701 research outputs found

    Noise suppression with high Mach number inlets

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    Experimental results were obtained for two types of high Mach number inlets, one with a translating centerbody and a fixed geometry inlet (collapsing cowl) with no centerbody. The aerodynamic and acoustic performance of these inlets was examined. The effects of area ratio, length/diameter ratio, and lip geometry were among several parameters investigated. The translating centerbody type inlet was found to be superior to the collapsing cowl both acoustically and aerodynamically, particularly for area ratios greater than 1.5. Comparison of length/diameter ratio and area ratio effects on performance near choked flow showed the latter to be more significant. Also, greater high frequency noise attenuation was achieved by increasing Mach number from low to high subsonic values

    Superfluidity and magnetism in multicomponent ultracold fermions

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    We study the interplay between superfluidity and magnetism in a multicomponent gas of ultracold fermions. Ward-Takahashi identities constrain possible mean-field states describing order parameters for both pairing and magnetization. The structure of global phase diagrams arises from competition among these states as functions of anisotropies in chemical potential, density, or interactions. They exhibit first and second order phase transition as well as multicritical points, metastability regions, and phase separation. We comment on experimental signatures in ultracold atoms.Comment: 4 pages, 3 figure

    Glutathione and Glutaredoxin—Key Players in Cellular Redox Homeostasis and Signaling

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    This Special Issue of Antioxidants on Glutathione (GSH) and Glutaredoxin (Grx) was designed to collect review articles and original research studies focused on advancing the current understanding of the roles of the GSH/Grx system in cellular homeostasis and disease processes. The tripeptide glutathione (GSH) is the most abundant non-enzymatic antioxidant/nucleophilic molecule in cells. In addition to various metabolic reactions involving GSH and its oxidized counterpart GSSG, oxidative post-translational modification (PTM) of proteins has been a focal point of keen interest in the redox field over the last few decades. In particular, the S-glutathionylation of proteins (protein-SSG formation), i.e., mixed disulfides between GSH and protein thiols, has been studied extensively. This reversible PTM can act as a regulatory switch to interconvert inactive and active forms of proteins, thereby mediating cell signaling and redox homeostasis. The unique architecture of the GSH molecule enhances its relative abundance in cells and contributes to the glutathionyl specificity of the primary catalytic activity of the glutaredoxin enzymes, which play central roles in redox homeostasis and signaling, and in iron metabolism in eukaryotes and prokaryotes under physiological and pathophysiological conditions. The class-1 glutaredoxins are characterized as cytosolic GSH-dependent oxidoreductases that catalyze reversible protein S-glutathionylation specifically, thereby contributing to the regulation of redox signal transduction and/or the protection of protein thiols from irreversible oxidation. This Special Issue includes nine other articles: three original studies and six review papers. Together, these ten articles support the central theme that GSH/Grx is a unique system for regulating thiol-redox hemostasis and redox-signal transduction, and the dysregulation of the GSH/Grx system is implicated in the onset and progression of various diseases involving oxidative stress. Within this context, it is important to appreciate the complementary functions of the GSH/Grx and thioredoxin systems not only in thiol-disulfide regulation but also in reversible S-nitrosylation. Several potential clinical applications have emerged from a thorough understanding of the GSH/Grx redox regulatory system at the molecular level, and in various cell types in vitro and in vivo, including, among others, the concept that elevating Grx content/activity could serve as an anti-fibrotic intervention; and discovering small molecules that mimic the inhibitory effects of S-glutathionylation on dimer association could identify novel anti-viral agents that impact the key protease activities of the HIV and SARS-CoV-2 viruses. Thus, this Special Issue on Glutathione and Glutaredoxin has focused attention and advanced understanding of an important aspect of redox biology, as well as spawning questions worthy of future study

