54,483 research outputs found
A formal definition and a new security mechanism of physical unclonable functions
The characteristic novelty of what is generally meant by a "physical
unclonable function" (PUF) is precisely defined, in order to supply a firm
basis for security evaluations and the proposal of new security mechanisms. A
PUF is defined as a hardware device which implements a physical function with
an output value that changes with its argument. A PUF can be clonable, but a
secure PUF must be unclonable. This proposed meaning of a PUF is cleanly
delineated from the closely related concepts of "conventional unclonable
function", "physically obfuscated key", "random-number generator", "controlled
PUF" and "strong PUF". The structure of a systematic security evaluation of a
PUF enabled by the proposed formal definition is outlined. Practically all
current and novel physical (but not conventional) unclonable physical functions
are PUFs by our definition. Thereby the proposed definition captures the
existing intuition about what is a PUF and remains flexible enough to encompass
further research. In a second part we quantitatively characterize two classes
of PUF security mechanisms, the standard one, based on a minimum secret
read-out time, and a novel one, based on challenge-dependent erasure of stored
information. The new mechanism is shown to allow in principle the construction
of a "quantum-PUF", that is absolutely secure while not requiring the storage
of an exponentially large secret. The construction of a PUF that is
mathematically and physically unclonable in principle does not contradict the
laws of physics.Comment: 13 pages, 1 figure, Conference Proceedings MMB & DFT 2012,
Kaiserslautern, German
The clinical effectiveness and cost-effectiveness of inhaler devices used in the routine management of chronic asthma in older children: a systematic review and economic evaluation
Background:
This review examines the clinical effectiveness and
cost-effectiveness of hand-held inhalers to deliver
medication for the routine management of chronic
asthma in children aged between 5 and 15 years.
Asthma is a common disease of the airways, with a
prevalence of treated asthma in 5–15-year-olds of
around 12% and an actual prevalence in the community
as high as 23%. Treatment for the condition
is predominantly by inhalation of medication. There
are three main types of inhaler device, pressurised
metered dose, breath actuated, and dry powder, with
the option of the attachment of a spacer to the first
two devices under some prescribed circumstances.
Two recent reviews have examined the clinical and
cost-effectiveness evidence on inhaler devices, but
one was for children aged under 5 years and the
comparison in the second was made between pressurised
metered dose inhalers and other types only.
Objectives:
This review examines the clinical effectiveness and
cost-effectiveness of manual pressurised metered
dose inhalers, breath-actuated metered dose
inhalers, and breath-actuated dry powder inhalers,
with and without spacers as appropriate, to deliver
medication for the routine management of chronic
asthma in children aged between 5 and 15 years.
Methods:
Two previous HTA reviews have compared the
effectiveness of inhaler devices, one focusing on
asthma in children aged under 5 years and the
other on asthma and chronic obstructive airways
disease in all age groups. For the current review, a
literature search was carried out to identify all
evidence relating to the use of inhalers in older
children with chronic asthma. A search of in-vitro
studies undertaken for one of the previous reviews
was also updated.
The data sources used were: 15 electronic bibliographic
databases; the reference lists of one of the
previous HTA reports and other relevant articles;
health services research-related internet resources;
and all sponsor submissions.
Studies were selected according to strict inclusion
and exclusion criteria, and relevant information
concerning effectiveness and patient compliance
and preference was extracted directly on to an
extraction/evidence table. Quality assurance
was monitored.
Economic evaluation was undertaken by reviewing
existing cost-effective evidence. Further economic
modelling was carried out, and tables constructed
to determine device cost-minimisation and
incremental quality-adjusted life-year (QALY)
thresholds between devices.
Results:
Number and quality of studies, and
direction of evidence:
Fourteen randomised controlled studies were
identified relating to the clinical effectiveness of
inhaler devices for delivering β2-agonists. A further
five were on devices delivering corticosteroids and
one concerned the delivery of cromoglicate.
Overall, there were no differences in clinical
efficacy between inhaler devices, but a pressurised
metered dose inhaler with a spacer would appear
to be more effective than one without. These
findings endorse those of a previous HTA review
but extend them to other inhaler devices.
Seven randomised controlled trials examined the
impact on clinical effectiveness of using a nonchlorofluorocarbon
(CFC) propellant in place of
a CFC propellant in metered dose inhalers, both
pressurised and breath activated, although only one
study considered the latter type. No differences were
found between inhalers containing either propellant.
