Methods of fitting multivariant functional models in the area of large computer exploita- tion final report, 23 may 1963 - 23 jul. 1965

Methods of fitting multivariant functional models in area of large computer exploitatio

A progressive refinement approach for the visualisation of implicit surfaces

Visualising implicit surfaces with the ray casting method is a slow procedure. The design cycle of a new implicit surface is, therefore, fraught with long latency times as a user must wait for the surface to be rendered before being able to decide what changes should be introduced in the next iteration. In this paper, we present an attempt at reducing the design cycle of an implicit surface modeler by introducing a progressive refinement rendering approach to the visualisation of implicit surfaces. This progressive refinement renderer provides a quick previewing facility. It first displays a low quality estimate of what the final rendering is going to be and, as the computation progresses, increases the quality of this estimate at a steady rate. The progressive refinement algorithm is based on the adaptive subdivision of the viewing frustrum into smaller cells. An estimate for the variation of the implicit function inside each cell is obtained with an affine arithmetic range estimation technique. Overall, we show that our progressive refinement approach not only provides the user with visual feedback as the rendering advances but is also capable of completing the image faster than a conventional implicit surface rendering algorithm based on ray casting

Computational Opioid Prescribing: A Novel Application of Clinical Pharmacokinetics

We implemented a pharmacokinetics-based mathematical modeling technique using algebra to assist pre-scribers with point-of-care opioid dosing. We call this technique computational opioid prescribing (COP). Because population pharmacokinetic parameter values are needed to estimate drug dosing regimen designs for individual patients using COP, and those values are not readily available to prescribers because they exist scattered in the vast pharmacology literature, we estimated the population pharmacokinetic parameter values for 12 commonly prescribed opioids from various sources using the bootstrap resampling technique. Our results show that opioid dosing regimen design, evaluation, and modification is feasible using COP. We conclude that COP is a new technique for the quantitative assessment of opioid dosing regimen design evaluation and adjustment, which may help prescribers to manage acute and chronic pain at the point-of-care. Potential benefits include opioid dose optimization and minimization of adverse opioid drug events, leading to potential improvement in patient treatment outcomes and safety

Policies on sexual expression in forensic psychiatric settings in different European countries

Background: Sexual expression by forensic psychiatric patients is poorly researched. Methods: Forensic experts representing 14 European countries were interviewed to explore the diverse ways in which sexual expression within forensic settings is handled. Results: No country had a national policy, although many had local policies or shared practices. Progressive approaches to patient sexuality were evident in nine of the countries sampled. The UK appeared the most prohibiting and excluding, its protocols apparently based on risk aversion and lack of emphasis or consideration of patients’ sexual needs. Conclusions: Uniform national policy supporting patients’ sexual expression would provide significant improvements

Couples that work full time and are happily married : myth or reality?

Este trabalho apresenta parte de uma pesquisa quantitativa cujo principal objetivo foi avaliar a satisfação no casamento de homens e mulheres que optaram por relacionamentos de duplo trabalho. Participaram do estudo 222 homens e 222 mulheres casados/as, funcionários/as em diversas instituições públicas de Brasília - DF. A maior concentração de respondentes de ambos os sexos está na faixa etária entre 31 a 40 anos. Os participantes responderam a um questionário demográfico e à Escala de Ajustamento Diádico - DAS. Os resultados mostraram que a maioria dos participantes está satisfeita com seus relacionamentos, sendo que as mulheres apresentaram média de satisfação inferior à dos homens. Quanto à percepção do futuro do relacionamento, ficou evidente o comprometimento de homens e mulheres em investirem na manutenção do casamento. Os resultados questionam a idéia vigente de falência do casamento e da família e apontam para uma transformação das relações. _________________________________________________________________________________________________________ ABSTRACTThis paper presents part of a quantitative research regarding marriages in which men and women are engaged in full time work. The main objective was to evaluate marital satisfaction in dual worker couples. Subjects were 222 married men and 222 married women that work in several public institutions in Brasilia - DF. The majority of the participants were between 31 to 40 years old. They answered a demographic questionnaire and the Dyadic Adjustment Scale - DAS. Results showed that the majority of participants were satisfied with their relationships although women presented lower satisfaction scores then men. Regarding the perception of the future of the relationship, the results showed that subjects were committed to preserve their marriage. These data question current ideas that marriages and families are outmoded and point in the direction of a transformation in interpersonal relationships

A MIQE-Compliant Real-Time PCR Assay for Aspergillus Detection

PMCID: PMC3393739This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited