Integrated design checkout of shuttle payload avionics interfaces

Orbiter/payload avionics integration testing in the shuttle program are discussed. Payloads show extensive orbiter interfaces. The three testing modes used to verify orbiter/payload avionics interfaces are described. These modes consist of orbiter testing using generic payload simulators, payload testing utilizing the actual payload and a high fidelity orbiter simulator, and interface testing with the actual orbiter and payload. Several special avionics techniques, such as the split flight computer technique were developed for this testing. Experience from the first six shuttle cargoes is reviewed and problems found in testing that would have hampered mission success are emphasized

Molecular emission from GG Carinae's circumbinary disk

The appearance of the B[e] phenomenon in evolved massive stars such as B[e] supergiants is still a mystery. While these stars are generally found to have disks that are cool and dense enough for efficient molecule and dust condensation, the origin of the disk material is still unclear. We aim at studying the kinematics and origin of the disk in the eccentric binary system GG Car, whose primary component is proposed to be a B[e] supergiant. Based on medium- and high-resolution near-infrared spectra we analyzed the CO-band emission detected from GG Car. The complete CO-band structure delivers information on the density and temperature of the emitting region, and the detectable 13CO bands allow us to constrain the evolutionary phase. In addition, the kinematics of the CO gas can be extracted from the shape of the first 12CO band head. We find that the CO gas is located in a ring surrounding the eccentric binary system, and its kinematics agrees with Keplerian rotation with a velocity, projected to the line of sight, of (80pm 1) km/s. The CO ring has a column density of (5pm 3)x10^21 cm^-2 and a temperature of 3200pm 500 K. In addition, the material is chemically enriched in 13CO, which agrees with the primary component being slightly evolved off the main sequence. We discuss two possible scenarios for the origin of the circumbinary disk: (i) non-conservative Roche lobe overflow, and (ii) the possibility that the progenitor of the primary component could have been a classical Be star. Neither can be firmly excluded, but for Roche lobe overflow to occur, a combination of stellar and orbital parameter extremawould be required.Fil: Kraus, M.. Astronomický ústav; República ChecaFil: Oksala, M. E.. Astronomický ústav; República ChecaFil: Nickeler, D. H.. Astronomický ústav; República ChecaFil: Muratore, M. F.. Universidad Nacional de la Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: Borges Fernandes, M.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; BrasilFil: Aret, A.. Tartu Observatory; EstoniaFil: Cidale, Lydia Sonia. Universidad Nacional de la Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: de Wit, W. J.. European Southern Observatory; Chil

Shell Model for Time-correlated Random Advection of Passive Scalars

We study a minimal shell model for the advection of a passive scalar by a Gaussian time correlated velocity field. The anomalous scaling properties of the white noise limit are studied analytically. The effect of the time correlations are investigated using perturbation theory around the white noise limit and non-perturbatively by numerical integration. The time correlation of the velocity field is seen to enhance the intermittency of the passive scalar.Comment: Replaced with final version + updated figure

Combined pigment and metatranscriptomic analysis reveals highly synchronized diel patterns of phenotypic light response across domains in the open oligotrophic ocean

Sunlight is the most important environmental control on diel fluctuations in phytoplankton activity, and understanding diel microbial processes is essential to the study of oceanic biogeochemical cycles. Yet, little is known about the in situ temporal dynamics of phytoplankton metabolic activities and their coordination across different populations. We investigated diel orchestration of phytoplankton activity in photosynthesis, photoacclimation, and photoprotection by analyzing pigment and quinone distributions in combination with metatranscriptomes in surface waters of the North Pacific Subtropical Gyre (NPSG). We found diel cycles in pigment abundances resulting from the balance of their synthesis and consumption. These dynamics suggest that night represents a metabolic recovery phase, refilling cellular pigment stores, while photosystems are remodeled towards photoprotection during daytime. Transcript levels of genes involved in photosynthesis and pigment metabolism had synchronized diel expression patterns among all taxa, reflecting the driving force light imparts upon photosynthetic organisms in the ocean, while other environmental factors drive niche differentiation. For instance, observed decoupling of diel oscillations in transcripts and related pigments indicates that pigment abundances are modulated by environmental factors extending beyond gene expression/regulation reinforcing the need to combine metatranscriptomics with proteomics and metabolomics to fully understand the timing of these critical processes in situ

Febrile Neutropenia Duration Is Associated with the Severity of Gut Microbiota Dysbiosis in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation Recipients

Febrile neutropenia (FN) is a common complication in pediatric patients receiving al-logeneic hematopoietic stem cell transplantation (HSCT). Frequently, a precise cause cannot be identified, and many factors can contribute to its genesis. Gut microbiota (GM) has been recently linked to many transplant-related complications, and may also play a role in the pathogenesis of FN. Here, we conducted a longitudinal study in pediatric patients receiving HSCT from three centers in Europe profiling their GM during the transplant course, particularly at FN onset. We found that a more stable GM configuration over time is associated with a shorter duration of fever. Moreover, patients with longer lasting fever exhibited higher pre-HSCT levels of Collinsella, Megasphaera, Prevotella and Roseburia and increased proportions of Eggerthella and Akkermansia at the engraftment. These results suggest a possible association of the GM with the genesis and course of FN. Data seem consistent with previous reports on the relationship of a so-called “healthy” GM and the reduction of transplant complications. To our knowledge, this is the first report in the pediatric HSCT setting. Future studies are warranted to define the underling biological mechanisms and possible clinical implications