A further 30 studies of varying quality, from 12 randomised
controlled trials to non-controlled studies,
were identified that concerned the impact of use
by, and preference for, inhaler type, and treatment
adherence in children. Differences between the
studies, and limitations in comparative data between
various inhaler device types, make it difficult to draw
any firm conclusions from this evidence.
Summary of benefits:
No obvious benefits for one inhaler device type
over another for use in children aged 5–15 years
were identified.
Costs and cost per quality-adjusted
life-year:
Two approaches have been taken: cost-minimisation
and QALY threshold. In the QALY threshold
approach, additional QALYs that each device must
produce compared with a cheaper device to achieve
an acceptable cost per QALY were calculated. Using
the cheapest and most expensive devices for delivering
200 μg of beclometasone per day, assuming no
cost offset for any device, and a threshold of £5000,
the largest QALY needed was 0.00807. With such
a small QALY increase, no intervention can be
categorically rejected as not cost-effective.
Conclusions:
Generalisability of findings:
On the available evidence there are no obvious
benefits for one inhaler device over another
when used by children aged 5–15 years with
chronic asthma. However, the evidence, in the
majority of cases, was compiled on children
with mild to moderate asthma and restricted
to a limited number of drugs. Therefore the
findings may not be generalisable to those at
the more severe end of the spectrum of the
disease or to inhaler devices delivering some
of the drugs used in the management of asthma.
Need for further research:
Many of the previous studies are likely to
have been underpowered. Further clinical
trials with a robust methodology, sufficient
power and qualitative components are needed
to demonstrate any differences in clinical
resource use and patients’ asthma symptoms.
Further studies should also include the
behavioural aspects of patients towards their
medication and its delivery mechanisms.
It is acknowledged that sufficient power may
prove impractical owing to the large numbers
of patients required
Making information accessible for the conservation and use of biodiversity. A novel initiative to facilitate access to information and use of agricultural and tree biodiversity
Poster presented at Science Week 2014 - Bioversity International HQ, Rome (Italy), 24-27 Feb 201
Optical studies of carrier and phonon dynamics in Ga_{1-x}Mn_{x}As
We present a time-resolved optical study of the dynamics of carriers and
phonons in Ga_{1-x}Mn_{x}As layers for a series of Mn and hole concentrations.
While band filling is the dominant effect in transient optical absorption in
low-temperature-grown (LT) GaAs, band gap renormalization effects become
important with increasing Mn concentration in Ga_{1-x}Mn_{x}As, as inferred
from the sign of the absorption change. We also report direct observation on
lattice vibrations in Ga1-xMnxAs layers via reflective electro-optic sampling
technique. The data show increasingly fast dephasing of LO phonon oscillations
for samples with increasing Mn and hole concentration, which can be understood
in term of phonon scattering by the holes.Comment: 13 pages, 3 figures replaced Fig.1 after finding a mistake in
previous versio
Supersymmetry in gauge theories with extra dimensions
We show that a quantum-mechanical N=2 supersymmetry is hidden in 4d mass
spectrum of any gauge invariant theories with extra dimensions. The N=2
supercharges are explicitly constructed in terms of differential forms. The
analysis can be extended to extra dimensions with boundaries, and for a single
extra dimension we clarify a possible set of boundary conditions consistent
with 5d gauge invariance, although some of the boundary conditions break 4d
gauge symmetries.Comment: 18 page
Cotunneling drag effect in Coulomb-coupled quantum dots
In Coulomb drag, a current flowing in one conductor can induce a voltage
across an adjacent conductor via the Coulomb interaction. The mechanisms
yielding drag effects are not always understood, even though drag effects are
sufficiently general to be seen in many low-dimensional systems. In this
Letter, we observe Coulomb drag in a Coulomb-coupled double quantum dot
(CC-DQD) and, through both experimental and theoretical arguments, identify
cotunneling as essential to obtaining a correct qualitative understanding of
the drag behavior.Comment: Main text: 5 pages, 5 figures; SM: 11 pages, 5 figures, 1 tabl
Design zero-voltage switching DC-DC buck converter
This report proposes an integrated, high switching frequency, zero-voltage-switching
dc-dc buck converter for battery charger application. The design and analysis of dc�dc buck converter with integrated inductor is presented. The converter has been
optimized to convert 12V input voltage to 5V at 1.5A maximum load current at
50MHz switching frequency. The converter has been simulated using an ORCAD
16.5 based simulation tool and result show that the switching losses using zero�voltage-switching technique is less compared to conventional buck converter
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