Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures

The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABAARs) at the appropriate synaptic sites. Synaptic GABAARs are constructed from α(1-3), β(1-3), and γ2 subunits, and neurons can target these subtypes to specific synapses. Here, we identify a 15-amino acid inhibitory synapse targeting motif (ISTM) within the α2 subunit that promotes the association between GABAARs and the inhibitory scaffold proteins collybistin and gephyrin. Using mice in which the ISTM has been introduced into the α1 subunit (Gabra1-2 mice), we show that the ISTM is critical for axo-axonic synapse formation, the efficacy of GABAergic neurotransmission, and seizure sensitivity. The Gabra1-2 mutation rescues seizure-induced lethality in Gabra2-1 mice, which lack axo-axonic synapses due to the deletion of the ISTM from the α2 subunit. Taken together, our data demonstrate that the ISTM plays a critical role in promoting inhibitory synapse formation, both in the axonic and somatodendritic compartments

Utility of Parental Mediation Model on Youth’s Problematic Online Gaming

The Parental Mediation Model PMM) was initially designed to regulate children’s attitudes towards the traditional media. In the present era, because of prevalent online media there is a need for similar regulative measures. Spending long hours on social media and playing online games increase the risks of exposure to the negative outcomes of online gaming. This paper initially applied the PMM developed by European Kids Online to (i) test the reliability and validity of this model and (ii) identify the effectiveness of this model in controlling problematic online gaming (POG). The data were collected from 592 participants comprising 296 parents and 296 students of four foreign universities, aged 16 to 22 years in Kuala Lumpur (Malaysia). The study found that the modified model of the five-factor PMM (Technical mediation, Monitoring mediation, Restrictive mediation, Active Mediation of Internet Safety, and Active mediation of Internet Use) functions as a predictor for mitigating POG. The findings suggest the existence of a positive relation between ‘monitoring’ and ‘restrictive’ mediation strategies and exposure to POG while Active Mediation of Internet Safety and Active mediation of Internet use were insignificant predictors. Results showed a higher utility of ‘technical’ strategies by the parents led to less POG. The findings of this study do not support the literature suggesting active mediation is more effective for reducing youth’s risky behaviour. Instead, parents need to apply more technical mediations with their children and adolescents’ Internet use to minimize the negative effects of online gaming

Algebras generated by two bounded holomorphic functions

We study the closure in the Hardy space or the disk algebra of algebras generated by two bounded functions, of which one is a finite Blaschke product. We give necessary and sufficient conditions for density or finite codimension of such algebras. The conditions are expressed in terms of the inner part of a function which is explicitly derived from each pair of generators. Our results are based on identifying z-invariant subspaces included in the closure of the algebra. Versions of these results for the case of the disk algebra are given.Comment: 22 pages ; a number of minor mistakes have been corrected, and some points clarified. Conditionally accepted by Journal d'Analyse Mathematiqu

Qudits of composite dimension, mutually unbiased bases and projective ring geometry

The $d^2$ Pauli operators attached to a composite qudit in dimension $d$ may be mapped to the vectors of the symplectic module $\mathcal{Z}_d^{2}$ ($\mathcal{Z}_d$ the modular ring). As a result, perpendicular vectors correspond to commuting operators, a free cyclic submodule to a maximal commuting set, and disjoint such sets to mutually unbiased bases. For dimensions $d=6,~10,~15,~12$, and 18, the fine structure and the incidence between maximal commuting sets is found to reproduce the projective line over the rings $\mathcal{Z}_{6}$, $\mathcal{Z}_{10}$, $\mathcal{Z}_{15}$, $\mathcal{Z}_6 \times \mathbf{F}_4$ and $\mathcal{Z}_6 \times \mathcal{Z}_3$, respectively.Comment: 10 pages (Fast Track communication). Journal of Physics A Mathematical and Theoretical (2008) accepte

Interpretations of Presburger Arithmetic in Itself

Presburger arithmetic PrA is the true theory of natural numbers with addition. We study interpretations of PrA in itself. We prove that all one-dimensional self-interpretations are definably isomorphic to the identity self-interpretation. In order to prove the results we show that all linear orders that are interpretable in (N,+) are scattered orders with the finite Hausdorff rank and that the ranks are bounded in terms of the dimension of the respective interpretations. From our result about self-interpretations of PrA it follows that PrA isn't one-dimensionally interpretable in any of its finite subtheories. We note that the latter was conjectured by A. Visser.Comment: Published in proceedings of LFCS 201

Number theoretic example of scale-free topology inducing self-organized criticality

In this work we present a general mechanism by which simple dynamics running on networks become self-organized critical for scale free topologies. We illustrate this mechanism with a simple arithmetic model of division between integers, the division model. This is the simplest self-organized critical model advanced so far, and in this sense it may help to elucidate the mechanism of self-organization to criticality. Its simplicity allows analytical tractability, characterizing several scaling relations. Furthermore, its mathematical nature brings about interesting connections between statistical physics and number theoretical concepts. We show how this model can be understood as a self-organized stochastic process embedded on a network, where the onset of criticality is induced by the topology.Comment: 4 pages, 3 figures. Physical Review Letters, in pres

Motherhood, Moral Authority and the Charismatic Matriarch in the Aftermath of Lethal Violence

Images of maternal suffering are an evocative and powerful means of communication in a world where the private grief of victims has increasingly become subject to commodification and public consumption. This article looks at the influence of bereaved mothers as symbols of respect, peace and dignity in the aftermath of violence, and as a result their persuasive presence in family activism. Drawing upon two case studies, this article explores the importance of victims’ stories in public life and, in particular, the presence of the charismatic matriarch in creating communities of solidarity, raising awareness of harms that have previously gone unheard and prompting policy change. It considers the ‘canonical’ story of the mother in public life and concludes by arguing that more attention should be paid to victims’ stories and their influence on policy-making, politics and eventually in becoming public grievances