69 research outputs found
Managing Dynamic User Communities in a Grid of Autonomous Resources
One of the fundamental concepts in Grid computing is the creation of Virtual
Organizations (VO's): a set of resource consumers and providers that join
forces to solve a common problem. Typical examples of Virtual Organizations
include collaborations formed around the Large Hadron Collider (LHC)
experiments. To date, Grid computing has been applied on a relatively small
scale, linking dozens of users to a dozen resources, and management of these
VO's was a largely manual operation. With the advance of large collaboration,
linking more than 10000 users with a 1000 sites in 150 counties, a
comprehensive, automated management system is required. It should be simple
enough not to deter users, while at the same time ensuring local site autonomy.
The VO Management Service (VOMS), developed by the EU DataGrid and DataTAG
projects[1, 2], is a secured system for managing authorization for users and
resources in virtual organizations. It extends the existing Grid Security
Infrastructure[3] architecture with embedded VO affiliation assertions that can
be independently verified by all VO members and resource providers. Within the
EU DataGrid project, Grid services for job submission, file- and database
access are being equipped with fine- grained authorization systems that take VO
membership into account. These also give resource owners the ability to ensure
site security and enforce local access policies. This paper will describe the
EU DataGrid security architecture, the VO membership service and the local site
enforcement mechanisms Local Centre Authorization Service (LCAS), Local
Credential Mapping Service(LCMAPS) and the Java Trust and Authorization
Manager.Comment: Talk from the 2003 Computing in High Energy and Nuclear Physics
(CHEP03), La Jolla, Ca, USA, March 2003, 7 pages, LaTeX, 5 eps figures. PSN
TUBT00
Ground-state correlations and final state interactions in the process 3He(e,e'pp)n
The two-proton emission process is theoretically investigated
using realistic three-nucleon wave functions and taking the final state
interaction into account by an approach which can be used when the value of the
three-nucleon invariant mass is either below or above the pion emission
threshold. Various kinematical conditions which enhance or minimize the effects
of the final state interaction are thoroughly analyzed.Comment: 26 pages, 12 eps-figures. Introduction and abstract updated, few
references added and Apendix A remove
The properties of the three-nucleon system with the dressed-bag model for nn interaction. I: New scalar three-body force
A multi-component formalism is developed to describe three-body systems with
nonstatic pairwise interactions and non-nucleonic degrees of freedom. The
dressed-bag model for interaction based on the formation of an
intermediate six-quark bag dressed by a -field is applied to the
system, where it results in a new three-body force between the six-quark bag
and a third nucleon. Concise variational calculations of bound states are
carried out in the dressed-bag model including the new three-body force. It is
shown that this three-body force gives at least half the total binding
energy, while the weight of non-nucleonic components in the H and He
wavefunctions can exceed 10%. The new force model provides a very good
description of bound states with a reasonable magnitude of the
coupling constant. The model can serve as a natural bridge between dynamical
description of few-nucleon systems and the very successful Walecka approach to
heavy nuclei and nuclear matter.Comment: 26 pages, Latex, 7 figure
Selected Topics in High Energy Semi-Exclusive Electro-Nuclear Reactions
We review the present status of the theory of high energy reactions with
semi-exclusive nucleon electro-production from nuclear targets. We demonstrate
how the increase of transferred energies in these reactions opens a complete
new window in studying the microscopic nuclear structure at small distances.
The simplifications in theoretical descriptions associated with the increase of
the energies are discussed. The theoretical framework for calculation of high
energy nuclear reactions based on the effective Feynman diagram rules is
described in details. The result of this approach is the generalized eikonal
approximation (GEA), which is reduced to Glauber approximation when nucleon
recoil is neglected. The method of GEA is demonstrated in the calculation of
high energy electro-disintegration of the deuteron and A=3 targets.