On the canonically invariant calculation of Maslov indices

After a short review of various ways to calculate the Maslov index appearing in semiclassical Gutzwiller type trace formulae, we discuss a coordinate-independent and canonically invariant formulation recently proposed by A Sugita (2000, 2001). We give explicit formulae for its ingredients and test them numerically for periodic orbits in several Hamiltonian systems with mixed dynamics. We demonstrate how the Maslov indices and their ingredients can be useful in the classification of periodic orbits in complicated bifurcation scenarios, for instance in a novel sequence of seven orbits born out of a tangent bifurcation in the H\'enon-Heiles system.Comment: LaTeX, 13 figures, 3 tables, submitted to J. Phys.

Generally covariant state-dependent diffusion

Statistical invariance of Wiener increments under SO(n) rotations provides a notion of gauge transformation of state-dependent Brownian motion. We show that the stochastic dynamics of non gauge-invariant systems is not unambiguously defined. They typically do not relax to equilibrium steady states even in the absence of extenal forces. Assuming both coordinate covariance and gauge invariance, we derive a second-order Langevin equation with state-dependent diffusion matrix and vanishing environmental forces. It differs from previous proposals but nevertheless entails the Einstein relation, a Maxwellian conditional steady state for the velocities, and the equipartition theorem. The over-damping limit leads to a stochastic differential equation in state space that cannot be interpreted as a pure differential (Ito, Stratonovich or else). At odds with the latter interpretations, the corresponding Fokker-Planck equation admits an equilibrium steady state; a detailed comparison with other theories of state-dependent diffusion is carried out. We propose this as a theory of diffusion in a heat bath with varying temperature. Besides equilibrium, a crucial experimental signature is the non-uniform steady spatial distribution.Comment: 24 page

Heat release by controlled continuous-time Markov jump processes

We derive the equations governing the protocols minimizing the heat released by a continuous-time Markov jump process on a one-dimensional countable state space during a transition between assigned initial and final probability distributions in a finite time horizon. In particular, we identify the hypotheses on the transition rates under which the optimal control strategy and the probability distribution of the Markov jump problem obey a system of differential equations of Hamilton-Bellman-Jacobi-type. As the state-space mesh tends to zero, these equations converge to those satisfied by the diffusion process minimizing the heat released in the Langevin formulation of the same problem. We also show that in full analogy with the continuum case, heat minimization is equivalent to entropy production minimization. Thus, our results may be interpreted as a refined version of the second law of thermodynamics.Comment: final version, section 2.1 revised, 26 pages, 3 figure

Enteral Nutrition in Pediatric Patients Undergoing Hematopoietic SCT Promotes the Recovery of Gut Microbiome Homeostasis

Hematopoietic stem cell transplantation (HSCT) is the first-line immunotherapy to treat several hematologic disorders, although it can be associated with many complications reducing the survival rate, such as acute graft-versus-host disease (aGvHD) and infections. Given the fundamental role of the gut microbiome (GM) for host health, it is not surprising that a suboptimal path of GM recovery following HSCT may compromise immune homeostasis and/or increase the risk of opportunistic infections, with an ultimate impact in terms of aGvHD onset. Traditionally, the first nutritional approach in post-HSCT patients is parenteral nutrition (PN), which is associated with several clinical adverse effects, supporting enteral nutrition (EN) as a preferential alternative. The aim of the study was to evaluate the impact of EN vs. PN on the trajectory of compositional and functional GM recovery in pediatric patients undergoing HSCT. The GM structure and short-chain fatty acid (SCFA) production profiles were analyzed longitudinally in twenty pediatric patients receiving HSCT-of which, ten were fed post-transplant with EN and ten with total PN. According to our findings, we observed the prompt recovery of a structural and functional eubiotic GM layout post-HSCT only in EN subjects, thus possibly reducing the risk of systemic infections and GvHD onset

Perturbations of Noise: The origins of Isothermal Flows

We make a detailed analysis of both phenomenological and analytic background for the "Brownian recoil principle" hypothesis (Phys. Rev. A 46, (1992), 4634). A corresponding theory of the isothermal Brownian motion of particle ensembles (Smoluchowski diffusion process approximation), gives account of the environmental recoil effects due to locally induced tiny heat flows. By means of local expectation values we elevate the individually negligible phenomena to a non-negligible (accumulated) recoil effect on the ensemble average. The main technical input is a consequent exploitation of the Hamilton-Jacobi equation as a natural substitute for the local momentum conservation law. Together with the continuity equation (alternatively, Fokker-Planck), it forms a closed system of partial differential equations which uniquely determines an associated Markovian diffusion process. The third Newton law in the mean is utilised to generate diffusion-type processes which are either anomalous (enhanced), or generically non-dispersive.Comment: Latex fil