Building a robust dialogue system with limited data

We describe robustness techniques used in the CommandTalk system at the recognition level, the parsing level, and th dia6ue level, and how these were influenced by the lack of domain data. We used interviews with subject matter experts (SME's) to develop a single grammar for recognition, understanding, and generation, thus eliminating the need for a robust parser. We broadened the coverage of the recognition grammar by allowing word insertions and deletions, and we implemented clarification and correction subdialogues to increase robustness at tte dialogue level. We discuss the applicability of these techniques to other domains

Design-for-test structure to facilitate test vector application with low performance loss in non-test mode.

A switching based circuit is described which allows application of voltage test vectors to internal nodes of a chip without the problem of backdriving. The new circuit has low impact on the performance of an analogue circuit in terms of loss of bandwidth and allows simple application of analogue test voltages into internal nodes. The circuit described facilitates implementation of the forthcoming IEEE 1149.4 DfT philosophy [1]

On Gauge-Invariant Decomposition of Nucleon Spin

We investigate the relation between the known decompositions of the nucleon spin into its constituents, thereby clarifying in what respect they are common and in what respect they are different essentially. The decomposition recently proposed by Chen et al. can be thought of as a nontrivial generalization of the gauge-variant Jaffe-Manohar decomposition so as to meet the gauge-invariance requirement of each term of the decomposition. We however point out that there is another gauge-invariant decomposition of the nucleon spin, which is closer to the Ji decomposition, while allowing the decomposition of the gluon total angular momentum into the spin and orbital parts. After clarifying the reason why the gauge-invariant decomposition of the nucleon spin is not unique, we discuss which decomposition is more preferable from the experimental viewpoint.Comment: The version to appear in Phys. Rev.

Reflections on the Limitations of Rational Discourse, Empirical Data, and Legal Mandates as Tools for the Achievement of Gender Equity in American Higher Education

Scholars and academicians implicitly accept and subscribe to the notion that reasoned discourse supported by empirical data is at the core of the academic enterprise. Theoretically, then, organizational change within the academy ought to be attainable through the use of rational processes based upon the systematic collection, analysis, and interpretation of data to define the scope of the problem and to identify logical solutions. However, the centuries-long attempt to achieve gender equity for women in institutions of higher education belies the truth of that belief in the power of reason as a catalyst for reforming American higher education. Beginning with the Seneca Falls Convention in 1848, moving through the mid-twentieth century’s flurry of legal initiatives, and including two waves of scholarly studies and investigations of sexism on campus, the dominant characteristic of all the efforts to achieve gender equity in American colleges and universities has been reliance on reasoned discourse and data-based argumentation. Yet, today, only sixteen percent of all college and university presidents are women and less than one in four private research university faculty are women while well over fifty percent of all students are women. This paper is a reflection on the limited successes achieved in the almost 150 years since the Seneca Falls Convention using traditionally accepted academic approaches to eradicate sexism in the academy. The origins of the thoughts, ideas, and opinions offered here are found in the work of the Senate Council Ad Hoc Committee on the Status of Women at the University of Kentucky (“UK”). That work represents one of several contemporary efforts to use reasoned discourse predicated on empirical data to stimulate progress toward gender equity on campus. As such, and placed in its historical context, the experience of this UK committee is a case study in the long tradition of effort to use logic and reason to attain equal opportunities for women in higher education. When combined with the recent efforts of eight other similar universities, the UK experience highlights the limitations of the traditional academic approach to brining about gender-related organizational change. Equally important, when viewed collectively, these nine institutional change efforts illuminate various elements of the deeply entrenched, nonrational sensibilities present on campuses that limit the effectiveness of reasoned discourse, empirical data, and even legal mandates as tools for the achievement of gender equity. This Article briefly traces the early history of women’s struggle to secure access to educational and employment opportunities in America’s colleges and universities. A synopsis of the findings of the “First Wave” of investigations in the late 1960s and early 1970s of gender in the academy provides a context for the various legal strategies undertaken to secure gender equity in academia during the same time period. In the late 1980s a “Second Wave” of studies on gender on campus emerged. The results and implications of both a single institutional case study and a nine institution comparative study are reported and analyzed

