729 research outputs found
Chimeras in Leaky Integrate-and-Fire Neural Networks: Effects of Reflecting Connectivities
The effects of nonlocal and reflecting connectivity are investigated in
coupled Leaky Integrate-and-Fire (LIF) elements, which assimilate the exchange
of electrical signals between neurons. Earlier investigations have demonstrated
that non-local and hierarchical network connectivity often induces complex
synchronization patterns and chimera states in systems of coupled oscillators.
In the LIF system we show that if the elements are non-locally linked with
positive diffusive coupling in a ring architecture the system splits into a
number of alternating domains. Half of these domains contain elements, whose
potential stays near the threshold, while they are interrupted by active
domains, where the elements perform regular LIF oscillations. The active
domains move around the ring with constant velocity, depending on the system
parameters. The idea of introducing reflecting non-local coupling in LIF
networks originates from signal exchange between neurons residing in the two
hemispheres in the brain. We show evidence that this connectivity induces novel
complex spatial and temporal structures: for relatively extensive ranges of
parameter values the system splits in two coexisting domains, one domain where
all elements stay near-threshold and one where incoherent states develop with
multileveled mean phase velocity distribution.Comment: 12 pages, 12 figure
Making Code Voting Secure against Insider Threats using Unconditionally Secure MIX Schemes and Human PSMT Protocols
Code voting was introduced by Chaum as a solution for using a possibly
infected-by-malware device to cast a vote in an electronic voting application.
Chaum's work on code voting assumed voting codes are physically delivered to
voters using the mail system, implicitly requiring to trust the mail system.
This is not necessarily a valid assumption to make - especially if the mail
system cannot be trusted. When conspiring with the recipient of the cast
ballots, privacy is broken.
It is clear to the public that when it comes to privacy, computers and
"secure" communication over the Internet cannot fully be trusted. This
emphasizes the importance of using: (1) Unconditional security for secure
network communication. (2) Reduce reliance on untrusted computers.
In this paper we explore how to remove the mail system trust assumption in
code voting. We use PSMT protocols (SCN 2012) where with the help of visual
aids, humans can carry out addition correctly with a 99\% degree of
accuracy. We introduce an unconditionally secure MIX based on the combinatorics
of set systems.
Given that end users of our proposed voting scheme construction are humans we
\emph{cannot use} classical Secure Multi Party Computation protocols.
Our solutions are for both single and multi-seat elections achieving:
\begin{enumerate}[i)]
\item An anonymous and perfectly secure communication network secure against
a -bounded passive adversary used to deliver voting,
\item The end step of the protocol can be handled by a human to evade the
threat of malware. \end{enumerate} We do not focus on active adversaries
Security and Privacy Issues in Wireless Mesh Networks: A Survey
This book chapter identifies various security threats in wireless mesh
network (WMN). Keeping in mind the critical requirement of security and user
privacy in WMNs, this chapter provides a comprehensive overview of various
possible attacks on different layers of the communication protocol stack for
WMNs and their corresponding defense mechanisms. First, it identifies the
security vulnerabilities in the physical, link, network, transport, application
layers. Furthermore, various possible attacks on the key management protocols,
user authentication and access control protocols, and user privacy preservation
protocols are presented. After enumerating various possible attacks, the
chapter provides a detailed discussion on various existing security mechanisms
and protocols to defend against and wherever possible prevent the possible
attacks. Comparative analyses are also presented on the security schemes with
regards to the cryptographic schemes used, key management strategies deployed,
use of any trusted third party, computation and communication overhead involved
etc. The chapter then presents a brief discussion on various trust management
approaches for WMNs since trust and reputation-based schemes are increasingly
becoming popular for enforcing security in wireless networks. A number of open
