1,059 research outputs found
Using airborne LiDAR Survey to explore historic-era archaeological landscapes of Montserrat in the eastern Caribbean
This article describes what appears to be the first archaeological application of airborne LiDAR survey to historic-era landscapes in the Caribbean archipelago, on the island of Montserrat. LiDAR is proving invaluable in extending the reach of traditional pedestrian survey into less favorable areas, such as those covered by dense neotropical forest and by ashfall from the past two decades of active eruptions by the Soufrière Hills volcano, and to sites in localities that are inaccessible on account of volcanic dangers. Emphasis is placed on two aspects of the research: first, the importance of ongoing, real-time interaction between the LiDAR analyst and the archaeological team in the field; and second, the advantages of exploiting the full potential of the three-dimensional LiDAR point cloud data for purposes of the visualization of archaeological sites and features
Angiogenic Effect of Bioactive Borate Glass Microfibers and Beads in the Hairless Mouse
The purpose of this project was to investigate the angiogenic mechanism of bioactive borate glass for soft tissue repair in a \u27hairless\u27 SKH1 mouse model. Subcutaneous microvascular responses to bioactive glass microfibers (45S5, 13-93B3, and 13-93B3Cu) and bioactive glass beads (13-93, 13-93B3, and 13-93B3Cu) were assessed via: noninvasive imaging of skin microvasculature; histomorphometry of microvascular densities; and quantitative PCR measurements of mRNA expression of VEGF and FGF-2 cytokines. Live imaging via dorsal skin windows showed the formation at two weeks of a halo-like structure infused with microvessels surrounding implanted borate-based 13-93B3 and 13-93B3Cu glass beads, a response not observed with silicate-based 13-93 glass beads. Quantitative histomorphometry of tissues implanted with plugs of 45S5, 13-93B3, and 13-93B3Cu glass microfibers revealed microvascular densities that were 1.6-, 2.3-, and 2.7-times higher, respectively, than the sham control values whereas 13-93, 13-93B3, and 13-93B3Cu glass beads caused the microvascular density to increase 1.3-, 1.6-, and 2.5-fold, respectively, relative to sham controls. Quantitative PCR measurements indicate a marginally significant increased expression of VEGF mRNA in tissues with 13-93B3Cu glass beads, an outcome that supported the hypothesis that copper-doped borate glass could promote VEGF expression followed by angiogenesis for enhanced wound healing
Field Studies of Crater Gradation in Gusev Crater and Meridiani Planum Using the Mars Exploration Rovers
The Mars Exploration Rovers Spirit and Opportunity investigated numerous craters since landing in Gusev crater (14.569degS, 175.473degE) and Meridiani Planum (1.946degS, 354.473degE) over the first 400 sols of their missions [1-4]. Craters at both sites are simple structures and vary in size and preservation state. Comparing observed and expected pristine morphology and using process-specific gradational signatures around terrestrial craters as a template [5-7] allows distinguishing gradation processes whose relative importance fundamentally differs from those responsible for most crater modification on the Earth
PTEN and phosphorylated AKT expression and prognosis in early- and late-stage non-small cell lung cancer
PSRs J0248+6021 and J2240+5832: Young Pulsars in the Northern Galactic Plane. Discovery, Timing, and Gamma-ray observations
Pulsars PSR J0248+6021 (rotation period P=217 ms and spin-down power Edot =
2.13E35 erg/s) and PSR J2240+5832 (P=140 ms, Edot = 2.12E35 erg/s) were
discovered in 1997 with the Nancay radio telescope during a northern Galactic
plane survey, using the Navy-Berkeley Pulsar Processor (NBPP) filter bank. GeV
gamma-ray pulsations from both were discovered using the Fermi Large Area
Telescope. Twelve years of radio and polarization data allow detailed
investigations. The two pulsars resemble each other both in radio and in
gamma-ray data. Both are rare in having a single gamma-ray pulse offset far
from the radio peak. The high dispersion measure for PSR J0248+6021 (DM = 370
pc cm^-3) is most likely due to its being within the dense, giant HII region W5
in the Perseus arm at a distance of 2 kpc, not beyond the edge of the Galaxy as
obtained from models of average electron distributions. Its high transverse
velocity and the low magnetic field along the line-of-sight favor this small
distance. Neither gamma-ray, X-ray, nor optical data yield evidence for a
pulsar wind nebula surrounding PSR J0248+6021. The gamma-ray luminosity for PSR
J0248+6021 is L_ gamma = (1.4 \pm 0.3)\times 10^34 erg/s. For PSR J2240+5832,
we find either L_gamma = (7.9 \pm 5.2) \times 10^34 erg/s if the pulsar is in
the Outer arm, or L_gamma = (2.2 \pm 1.7) \times 10^34 erg/s for the Perseus
arm. These luminosities are consistent with an L_gamma ~ sqrt(Edot) rule.
Comparison of the gamma-ray pulse profiles with model predictions, including
the constraints obtained from radio polarization data, favor emission in the
far magnetosphere. These two pulsars differ mainly in their inclination angles
and acceleration gap widths, which in turn explains the observed differences in
the gamma-ray peak widths.Comment: 13 pages, Accepted to Astronomy & Astrophysic
Patient-specific instrumentation does not improve radiographic alignment or clinical outcomes after total knee arthroplasty: A meta-analysis
Background and purpose: Patient-specific instrumentation (PSI) for total knee arthroplasty (TKA) has been introduced to improve alignment and reduce outliers, increase efficiency, and reduce operation time. In order to improve our understanding of the outcomes of patient-specific instrumentation, we conducted a meta-analysis.
