Experimental and theoretical investigations of a rectangular grating structure for low-voltage traveling wave tube amplifiers

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Ground-Rupturing Earthquakes on the Northern Big Bend of the San Andreas Fault, California, 800 A.D. to Present

Paleoseismic data on the timing of ground-rupturing earthquakes constrain the recurrence behavior of active faults and can provide insight on the rupture history of a fault if earthquakes dated at neighboring sites overlap in age and are considered correlative. This study presents the evidence and ages for 11 earthquakes that occurred along the Big Bend section of the southern San Andreas Fault at the Frazier Mountain paleoseismic site. The most recent earthquake to rupture the site was the Mw7.7–7.9 Fort Tejon earthquake of 1857. We use over 30 trench excavations to document the structural and sedimentological evolution of a small pull-apart basin that has been repeatedly faulted and folded by ground-rupturing earthquakes. A sedimentation rate of 0.4 cm/yr and abundant organic material for radiocarbon dating contribute to a record that is considered complete since 800 A.D. and includes 10 paleoearthquakes. Earthquakes have ruptured this location on average every ~100 years over the last 1200 years, but individual intervals range from ~22 to 186 years. The coefficient of variation of the length of time between earthquakes (0.7) indicates quasiperiodic behavior, similar to other sites along the southern San Andreas Fault. Comparison with the earthquake chronology at neighboring sites along the fault indicates that only one other 1857-size earthquake could have occurred since 1350 A.D., and since 800 A.D., the Big Bend and Mojave sections have ruptured together at most 50% of the time in Mw ≥ 7.3 earthquakes

The 2011 Mw 7.1 Van (Eastern Turkey) earthquake

[1] We use interferometric synthetic aperture radar (InSAR), body wave seismology, satellite imagery, and field observations to constrain the fault parameters of the Mw 7.1 2011 Van (Eastern Turkey) reverse-slip earthquake, in the Turkish-Iranian plateau. Distributed slip models from elastic dislocation modeling of the InSAR surface displacements from ENVISAT and COSMO-SkyMed interferograms indicate up to 9 m of reverse and oblique slip on a pair of en echelon NW 40 °–54 ° dipping fault planes which have surface extensions projecting to just 10 km north of the city of Van. The slip remained buried and is relatively deep, with a centroid depth of 14 km, and the rupture reaching only within 8–9 km of the surface, consistent with the lack of significant ground rupture. The up-dip extension of this modeled WSW striking fault plane coincides with field observations of weak ground deformation seen on the western of the two fault segments and has a dip consistent with that seen at the surface in fault gouge exposed in Quaternary sediments. No significant coseismic slip is found in the upper 8 km of the crust above the main slip patches, except for a small region on the eastern segment potentially resulting from the Mw 5.9 aftershock on the same day. We perform extensive resolution tests on the data to confirm the robustness of the observed slip deficit in the shallow crust. We resolve a steep gradient in displacement at the point where the planes of the two fault segments ends are inferred to abut at depth, possibly exerting some structural control on rupture extent

The chemical stability of abasic RNA compared to abasic DNA

We describe the synthesis of an abasic RNA phosphoramidite carrying a photocleavable 1-(2-nitrophenyl)ethyl (NPE) group at the anomeric center and a triisopropylsilyloxymethyl (TOM) group as 2′-O-protecting group together with the analogous DNA and the 2′-OMe RNA abasic building blocks. These units were incorporated into RNA-, 2′-OMe-RNA- and DNA for the purpose of studying their chemical stabilities towards backbone cleavage in a comparative way. Stability measurements were performed under basic conditions (0.1 M NaOH) and in the presence of aniline (pH 4.6) at 37°C. The kinetics and mechanisms of strand cleavage were followed by High pressure liquid chromotography and ESI-MS. Under basic conditions, strand cleavage at abasic RNA sites can occur via β,δ-elimination and 2′,3′-cyclophosphate formation. We found that β,δ-elimination was 154-fold slower compared to the same mechanism in abasic DNA. Overall strand cleavage of abasic RNA (including cyclophosphate formation) was still 16.8 times slower compared to abasic DNA. In the presence of aniline at pH 4.6, where only β,δ-elimination contributes to strand cleavage, a 15-fold reduced cleavage rate at the RNA abasic site was observed. Thus abasic RNA is significantly more stable than abasic DNA. The higher stability of abasic RNA is discussed in the context of its potential biological role

Validation of meter-scale surface faulting offset measurements from high-resolution topographic data

