The BAHAMAS project: Effects of dynamical dark energy on large-scale structure

In this work we consider the impact of spatially-uniform but time-varying dark energy (or `dynamical dark energy', DDE) on large-scale structure in a spatially flat universe, using large cosmological hydrodynamical simulations that form part of the BAHAMAS project. As DDE changes the expansion history of the universe, it impacts the growth of structure. We explore variations in DDE that are constrained to be consistent with the cosmic microwave background. We find that DDE can affect the clustering of matter and haloes at the ~10% level (suppressing it for so-called `freezing' models, while enhancing it for `thawing' models), which should be distinguishable with upcoming large-scale structure surveys. DDE cosmologies can also enhance or suppress the halo mass function (with respect to LCDM) over a wide range of halo masses. The internal properties of haloes are minimally affected by changes in DDE, however. Finally, we show that the impact of baryons and associated feedback processes is largely independent of the change in cosmology and that these processes can be modelled separately to typically better than a few percent accurac

Diffraction Considerations for Planar Detectors in the Few-Mode Limit

Filled arrays of bolometers are currently being employed for use in astronomy from the far-infrared through millimeter parts of the electromagnetic spectrum. Because of the large range of wavelengths for which such detectors are applicable, the number of modes supported by a pixel will vary according to the specific application of a given available technology. We study the dependence of image fidelity and induced polarization on the size of the pixel by employing a formalism in which diffraction due to the pixel boundary is treated by propagating the second-order statistical correlations of the radiation field through a model optical system. We construct polarized beam pattern images of square pixels for various ratios of p/\lambda where p is the pixel size and \lambda is the wavelength of the radiation under consideration. For the limit in which few modes are supported by the pixel (p/\lambda<1), we find that the diffraction due to the pixel edges is non-negligible and hence must be considered along with the telescope diffraction pattern in modeling the ultimate spatial resolution of an imaging system. For the case in which the pixel is over-moded (p/\lambda>1), the geometric limit is approached as expected. This technique gives a quantitative approach to optimize the imaging properties of arrays of planar detectors in the few-mode limit.Comment: 20 pages, 8 figure

The ARTEMIS simulations: stellar haloes of Milky Way-mass galaxies

We introduce the Assembly of high-ResoluTion Eagle-simulations of MIlky Way-type galaxieS (ARTEMIS) simulations, a new set of 42 zoomed-in, high-resolution (baryon particle mass of ≈2×104M⊙h−1⁠), hydrodynamical simulations of galaxies residing in haloes of Milky Way mass, simulated with the EAGLE galaxy formation code with re-calibrated stellar feedback. In this study, we analyse the structure of stellar haloes, specifically the mass density, surface brightness, metallicity, colour, and age radial profiles, finding generally very good agreement with recent observations of local galaxies. The stellar density profiles are well fitted by broken power laws, with inner slopes of ≈−3, outer slopes of ≈−4, and break radii that are typically ≈20–40 kpc. The break radii generally mark the transition between in situ formation and accretion-driven formation of the halo. The metallicity, colour, and age profiles show mild large-scale gradients, particularly when spherically averaged or viewed along the major axes. Along the minor axes, however, the profiles are nearly flat, in agreement with observations. Overall, the structural properties can be understood by two factors: that in situ stars dominate the inner regions and that they reside in a spatially flattened distribution that is aligned with the disc. Observations targeting both the major and minor axes of galaxies are thus required to obtain a complete picture of stellar haloes

Testing extensions to LCDM on small scales with forthcoming cosmic shear surveys

We investigate the constraining power of forthcoming Stage-IV weak lensing surveys (Euclid, LSST, and NGRST) for extensions to the LCDM model on small scales, via their impact on the cosmic shear power spectrum. We use high-resolution cosmological simulations to calculate how warm dark matter (WDM), self-interacting dark matter (SIDM) and a running of the spectral index affect the non-linear matter power spectrum, P(k), as a function of scale and redshift. We evaluate the cosmological constraining power using synthetic weak lensing observations derived from these power spectra and that take into account the anticipated source densities, shape noise and cosmic variance errors of upcoming surveys. We show that upcoming Stage-IV surveys will be able to place useful, independent constraints on both WDM models (ruling out models with a particle mass of 10 cm^2 g^-1) through their effects on the small-scale cosmic shear power spectrum. Similarly, they will be able to strongly constrain cosmologies with a running spectral index. Finally, we explore the error associated with the cosmic shear cross-spectrum between tomographic bins, finding that it can be significantly affected by Poisson noise (the standard assumption is that the Poisson noise cancels between tomographic bins). We provide a new analytic form for the error on the cross-spectrum which accurately captures this effect

