger unit and one of the flow rates. Several heat exchanger units in an oil refinery were successfully monitored by means of this method, and it was found that the variations in the physical properties did not significantly affect the results obtained for the particular plant under study

Function of cofactor Akirin2 in the regulation of gene expression in model human Caucasian neutrophil-like HL60 cells

The Akirin family of transcription cofactors are involved throughout the metazoan in the regulation of different biological processes (BPs) such as immunity, interdigital regression, muscle and neural development. Akirin do not have catalytic or DNA-binding capability and exert its regulatory function primarily through interacting proteins such as transcription factors, chromatin remodelers, and RNA-associated proteins. In the present study, we focused on the human Akirin2 regulome and interactome in neutrophil-like model human Caucasian promyelocytic leukemia HL60 cells. Our hypothesis is that metazoan evolved to have Akirin2 functional complements and different Akirin2-mediated mechanisms for the regulation of gene expression. To address this hypothesis, experiments were conducted using transcriptomics, proteomics and systems biology approaches in akirin2 knockdown and wildtype (WT) HL60 cells to characterize Akirin2 gene/protein targets, functional complements and to provide evidence of different mechanisms that may be involved in Akirin2-mediated regulation of gene expression. The results revealed Akirin2 gene/protein targets in multiple BPs with higher representation of immunity and identified immune response genes as candidate Akirin2 functional complements. In addition to linking chromatin remodelers with transcriptional activation, Akirin2 also interacts with histone H3.1 for regulation of gene expression. © 2021 The Author(s)