10,110 research outputs found
Short-term, medium-term and long-term effects of early parenting interventions in low- and middle-income countries: a systematic review
INTRODUCTION: Parenting interventions during early childhood are known to improve various child development outcomes immediately following programme implementation. However, less is known about whether these initial benefits are sustained over time. METHODS: We conducted a systematic literature review of parenting interventions in low- and middle-income countries (LMICs) that were delivered during the first 3 years of life and had completed a follow-up evaluation of the intervention cohort at least 1 year after the primary postintervention endpoint. We summarized intervention effects over time by child-level and parent-level outcomes as well as by timing of follow-up rounds in the short-term (1-3 years after programme completion), medium-term (4-9 years), and long-term (10+ years). We also conducted exploratory meta-analyses to compare effects on children's cognitive and behavioral development by these subgroups of follow-up rounds. RESULTS: We identified 24 articles reporting on seven randomised controlled trials of parenting interventions delivered during early childhood that had at least one follow-up study in seven LMICs. The majority of follow-up studies were in the short-term. Three trials conducted a medium-term follow-up evaluation, and only two trials conducted a long-term follow-up evaluation. Although trials consistently supported wide-ranging benefits on early child development outcomes immediately after programme completion, results revealed a general fading of effects on children's outcomes over time. Short-term effects were mixed, and medium-term and long-term effects were largely inconclusive. The exploratory meta-analysis on cognitive development found that pooled effects were significant at postintervention and in the short-term (albeit smaller in magnitude), but the effects were not significant in the medium-term and long-term. For behavioural development, the effects were consistently null over time. CONCLUSIONS: There have been few longer-term follow-up studies of early parenting interventions in LMICs. Greater investments in longitudinal intervention cohorts are needed in order to gain a more comprehensive understanding of the effectiveness of parenting interventions over the life course and to improve the design of future interventions so they can have greater potential for achieving and sustaining programme benefits over time
A simple physical model for scaling in protein-protein interaction networks
It has recently been demonstrated that many biological networks exhibit a
scale-free topology where the probability of observing a node with a certain
number of edges (k) follows a power law: i.e. p(k) ~ k^-g. This observation has
been reproduced by evolutionary models. Here we consider the network of
protein-protein interactions and demonstrate that two published independent
measurements of these interactions produce graphs that are only weakly
correlated with one another despite their strikingly similar topology. We then
propose a physical model based on the fundamental principle that (de)solvation
is a major physical factor in protein-protein interactions. This model
reproduces not only the scale-free nature of such graphs but also a number of
higher-order correlations in these networks. A key support of the model is
provided by the discovery of a significant correlation between number of
interactions made by a protein and the fraction of hydrophobic residues on its
surface. The model presented in this paper represents the first physical model
for experimentally determined protein-protein interactions that comprehensively
reproduces the topological features of interaction networks. These results have
profound implications for understanding not only protein-protein interactions
but also other types of scale-free networks.Comment: 50 pages, 17 figure
Quasiparticle Interference on the Surface of Topological Crystalline Insulator Pb(1-x)Sn(x)Se
Topological crystalline insulators represent a novel topological phase of
matter in which the surface states are protected by discrete point
group-symmetries of the underlying lattice. Rock-salt lead-tin-selenide alloy
is one possible realization of this phase which undergoes a topological phase
transition upon changing the lead content. We used scanning tunneling
microscopy (STM) and angle resolved photoemission spectroscopy (ARPES) to probe
the surface states on (001) PbSnSe in the topologically
non-trivial (x=0.23) and topologically trivial (x=0) phases. We observed
quasiparticle interference with STM on the surface of the topological
crystalline insulator and demonstrated that the measured interference can be
understood from ARPES studies and a simple band structure model. Furthermore,
our findings support the fact that PbSnSe and PbSe have
different topological nature.Comment: 5 pages, 4 figure
Cluster Model of Decagonal Tilings
A relaxed version of Gummelt's covering rules for the aperiodic decagon is
considered, which produces certain random-tiling-type structures. These
structures are precisely characterized, along with their relationships to
various other random tiling ensembles. The relaxed covering rule has a natural
realization in terms of a vertex cluster in the Penrose pentagon tiling. Using
Monte Carlo simulations, it is shown that the structures obtained by maximizing
the density of this cluster are the same as those produced by the corresponding
covering rules. The entropy density of the covering ensemble is determined
using the entropic sampling algorithm. If the model is extended by an
additional coupling between neighboring clusters, perfectly ordered structures
are obtained, like those produced by Gummelt's perfect covering rules.Comment: 10 pages, 20 figures, RevTeX; minor changes; to be published in Phys.
Rev.