problems in security and privacy issues for WMNs are subsequently discussed
before the chapter is finally concluded.Comment: 62 pages, 12 figures, 6 tables. This chapter is an extension of the
author's previous submission in arXiv submission: arXiv:1102.1226. There are
some text overlaps with the previous submissio
Tumor-infiltrating lymphocytes in patients receiving trastuzumab/pertuzumab-based chemotherapy : a TRYPHAENA Substudy
Background: There is an urgent requirement to identify biomarkers to tailor treatment in human epidermal growth factor receptor 2 (HER2)-amplified early breast cancer treated with trastuzumab/pertuzumab-based chemotherapy. Methods: Among the 225 patients randomly assigned to trastuzumab/pertuzumab concurrently or sequentially with an anthracycline-containing regimen or concurrently with an anthracycline-free regimen in the Tryphaena trial, we determined the percentage of tumor-infiltrating lymphocytes (TILs) at baseline in 213 patients, of which 126 demonstrated a pathological complete response (pCR; ypT0/is ypN0), with 28 demonstrating event-free survival (EFS) events. We investigated associations between baseline TIL percentage and either pCR or EFS after adjusting for clinicopathological characteristics using logistic and Cox regression models, respectively. To understand TIL biology, we evaluated associations between baseline TILs and baseline tumor gene expression data (800 gene set by NanoString) in a subset of 173 patients. All statistical tests were two-sided. Results: Among the patients with measurable TILs at baseline, the median level was 14.1% (interquartile range = 7.1%-32.4%). After adjusting for clinicopathological characteristics, baseline percentage TIL was not associated with pCR (adjusted odds ratio [aOR] for every 10-percentage unit increase in TILs = 1.12, 95% confidence interval [CI] = 0.95 to 1.31, P = .17). At a median follow-up of 4.7 years, for every increase in baseline TILs of 10%, there was a 25% reduction in the hazard for an EFS event (aOR = 0.75, 95% CI = 0.56 to 1.00, P = .05) after adjusting for baseline clinicopathological characteristics and pCR. Additionally, genes associated with epithelial-mesenchymal transition, angiogenesis, and T-cell inhibition such as SNAIL1, ZEB1, NOTCH3, and B7-H3 were statistically significantly inversely correlated with percentage TIL. Conclusions: Baseline TIL percentage provides independent prognostic information in patients treated with trastuzumab/pertuzumab-based neoadjuvant chemotherapy. However, further validation is required
Genetic analysis of peripheral nerve conduction velocity in twins
We studied variation in peripheral nerve conduction velocity (PNCV) and intelligence in a group of 16-year-old Dutch twins. It has been suggested that both brain nerve conduction velocity and PNCV are positively correlated with intelligence (Reed, 1984) and that heritable differences in NCV may explain part of the well established heritability of intelligence. The Standard Progressive Matrices test was administered to 210 twin pairs to obtain IQ scores. Median nerve PNCV was determined in a subgroup of 156 pairs. Genetic analyses showed a heritability of 0.65 for Raven IQ score and 0.77 for PNCV. However, there was no significant phenotypic correlation between IQ score and PNCV. © 1995 Plenum Publishing Corporation
Prognostic gene network modules in breast cancer hold promise
A substantial proportion of lymph node-negative patients who receive adjuvant chemotherapy do not derive any benefit from this aggressive and potentially toxic treatment. However, standard histopathological indices cannot reliably detect patients at low risk of relapse or distant metastasis. In the past few years several prognostic gene expression signatures have been developed and shown to potentially outperform histopathological factors in identifying low-risk patients in specific breast cancer subgroups with predictive values of around 90%, and therefore hold promise for clinical application. We envisage that further improvements and insights may come from integrative expression pathway analyses that dissect prognostic signatures into modules related to cancer hallmarks
Respective Prognostic Value of Genomic Grade and Histological Proliferation Markers in Early Stage (pN0) Breast Carcinoma
