Validation Methods Research for Fault-Tolerant Avionics and Control Systems Sub-Working Group Meeting. CARE 3 peer review

A computer aided reliability estimation procedure (CARE 3), developed to model the behavior of ultrareliable systems required by flight-critical avionics and control systems, is evaluated. The mathematical models, numerical method, and fault-tolerant architecture modeling requirements are examined, and the testing and characterization procedures are discussed. Recommendations aimed at enhancing CARE 3 are presented; in particular, the need for a better exposition of the method and the user interface is emphasized

An application of the multivariate extended Poisson distribution in 2 times 2 contingency tables Final report

Application of multivariate extended Poisson distribution

Validation Methods Research for Fault-Tolerant Avionics and Control Systems: Working Group Meeting, 2

The validation process comprises the activities required to insure the agreement of system realization with system specification. A preliminary validation methodology for fault tolerant systems documented. A general framework for a validation methodology is presented along with a set of specific tasks intended for the validation of two specimen system, SIFT and FTMP. Two major areas of research are identified. First, are those activities required to support the ongoing development of the validation process itself, and second, are those activities required to support the design, development, and understanding of fault tolerant systems

Facile preparation of agarose-chitosan hybrid materials and nanocomposite ionogels using an ionic liquid via dissolution, regeneration and sol-gel transition

We report simultaneous dissolution of agarose (AG) and chitosan (CH) in varying proportions in an ionic liquid (IL), 1-butyl-3-methylimidazolium chloride [C4mim][Cl]. Composite materials were constructed from AG-CH-IL solutions using the antisolvent methanol, and IL was recovered from the solutions. Composite materials could be uniformly decorated with silver oxide (Ag2O) nanoparticles (Ag NPs) to form nanocomposites in a single step by in situ synthesis of Ag NPs in AG-CH-IL sols, wherein the biopolymer moiety acted as both reducing and stabilizing agent. Cooling of Ag NPs-AG-CH-IL sols to room temperature resulted in high conductivity and high mechanical strength nanocomposite ionogels. The structure, stability and physiochemical properties of composite materials and nanocomposites were characterized by several analytical techniques, such as Fourier transform infrared (FTIR), CD spectroscopy, differential scanning colorimetric (DSC), thermogravimetric analysis (TGA), gel permeation chromatography (GPC), and scanning electron micrography (SEM). The result shows that composite materials have good thermal and conformational stability, compatibility and strong hydrogen bonding interactions between AG-CH complexes. Decoration of Ag NPs in composites and ionogels was confirmed by UV-Vis spectroscopy, SEM, TEM, EDAX and XRD. The mechanical and conducting properties of composite ionogels have been characterized by rheology and current-voltage measurements. Since Ag NPs show good antimicrobial activity, Ag NPs -AG-CH composite materials have the potential to be used in biotechnology and biomedical applications whereas nanocomposite ionogels will be suitable as precursors for applications such as quasi-solid dye sensitized solar cells, actuators, sensors or electrochromic displays

High Tc Superconductors -- A Variational Theory of the Superconducting State

We use a variational approach to gain insight into the strongly correlated d-wave superconducting state of the high Tc cuprates at T=0. We show that strong correlations lead to qualitatively different trends in pairing and phase coherence: the pairing scale decreases monotonically with hole doping while the SC order parameter shows a non-monotonic dome. We obtain detailed results for the doping-dependence of a large number of experimentally observable quantities, including the chemical potential, coherence length, momentum distribution, nodal quasiparticle weight and dispersion, incoherent features in photoemission spectra, optical spectral weight and superfluid density. Most of our results are in remarkable quantitative agreement with existing data and some of our predictions, first reported in Phys. Rev. Lett. {\bf 87}, 217002 (2001), have been recently verified.Comment: (Minor revisions, 1 figure added, version to appear in PRB) 23 RevTeX pages, 11 eps figs, long version of cond-mat/0101121, contains detailed comparisons with experiments, analytical insights, technical aspects of the calculation, and comparison with slave boson MF

The Nefarious Nexus of Noncoding RNAs in Cancer

The past decade has witnessed enormous progress, which has seen the noncoding RNAs (ncRNAs) turn from the so called dark matter RNA to critical functional molecules, influencing most physiological processes in development and disease contexts. Many ncRNAs interact with each other and are part of networks that influence the cell transcriptome and proteome and consequently the outcome of biological processes. The regulatory circuits controlled by ncRNAs have become increasingly more relevant in cancer. Further understanding of these complex network interactions and how ncRNAs are regulated, is paving the way for the identification of better therapeutic strategies in cancer