Field theory of scaling lattice models. The Potts antiferromagnet

In contrast to what happens for ferromagnets, the lattice structure participates in a crucial way to determine existence and type of critical behaviour in antiferromagnetic systems. It is an interesting question to investigate how the memory of the lattice survives in the field theory describing a scaling antiferromagnet. We discuss this issue for the square lattice three-state Potts model, whose scaling limit as T->0 is argued to be described exactly by the sine-Gordon field theory at a specific value of the coupling. The solution of the scaling ferromagnetic case is recalled for comparison. The field theory describing the crossover from antiferromagnetic to ferromagnetic behaviour is also introduced.Comment: 11 pages, to appear in the proceedings of the NATO Advanced Research Workshop on Statistical Field Theories, Como 18-23 June 200

Darbepoetin alfa given every 1 or 2 weeks alleviates anaemia associated with cancer chemotherapy.

In part A of this study, patients were randomised to cohorts receiving darbepoetin alfa at doses of 0.5 to 8.0 m.c.g x kg(-1) x wk(-1) or to a control group receiving epoetin alfa at an initial dose of 150 U x kg(-1) three times weekly. In part B, the cohorts were darbepoetin alfa 3.0 to 9.0 m.c.g x kg(-1) every 2 weeks or epoetin alfa, initial dose 40 000 U x wk(-1). Safety was assessed by adverse events, changes in blood pressure, and formation of antibodies to darbepoetin alfa. Efficacy was assessed by several haematologic endpoints, including change in haemoglobin from baseline. The adverse event profile of darbepoetin alfa was similar to that of epoetin alfa. No relationship between the rapidity of haemoglobin response and any adverse event was observed. No antibodies to darbepoetin alfa were detected. Higher doses of darbepoetin alfa increased the proportion of patients with a haemoglobin response and decreased the median time to response. The overall dose of darbepoetin alfa required to produce a mean increase in haemoglobin does not increase when the dosing interval is increased from 1 to 2 weeks. Therapy with darbepoetin alfa is safe and effective in producing a dose-related increase in haemoglobin levels in patients with cancer receiving chemotherapy

Age- and activity-related differences in the abundance of Myosin essential and regulatory light chains in human muscle

Traditional methods for phenotyping skeletal muscle (e.g., immunohistochemistry) are labor-intensive and ill-suited to multixplex analysis, i.e., assays must be performed in a series. Addressing these concerns represents a largely unmet research need but more comprehensive parallel analysis of myofibrillar proteins could advance knowledge regarding age- and activity-dependent changes in human muscle. We report a label-free, semi-automated and time efficient LC-MS proteomic workflow for phenotyping the myofibrillar proteome. Application of this workflow in old and young as well as trained and untrained human skeletal muscle yielded several novel observations that were subsequently verified by multiple reaction monitoring (MRM).We report novel data demonstrating that human ageing is associated with lesser myosin light chain 1 content and greater myosin light chain 3 content, consistent with an age-related reduction in type II muscle fibers. We also disambiguate conflicting data regarding myosin regulatory light chain, revealing that age-related changes in this protein more closely reflect physical activity status than ageing per se. This finding reinforces the need to control for physical activity levels when investigating the natural process of ageing. Taken together, our data confirm and extend knowledge regarding age- and activity-related phenotypes. In addition, the MRM transitions described here provide a methodological platform that can be fine-tuned to suite multiple research needs and thus advance myofibrillar phenotyping

Determining matrix elements and resonance widths from finite volume: the dangerous mu-terms

