New twist field couplings from the partition function for multiply wrapped D-branes

We consider toroidal compactifications of bosonic string theory with particular regard to the phases (cocycles) necessary for a consistent definition of the vertex operators, the boundary states and the T-duality rules. We use these ingredients to compute the planar multi-loop partition function describing the interaction among magnetized or intersecting D-branes, also in presence of open string moduli. It turns out that unitarity in the open string channel crucially depends on the presence of the cocycles. We then focus on the 2-loop case and study the degeneration limit where this partition function is directly related to the tree-level 3-point correlators between twist fields. These correlators represent the main ingredient in the computation of Yukawa couplings and other terms in the effective action for D-brane phenomenological models. By factorizing the 2-loop partition function we are able to compute the 3-point couplings for abelian twist fields on generic non-factorized tori, thus generalizing previous expressions valid for the 2-torus.Comment: 36 pages, 1 figure; v2: typos corrected, proof in the Appendix improve

The Lorentz force between D0 and D6 branes in string and M(atrix) theory

We use different techniques to analyze the system formed by a D0 brane and a D6 brane (with background gauge fields) in relative motion. In particular, using the closed string formalism of boosted boundary states, we show the presence of a term linear in the velocity, corresponding to the Lorentz force experienced by the D0 brane moving in the magnetic background produced by the D6 brane. This term, that was missed in previous analyses of this system, comes entirely from the R-R odd spin structure and is also reproduced by a M(atrix) theory calculation.Comment: 13 pages, plain LaTeX; some clarifying comments and a reference adde

Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory

The present study was aimed at establishing whether the mTOR pathway and its downstream effector p70S6K in CA3 pyramidal neurons are under the modulation of the cholinergic input to trigger the formation of long term memories, similar to what we demonstrated in CA1 hippocampus. We performed in vivo behavioral experiments using the step down inhibitory avoidance test in adult Wistar rats to evaluate memory formation under different conditions. We examined the effects of rapamycin, an inhibitor of mTORC1 formation, scopolamine, a muscarinic receptor antagonist or mecamylamine, a nicotinic receptor antagonist, on short and long term memory formation and on the functionality of the mTOR pathway. Acquisition was conducted 30 min after i.c.v. injection of rapamycin. Recall testing was performed 1h, 4h or 24h after acquisition. We found that (1) mTOR and p70S6K activation in CA3 pyramidal neurons were involved in long term memory formation; (2) rapamycin significantly inhibited mTOR and of p70S6K activation at 4h, and long term memory impairment 24h after acquisition; (3) scopolamine impaired short but not long term memory, with an early increase of mTOR/p70S6K activation at 1h followed by stabilization at longer times; (4) mecamylamine and scopolamine co-administration impaired short term memory at 1h and 4h and reduced the scopolamine-induced increase of mTOR/p70S6K activation at 1h and 4h; (5) mecamylamine and scopolamine treatment did not impair long term memory formation; (6) unexpectedly, rapamycin increased mTORC2 activation in microglial cells. Our results demonstrate that in CA3 pyramidal neurons the mTOR/p70S6K pathway is under the modulation of the cholinergic system and is involved in long-term memory encoding, and are consistent with the hypothesis that the CA3 region of the hippocampus is involved in memory mechanisms based on rapid, one-trial object–place learning and recall. Furthermore, our results are in accordance with previous reports that selective molecular mechanisms underlie either short term memory, long term memory, or both. Furthermore, our discovery that administration of rapamycin increased the activation of mTORC2 in microglial cells supports a reappraisal of the beneficial/adverse effects of rapamycin administration

Two-loop Yang-Mills diagrams from superstring amplitudes

Starting from the superstring amplitude describing interactions among D-branes with a constant world-volume field strength, we present a detailed analysis of how the open string degeneration limits reproduce the corresponding field theory Feynman diagrams. A key ingredient in the string construction is represented by the twisted (Prym) super differentials, as their periods encode the information about the background field. We provide an efficient method to calculate perturbatively the determinant of the twisted period matrix in terms of sets of super-moduli appropriate to the degeneration limits. Using this result we show that there is a precise one-to-one correspondence between the degeneration of different factors in the superstring amplitudes and one-particle irreducible Feynman diagrams capturing the gauge theory effective action at the two-loop level.Comment: 42 pages plus appendices, 10 figure

Classical Solutions in Two-Dimensional String Theory and Gravitational Collapse

A general solution to the $D=2$ 1-loop beta functions equations including tachyonic back reaction on the metric is presented. Dynamical black hole (classical) solutions representing gravitational collapse of tachyons are constructed. A discussion on the correspondence with the matrix-model approach is given.Comment: 7 pages, UTTG-31-9

Global entrainment of transcriptional systems to periodic inputs

This paper addresses the problem of giving conditions for transcriptional systems to be globally entrained to external periodic inputs. By using contraction theory, a powerful tool from dynamical systems theory, it is shown that certain systems driven by external periodic signals have the property that all solutions converge to a fixed limit cycle. General results are proved, and the properties are verified in the specific case of some models of transcriptional systems. The basic mathematical results needed from contraction theory are proved in the paper, making it self-contained

Shoes and Insoles: The Influence on Motor Tasks Related to Walking Gait Variability and Stability

The rhythmic control of the lower limb muscles influences the cycle-to-cycle variability during a walking task. The benefits of insoles, commonly used to improve the walking gait, have been little studied. Therefore, the aim of this study was to assess the walking gait variability and stability on different walking conditions (without shoes, WTS, with shoes, WS, with shoes and insoles, WSI) related to brain activity. Twelve participants randomly (WTS/WS/WSI) walked on a treadmill at 4 km/h for 10 min. Kinematic analysis (i.e., footstep and gait variability), brain activation (beta wave signal), rating of perceived exertion (RPE, CR-10 scale), and time domain measures of walking variability were assessed. The maximum Lyapunov exponent (LyE) on the stride cycle period\u2019s datasets was also calculated. Stride length and cycle calculated for all walking conditions were 61.59 \ub1 2.53/63.38 \ub1 1.43/64.09 \ub1 2.40 cm and 1.11 \ub1 0.03/1.14 \ub1 0.03/1.15 \ub1 0.04 s (F1,10 = 4.941/p = 0.01, F1,10 = 4.938/p = 0.012) for WTS, WS, WSI, respectively. Beta wave (F1,10 = 564.201/p = 0.0001) was higher in WTS compared to WS and WSI. Analysis of variance\u2019s (ANOVA) LyE showed a F1,10 = 3.209/p = 0.056, while post hoc analysis showed a significant effect between WS and WSI with p = 0.023, and nonsignificant effects between WTS and WS/WSI (p = 0.070/0.607), respectively. Small perturbations of the foot can influence the control of gait rhythmicity by increasing the variability in a dissipative deterministic regimen

Surface modification of basalt fibres with ZnO nanorods and its effect on thermal and mechanical properties of pla-based composites

The composites based on basalt fibres and poly(lactic acid) (PLA) show promising applications in biomedical and automotive fields, but their mechanical performance is still largely hindered by poor interfacial properties. Zinc oxide nanorods have been successfully used to tune the PLA/basalt fibre interface by growing them on commercially available basalt fabrics. The hierarchical fibres significantly enhanced the mechanical properties of PLA-based composites, especially their flexural strength and stiffness. These values are 26% and 22% higher than those of unmodified basalt/PLA composites, and 24% and 34% higher than those of glass/PLA composites used as a baseline. The increase in tensile and flexural properties hinges on the mechanical interlocking action promoted by ZnO nanorods and on the creation of a compact transcrystallinity structure. A degradation of PLA matrix was detected but it was positively counteracted by the better interfacial stress transfer. This study offers a novel approach for modifying the fibre–matrix interface of biocomposites intended for high-performance applications

Mucoadhesive polymers for oral transmucosal drug delivery: a review

he oral mucosa offers an interesting site for the application of dosage forms that release drugs within/throughout the oral mucosa, by assuring a high drug bioavailability for topic and systemic effects. However, the relative permeability of the oral mucosa and the washing effect related to the oral fluids and mechanical stresses must be considered in the formulation of oral dosage forms. Since a sustained drug release can be guaranteed only if dosage forms remain in contact with the oral site of absorption/application for a prolonged time, the development of mucoadhesive dosage forms is mandatory. The mucoadhesion is a complex phenomenon and the mucoadhesive bond consists of two different parts, the mucoadhesive polymers and the mucous substrate. In addition to factors related to the oral mucosa and oral environment features, the physical-chemical characteristics of mucoadhesive polymers must be also considered as factors influencing the mucoadhesive bonds. While it is not possible to modify the mucosal features or it is possible to modify or inhibit only in part certain mucosal processes, the knowledge of polymer properties influencing mucoadhesive bonds allows to modify or to control these properties in developing increasingly effective mucoadhesive systems. The aims of this review are to discuss the several mechanisms and factors behind the phenomenon of mucoadhesion with particular reference to the features of the oral environment, oral mucosa, and polymeric compounds influencing mucoadhesion process. Finally, a brief mention to the main mucoadhesive dosage forms designed for oral transmucosal drug delivery is made