627 research outputs found
Random matrix models with log-singular level confinement: method of fictitious fermions
Joint distribution function of N eigenvalues of U(N) invariant random-matrix
ensemble can be interpreted as a probability density to find N fictitious
non-interacting fermions to be confined in a one-dimensional space. Within this
picture a general formalism is developed to study the eigenvalue correlations
in non-Gaussian ensembles of large random matrices possessing non-monotonic,
log-singular level confinement. An effective one-particle Schroedinger equation
for wave-functions of fictitious fermions is derived. It is shown that
eigenvalue correlations are completely determined by the Dyson's density of
states and by the parameter of the logarithmic singularity. Closed analytical
expressions for the two-point kernel in the origin, bulk, and soft-edge scaling
limits are deduced in a unified way, and novel universal correlations are
predicted near the end point of the single spectrum support.Comment: 13 pages (latex), Presented at the MINERVA Workshop on Mesoscopics,
Fractals and Neural Networks, Eilat, Israel, March 199
Cefazolin Prophylaxis for Total Joint Arthroplasty: Obese Patients Are Frequently Underdosed and at Increased Risk of Periprosthetic Joint Infection
Background
One of the most effective prophylactic strategies against periprosthetic joint infection (PJI) is administration of perioperative antibiotics. Many orthopedic surgeons are unaware of the weight-based dosing protocol for cefazolin. This study aimed at elucidating what proportion of patients receiving cefazolin prophylaxis are underdosed and whether this increases the risk of PJI.
Methods
A retrospective study of 17,393 primary total joint arthroplasties receiving cefazolin as perioperative prophylaxis from 2005 to 2017 was performed. Patients were stratified into 2 groups (underdosed and adequately dosed) based on patient weight and antibiotic dosage. Patients who developed PJI within 1 year following index procedure were identified. A bivariate and multiple logistic regression analyses were performed to control for potential confounders and identify risk factors for PJI.
Results
The majority of patients weighing greater than 120 kg (95.9%, 944/984) were underdosed. Underdosed patients had a higher rate of PJI at 1 year compared with adequately dosed patients (1.51% vs 0.86%, P = .002). Patients weighing greater than 120 kg had higher 1-year PJI rate than patients weighing less than 120 kg (3.25% vs 0.83%, P < .001). Patients who were underdosed (odds ratio, 1.665; P = .006) with greater comorbidities (odds ratio, 1.259; P < .001) were more likely to develop PJI at 1 year.
Conclusion
Cefazolin underdosing is common, especially for patients weighing more than 120 kg. Our study reports that underdosed patients were more likely to develop PJI. Orthopedic surgeons should pay attention to the weight-based dosing of antibiotics in the perioperative period to avoid increasing risk of PJI
Entanglement and nonclassicality for multi-mode radiation field states
Nonclassicality in the sense of quantum optics is a prerequisite for
entanglement in multi-mode radiation states. In this work we bring out the
possibilities of passing from the former to the latter, via action of
classicality preserving systems like beamsplitters, in a transparent manner.
For single mode states, a complete description of nonclassicality is available
via the classical theory of moments, as a set of necessary and sufficient
conditions on the photon number distribution. We show that when the mode is
coupled to an ancilla in any coherent state, and the system is then acted upon
by a beamsplitter, these conditions turn exactly into signatures of NPT
entanglement of the output state. Since the classical moment problem does not
generalize to two or more modes, we turn in these cases to other familiar
sufficient but not necessary conditions for nonclassicality, namely the Mandel
parameter criterion and its extensions. We generalize the Mandel matrix from
one-mode states to the two-mode situation, leading to a natural classification
of states with varying levels of nonclassicality. For two--mode states we
present a single test that can, if successful, simultaneously show
nonclassicality as well as NPT entanglement. We also develop a test for NPT
entanglement after beamsplitter action on a nonclassical state, tracing
carefully the way in which it goes beyond the Mandel nonclassicality test. The
result of three--mode beamsplitter action after coupling to an ancilla in the
ground state is treated in the same spirit. The concept of genuine tripartite
entanglement, and scalar measures of nonclassicality at the Mandel level for
two-mode systems, are discussed. Numerous examples illustrating all these
concepts are presented.Comment: Latex, 46 page
Maximum entropy and the problem of moments: A stable algorithm
We present a technique for entropy optimization to calculate a distribution
from its moments. The technique is based upon maximizing a discretized form of
the Shannon entropy functional by mapping the problem onto a dual space where
an optimal solution can be constructed iteratively. We demonstrate the
performance and stability of our algorithm with several tests on numerically
difficult functions. We then consider an electronic structure application, the