Subsequently we generalize the obtained formulae for A>3 nuclei. The relation
of GEA to the Glauber theory is analyzed. Then based on the GEA framework we
discuss some of the phenomena which can be studied in exclusive reactions,
these are: nuclear transparency and short-range correlations in nuclei. We
illustrate how light-cone dynamics of high-energy scattering emerge naturally
in high energy electro-nuclear reactions.Comment: LaTex file with 51 pages and 23 eps figure
EMI Security Architecture
This document describes the various architectures of the three middlewares that comprise the EMI software stack. It also outlines the common efforts in the security area that allow interoperability between these middlewares. The assessment of the EMI Security presented in this document was performed internally by members of the Security Area of the EMI project
Lympho-vascular invasion in BRCA related breast cancer compared to sporadic controls
<p>Abstract</p> <p>Background</p> <p>Germline mutations in the BRCA1 gene predispose to the development of breast cancer, exhibiting a specific histological phenotype. Identification of possible hallmarks of these tumors is important for selecting patients for genetic screening and provides inside in carcinogenetic pathways.</p> <p>Since BRCA1-associated breast cancers have pushing borders that prevent them from easily reaching vessels and are often of the medullary (like) type that is known to have a low rate of lympho-vascular invasion (LVI), we hypothesized that absence of LVI could characterize BRCA1 related breast cancer.</p> <p>Methods</p> <p>A population of 68 BRCA1 related invasive breast cancers was evaluated for LVI by an experienced breast pathologist blinded to mutation status, and compared to a control group matched for age, grade and tumor type.</p> <p>Results</p> <p>LVI was present in 25.0% of BRCA1 related cases, compared to 20.6% of controls (P = 0.54, OR = 1.29, CI 0.58-2.78).</p> <p>Conclusion</p> <p>LVI is frequent in BRCA1 germline mutation related breast cancers, but seems to occur as often in sporadic controls matched for age, grade and tumor type. Apparently, these hereditary cancers find their way to the blood and lymph vessels despite their well demarcation and often medullary differentiation.</p
Expression of hypoxia-inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast
INTRODUCTION: Hypoxia-inducible factor 1 (HIF-1) alpha and its downstream targets carbonic anhydrase IX (CAIX) and vascular endothelial growth factor (VEGF) are key factors in the survival of proliferating tumor cells in a hypoxic microenvironment. We studied the expression and prognostic relevance of HIF-1α and its downstream targets in phyllodes tumors and fibroadenomas of the breast. METHODS: The expression of HIF-1α, CAIX, VEGF and p53 was investigated by immunohistochemistry in a group of 37 primary phyllodes tumors and 30 fibroadenomas with known clinical follow-up. The tumor microvasculature was visualized by immunohistochemistry for CD31. Proliferation was assessed by Ki67 immunostaining and mitotic counts. Being biphasic tumors, immunoquantification was performed in the stroma and epithelium. RESULTS: Only two fibroadenomas displayed low-level stromal HIF-1α reactivity in the absence of CAIX expression. Stromal HIF-1α expression was positively correlated with phyllodes tumor grade (P = 0.001), with proliferation as measured by Ki67 expression (P < 0.001) and number of mitoses (P < 0.001), with p53 accumulation (P = 0.003), and with global (P = 0.015) and hot-spot (P = 0.031) microvessel counts, but not with CAIX expression. Interestingly, concerted CAIX and HIF-1α expression was frequently found in morphologically normal epithelium of phyllodes tumors. The distance from the epithelium to the nearest microvessels was higher in phyllodes tumors as compared with in fibroadenomas. Microvessel counts as such did not differ between fibroadenomas and phyllodes tumors, however. High expression of VEGF was regularly found in both tumors, with only a positive relation between stromal VEGF and grade in phyllodes tumors (P = 0.016). Stromal HIF-1α overexpression in phyllodes tumors was predictive of disease-free survival (P = 0.032). CONCLUSION: These results indicate that HIF-1α expression is associated with diminished disease-free survival and may play an important role in stromal progression of breast phyllodes tumors. In view of the absence of stromal CAIX expression in phyllodes tumors, stromal upregulation of HIF-1α most probably arises from hypoxia-independent pathways, with p53 inactivation as one possible cause. In contrast, coexpression of HIF-1α and CAIX in the epithelium in phyllodes tumors points to epithelial hypoxia, most probably caused by relatively distant blood vessels. On the other hand, HIF-1α and CAIX seem to be of minor relevance in breast fibroadenomas
Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU
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