Comparing AdS/CFT Calculations to HERA F_2 Data

We show that HERA data for the inclusive structure function F_2(x,Q^2) at small Bjorken-x and Q^2 can be reasonably well described by a color-dipole model with an AdS/CFT-inspired dipole-proton cross section. The model contains only three free parameters fitted to data. In our AdS/CFT-based parameterization the saturation scale varies in the range of 1-3 GeV becoming independent of energy/Bjorken-x at very small x. This leads to the prediction of x-independence of the F_2 and F_L structure functions at very small x. We provide predictions for F_2 and F_L in the kinematic regions of future experiments. We discuss the limitations of our approach and its applicability region, and argue that our AdS/CFT-based model of non-perturbative physics could be viewed as complimentary to the perturbative description of data based on saturation/Color Glass Condensate physics.Comment: 23 pages, 10 figures; v3: new plots added showing our model predictions for charm and longitudinal structure functions and photoproduction cross-section, discussion extended. The version to appear in PR

Trends in 5-, 10-, 20-, and 30-year survival rates of beta-thalassemia patients in Southern Iran, 1995-2016: A retrospective cohort study

Background: There is currently lack of knowledge about survival trend analysis of thalassemia patients. Therefore, the aim of the present study was to assess 5-, 10-, 20-, and 30-year survival of thalassemia patients over a 20- year time period. Methods: In this retrospective cohort study, we analysed the data of 982 beta-thalassemia patients in Iran. Birth cohort and traditional cohort analyses were used to obtain the 5-, 10-, 20-, and 30-year survival rates in various time intervals between 1995 and 2016. Results: Five and 10-year survival rates remained unchanged since 1995-2016. Overall, 20- and 30-year survival rates were lower in younger birth cohorts than older ones. A declining trend was found in 20-year survival rate from 1995 to 2000 for all and also for thalassemia major patients, but was stable from 2001 to 2016. In addition, there was a declining trend in 30-year survival rate from 1995 to 2008 for all and also for thalassemia major patients, but was an increased trend from 2009 to 2016. Conclusion: Over the past two decades and in recent birth cohorts, the 20- and 30-year survival rates has declined. In other words, declining survival trends in the birth cohorts may be associated with some different causes of mortality such as exposure to the toxic effects of iron over time and the occurrence of disease-related mortality

A light-front coupled cluster method

A new method for the nonperturbative solution of quantum field theories is described. The method adapts the exponential-operator technique of the standard many-body coupled-cluster method to the Fock-space eigenvalue problem for light-front Hamiltonians. This leads to an effective eigenvalue problem in the valence Fock sector and a set of nonlinear integral equations for the functions that define the exponential operator. The approach avoids at least some of the difficulties associated with the Fock-space truncation usually used.Comment: 8 pages, 1 figure; to appear in the proceedings of LIGHTCONE 2011, 23-27 May 2011, Dalla

Predicting Outcomes of Hormone and Chemotherapy in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) Study by Biochemically-inspired Machine Learning