Patients and methods: We identified randomized and quasi-randomized controlled trials (RCTs) comparing patient-specific and conventional instrumentation in TKA. Weighted mean differences and risk ratios were determined for radiographic accuracy, operation time, hospital stay, blood loss, number of surgical trays required, and patient-reported outcome measures.
Results: 21 RCTs involving 1,587 TKAs were included. Patient-specific instrumentation resulted in slightly more accurate hip-knee-ankle axis (0.3°), coronal femoral alignment (0.3°, femoral flexion (0.9°), tibial slope (0.7°), and femoral component rotation (0.5°). The risk ratio of a coronal plane outlier (\u3e 3° deviation of chosen target) for the tibial component was statistically significantly increased in the PSI group (RR = 1.64). No significance was found for other radiographic measures. Operation time, blood loss, and transfusion rate were similar. Hospital stay was significantly shortened, by approximately 8 h, and the number of surgical trays used decreased by 4 in the PSI group. Knee Society scores and Oxford knee scores were similar.
Interpretation: Patient-specific instrumentation does not result in clinically meaningful improvement in alignment, fewer outliers, or better early patient-reported outcome measures. Efficiency is improved by reducing the number of trays used, but PSI does not reduce operation time
Eight gamma-ray pulsars discovered in blind frequency searches of Fermi LAT data
We report the discovery of eight gamma-ray pulsars in blind frequency
searches using the LAT, onboard the Fermi Gamma-ray Space Telescope. Five of
the eight pulsars are young (tau_c10^36 erg/s), and
located within the Galactic plane (|b|<3 deg). The remaining three are older,
less energetic, and located off the plane. Five pulsars are associated with
sources included in the LAT bright gamma-ray source list, but only one, PSR
J1413-6205, is clearly associated with an EGRET source. PSR J1023-5746 has the
smallest characteristic age (tau_c=4.6 kyr) and is the most energetic
(Edot=1.1E37 erg/s) of all gamma-ray pulsars discovered so far in blind
searches. PSRs J1957+5033 and J2055+25 have the largest characteristic ages
(tau_c~1 Myr) and are the least energetic (Edot~5E33 erg/s) of the
newly-discovered pulsars. We present the timing models, light curves, and
detailed spectral parameters of the new pulsars. We used recent XMM
observations to identify the counterpart of PSR J2055+25 as XMMU
J205549.4+253959. In addition, publicly available archival Chandra X-ray data
allowed us to identify the likely counterpart of PSR J1023-5746 as a faint,
highly absorbed source, CXOU J102302.8-574606. The large X-ray absorption
indicates that this could be among the most distant gamma-ray pulsars detected
so far. PSR J1023-5746 is positionally coincident with the TeV source HESS
J1023-575, located near the young stellar cluster Westerlund 2, while PSR
J1954+2836 is coincident with a 4.3 sigma excess reported by Milagro at a
median energy of 35 TeV. Deep radio follow-up observations of the eight pulsars
resulted in no detections of pulsations and upper limits comparable to the
faintest known radio pulsars, indicating that these can be included among the
growing population of radio-quiet pulsars in our Galaxy being uncovered by the
LAT, and currently numbering more than 20.Comment: Submitted to Ap
Forced solitary waves and fronts past submerged obstacles
Herein, an efficient numerical method is presented to describe the flow of a liquid in an open channel with various types of bottom configurations. The method is developed for steady two-dimensional potential free surface flows. The resulting nonlinear problem is solved numerically by boundary integral equation methods. In addition weakly nonlinear solutions are derived. New solutions which complement those of Dias and Vanden-Broeck [J. Fluid Mech. 59, 93–102 (2004)] are presented. Furthermore some solutions for channel flows past dips in the bottom are discussed
Shallow radar (SHARAD) sounding observations of the Medusae Fossae Formation, Mars
The SHARAD (shallow radar) sounding radar on the Mars Reconnaissance Orbiter detects subsurface reflections in the eastern and western parts of the Medusae Fossae Formation (MFF). The radar waves penetrate up to 580 m of the MFF and detect clear subsurface interfaces in two locations: west MFF between 150 and 155◦ E and east MFF between 209 and 213◦ E. Analysis of SHARAD radargrams suggests that the real part of the permittivity is ∼3.0, which falls within the range of permittivity values inferred from MARSIS data for thicker parts of the MFF. The SHARAD data cannot uniquely determine the composition of the MFF material, but the low permittivity implies that the upper few hundred meters of the MFF material has a high porosity. One possibility is that the MFF is comprised of low-density welded or interlocked pyroclastic deposits that are capable of sustaining the steep-sided yardangs and ridges seen in imagery. The SHARAD surface echo power across the MFF is low relative to typical martian plains, and completely disappears in parts of the east MFF that correspond to the radar-dark Stealth region. These areas are extremely rough at centimeter to meter scales, and the lack of echo power is most likely due to a combination of surface roughness and a low near-surface permittivity that reduces the echo strength from any locally flat regions. There is also no radar evidence for internal layering in any of the SHARAD data for the MFF, despite the fact that tens-of-meters scale layering is apparent in infrared and visible wavelength images of nearby areas. These interfaces may not be detected in SHARAD data if their permittivity contrasts are low, or if the layers are discontinuous. The lack of closely spaced internal radar reflectors suggests that the MFF is not an equatorial analog to the current martian polar deposits, which show clear evidence of multiple internal layers in SHARAD dat
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