The Probability Density of the Higgs Boson Mass

The LEP Collaborations have reported a small excess of events in their combined Higgs boson analysis at center of mass energies up to about 208 GeV. In this communication, I present the result of a calculation of the probability distribution function of the Higgs boson mass which can be rigorously obtained if the validity of the Standard Model is assumed. It arises from the combination of the most recent set of precision electroweak data and the current results of the Higgs searches at LEP 2.Comment: 3 pages, 2 figure

Interleukin-17 is required for control of chronic lung infection caused by Pseudomonas aeruginosa

Chronic pulmonary infection with Pseudomonas aeruginosa is a feature of cystic fibrosis (CF) and other chronic lung diseases. Cytokines of the IL-17 family have been proposed as important in the host response to P. aeruginosa infection through augmenting antibacterial immune responses, although their pro-inflammatory effect may contribute to lung damage that occurs as a result of chronic infection. We set out to explore the role of IL-17 in the host response to chronic P. aeruginosa infection. We used a murine model of chronic pulmonary infection with CF-related strains of P. aeruginosa. We demonstrate that IL-17 cytokine signaling is essential for survival and prevention of chronic infection at 2 weeks post-inoculation using two different P. aeruginosa strains. Following infection, there was a marked expansion of cells within mediastinal lymph nodes, comprised mainly of innate lymphoid cells (ILCs); ∼90% of IL-17 producing cells had markers consistent with Group 3 ILCs. A smaller percentage of IL-17+ cells had markers consistent with a B1 phenotype. In lung homogenates 14 days following infection, there was a significant expansion of IL-17+ cells – about 50% of these were CD3+, split equally between CD4+ Th17 cells and γδ T cells, while the CD3- IL-17+ cells were almost exclusively Group 3 ILCs. Further experiments with B cell deficient mice showed that B cell production of IL-17 or natural antibodies did not provide any defence against chronic P. aeruginosa infection. Thus, IL-17 rather than antibody is a key element in host defence against chronic pulmonary infection with P. aeruginosa

A randomised control trial assessing the effect of a Mediterranean diet on the symptoms of depression in young men (the "AMMEND" study): A study protocol.

Depression affects approximately 350 million people worldwide. Evidence suggests that diet plays an important role with the Mediterranean diet displaying promising preliminary results. Currently, most of the research is conducted on women and older adults however, the majority of mental illnesses occur before the age of 25. Men are less likely to seek help than women with only 13% of young men aged 15-24 seeking help for their mental health. Young men are hugely underrepresented in the current research which poses a significant issue. A 12-week randomised control trial will be conducted to examine the effect of a Mediterranean diet on the symptoms of depression in young men aged 18-25. Participants will be randomised to either follow a Mediterranean diet or receive the inactive control therapy befriending. Participants will attend 3 appointments at baseline, week 6 and week 12. The main outcome will be changes to the Becks depression Inventory score. This research aims to answer the question of whether diet can be used effectively in this population. This will be the first trial to examine the effect of a Mediterranean diet on the symptoms of depression in young men. This trial will help fill a significant research gap, contribute to the growing field of nutritional psychiatry, guide future research and inform advice given by clinicians to this specific demographic

The Bioavailability of Various Oral Forms of Folate Supplementation in Healthy Populations and Animal Models: A Systematic Review

