8,029 research outputs found
El sĂndrome de caquexia tumoral
En este trabajo realizamos una revisiĂłn de los mecanismos patogĂ©nicos que intervienen en el desarrollo de la caquexia tumoral, asĂ como de sus consecuencias clĂnicas y de las medidas terapĂ©uticas que podemos establecer para su tratamiento.This paper is a review of the pathogenesis of tumoral cachexia. Also, we present the main clinical signs of this syndrome and the therapeutic protocols to treat it
Subaru Spectroscopy and Spectral Modeling of Cygnus A
We present high angular resolution (0.5) MIR spectra
of the powerful radio galaxy, Cygnus A, obtained with the Subaru telescope. The
overall shape of the spectra agree with previous high angular resolution MIR
observations, as well as previous Spitzer spectra. Our spectra, both on and off
nucleus, show a deep silicate absorption feature. The absorption feature can be
modeled with a blackbody obscured by cold dust or a clumpy torus. The deep
silicate feature is best fit by a simple model of a screened blackbody,
suggesting foreground absorption plays a significant, if not dominant role, in
shaping the spectrum of Cygnus A. This foreground absorption prevents a clear
view of the central engine and surrounding torus, making it difficult to
quantify the extent the torus attributes to the obscuration of the central
engine, but does not eliminate the need for a torus in Cygnus A
Myocarditis evolving in cardiomyopathy: When genetics and offending causes work together
Myocarditis is an infectious-inflammatory disease often superimposed to individual genetic background which could favour or inhibit its progression into a chronic heart muscle disorder (most often dilated cardiomyopathy, rarely arrhythmogenic, or right-sided cardiomyopathy). Post-myocarditis cardiomyopathy is likely caused by a complex interaction between the viral infection and an individual predisposition. Some viruses are able to highlight a clinical phenotype replicating a model similar to the genetically determined conditions, while other can affect the resolution or the progressive remodelling of the left ventricle after the infectious process. The identification of specific individual genetic backgrounds, or genes favouring the progression of the disease, are important future research goals for precision medicine aiming at a specific and individualized treatment for patients affected with myocarditis
The cost of an ALP solution to the neutral -anomalies
The neutral anomalies in decays are analysed in terms of the tree-level
exchange of an axion-like-particle (ALP), within the effective field theory
framework. The complete two-dimensional parameter space for ALP couplings to
electrons and muons is explored. The solutions to and to the two energy
bins of are confronted with the impact of ALP exchange on other
observables (meson oscillations, leptonic and semileptonic decays of mesons
including searches for new resonances, astrophysical constraints), as well as
with the theoretical domain of validity of the effective theory. Solutions
based on ALPs heavier than mesons, or lighter than twice the muon mass, are
shown to be excluded. In contrast, the exchange of on-shell ALPs provides
solutions to and/or within sensitivity which are
technically compatible with those constraints; these solutions can be in
addition compatible with the data on the of the electron but not
simultaneously with those on the of the muon. Furthermore, a ''golden ALP
mass'' is identified at the frontier between the two energy bin windows of
, which could simultaneously explain these two
anomalies together with ; this calls for the convenience of different
energy binning which would easily clear up this (unlikely) possibility. The
impact of smearing on data analysis is also discussed.Comment: 50 pages, 15 figure
Current-oscillator correlation and Fano factor spectrum of quantum shuttle with finite bias voltage and temperature
A general master equation is derived to describe an electromechanical
single-dot transistor in the Coulomb blockade regime. In the equation, Fermi
distribution functions in the two leads are taken into account, which allows
one to study the system as a function of bias voltage and temperature of the
leads. Furthermore, we treat the coherent interaction mechanism between
electron tunneling events and the dynamics of excited vibrational modes.
Stationary solutions of the equation are numerically calculated. We show
current through the oscillating island at low temperature appears step like
characteristics as a function of the bias voltage and the steps depend on mean
phonon number of the oscillator. At higher temperatures the current steps would
disappear and this event is accompanied by the emergence of thermal noise of
the charge transfer. When the system is mainly in the ground state, zero
frequency Fano factor of current manifests sub-Poissonian noise and when the
system is partially driven into its excited states it exhibits super-Poissonian
noise. The difference in the current noise would almost be removed for the
situation in which the dissipation rate of the oscillator is much larger than
the bare tunneling rates of electrons.Comment: 14 pages, 8 figure
BelastungsabhÀngige vertikale Doppelbilder und Ptosis
Zusammenfassung: Eine 43-jĂ€hrige Patientin wurde uns vorgestellt, da seit 2-3Monaten ihr linkes Augenlid in wechselnder AusprĂ€gung hing. Ferner nahm sie auch Doppelbilder in Extrempositionen oder nach schnellen Augenbewegungen wahr und war lichtempfindlich. Die Diagnose ergab ein Keilbeinmeningeom. Es wurde in der Folge 2-mal innerhalb von 3Monaten mittels Radiopeptidtherapie mit 90Y-DOTATOC (Somatostatin-Analogon) behandelt. Bei unserer Patientin fĂŒhrte diese Therapie zu einer Volumenreduktion des Tumors sowie zu einer klinischen Verbesserung und dann Stabilisierun
PATHOS: A Brief Screening Application for Assessing Sexual Addiction
Sexual addiction is estimated to afflict up to 3% to 6% of the population. However, many clinicians lack clear criteria for detecting potential cases.