Genomic aberrations and gene expression-defined subtypes in the large METABRIC patient cohort have been used to stratify and predict survival. The present study used normalized gene expression signatures of paclitaxel drug response to predict outcome for different survival times in METABRIC patients receiving hormone (HT) and, in some cases, chemotherapy (CT) agents. This machine learning method, which distinguishes sensitivity vs. resistance in breast cancer cell lines and validates predictions in patients; was also used to derive gene signatures of other HT (tamoxifen) and CT agents (methotrexate, epirubicin, doxorubicin, and 5-fluorouracil) used in METABRIC. Paclitaxel gene signatures exhibited the best performance, however the other agents also predicted survival with acceptable accuracies. A support vector machine (SVM) model of paclitaxel response containing genes ABCB1, ABCB11, ABCC1, ABCC10, BAD, BBC3, BCL2, BCL2L1, BMF, CYP2C8, CYP3A4, MAP2, MAP4, MAPT, NR1I2, SLCO1B3, TUBB1, TUBB4A, and TUBB4B was 78.6% accurate in predicting survival of 84 patients treated with both HT and CT (median survival ≥ 4.4 yr). Accuracy was lower (73.4%) in 304 untreated patients. The performance of other machine learning approaches was also evaluated at different survival thresholds. Minimum redundancy maximum relevance feature selection of a paclitaxel-based SVM classifier based on expression of genes BCL2L1, BBC3, FGF2, FN1, and TWIST1 was 81.1% accurate in 53 CT patients. In addition, a random forest (RF) classifier using a gene signature ( ABCB1, ABCB11, ABCC1, ABCC10, BAD, BBC3, BCL2, BCL2L1, BMF, CYP2C8, CYP3A4, MAP2, MAP4, MAPT, NR1I2,SLCO1B3, TUBB1, TUBB4A, and TUBB4B) predicted \u3e3-year survival with 85.5% accuracy in 420 HT patients. A similar RF gene signature showed 82.7% accuracy in 504 patients treated with CT and/or HT. These results suggest that tumor gene expression signatures refined by machine learning techniques can be useful for predicting survival after drug therapies

Post-Eocene coupled oroclines in the Talesh (NW Iran): paleomagnetic constraints

The Talesh Mountains (NW Iran) witnessed a long deformation history from the Triassic Cimmerian orogeny to the ongoing Arabia-Eurasia collision. This protracted multi-stage deformation has generated a remarkably curved orogen with a puzzling kinematic and deformational history. In this study, we investigate the origin of the Talesh curvature through paleomagnetic analyses on rocks of Paleozoic, Mesozoic and Cenozoic age. Our results indicate that at least two major, large-scale, vertical-axis-rotations took place since the Late Cretaceous: 1) a pre-Eocene 73° ± 17° clockwise rotation and 2) post-Eocene differential rotations that formed the Z-shaped mountain belt within a crustal-scale shear zone. The latter involved an increasing amount of clockwise (CW) rotation from south (16°) to north (48°). The orocline formation likely started during the Oligocene where an approximately east-west oriented mountain belt was buckled by the Arabia-Eurasia collision, with Arabia acting as a rigid indenter and the South Caspian basin as a rigid backstop. We hypothesise that the NE-SW oriented Aras and Lahijan fault zones, inherited from transform faults related to the Mesozoic opening of the Caspian-Black Sea back-arc, accommodated the coupled orocline formation

Whightman function and scalar Casimir densities for a wedge with a cylindrical boundary

Whightman function, vacuum expectation values of the field square, and the energy-momentum tensor are investigated for a scalar field inside a wedge with and without a coaxial cylindrical boundary. Dirichlet boundary conditions are assumed on the bounding surfaces. The vacuum energy-momentum tensor is evaluated in the general case of the curvature coupling parameter. Making use of a variant of the generalized Abel-Plana formula, expectation values are presented as the sum of two terms. The first one corresponds to the geometry without a cylindrical boundary and the second one is induced by the presence of this boundary. The asymptotic behaviour of the field square, vacuum energy density and stresses near the boundaries are investigated. The additional vacuum forces acting on the wedge sides due the presence of the cylindrical boundary are evaluated and it is shown that these forces are attractive. As a limiting case, the geometry of two parallel plates perpendicularly intersected by a third one is analyzed.Comment: 19 pages, 6 figures, new section is added on the VEVs for the region outside the cylidrical shell, discussion and references added, accepted for publication in J. Phys.

Predictions for p+p+Pb Collisions at sNN=5\sqrt{s_{NN}} = 5 TeV: Comparison with Data

Predictions made in Albacete {\it et al} prior to the LHC $p+$Pb run at $\sqrt{s_{NN}} = 5$ TeV are compared to currently available data. Some predictions shown here have been updated by including the same experimental cuts as the data. Some additional predictions are also presented, especially for quarkonia, that were provided to the experiments before the data were made public but were too late for the original publication are also shown here.Comment: 55 pages 35 figure