Flexibility within the Heads of Muscle Myosin-2 Molecules

We show that negative-stain electron microscopy and image processing of nucleotide-free (apo) striated muscle myosin-2 subfragment-1 (S1), possessing one light chain or both light chains, is capable of resolving significant amounts of structural detail. The overall appearance of the motor and the lever is similar in rabbit, scallop and chicken S1. Projection matching of class averages of the different S1 types to projection views of two different crystal structures of apo S1 shows that all types most commonly closely resemble the appearance of the scallop S1 structure rather than the methylated chicken S1 structure. Methylation of chicken S1 has no effect on the structure of the molecule at this resolution: it too resembles the scallop S1 crystal structure. The lever is found to vary in its angle of attachment to the motor domain, with a hinge point located in the so-called pliant region between the converter and the essential light chain. The chicken S1 crystal structure lies near one end of the range of flexion observed. The Gaussian spread of angles of flexion suggests that flexibility is driven thermally, from which a torsional spring constant of ~ 23 pN·nm/rad2 is estimated on average for all S1 types, similar to myosin-5. This translates to apparent cantilever-type stiffness at the tip of the lever of 0.37 pN/nm. Because this stiffness is lower than recent estimates from myosin-2 heads attached to actin, we suggest that binding to actin leads to an allosteric stiffening of the motor–lever junction

On the analysis of sedimentation velocity in the study of protein complexes

Sedimentation velocity analytical ultracentrifugation has experienced a significant transformation, precipitated by the possibility of efficiently fitting Lamm equation solutions to the experimental data. The precision of this approach depends on the ability to account for the imperfections of the experiment, both regarding the sample and the instrument. In the present work, we explore in more detail the relationship between the sedimentation process, its detection, and the model used in the mathematical data analysis. We focus on configurations that produce steep and fast-moving sedimentation boundaries, such as frequently encountered when studying large multi-protein complexes. First, as a computational tool facilitating the analysis of heterogeneous samples, we introduce the strategy of partial boundary modeling. It can simplify the modeling by restricting the direct boundary analysis to species with sedimentation coefficients in a predefined range. Next, we examine factors related to the experimental detection, including the magnitude of optical aberrations generated by out-of-focus solution columns at high protein concentrations, the relationship between the experimentally recorded signature of the meniscus and the meniscus parameter in the data analysis, and the consequences of the limited radial and temporal resolution of the absorbance optical scanning system. Surprisingly, we find that large errors can be caused by the finite scanning speed of the commercial absorbance optics, exceeding the statistical errors in the measured sedimentation coefficients by more than an order of magnitude. We describe how these effects can be computationally accounted for in SEDFIT and SEDPHAT

A bi-directional relationship between obesity and health-related quality of life : evidence from the longitudinal AusDiab study

Objective: To assess the prospective relationship between obesity and health-related quality of life, including a novel assessment of the impact of health-related quality of life on weight gain.Design and setting: Longitudinal, national, population-based Australian Diabetes, Obesity and Lifestyle (AusDiab) study, with surveys conducted in 1999/2000 and 2004/2005.Participants: A total of 5985 men and women aged 25 years at study entry.Main outcome measure(s): At both time points, height, weight and waist circumference were measured and self-report data on health-related quality of life from the SF-36 questionnaire were obtained. Cross-sectional and bi-directional, prospective associations between obesity categories and health-related quality of life were assessed.Results: Higher body mass index (BMI) at baseline was associated with deterioration in health-related quality of life over 5 years for seven of the eight health-related quality of life domains in women (all P0.01, with the exception of mental health, P&gt;0.05), and six out of eight in men (all P&lt;0.05, with the exception of role-emotional, P=0.055, and mental health, P&gt;0.05). Each of the quality-of-life domains related to mental health as well as the mental component summary were inversely associated with BMI change (all P&lt;0.0001 for women and P0.01 for men), with the exception of vitality, which was significant in women only (P=0.008). For the physical domains, change in BMI was inversely associated with baseline general health in women only (P=0.023).Conclusions: Obesity was associated with a deterioration in health-related quality of life (including both physical and mental health domains) in this cohort of Australian adults followed over 5 years. Health-related quality of life was also a predictor of weight gain over 5 years, indicating a bi-directional association between obesity and health-related quality of life. The identification of those with poor health-related quality of life may be important in assessing the risk of future weight gain, and a focus on health-related quality of life may be beneficial in weight management strategies.<br /