93 research outputs found
Time to AIDS from 1992 to 1999 in HIV-1-Infected Subjects with Known Date of Infection.
To estimate the change in AIDS incubation time during three periods characterized by different availability of antiretroviral treatments, data from the French Hospital Database on HIV of 4702 HIV-1-positive subjects with a documented date of infection were analyzed. Times from seroconversion to AIDS were compared in three periods: period 1 from January 1992 to June 1995 (monotherapy); period 2 from July 1995 to June 1996 (dual therapy); and period 3 from July 1996 to June 1999 (triple therapy). Nonparametric survival analyses were performed to account for staggered entries in the database and during each period. From periods 1 to 3, antiretroviral treatments were initiated earlier after infection, more subjects were treated, and the nature of regimens changed (25.6% of subjects were treated with monotherapy in period 1, 34.6% were treated with dual therapy in period 2, and 53.4% were treated with triple therapy in period 3). Compared with period 1, the relative hazard (RH) of AIDS was 0.31 in period 3 (95% confidence interval [CI]: 0.24-0.39). When comparing period 3 with period 2, the RH of AIDS was 0.36 (CI: 0.29-0.45). Assuming a log normal distribution, the median time to AIDS was estimated as 8.0 years in period 1 (CI: 6.0-10.6), 9.8 years in period 2 (CI: 8.5, 11.2), and 20.0 years in period 3 (CI: 17.1-23.3). This lengthening in time to AIDS from 1992 to 1999 was particularly marked in the period after the introduction of triple therapy, including protease inhibitors
The diagnostic accuracy and cost-effectiveness of magnetic resonance spectroscopy and enhanced magnetic resonance imaging techniques in aiding the localisation of prostate abnormalities for biopsy : a systematic review and economic evaluation
Peer reviewedPublisher PD
On the Relativistic Description of the Nucleus
We discuss a relativistic theory of the atomic nuclei in the framework of the
hamiltonian formalism and of the mesonic model of the nucleus. Attention is
paid to the translational invariance of the theory. Our approach is centered on
the concept of spectral amplitude, a function in the Dirac spinor space. We
derive a Lorentz covariant equation for the latter, which requires as an input
the baryon self-energy. For this we either postulate the most general
Lorentz-Poincar\'e invariant expression or perform a calculation via a
Bethe-Salpeter equation starting from a nucleon-nucleus interaction. We discuss
the features of the nuclear spectrum obtained in the first instance. Finally
the general constraints the self-energy should satisfy because of analyticity
and Poincar\'e covariance are discussed
Using health surveillance systems data to assess the impact of AIDS and antiretroviral treatment on adult morbidity and mortality in Botswana
Introduction: Botswana's AIDS response included free antiretroviral treatment (ART) since 2002, achieving 80% coverage of persons with CD450% and >30% through 2011, while continuing to increase in older women. Conclusions: Adult mortality in Botswana fell markedly as ART coverage increased. HIV prevalence declines may reflect ART-associated reductions in sexual transmission. Triangulation of surveillance system data offers a reasonable approach to evaluate impact of HIV/AIDS interventions, complementing cohort approaches that monitor individual-level health outcomes
Effects of Short Range Correlations on Ca Isotopes
The effect of Short Range Correlations (SRC) on Ca isotopes is studied using
a simple phenomenological model. Theoretical expressions for the charge
(proton) form factors, densities and moments of Ca nuclei are derived. The role
of SRC in reproducing the empirical data for the charge density differences is
examined. Their influence on the depletion of the nuclear Fermi surface is
studied and the fractional occupation probabilities of the shell model orbits
of Ca nuclei are calculated. The variation of SRC as function of the mass
number is also discussed.Comment: 11 pages (RevTex), 6 Postscript figures available upon request at
[email protected] Physical Review C in prin
Three-body dN interaction in the analysis of the 12C(pol_d,d') reaction at 270 MeV
We have measured the cross sections and analyzing powers Ay and Ayy for the
elastic and inelastic scattering of deuterons from the 0+(g.s.), 2+(4.44 MeV),
3-(9.64 MeV), 1+(12.71 MeV), and 2-(18.3 MeV) states in 12C at an incident
energy of 270 MeV. The data are compared with microscopic distorted-wave
impulse approximation calculations where the projectile-nucleon effective
interactionis taken from the three-nucleon t-matrix given by rigorous Faddeev
calculations presently available at intermediate energies. The agreement
between theory and data compares well with that for the (p,p') reactions at
comparable incident energies/nucleon.Comment: 17 pages, 3 Postscript figure
Role of the Nuclear and Electromagnetic Interactions in the Coherent Dissociation of the Relativistic Li Nucleus into the H + He Channel
The differential cross section in the transverse momentum and a total
cross section of mb for the coherent dissociation of a 3-A-GeV/
Li nucleus through the HHe channel have been measured on emulsion
nuclei. The observed dependence of the cross section is explained by the
predominant supposition of the nuclear diffraction patterns on light (C, N, O)
and heavy (Br, Ag) emulsion nuclei. The contributions to the cross section from
nuclear diffraction ( MeV/) and Coulomb MeV/)
dissociations are calculated to be 40.7 and 4 mb, respectively.Comment: ISSN 0021-3640, Pleiades Publishing, Ltd., 200
Microscopic theories of neutrino-^{12}C reactions
In view of the recent experiments on neutrino oscillations performed by the
LSND and KARMEN collaborations as well as of future experiments, we present new
theoretical results of the flux averaged and
cross sections. The approaches used are
charge-exchange RPA, charge-exchange RPA among quasi-particles (QRPA) and the
Shell Model. With a large-scale shell model calculation the exclusive cross
sections are in nice agreement with the experimental values for both reactions.