electronic density of states of amorphous silica and study the convergence of
Fermi level with increasing number of moments.Comment: 4 pages including 3 figure
Lyapunov exponent and natural invariant density determination of chaotic maps: An iterative maximum entropy ansatz
We apply the maximum entropy principle to construct the natural invariant
density and Lyapunov exponent of one-dimensional chaotic maps. Using a novel
function reconstruction technique that is based on the solution of Hausdorff
moment problem via maximizing Shannon entropy, we estimate the invariant
density and the Lyapunov exponent of nonlinear maps in one-dimension from a
knowledge of finite number of moments. The accuracy and the stability of the
algorithm are illustrated by comparing our results to a number of nonlinear
maps for which the exact analytical results are available. Furthermore, we also
consider a very complex example for which no exact analytical result for
invariant density is available. A comparison of our results to those available
in the literature is also discussed.Comment: 16 pages including 6 figure
Coherent states of a charged particle in a uniform magnetic field
The coherent states are constructed for a charged particle in a uniform
magnetic field based on coherent states for the circular motion which have
recently been introduced by the authors.Comment: 2 eps figure
Two-band random matrices
Spectral correlations in unitary invariant, non-Gaussian ensembles of large
random matrices possessing an eigenvalue gap are studied within the framework
of the orthogonal polynomial technique. Both local and global characteristics
of spectra are directly reconstructed from the recurrence equation for
orthogonal polynomials associated with a given random matrix ensemble. It is
established that an eigenvalue gap does not affect the local eigenvalue
correlations which follow the universal sine and the universal multicritical
laws in the bulk and soft-edge scaling limits, respectively. By contrast,
global smoothed eigenvalue correlations do reflect the presence of a gap, and
are shown to satisfy a new universal law exhibiting a sharp dependence on the
odd/even dimension of random matrices whose spectra are bounded. In the case of
unbounded spectrum, the corresponding universal `density-density' correlator is
conjectured to be generic for chaotic systems with a forbidden gap and broken
time reversal symmetry.Comment: 12 pages (latex), references added, discussion enlarge
Total Widths And Slopes From Complex Regge Trajectories
Maximally complex Regge trajectories are introduced for which both Re
and Im grow as ( small and
positive). Our expression reduces to the standard real linear form as the
imaginary part (proportional to ) goes to zero. A scaling formula for
the total widths emerges: constant for large M, in very
good agreement with data for mesons and baryons. The unitarity corrections also
enhance the space-like slopes from their time-like values, thereby resolving an
old problem with the trajectory in charge exchange. Finally, the
unitarily enhanced intercept, , \nolinebreak is in
good accord with the Donnachie-Landshoff total cross section analysis.Comment: 9 pages, 3 Figure
Vector Continued Fractions using a Generalised Inverse
A real vector space combined with an inverse for vectors is sufficient to
define a vector continued fraction whose parameters consist of vector shifts
and changes of scale. The choice of sign for different components of the vector
inverse permits construction of vector analogues of the Jacobi continued
fraction. These vector Jacobi fractions are related to vector and scalar-valued
polynomial functions of the vectors, which satisfy recurrence relations similar
to those of orthogonal polynomials. The vector Jacobi fraction has strong
convergence properties which are demonstrated analytically, and illustrated
numerically.Comment: Published form - minor change
Function reconstruction as a classical moment problem: A maximum entropy approach
We present a systematic study of the reconstruction of a non-negative
function via maximum entropy approach utilizing the information contained in a
finite number of moments of the function. For testing the efficacy of the
approach, we reconstruct a set of functions using an iterative entropy
optimization scheme, and study the convergence profile as the number of moments
is increased. We consider a wide variety of functions that include a
distribution with a sharp discontinuity, a rapidly oscillatory function, a
distribution with singularities, and finally a distribution with several spikes
and fine structure. The last example is important in the context of the
determination of the natural density of the logistic map. The convergence of
the method is studied by comparing the moments of the approximated functions
with the exact ones. Furthermore, by varying the number of moments and
iterations, we examine to what extent the features of the functions, such as
the divergence behavior at singular points within the interval, is reproduced.
The proximity of the reconstructed maximum entropy solution to the exact
solution is examined via Kullback-Leibler divergence and variation measures for
different number of moments.Comment: 20 pages, 17 figure
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