Studies of active fault zones have flourished with the availability of high-resolution topographic data, particularly where airborne light detection and ranging (lidar) and structure from motion (SfM) data sets provide a means to remotely analyze submeter-scale fault geomorphology. To determine surface offset at a point along a strike-slip earthquake rupture, geomorphic features (e.g., stream channels) are measured days to centuries after the event. Analysis of these and cumulatively offset features produces offset distributions for successive earthquakes that are used to understand earthquake rupture behavior. As researchers expand studies to more varied terrain types, climates, and vegetation regimes, there is an increasing need to standardize and uniformly validate measurements of tectonically displaced geomorphic features. A recently compiled catalog of nearly 5000 earthquake offsets across a range of measurement and reporting styles provides insight into quality rating and uncertainty trends from which we formulate best-practice and reporting recommendations for remote studies. In addition, a series of public and beginner-level studies validate the remote methodology for a number of tools and emphasize considerations to enhance measurement accuracy and precision for beginners and professionals. Our investigation revealed that (1) standardizing remote measurement methods and reporting quality rating schemes is essential for the utility and repeatability of fault-offset measurements; (2) measurement discrepancies often involve misinterpretation of the offset geomorphic feature and are a function of the investigator’s experience; (3) comparison of measurements made by a single investigator in different climatic regions reveals systematic differences in measurement uncertainties attributable to variation in feature preservation; (4) measuring more components of a displaced geomorphic landform produces more consistently repeatable estimates of offset; and (5) inadequate understanding of pre-event morphology and post-event modifications represents a greater epistemic limitation than the aleatoric limitations of the measurement process

Parenting the Premature Infant: Potential Iatrogenesis from the Neonatal Intensive Care Experience

(1) Developmental outcomes of premature infants are associated with the quality of the home environment and the level of parenting skills the family possesses. Successful development of the parenting role may be negatively influenced by the Neonatal Intensive Care Unit (NICU) environment and nursing practices. Identification of interventions that promote the development of parenting skills in the NICU can potentially improve developmental outcomes for premature infants.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73814/1/j.1524-475X.1996.00046.x.pd

Challenges of caring for children with mental disorders: Experiences and views of caregivers attending the outpatient clinic at Muhimbili National Hospital, Dar es Salaam - Tanzania

It is estimated that world-wide up to 20 % of children suffer from debilitating mental illness. Mental disorders that pose a significant concern include learning disorders, hyperkinetic disorders (ADHD), depression, psychosis, pervasive development disorders, attachment disorders, anxiety disorders, conduct disorder, substance abuse and eating disorders. Living with such children can be very stressful for caregivers in the family. Therefore, determination of challenges of living with these children is important in the process of finding ways to help or support caregivers to provide proper care for their children. The purpose of this study was to explore the psychological and emotional, social, and economic challenges that parents or guardians experience when caring for mentally ill children and what they do to address or deal with them. A qualitative study design using in-depth interviews and focus group discussions was applied. The study was conducted at the psychiatric unit of Muhimbili National Hospital in Tanzania. Two focus groups discussions (FGDs) and 8 in-depth interviews were conducted with caregivers who attended the psychiatric clinic with their children. Data analysis was done using content analysis. The study revealed psychological and emotional, social, and economic challenges caregivers endure while living with mentally ill children. Psychological and emotional challenges included being stressed by caring tasks and having worries about the present and future life of their children. They had feelings of sadness, and inner pain or bitterness due to the disturbing behaviour of the children. They also experienced some communication problems with their children due to their inability to talk. Social challenges were inadequate social services for their children, stigma, burden of caring task, lack of public awareness of mental illness, lack of social support, and problems with social life. The economic challenges were poverty, child care interfering with various income generating activities in the family, and extra expenses associated with the child's illness. Caregivers of mentally ill children experience various psychological and emotional, social, and economic challenges. Professional assistance, public awareness of mental illnesses in children, social support by the government, private sector, and non-governmental organizations (NGOs) are important in addressing these challenges

Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair

Critical for transcription initiation and bulky lesion DNA repair, TFIIH provides an exemplary system to connect molecular mechanisms to biological outcomes due to its strong genetic links to different specific human diseases. Recent advances in structural and computational biology provide a unique opportunity to re-examine biologically relevant molecular structures and develop possible mechanistic insights for the large dynamic TFIIH complex. TFIIH presents many puzzles involving how its two SF2 helicase family enzymes, XPB and XPD, function in transcription initiation and repair: how do they initiate transcription, detect and verify DNA damage, select the damaged strand for incision, coordinate repair with transcription and cell cycle through Cdk-activating-kinase (CAK) signaling, and result in very different specific human diseases associated with cancer, aging, and development from single missense mutations? By joining analyses of breakthrough cryo-electron microscopy (cryo-EM) structures and advanced computation with data from biochemistry and human genetics, we develop unified concepts and molecular level understanding for TFIIH functions with a focus on structural mechanisms. We provocatively consider that TFIIH may have first evolved from evolutionary pressure for TCR to resolve arrested transcription blocks to DNA replication and later added its key roles in transcription initiation and global DNA repair. We anticipate that this level of mechanistic information will have significant impact on thinking about TFIIH, laying a robust foundation suitable to develop new paradigms for DNA transcription initiation and repair along with insights into disease prevention, susceptibility, diagnosis and interventions