The inclusive cross section for coming from the decay-in-flight of
is to be compared to the experimental value
of , while the one due to
coming from the decay-at-rest of is which
agrees within experimental error bars with the measured values. The shell model
prediction for the decay-in-flight neutrino cross section is reduced compared
to the RPA one. This is mainly due to the different kind of correlations taken
into account in the calculation of the spin modes and partially due to the
shell-model configuration basis which is not large enough, as we show using
arguments based on sum-rules.Comment: 17 pages, latex, 5 figure
Cosmological model with macroscopic spin fluid
We consider a Friedmann-Robertson-Walker cosmological model with some exotic
perfect fluid with spin known as the Weyssenhoff fluid. The possibility that
the dark energy may be described in part by the Weyssenhoff fluid is discussed.
The observational constraint coming from supernovae type Ia observations is
established. This result indicates that, whereas the cosmological constant is
still needed to explain current observations, the model with spin fluid is
admissible. For high redshifts the differences between the model with
spin fluid and the cold dark matter model with a cosmological constant become
detectable observationally for the flat case with .
From the maximum likelihood method we obtain the value of
. This gives us the limit
at the level. While the model with
``brane effects'' is preferred by the supernovae Ia data, the model with spin
fluid is statistically admissible. For comparison, the limit on the spin fluid
coming from cosmic microwave background anisotropies is also obtained. The
uncertainties in the location of a first peak give the interval . From big bang nucleosynthesis we
obtain the strongest limit . The
interconnection between the model considered and brane models is also pointed
out.Comment: RevTeX4, 15 pages, 10 figures; some minor change
Estimating the Capacity for ART Provision in Tanzania with the Use of Data on Staff Productivity and Patient Losses
BACKGROUND: International targets for access to antiretroviral therapy (ART) have over-estimated the capacity of health systems in low-income countries in Sub-Saharan Africa. The WHO target for number on treatment by end 2005 for Tanzania was 10 times higher than actually achieved. The target of the national Care and Treatment Plan (CTP) was also not reached. We aimed at estimating the capacity for ART provision and created five scenarios for ART production given existing resource limitations. METHODS: A situation analysis including scrutiny of staff factors, such as available data on staff and patient factors including access to ART and patient losses, made us conclude that the lack of clinical staff is the main limiting factor for ART scale-up, assuming that sufficient drugs and supplies are provided by donors. We created a simple formula to estimate the number of patients on ART based on availability and productivity of clinical staff, time needed to initiate vs maintain a patient on ART and patient losses using five different scenarios with varying levels of these parameters. FINDINGS: Our scenario assuming medium productivity (40% higher than that observed in 2002) and medium loss of patients (20% in addition to 15% first-year mortality) coincides with the actual reported number of patients initiated on ART up to 2008, but is considerably below the national CTP target of 90% coverage for 2009, corresponding to 420,000 on ART and 710,000 life-years saved (LY's). Our analysis suggests that a coverage of 40% or 175,000 on treatment and 350,000 LY's saved is more achievable. CONCLUSION: A comparison of our scenario estimations and actual output 2006-2008 indicates that a simple user-friendly dynamic model can estimate the capacity for ART scale-up in resource-poor settings based on identification of a limiting staff factor and information on availability of this staff and patient losses. Thus, it is possible to set more achievable targets
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