Objectives: The present studies were conducted to assess the effectiveness of a brief sexual addiction screening instrument (ie, PATHOS Questionnaire) to correctly classify patients being treated for sex addiction and healthy volunteers.
Methods: In study 1, a 6-item questionnaire, which utilizes the mnemonic PATHOS, was examined in regard to sensitivity and specificity using a sample combining patients being treated for sex addiction and healthy volunteers (970 men/80.2% patients; 938 women/63.8% patients). In study 2, a cross-validation sample of 672 men (93% patients) and 241 women (35.3% patients) completed the PATHOS screener.
Results: Results of receiver operating characteristics analyses in study 1 demonstrated that the PATHOS captured 92.6% of the area under the curve and achieved 88.3% sensitivity and 81.6% specificity for classifying the male sample (n = 963) as patients and healthy subjects using a cutoff score of 3. Similarly, the PATHOS captured 90.2% of the area under the curve and, with a cutoff of 3, achieved 80.9% sensitivity and 87.2% specificity for the female sample (n = 808). In study 2, results of receiver operating characteristics analyses indicated that the PATHOS captured 85.1% of the area under the curve, with sensitivity of 70.7% and specificity of 86.9% for men (cutoff of 3). For women, the PATHOS captured 80.9% of the area under the curve and achieved 69.7% sensitivity and 85.1% specificity with the cutoff of 3.
Conclusions: These studies provide support for the use of the PATHOS as a screening instrument to detect potential sexual addiction cases in clinical settings
The role country of birth plays in receiving disability pensions in relation to patterns of health care utilisation and socioeconomic differences: a multilevel analysis of Malmo, Sweden
BACKGROUND: People of low socioeconomic status have worse health and a higher probability of being granted a disability pension than people of high socioeconomic status. It is also known that public and private general physicians and public and private specialists have varying practices for issuing sick leave certificates (which, if longstanding, may become the basis of disability pensions). However, few studies have investigated the influence of a patient's country of birth in this context. METHODS: We used multilevel logistic regression analysis with individuals (first level) nested within countries of birth (second level). We analysed the entire population between the ages of 40 and 64 years (n = 80 212) in the city of Malmo, Sweden, in 2003, and identified 73% of that population who had visited a physician at least once during that year. We studied the associations between individuals and country of birth socioeconomic characteristics, as well as individual utilisation of different kinds of physicians in relation to having been granted a disability pension. RESULTS: Living alone (OR(women )= 1.72, 95% CI: 1.62â1.82; OR(men )= 2.64, 95% CI: 2.46â2.83) and having limited educational achievement (OR(women )= 2.14, 95% CI: 2.00â2.29; OR(men )= 2.12, 95% CI: 1.98â2.28) were positively associated with having a disability pension. Utilisation of public specialists was associated with a higher probability (OR(women )= 2.11, 95% CI: 1.98â2.25; OR(men )= 2.16, 95% CI: 2.01â2.32) and utilisation of private GPs with a lower probability (OR(men )= 0.76, 95% CI: 0.69â0.83) of having a disability pension. However, these associations differed by countries of birth. Over and above individual socioeconomic status, men from middle income countries had a higher probability of having a disability pension (OR(men )= 1.61, 95% CI: 1.06â2.44). CONCLUSION: The country of one's birth appears to play a significant role in understanding how individual socioeconomic differences bear on the likelihood of receiving a disability pension and on associated patterns of health care utilisation
Comparison between adult and foetal adnexa derived equine post-natal mesenchymal stem cells
Background Little is known about the differences among adult and foetal equine mesenchymal stem cells (MSCs), and no data exist about their comparative ultrastructural morphology. The aim of this study was to describe and compare characteristics, immune properties, and ultrastructural morphology of equine adult (bone marrow: BM, and adipose tissue: AT) and foetal adnexa derived (umbilical cord blood: UCB, and Wharton's jelly: WJ) MSCs. Results No differences were observed in proliferation during the first 3 passages. While migration ability was similar among cells, foetal MSCs showed a higher adhesion ability, forming smaller spheroids after hanging drop culture (P < 0.05). All MSCs differentiated toward adipogenic, chondrogenic and osteogenic lineages, only tenogenic differentiation was less evident for WJ-MSCs. Data obtained by PCR confirmed MHC1 expression and lack of MHC2 expression in all four cell types. Foetal adnexa MSCs were positive for genes specific for anti-inflammatory and angiogenic factors (IL6, IL8, IL beta 1) and WJ-MSCs were the only positive for OCT4 pluripotency gene. At immunofluorescence all cells expressed typical mesenchymal markers (alpha-SMA, N-cadherin), except for BM-MSCs, which did not express N-cadherin. By transmission electron microscopy, it was observed that WJ-MSCs had a higher (P < 0.05) number of microvesicles compared to adult MSCs, and UCB-MSCs showed more microvesicles than BM-MSCs (P < 0.05). AT-MSCs had a lower number of mitochondria than WJ-MSCs (P < 0.05), and mitochondrial area was higher for WJ-MSCs compared to UCB and AT-MSCs (P < 0.05). Conclusions Results demonstrate that MSCs from adult and foetal tissues have different characteristics, and foetal MSCs, particularly WJ derived ones, seem to have some charactestics that warrant further investigation into potential advantages for clinical application
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