The standard numerical approach to determining matrix elements of local operators and width of resonances uses the finite volume dependence of energy levels and matrix elements. Finite size corrections that decay exponentially in the volume are usually neglected or taken into account using perturbation expansion in effective field theory. Using two-dimensional sine-Gordon field theory as "toy model" it is shown that some exponential finite size effects could be much larger than previously thought, potentially spoiling the determination of matrix elements in frameworks such as lattice QCD. The particular class of finite size corrections considered here are mu-terms arising from bound state poles in the scattering amplitudes. In sine-Gordon model, these can be explicitly evaluated and shown to explain the observed discrepancies to high precision. It is argued that the effects observed are not special to the two-dimensional setting, but rather depend on general field theoretic features that are common with models relevant for particle physics. It is important to understand these finite size corrections as they present a potentially dangerous source of systematic errors for the determination of matrix elements and resonance widths.Comment: 26 pages, 13 eps figures, LaTeX2e fil

TBA, NLO Luscher correction, and double wrapping in twisted AdS/CFT

The ground-state energy of integrably-twisted theories is analyzed in finite volume. We derive the leading and next-to-leading order (NLO) L\"uscher-type corrections for large volumes of the vacuum energy for integrable theories with twisted boundary conditions and twisted S-matrix. We then derive the twisted thermodynamic Bethe ansatz (TBA) equations to describe exactly the ground state, from which we obtain an untwisted Y-system. The two approaches are compared by expanding the TBA equations to NLO, and exact agreement is found. We give explicit results for the O(4) model and for the three-parameter family of $\gamma$-deformed (non-supersymmetric) planar AdS/CFT model, where the ground-state energy can be nontrivial and can acquire finite-size corrections. The NLO corrections, which correspond to double-wrapping diagrams, are explicitly evaluated for the latter model at six loops.Comment: 42 pages, 2 figures, v2: references added, v3: minor correction

Comments on the Mirror TBA

We discuss various aspects of excited state TBA equations describing the energy spectrum of the AdS_5 \times S^5 strings and, via the AdS/CFT correspondence, the spectrum of scaling dimensions of N = 4 SYM local operators. We observe that auxiliary roots which are used to partially enumerate solutions of the Bethe-Yang equations do not play any role in engineering excited state TBA equations via the contour deformation trick. We further argue that the TBA equations are in fact written not for a particular string state but for the whole superconformal multiplet, and, therefore, the psu(2,2|4) invariance is built in into the TBA construction.Comment: 28 pages, 1 figure, v2: misprints are correcte

Strangeness production in antiproton-nucleus collisions

Antiproton annihilations on nuclei provide a very interesting way to study the behaviour of strange particles in the nuclear medium. In low energy $\bar p$ annihilations, the hyperons are produced mostly by strangeness exchange mechanisms. Thus, hyperon production in $\bar p A$ interactions is very sensitive to the properties of the antikaon-nucleon interaction in nuclear medium. Within the Giessen Boltzmann-Uehling-Uhlenbeck transport model (GiBUU), we analyse the experimental data on $\Lambda$ and $K^0_S$ production in $\bar p A$ collisions at $p_{\rm lab}=0.2-4$ GeV/c. A satisfactory overall agreement is reached, except for the $K^0_S$ production in $\bar p+^{20}$Ne collisions at $p_{\rm lab}=608$ MeV/c, where we obtain substantially larger $K^0_S$ production rate. We also study the $\Xi$ hyperon production, important in view of the forthcoming experiments at FAIR and J-PARC.Comment: 8 pages, 4 figures, invited talk given by A.B. Larionov at the 10th International Conference on Low Energy Antiproton Physics (LEAP2011), Vancouver, Canada, Apr 27 - May 1, 2011, Hyperfine Interact. in pres

Lifting asymptotic degeneracies with the Mirror TBA

We describe a qualitative feature of the AdS_5 x S^5 string spectrum which is not captured by the asymptotic Bethe ansatz. This is reflected by an enhanced discrete symmetry in the asymptotic limit, whereby extra energy degeneracy enters the spectrum. We discuss how finite size corrections should lift this degeneracy, through both perturbative (Luscher) and non-perturbative approaches (the Mirror TBA), and illustrate this explicitly on two such asymptotically degenerate states.Comment: v3, 20 pages, 1 figure, 2 tables, as publishe