Genomic grade (GG) is a 97-gene signature which improves the accuracy and prognostic value of histological grade (HG) in invasive breast carcinoma. Since most of the genes included in the GG are involved in cell proliferation, we performed a retrospective study to compare the prognostic value of GG, Mitotic Index and Ki67 score.A series of 163 consecutive breast cancers was retained (pT1-2, pN0, pM0, 10-yr follow-up). GG was computed using MapQuant Dx(R).GG was low (GG-1) in 48%, high (GG-3) in 31% and equivocal in 21% of cases. For HG-2 tumors, 50% were classified as GG-1, 18% as GG-3 whereas 31% remained equivocal. In a subgroup of 132 ER+/HER2- tumors GG was the most significant prognostic factor in multivariate Cox regression analysis adjusted for age and tumor size (HR = 5.23, p = 0.02).In a reference comprehensive cancer center setting, compared to histological grade, GG added significant information on cell proliferation in breast cancers. In patients with HG-2 carcinoma, applying the GG to guide the treatment scheme could lead to a reduction in adjuvant therapy prescription. However, based on the results observed and considering (i) the relatively close prognostic values of GG and Ki67, (ii) the reclassification of about 30% of HG-2 tumors as Equivocal GG and (iii) the economical and technical requirements of the MapQuant micro-array GG test, the availability in the near future of a PCR-based Genomic Grade test with improved performances may lead to an introduction in clinical routine of this test for histological grade 2, ER positive, HER2 negative breast carcinoma
International Agency for Research on Cancer Workshop on 'Expression array analyses in breast cancer taxonomy'
In May 2006, a workshop on Expression array analyses in breast cancer taxonomy was held at the International Agency for Research on Cancer (IARC). The workshop covered an array of topics from the validity of the currently defined breast tumor subtypes and other expression profile-based signatures to the technical limitations of expression analysis and the types of platforms on which these omics results will eventually reach clinical practice. Overall, the workshop participants believed firmly that tumor taxonomy is likely to yield improved prognostic and predictive markers. Even so, further standardization and validation are required before clinical trials are set in motion
Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer
Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER-) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however, there is no formal evidence for it. Here, we provide experimental evidence that ER- breast cancer cells that survived high-dose Doxorubicin and Methotrexate based chemotherapies elicit a state of immunological dormancy. Hallmark of this dormant phenotype is the sustained activation of the IRF7/IFN-beta/IFNAR axis subsisting beyond chemotherapy treatment. Upregulation of IRF7 in treated cancer cells promoted resistance to chemotherapy, reduced cell growth and induced switching of the response from a myeloid derived suppressor cell-dominated immune response to a CD4(+)/CD8(+) T cell-dependent anti-tumor response. IRF7 silencing in tumor cells or systemic blocking of IFNAR reversed the state of dormancy, while spontaneous escape from dormancy was associated with loss of IFN-beta production. Presence of IFN-beta in the circulation of ER- breast cancer patients treated with neoadjuvant Epirubicin chemotherapy correlated with a significantly longer distant metastasis-free survival. These findings establish chemotherapy-induced immunological dormancy in ER- breast cancer as a novel concept for (neo)adjuvant chemotherapy activity, and implicate sustained activation of the IRF7/IFN-beta/IFNAR pathway in this effect. Further, IFN-beta emerges as a potential predictive biomarker and therapeutic molecule to improve outcome of ER- breast cancer patients treated with (neo)adjuvant chemotherapy.Peer reviewe
On The Broadcast and Validity-Checking Security of PKCS #1 v1.5 Encryption
(article recompensé par le "Best Student Paper Award")International audienceThis paper describes new attacks on PKCS #1 v1.5, a deprecated but still widely used RSA encryption standard. The first cryptanalysis is a broadcast attack, allowing the opponent to reveal an identical plaintext sent to different recipients. This is nontrivial because different randomizers are used for different encryptions (in other words, plaintexts coincide only partially). The second attack predicts, using a single query to a validity checking oracle, which of two chosen plaintexts corresponds to a challenge ciphertext. The attack's success odds are very high. The two new attacks rely on different mathematical tools and underline the need to accelerate the phase out of PKCS #1 v1.5
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