Asymptotic step profiles from a nonlinear growth equation for vicinal surfaces
We study a recently proposed nonlinear evolution equation describing the
collective step meander on a vicinal surface subject to the Bales-Zangwill
growth instability [O. Pierre-Louis et al., Phys. Rev. Lett. (80), 4221
(1998)]. A careful numerical analysis shows that the dynamically selected step
profile consists of sloped segments, given by an inverse error function and
steepening as sqrt(t), which are matched to pieces of a stationary
(time-independent) solution describing the maxima and minima. The effect of
smoothening by step edge diffusion is included heuristically, and a
one-parameter family of evolution equations is introduced which contains
relaxation by step edge diffusion and by attachment-detachment as special
cases. The question of the persistence of an initially imposed meander
wavelength is investigated in relation to recent experiments.Comment: 4 pages, 5 included figures. Typo in Eq.(5) corrected, section
headlines added and Ref.[12] update
On the driven Frenkel-Kontorova model: II. Chaotic sliding and nonequilibrium melting and freezing
The dynamical behavior of a weakly damped harmonic chain in a spatially
periodic potential (Frenkel-Kontorova model) under the subject of an external
force is investigated. We show that the chain can be in a spatio-temporally
chaotic state called fluid-sliding state. This is proven by calculating
correlation functions and Lyapunov spectra. An effective temperature is
attributed to the fluid-sliding state. Even though the velocity fluctuations
are Gaussian distributed, the fluid-sliding state is clearly not in equilibrium
because the equipartition theorem is violated. We also study the transition
between frozen states (stationary solutions) and=7F molten states
(fluid-sliding states). The transition is similar to a first-order phase
transition, and it shows hysteresis. The depinning-pinning transition
(freezing) is a nucleation process. The frozen state contains usually two
domains of different particle densities. The pinning-depinning transition
(melting) is caused by saddle-node bifurcations of the stationary states. It
depends on the history. Melting is accompanied by precursors, called
micro-slips, which reconfigurate the chain locally. Even though we investigate
the dynamics at zero temperature, the behavior of the Frenkel-Kontorova model
is qualitatively similar to the behavior of similar models at nonzero
temperature.Comment: Written in RevTeX, 13 figures in PostScript, appears in PR
Molecular Line Observations of the Small Protostellar Group L1251B
We present molecular line observations of L1251B, a small group of pre- and
protostellar objects, and its immediate environment in the dense C18O core
L1251E. These data are complementary to near-infrared, submillimeter and
millimeter continuum observations reported by Lee et al. (2006, ApJ, 648, 491;
Paper I). The single-dish data of L1251B described here show very complex
kinematics including infall, rotation and outflow motions, and the
interferometer data reveal these in greater detail. Interferometer data of N2H+
1-0 suggest a very rapidly rotating flattened envelope between two young
stellar objects, IRS1 and IRS2. Also, interferometer data of CO 2-1 resolve the
outflow associated with L1251B seen in single-dish maps into a few narrow and
compact components. Furthermore, the high resolution data support recent
theoretical studies of molecular depletions and enhancements that accompany the
formation of protostars within dense cores. Beyond L1251B, single-dish data are
also presented of a dense core located ~150" to the east that, in Paper I, was
detected at 850 micron but has no associated point sources at near- and
mid-infrared wavelengths. The relative brightness between molecules, which have
different chemical timescales, suggests it is less chemically evolved than
L1251B. This core may be a site for future star formation, however, since line
profiles of HCO+, CS, and HCN show asymmetry with a stronger blue peak, which
is interpreted as an infall signature.Comment: 46 pages, 18 figures. Accepted for publication in Ap
Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice
Potassium (K+) channels shape the response properties of neurons. Although enormous progress has been made to characterize K+ channels in the primary auditory neurons, the molecular identities of many of these channels and their contributions to hearing in vivo remain unknown. Using a combination of RNA sequencing and single molecule fluorescent in situ hybridization, we localized expression of transcripts encoding the sodium-activated potassium channels K(Na)1.1(SLO2.2/Slack) and K(Na)1.2 (SLO2.1/Slick) to the primary auditory neurons (spiral ganglion neurons, SGNs). To examine the contribution of these channels to function of the SGNs in vivo, we measured auditory brainstem responses in K(Na)1.1/1.2 double knockout (DKO) mice. Although auditory brainstem response (wave I) thresholds were not altered, the amplitudes of suprathreshold responses were reduced in DKO mice. This reduction in amplitude occurred despite normal numbers and molecular architecture of the SGNs and their synapses with the inner hair cells. Patch clamp electrophysiology of SGNs isolated from DKO mice displayed altered membrane properties, including reduced action potential thresholds and amplitudes. These findings show that K(Na)1 channel activity is essential for normal cochlear function and suggest that early forms of hearing loss may result from physiological changes in the activity of the primary auditory neurons
Orbital ordering and enhanced magnetic frustration of strained BiMnO3 thin films
Epitaxial thin films of multiferroic perovskite BiMnO3 were synthesized on
SrTiO3 substrates, and orbital ordering and magnetic properties of the thin
films were investigated. The ordering of the Mn^{3+} e_g orbitals at a wave
vector (1/4 1/4 1/4) was detected by Mn K-edge resonant x-ray scattering. This
peculiar orbital order inherently contains magnetic frustration. While bulk
BiMnO3 is known to exhibit simple ferromagnetism, the frustration enhanced by
in-plane compressive strains in the films brings about cluster-glass-like
properties.Comment: 8 pages, 4 figures, accepted to Europhysics Letter
- …