© 2019, Mary Ann Liebert, Inc. Background and aims: Folate is an essential nutrient required for many different functions in the body. It is particularly important for DNA synthesis, immune functions, and during pregnancy. Folate supplements are commonly prescribed by health professionals for a number of different conditions, however, the absorption of the different derivatives remains unclear. The aim of this review was to assess the bioavailability of various forms of folate supplements in healthy populations and animal models. Methods: A systematic literature review was conducted of original research, which assessed the bioavailability of different oral forms of folate in healthy adults or animal models. The following databases were searched: PubMed (U.S. National Library of Medicine), ProQuest Medical Collection (ProQuest) and ScienceDirect (Elsevier) up to March 30, 2017. The inclusion criteria consisted of both animal and human research, no disease state or condition, and assessed levels after an intervention of a folate derivative. Results: A total of 23 studies out of 5226 met the full inclusion criteria. Of these, 4 were animal studies and 19 were human studies. There was variation in supplement forms used with the most commonly tested being folic acid followed by 5-methylenetetrahydrofolate (5-MTHF). Dosages ranged from 25 μg up to 200 mg. Only three studies found a statistically significant difference in folate bioavailability when evaluating different supplement forms. These studies found 5-MTHF to be more effective at increasing folate levels in participants. Conclusions: This review has found a number of methodological limitations and conflicting results. Only three out of the 23 studies assessed found a statistically significant difference between different supplemental forms of folate. Quality absorption studies assessing the bioavailability of oral folate supplements are crucial if clinicians are to make effective evidence-based recommendations. More research is required for greater clarification regarding the bioavailability of these supplements

IL-17 can be protective or deleterious in murine pneumococcal pneumonia

Streptococcus pneumoniae is the major bacterial cause of community-acquired pneumonia, and the leading agent of childhood pneumonia deaths worldwide. Nasal colonization is an essential step prior to infection. The cytokine IL-17 protects against such colonization and vaccines that enhance IL-17 responses to pneumococcal colonization are being developed. The role of IL-17 in host defence against pneumonia is not known. To address this issue, we have utilized a murine model of pneumococcal pneumonia in which the gene for the IL-17 cytokine family receptor, Il17ra, has been inactivated. Using this model, we show that IL-17 produced predominantly from γδ T cells protects mice against death from the invasive TIGR4 strain (serotype 4) which expresses a relatively thin capsule. However, in pneumonia produced by two heavily encapsulated strains with low invasive potential (serotypes 3 and 6B), IL-17 significantly enhanced mortality. Neutrophil uptake and killing of the serotype 3 strain was significantly impaired compared to the serotype 4 strain and depletion of neutrophils with antibody enhanced survival of mice infected with the highly encapsulated SRL1 strain. These data strongly suggest that IL-17 mediated neutrophil recruitment to the lungs clears infection from the invasive TIGR4 strain but that lung neutrophils exacerbate disease caused by the highly encapsulated pneumococcal strains. Thus, whilst augmenting IL-17 immune responses against pneumococci may decrease nasal colonization, this may worsen outcome during pneumonia caused by some strains

A simple formula for pooling knowledge about a quantum system

When various observers obtain information in an independent fashion about a classical system, there is a simple rule which allows them to pool their knowledge, and this requires only the states-of-knowledge of the respective observers. Here we derive an equivalent quantum formula. While its realm of applicability is necessarily more limited, it does apply to a large class of measurements, and we show explicitly for a single qubit that it satisfies the intuitive notions of what it means to pool knowledge about a quantum system. This analysis also provides a physical interpretation for the trace of the product of two density matrices.Comment: 5 pages, Revtex

They are friendly but they don\u27t want to be friends with you : A narrative inquiry into Chinese nursing students\u27 learning experiences in Australia

There is increasing interest in the phenomena of international student mobility and the growing global demand for skilled nurses. Little is known, however, about the learning experiences of Chinese nursing students at Australian universities. This study begins to address this gap. A narrative inquiry methodology was employed. In-depth interviews and focus group discussions, along with field notes and observations were conducted with six Chinese undergraduate nursing students studying undergraduate nursing in Western Australia. Chinese nursing students in Australia experienced fear and anxiety, driven by unfamiliarity with the hospital environment, education methods, and assessment expectations. Clinical placement experiences in Australian health services were identified by participants as the most stressful learning experience. Forming friendships with domestic students was difficult and rare for these students: none made friends with local students or joined university groups. Despite the challenges they experienced, the participants were motivated and adaptive to a new culture and learning methods, and all, demonstrated academic success. This study provides new knowledge about the learning experiences of Chinese nursing students at Australian universities. Many of the issues identified relate to the wider discussion around effective support for international students

The health care utilisation and out-of-pocket expenditure associated with Australian stroke survivors aged 55 and over.