Pluripotent stem cells and their dynamic niche

Cell-seeded implants are a regenerative medicine strategy that aims to replace injured tissue and restore tissue function. Pluripotent stem cells are promising cell candidates for the development of regenerative medicine therapies as they have the ability to self-renew and commit towards numerous cell types. In vivo, stem cells reside in a dynamic niche, a stem cell-specific microenvironment that possesses chemical, biological and mechanical cues, which drive the stem cell fate and renewal. The connection between stem cells and their niche is a two-way relationship consisting of both cell–cell interac‐tion and cell–extracellular matrix (ECM) interactions. An alternative regenerative medicine approach is the manipulation of the stem cell microenvironment. Hence, novel strategies have been developed including 3D biomaterials and bioreactor technologies providing topographical, chemical and mechanical cues to recreate the stem cell niche. Understanding the mechanisms controlling stem cell fate and the dynamic nature of thestem cell niche will enable researchers to replicate this stem cell-specific microenvironment, and therefore, harness and control the valuable attributes which stem cells possess. This chapter elucidates the importance of pluripotent stem cells and their dynamic niche in regenerative medicine. It further presents novel strategies to replicate chemical, topographical and mechanical stimuli which are essential for the regulation of stem cell fate and hence tissue regeneration

Supporting the Old but Neglecting the Young? The Two Faces of Ageism

Ageism is the most prevalent form of prejudice and is experienced by both older and younger people. Little is known about whether these experiences are interdependent or have common origins. We analyze data from 8,117 older (aged 70 and over) and 11,647 younger respondents (15–29 years) in representative samples from 29 countries in the European Social Survey. Using multilevel structural equation modeling, we test the hypothesis that older people are less likely, and younger people more likely, to suffer age discrimination if they live in a country with stronger structural support for older people. We also test the hypothesis that although stronger social norm against age discrimination reduce age discrimination suffered by older people it does not inhibit discrimination against younger people. These hypotheses are supported, and the results underline the neglected problem of ageism toward youth. Findings highlight that strategies for reducing age prejudice must address ageism as a multigenerational challenge, requiring attention to intergenerational cohesion and resource distribution between ages

Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation.

Nanocarriers can deliver a wide variety of drugs, target them to sites of interest, and protect them from degradation and inactivation by the body. They have the capacity to improve drug action and decrease undesirable systemic effects. We have previously developed a well-defined non-toxic PEG-dendritic block telodendrimer for successful delivery of chemotherapeutics agents and, in these studies, we apply this technology for therapeutic development in asthma. In these proof-of-concept experiments, we hypothesized that dexamethasone contained in self-assembling nanoparticles (Dex-NP) and delivered systemically would target the lung and decrease allergic lung inflammation and airways hyper-responsiveness to a greater degree than equivalent doses of dexamethasone (Dex) alone. We found that ovalbumin (Ova)-exposed mice treated with Dex-NP had significantly fewer total cells (2.78 ± 0.44 × 10(5) (n = 18) vs. 5.98 ± 1.3 × 10(5) (n = 13), P<0.05) and eosinophils (1.09 ± 0.28 × 10(5) (n = 18) vs. 2.94 ± 0.6 × 10(5) (n = 12), p<0.05) in the lung lavage than Ova-exposed mice alone. Also, lower levels of the inflammatory cytokines IL-4 (3.43 ± 1.2 (n = 11) vs. 8.56 ± 2.1 (n = 8) pg/ml, p<0.05) and MCP-1 (13.1 ± 3.6 (n = 8) vs. 28.8 ± 8.7 (n = 10) pg/ml, p<0.05) were found in lungs of the Dex-NP compared to control, and they were not lower in the Dex alone group. In addition, respiratory system resistance was lower in the Dex-NP compared to the other Ova-exposed groups suggesting a better therapeutic effect on airways hyperresponsiveness. Taken together, these findings from early-stage drug development studies suggest that the encapsulation and protection of anti-inflammatory agents such as corticosteroids in nanoparticle formulations can improve efficacy. Further development of novel drugs in nanoparticles is warranted to explore potential treatments for chronic inflammatory diseases such as asthma

Journal of African Christian Biography: v. 4, no. 2

A publication of the Dictionary of African Christian Biography with U.S. offices located at the Center for Global Christianity and Mission at Boston University. This issue focuses on: 1. Tributes to Lamin Sanneh by friends, family, colleagues, scholars, a Bible translator, and an editor. 2. Biographies by Lamin Sanneh in the DACB. 3. A selected bibliography by Lamin Sanneh, compiled by B. Restrick. 4. Book Notes, compiled by B. Restric