108 research outputs found
Test of Information Theory on the Boltzmann Equation
We examine information theory using the steady-state Boltzmann equation. In a
nonequilibrium steady-state system under steady heat conduction, the
thermodynamic quantities from information theory are calculated and compared
with those from the steady-state Boltzmann equation. We have found that
information theory is inconsistent with the steady-state Boltzmann equation.Comment: 12 page
Kinetic Theory of a Dilute Gas System under Steady Heat Conduction
The velocity distribution function of the steady-state Boltzmann equation for
hard-core molecules in the presence of a temperature gradient has been obtained
explicitly to second order in density and the temperature gradient. Some
thermodynamical quantities are calculated from the velocity distribution
function for hard-core molecules and compared with those for Maxwell molecules
and the steady-state Bhatnagar-Gross-Krook(BGK) equation. We have found
qualitative differences between hard-core molecules and Maxwell molecules in
the thermodynamical quantities, and also confirmed that the steady-state BGK
equation belongs to the same universality class as Maxwell molecules.Comment: 36 pages, 4 figures, 5 table
Assessment of Gas-Surface Interaction Models for Computation of Rarefied Hypersonic Flow
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76727/1/AIAA-36375-113.pd
A Dual Function for Prickle in Regulating Frizzled Stability during Feedback-Dependent Amplification of Planar Polarity
The core planar polarity pathway coordinates epithelial cell polarity during animal development, and loss of its activity gives rise to a range of defects, from aberrant morphogenetic cell movements to failure to correctly orient structures, such as hairs and cilia. The core pathway functions via a mechanism involving segregation of its protein components to opposite cells ends, where they form asymmetric intracellular complexes that couple cell-cell polarity. This segregation is a self-organizing process driven by feedback interactions between the core proteins themselves. Despite intense efforts, the molecular pathways underlying feedback have proven difficult to elucidate using conventional genetic approaches. Here we investigate core protein function during planar polarization of the Drosophila wing by combining quantitative measurements of protein dynamics with loss-of-function genetics, mosaic analysis, and temporal control of gene expression. Focusing on the key core protein Frizzled, we show that its stable junctional localization is promoted by the core proteins Strabismus, Dishevelled, Prickle, and Diego. In particular, we show that the stabilizing function of Prickle on Frizzled requires Prickle activity in neighboring cells. Conversely, Prickle in the same cell has a destabilizing effect on Frizzled. This destabilizing activity is dependent on the presence of Dishevelled and blocked in the absence of Dynamin and Rab5 activity, suggesting an endocytic mechanism. Overall, our approach reveals for the first time essential in vivo stabilizing and destabilizing interactions of the core proteins required for self-organization of planar polarity
Endocytic and Recycling Endosomes Modulate Cell Shape Changes and Tissue Behaviour during Morphogenesis in Drosophila
During development tissue deformations are essential for the generation of organs and to provide the final form of an organism. These deformations rely on the coordination of individual cell behaviours which have their origin in the modulation of subcellular activities. Here we explore the role endocytosis and recycling on tissue deformations that occur during dorsal closure of the Drosophila embryo. During this process the AS contracts and the epidermis elongates in a coordinated fashion, leading to the closure of a discontinuity in the dorsal epidermis of the Drosophila embryo. We used dominant negative forms of Rab5 and Rab11 to monitor the impact on tissue morphogenesis of altering endocytosis and recycling at the level of single cells. We found different requirements for endocytosis (Rab5) and recycling (Rab11) in dorsal closure, furthermore we found that the two processes are differentially used in the two tissues. Endocytosis is required in the AS to remove membrane during apical constriction, but is not essential in the epidermis. Recycling is required in the AS at early stages and in the epidermis for cell elongation, suggesting a role in membrane addition during these processes. We propose that the modulation of the balance between endocytosis and recycling can regulate cellular morphology and tissue deformations during morphogenesis
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