Image analysis for cosmology: results from the GREAT10 Galaxy Challenge

In this paper, we present results from the weak-lensing shape measurement GRavitational lEnsing Accuracy Testing 2010 (GREAT10) Galaxy Challenge. This marks an order of magnitude step change in the level of scrutiny employed in weak-lensing shape measurement analysis. We provide descriptions of each method tested and include 10 evaluation metrics over 24 simulation branches. GREAT10 was the first shape measurement challenge to include variable fields; both the shear field and the point spread function (PSF) vary across the images in a realistic manner. The variable fields enable a variety of metrics that are inaccessible to constant shear simulations, including a direct measure of the impact of shape measurement inaccuracies, and the impact of PSF size and ellipticity, on the shear power spectrum. To assess the impact of shape measurement bias for cosmic shear, we present a general pseudo-Cℓ formalism that propagates spatially varying systematics in cosmic shear through to power spectrum estimates. We also show how one-point estimators of bias can be extracted from variable shear simulations. The GREAT10 Galaxy Challenge received 95 submissions and saw a factor of 3 improvement in the accuracy achieved by other shape measurement methods. The best methods achieve sub-per cent average biases. We find a strong dependence on accuracy as a function of signal-to-noise ratio, and indications of a weak dependence on galaxy type and size. Some requirements for the most ambitious cosmic shear experiments are met above a signal-to-noise ratio of 20. These results have the caveat that the simulated PSF was a ground-based PSF. Our results are a snapshot of the accuracy of current shape measurement methods and are a benchmark upon which improvement can be brought. This provides a foundation for a better understanding of the strengths and limitations of shape measurement method

Silicon in the dust formation zone of IRC +10216 as observed with PACS and SPIRE on board Herschel

The interstellar medium is enriched primarily by matter ejected from evolved low and intermediate mass stars. The outflows from these stars create a circumstellar envelope in which a rich gas-phase and dust-nucleation chemistry takes place. We observed the nearest carbon-rich evolved star, IRC+10216, using the PACS (55-210 {\mu}m) and SPIRE (194-672 {\mu}m) spectrometers on board Herschel. We find several tens of lines from SiS and SiO, including lines from the v=1 vibrational level. For SiS these transitions range up to J=124-123, corresponding to energies around 6700K, while the highest detectable transition is J=90-89 for SiO, which corresponds to an energy around 8400K. Both species trace the dust formation zone of IRC+10216, and the broad energy ranges involved in their detected transitions permit us to derive the physical properties of the gas and the particular zone in which each species has been formed. This allows us to check the accuracy of chemical thermodynamical equilibrium models and the suggested depletion of SiS and SiO due to accretion onto dust grains

Spectroscopic observations of the candidate sgB[e]/X-ray binary CI Cam

We present a compilation of spectroscopic observations of the sgB[e] star CI Cam. This includes data from before, during, and after its 1998 outburst. The object shows a rich emission line spectrum originating from circumstellar material, rendering it difficult to determine the nature of either star involved or the cause of the outburst. We collate pre-outburst data to determine the state of the system before this occurred and provide a baseline for comparison with later data. During the outburst all lines become stronger, and hydrogen and helium lines become significantly broader and asymmetric. After the outburst, spectral changes persist for at least three years, with FeII and [NII] lines still a factor of ~2 above the pre-outburst level and HeI, HeII, and NII lines suppressed by a factor of 2-10. We find that the spectral properties of CI Cam are similar to other sgB[e] stars and therefore suggest that the geometry of the circumstellar material is similar to that proposed for the other objects: a two component outflow, with a fast, hot, rarefied polar wind indistinguishable from that of a normal supergiant and a dense, cooler equatorial outflow with a much lower velocity. We suggest that CI Cam is among the hotter members of the class and is viewed nearly pole-on. The nature of the compact object and the mechanism for the outburst remain uncertain, although it is likely that the compact object is a black hole or neutron star, and that the outburst was precipitated by its passage through the equatorial material. We suggest that this prompted a burst of supercritical accretion resulting in ejection of much of the material, which was later seen as an expanding radio remnant. [Abbreviated]Comment: 25 pages including figures. Accepted for publication in A&

Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis

Inflammatory cytokines and endogenous anti-oxidants are variables affecting disease progression in multiple sclerosis (MS). Here we demonstrate the dual capacity of triterpenoids to simultaneously repress production of IL-17 and other pro-inflammatory mediators while exerting neuroprotective effects directly through Nrf2-dependent induction of anti-oxidant genes. Derivatives of the natural triterpene oleanolic acid, namely CDDO-trifluoroethyl-amide (CDDO-TFEA), completely suppressed disease in a murine model of MS, experimental autoimmune encephalomyelitis (EAE), by inhibiting Th1 and Th17 mRNA and cytokine production. Encephalitogenic T cells recovered from treated mice were hypo-responsive to myelin antigen and failed to adoptively transfer the disease. Microarray analyses showed significant suppression of pro-inflammatory transcripts with concomitant induction of anti-inflammatory genes including Ptgds and Hsd11b1. Finally, triterpenoids induced oligodendrocyte maturation in vitro and enhanced myelin repair in an LPC-induced non-inflammatory model of demyelination in vivo. These results demonstrate the unique potential of triterpenoid derivatives for the treatment of neuroinflammatory disorders such as MS

Diagnosis of longitudinally extensive transverse myelitis

Longitudinally extensive transverse myelitis (LETM) is a neurological condition characterised by a contiguous inflammatory lesion of the spinal cord. LETM is often associated with the autoimmune central nervous system disease neuromyelitis optica (NMO) and rarely with multiple sclerosis. The discovery of the NMO-IgG antibody, provides a useful serological marker of LETM associated with the NMO disease spectrum (LETM and/or optic neuritis). Here, the authors report two cases of LETM, which differ in disease severity and NMO-IgG antibody serological status

FUSE and HST ultraviolet observations of the disc wind of RW Sextantis

We present Far Ultraviolet Spectroscopic Explorer (FUSE) satellite time-series data of the low-inclination, nova-like cataclysmic variable RW Sex. The data span the wavelength range between ∼905 and 1188 Å, which contains the resonance lines of C iii, N iii, S iv, P v, S vi and O vi. All these spectral lines are present in the form of blueshifted absorption components, with no evidence for the lines redward of rest velocity; the FUSE data probe the fast disc-wind of RW Sex. The time-variable nature of these features is established. Substantial line profile variability is observed, confined between ∼−1000 and 0 km s−1 , and modulated on the orbital period of the system (∼0.245 d) . The fundamental characteristics of the temporal behaviour are very similar between the low and high ionization lines. The wind-dominated lines exhibit a cyclic increase in absorption optical depth which is accompanied by a shift in the maximum absorption velocity from ∼−1000 km s−1 to near zero velocity. We argue that the empirical evidence from the FUSE analysis supports an interpretation of blueshifted absorptive changes as opposed to the action of a variable (in velocity) blueshifted (perhaps disc-formed) emission component. This conclusion is further bolstered by an analysis of archival Hubble Space Telescope (HST) Goddard High Resolution Spectrograph (GHRS) data of RW Sex. We discuss a phenomenological picture of the ultraviolet (UV) line profile variability where the symmetry of a confined bipolar wind in RW Sex is broken by assuming that the outflow is oblique, perhaps because it is seated on a warped or tilted disc. The temporal UV absorption properties of non-eclipsing nova-like systems are compared