    Density Induced Quantum Phase Transitions in Triplet Superconductors

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    We consider the possibility of quantum phase transitions in the ground state of triplet superconductors where particle density is the tunning parameter. For definiteness, we focus on the case of one band quasi-one-dimensional triplet superconductors but many of our conclusions regarding the nature of the transition are quite general. Within the functional integral formulation, we calculate the electronic compressibility and superfluid density tensor as a function of the particle density for various triplet order parameter symmetries and find that these quantities are non-analytic when a critical value of the particle density is reached.Comment: 4 pages, 3 figure

    Recent Progress in Droplet-Based Manufacturing Research

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    This article reports the recent progress of re-search made in the Droplet-Based Manufacturing Laboratory at MIT. The study has been focused on obtaining a fundamental understanding of microdroplet deposition and applying the technology to various practical applications. Specific scientific contributions include the development of an analytical model for droplet splashing/recoiling, an in situ droplet size control methodology, and a study of microstructure design for spray forming. The research per-formed in the lab provides both fundamental knowledge base and practical process developments for a range of manufacturing applications, including electronics packaging, spray forming and freeform fabrication.Singapore-MIT Alliance (SMA

    Entropic Regularization Approach for Mathematical Programs with Equilibrium Constraints

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    A new smoothing approach based on entropic perturbation is proposed for solving mathematical programs with equilibrium constraints. Some of the desirable properties of the smoothing function are shown. The viability of the proposed approach is supported by a computationalstudy on a set of well-known test problems

    On the Finite Termination of An Entropy Function Based Smoothing Newton Method for Vertical Linear Complementarity Problems

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    By using a smooth entropy function to approximate the non-smooth max-type function, a vertical linear complementarity problem (VLCP) can be treated as a family of parameterized smooth equations. A Newton-type method with a testing procedure is proposed to solve such a system. We show that the proposed algorithm finds an exact solution of VLCP in a finite number of iterations, under some conditions milder than those assumed in literature. Some computational results are included to illustrate the potential of this approach

    Symmetry analysis of crystalline spin textures in dipolar spinor condensates

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    We study periodic crystalline spin textures in spinor condensates with dipolar interactions via a systematic symmetry analysis of the low-energy effective theory. By considering symmetry operations which combine real and spin space operations, we classify symmetry groups consistent with non-trivial experimental and theoretical constraints. Minimizing the energy within each symmetry class allows us to explore possible ground states.Comment: 19 pages, 4 figure

    Bell inequalities for three systems and arbitrarily many measurement outcomes

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    We present a family of Bell inequalities for three parties and arbitrarily many outcomes, which can be seen as a natural generalization of the Mermin Bell inequality. For a small number of outcomes, we verify that our inequalities define facets of the polytope of local correlations. We investigate the quantum violations of these inequalities, in particular with respect to the Hilbert space dimension. We provide strong evidence that the maximal quantum violation can only be reached using systems with local Hilbert space dimension exceeding the number of measurement outcomes. This suggests that our inequalities can be used as multipartite dimension witnesses.Comment: v1 6 pages, 4 tables; v2 Published version with minor typos correcte

    Generating nonclassical correlations without fully aligning measurements

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    We investigate the scenario where spatially separated parties perform measurements in randomly chosen bases on an N-partite Greenberger-Horne-Zeilinger state. We show that without any alignment of the measurements, the observers will obtain correlations that violate a Bell inequality with a probability that rapidly approaches 1 as N increases and that this probability is robust against noise. We also prove that restricting these randomly chosen measurements to a plane perpendicular to a common direction will always generate correlations that violate some Bell inequality. Specifically, if each observer chooses their two measurements to be locally orthogonal, then the N observers will violate one of two Bell inequalities by an amount that increases exponentially with N. These results are also robust against noise and perturbations of each observer's reference direction from the common direction.Comment: v2: Essentially published version (with typos fixed, results updated in Table 2 and Figure 4 replaced); v1: 16 pages, 5 figures, 2 tables, comments welcom
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