OBJECTIVE: Stroke is a major cause of mortality and disability worldwide. People with stroke have a number of options available to treat post-stroke related symptoms and challenges. The aim of this study was to assess the use of healthcare services, self-care practices and out-of-pocket expenses associated with post-stroke healthcare. METHODS: We retrospectively analysed data collected between April and October 2017 from a survey of 576 participants aged 55 to 96 from the 45 and Up Study, NSW (Australia), who had earlier reported a clinical diagnosis of stroke. Participants were asked about their use of health care services, including conventional medicine practitioners and medications, complementary medicine practitioners, practices and products and the respective associated out-of-pocket expenditure for each. RESULTS: Amongst the total of 576 individuals who participated in the study, 39% consulted a doctor, 18% consulted an allied health practitioner, and 8% consulted a complementary medicine practitioner in the previous year for their stroke. Participants' average combined out-of-pocket expenditure for post-stroke related healthcare was AU$386.4 per annum. Extrapolated to all Australians with stroke, aged 55 years and over, the total out-of-pocket expenditure for post-stroke related healthcare is estimated to be AU$42 million per annum. CONCLUSIONS: Post-stroke individuals used a wide range of health services and various self-care practices for stroke rehabilitation. Such healthcare utilisation is associated with significant annual out-of-pocket expenditure. Given the socioeconomic burden of stroke, further research is required to identify the barriers and facilitators of self-care among patients with stroke and explore the cost-effectiveness of the wide range of treatments(s) utilised for post-stroke care

The Golden Channel at a Neutrino Factory revisited: improved sensitivities from a Magnetised Iron Neutrino Detector

This paper describes the performance and sensitivity to neutrino mixing parameters of a Magnetised Iron Neutrino Detector (MIND) at a Neutrino Factory with a neutrino beam created from the decay of 10 GeV muons. Specifically, it is concerned with the ability of such a detector to detect muons of the opposite sign to those stored (wrong-sign muons) while suppressing contamination of the signal from the interactions of other neutrino species in the beam. A new more realistic simulation and analysis, which improves the efficiency of this detector at low energies, has been developed using the GENIE neutrino event generator and the GEANT4 simulation toolkit. Low energy neutrino events down to 1 GeV were selected, while reducing backgrounds to the $10^{-4}$ level. Signal efficiency plateaus of ~60% for $\nu_\mu$ and ~70% for $\bar{\nu}_\mu$ events were achieved starting at ~5 GeV. Contamination from the $\nu_\mu\rightarrow \nu_\tau$ oscillation channel was studied for the first time and was found to be at the level between 1% and 4%. Full response matrices are supplied for all the signal and background channels from 1 GeV to 10 GeV. The sensitivity of an experiment involving a MIND detector of 100 ktonnes at 2000 km from the Neutrino Factory is calculated for the case of $\sin^2 2\theta_{13}\sim 10^{-1}$. For this value of $\theta_{13}$, the accuracy in the measurement of the CP violating phase is estimated to be $\Delta \delta_{CP}\sim 3^\circ - 5^\circ$, depending on the value of $\delta_{CP}$, the CP coverage at $5\sigma$ is 85% and the mass hierarchy would be determined with better than $5\sigma$ level for all values of $\delta_{CP}$

Toroidal magnetized iron neutrino detector for a neutrino factory

A neutrino factory has unparalleled physics reach for the discovery and measurement of CP violation in the neutrino sector. A far detector for a neutrino factory must have good charge identification with excellent background rejection and a large mass. An elegant solution is to construct a magnetized iron neutrino detector (MIND) along the lines of MINOS, where iron plates provide a toroidal magnetic field and scintillator planes provide 3D space points. In this paper, the current status of a simulation of a toroidal MIND for a neutrino factory is discussed in light of the recent measurements of large θ13. The response and performance using the 10 GeV neutrino factory configuration are presented. It is shown that this setup has equivalent δCP reach to a MIND with a dipole field and is sensitive to the discovery of CP violation over 85% of the values of δCP