Loss of 5-hydroxymethylcytosine is a frequent event in peripheral T-cell lymphomas.

International audienc

Building block libraries and structural considerations in the self-assembly of polyoxometalate and polyoxothiometalate systems

Inorganic metal-oxide clusters form a class of compounds that are unique in their topological and electronic versatility and are becoming increasingly more important in a variety of applications. Namely, Polyoxometalates (POMs) have shown an unmatched range of physical properties and the ability to form structures that can bridge several length scales. The formation of these molecular clusters is often ambiguous and is governed by self-assembly processes that limit our ability to rationally design such molecules. However, recent years have shown that by considering new building block principles the design and discovery of novel complex clusters is aiding our understanding of this process. Now with current progress in thiometalate chemistry, specifically polyoxothiometalates (POTM), the field of inorganic molecular clusters has further diversified allowing for the targeted development of molecules with specific functionality. This chapter discusses the main differences between POM and POTM systems and how this affects synthetic methodologies and reactivities. We will illustrate how careful structural considerations can lead to the generation of novel building blocks and further deepen our understanding of complex systems

Оценка осадков в прибрежных районах Антарктики в глобальной модели атмосферы LMDZ6 с использованием наземных радиолокационных наблюдений

In the current context of climate change in the poles, one of the objectives of the APRES3 (Antarctic Precipitation Remote Sensing from Surface and Space) project was to characterize the vertical structure of precipitation in order to better simulate it. Precipitation simulated by models in Antarctica is currently very widespread and it overestimates the data. Sensitivity studies have been conducted using a global climate model and compared to the observations obtained at the Dumont d’Urville coast station, obtained by a Micro Rain Radar (MRR). The LMDz/IPSL general circulation model, with zoomed configuration over Dumont d’Urville, has been considered for this study. A sensitivity study was conducted on the physical and numerical parameters of the LMDz model with the aim of estimating their contribution to the precipitation simulation. Sensitivity experiments revealed that changes in the sedimentation and sublimation parameters do not significantly impact precipitation rate. However, dissipation of the LMDz model, which is a numerical process that dissipates spatially excessive energy and keeps the model stable, impacts precipitation indirectly but very strongly. A suitable adjustment of the dissipation reduces significantly precipitation over Antarctic peripheral area, thus providing a simulated profile in better agreement with the MRR observations.В текущем тренде изменения климата на полюсах одна из задач проекта APRES3 (Дистанционное зондирование осадков в Антарктике с поверхности и из космоса) заключается в том, чтобы уточнить вертикальную структуру осадков и повысить качество их прогноза. Известные результаты моделирования осадков в Антарктиде базируются на данных с высокой степенью неопределенности и сильно разнятся. Исследование избирательной чувствительности расчета осадков проводилось на основе глобальной климатической модели и сопоставлялось с наблюдениями, полученными с помощью метеорадара (MRR) на береговой станции Дюмон-д’Юрвиль. Использовалась LMDz/IPSL-модель общей циркуляции с повышенной детализацией в районе станции Дюмон-д’Юрвиль. Была выполнена оценка вклада физических и численных параметров данной модели в расчет осадков. Вычислительные эксперименты показали, что изменения параметров седиментации и сублимации не влияют существенно на прогнозируемую скорость выпадения осадков. Однако диссипация, возникающая в модели LMDz в процессе вычислений, рассеивая пространственно избыточную энергию и обеспечивая устойчивость модели, хотя и косвенно, но очень сильно влияет на рассчитываемую величину осадков. Адекватная подгонка уровня рассеивания при моделировании значительно снижает количество осадков в периферийных районах Антарктики, обеспечивая таким образом лучшее согласование моделируемого профиля с данными метеорадарных наблюдений

SNIFS: a wideband integral field spectrograph with microlens arrays

Supernova

Dolphins at the British Museum: Zoomorphic Calusa Sinkers

The subject of everyday or “mundane” artistic expression in Native American material culture does not always take into account the idea that aesthetic design can have explicit practical as well as decorative function. This article explores this idea through objects from the Floridian archaeological collections at the British Museum

Experimental demonstration of extended depth-of-field f/1.2 visible High Definition camera with jointly optimized phase mask and real-time digital processing

Increasing the depth of field (DOF) of compact visible high resolution cameras while maintaining high imaging performance in the DOF range is crucial for such applications as night vision goggles or industrial inspection. In this paper, we present the end-to-end design and experimental validation of an extended depth-of-field visible High Definition camera with a very small f-number, combining a six-ring pyramidal phase mask in the aperture stop of the lens with a digital deconvolution. The phase mask and the deconvolution algorithm are jointly optimized during the design step so as to maximize the quality of the deconvolved image over the DOF range. The deconvolution processing is implemented in real-time on a Field-Programmable Gate Array and we show that it requires very low power consumption. By mean of MTF measurements and imaging experiments we experimentally characterize the performance of both cameras with and without phase mask and thereby demonstrate a significant increase in depth of field of a factor 2.5, as it was expected in the design step

Monomorphic epitheliotropic intestinal T-cell lymphoma comprises morphologic and genomic heterogeneity impacting outcome.

Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare aggressive T-cell lymphoma most reported in Asia. We performed a comprehensive clinical, pathological and genomic study of 71 European MEITL patients (36 males; 35 females, median age 67 years). The majority presented with gastrointestinal involvement and had emergency surgery, and 40% had stage IV disease. The tumors were morphologically classified into two groups: typical (58%) and atypical (i.e. nonmonomorphic or with necrosis, angiotropism or starry-sky pattern) (42%), sharing a homogeneous immunophenotypic profile (CD3+ (98%) CD4- (94%) CD5- (97%) CD7+ (97%) CD8+ (90%) CD56+ (86%) CD103+ (80%) cytotoxic marker+ (98%)) with more frequent expression of TCRgd (50%) than TCRab (32%). MYC expression (30% of cases) partly reflecting MYC gene locus alterations, correlated with nonmonomorphic cytology. Almost all cases (97%) harbored deleterious mutation(s) and/or deletion of the SETD2 gene and 90% had defective H3K36 trimethylation. Other frequently mutated genes were STAT5B (57%), JAK3 (50%), TP53 (35%) JAK1 (12.5%), BCOR and ATM (11%). Both TP53 mutations and MYC expression correlated with atypical morphology. The median overall survival (OS) of 63 patients (43/63 only received chemotherapy after initial surgery) was 7.8 months. Multivariate analysis found a strong negative impact on outcome of MYC expression, TP53 mutation, STAT5B mutation and poor performance status while aberrant B-cell marker expression (20% of cases) correlated with better survival. In conclusion, MEITL is an aggressive disease with resistance to conventional therapy, predominantly characterized by driver gene alterations deregulating histone methylation and JAK/STAT signalling and encompasses genetic and morphologic variants associated with very high clinical risk

Landuse and soil degradation in the southern Maya lowlands, from Pre-Classic to Post-Classic times : The case of La Joyanca (Petén, Guatemala)

International audienceThis work focuses on the impact of Maya agriculture on soil degradation. In site and out site studies in the area of the city of La Joyanca (NW Petén) show that "Maya clays" do not constitute a homogeneous unit, but represent a complex sedimentary record. A high resolution analysis leads us to document changes in rates and practices evolving in time in relation with major socio-political and economic changes. It is possible to highlight extensive agricultural practices between Early Pre-classical to Late Pre-classical times. Intensification occurs in relation with reduction of the fallow duration during Pre-classic to Classic periods. The consequences of these changes on soil erosion are discussed. However, it does not seem that the agronomic potential of the soils was significantly degraded before the end of the Classic period