Consistency of Lorentz-invariance violation neutrino scenarios in time delay analyses

Modifications inspired by quantum gravity in the kinematics of special relativity can manifest in various ways, including anomalies in the time of flight of massless particles and the emergence of decay channels for otherwise stable particles. Typically, these effects are studied independently; however, it may be necessary to combine both to perform a consistent analysis. In this work, we study the interplay between time-of-flight anomalies and neutrino instability in the context of a flavor-independent high-energy Lorentz-invariance violation (LIV) in the neutrino sector. Ensuring compatibility between both types of effects imposes strong constraints on the existence of early neutrinos with energies exceeding a maximum value determined by the scale of new physics. Such constraints depend on the specific LIV scenario and should be integrated into searches for high-energy neutrinos from gamma-ray bursts exhibiting LIV time shifts.Comment: 14 pages, 6 figure

Decay of superluminal neutrinos in the collinear approximation

The kinematics of the three body decay, with a modified energy-momentum relation of the particles due to a violation of Lorentz invariance, is presented in detail in the collinear approximation. The results are applied to the decay of superluminal neutrinos producing an electron-positron or a neutrino-antineutrino pair. Explicit expressions for the energy distributions, required for a study of the cascade of neutrinos produced in the propagation of superluminal neutrinos, are derived.Comment: 13 pages, 3 figure

Testing Lorentz invariance violation using cosmogenic neutrinos

Secondary messengers such as neutrinos and photons are expected to be produced in interactions of ultra-high-energy cosmic rays (UHECRs) with extragalactic background photons. Their propagation could be altered by the effects of Lorentz invariance violation. In this work, we have developed an extension of the SimProp code that includes some Lorentz-violating scenarios affecting the propagation of neutrinos. We present the corresponding expected cosmogenic neutrino fluxes for three different astrophysical scenarios for the production of UHECRs. These results can be used to put constraints on the scale of Lorentz violation in the neutrino sector.Comment: 8 pages. Proceedings for the 38th International Cosmic Ray Conference (ICRC) 202

Hydrodynamic modelling and operational oceanography for oil-spill events in the andalusian coast: a real case study during the fedra accident (October 2008)

Peer Reviewe

The effect of thermophoresis on the discharge parameters in complex plasma experiments

Thermophoresis is a tool often applied in complex plasma experiments. One of the usual stated benefits over other experimental tools is that changes induced by thermophoresis neither directly depend on, nor directly influence, the plasma parameters. From electronic data, plasma emission profiles in the sheath, and Langmuir probe data in the plasma bulk, we conclude that this assumption does not hold. An important effect on the levitation of dust particles in argon plasma is observed as well. The reason behind the changes in plasma parameters seems to be the change in neutral atom density accompanying the increased gas temperature while running at constant pressure.Comment: 14 pages, 12 figure

Large-scale database mining reveals hidden trends and future directions for cancer immunotherapy

LLC Cancer immunotherapy has fundamentally changed the landscape of oncology in recent years and significant resources are invested into immunotherapy research. It is in the interests of researchers and clinicians to identify promising and less promising trends in this field in order to rationally allocate resources. This requires a quantitative large-scale analysis of cancer immunotherapy related databases. We developed a novel tool for text mining, statistical analysis and data visualization of scientific literature data. We used this tool to analyze 72002 cancer immunotherapy publications and 1469 clinical trials from public databases. All source codes are available under an open access license. The contribution of specific topics within the cancer immunotherapy field has markedly shifted over the years. We show that the focus is moving from cell-based therapy and vaccination towards checkpoint inhibitors, with these trends reaching statistical significance. Rapidly growing subfields include the combination of chemotherapy with checkpoint blockade. Translational studies have shifted from hematological and skin neoplasms to gastrointestinal and lung cancer and from tumor antigens and angiogenesis to tumor stroma and apoptosis. This work highlights the importance of unbiased large-scale database mining to assess trends in cancer research and cancer immunotherapy in particular. Researchers, clinicians and funding agencies should be aware of quantitative trends in the immunotherapy field, allocate resources to the most promising areas and find new approaches for currently immature topics

Remineralization of demineralized dentin using a dual analog system.

ObjectiveImproved methods are needed to remineralize dentin caries in order to promote conservation of dentin tissue and minimize the surgical interventions that are currently required for clinical treatment. Here, we test the hypothesis that bulk substrates can be effectively mineralized via a dual analog system proposed by others, using a tripolyphosphate (TPP) "templating analog" and a poly(acrylic acid) (PAA) or poly(aspartic acid) (pAsp) "sequestration analog," the latter of which generates the polymer-induced liquid-precursor (PILP) mineralization process studied in our laboratory.Material & methodsDemineralized human dentin slices were remineralized with and without pre-treatment with TPP, using either PAA or pAsp as the PILP process-directing agent. A control experiment with no polymer present was used for comparison.ResultsNo mineralization was observed in any of the PAA groups. In both the pAsp and no polymer groups, TPP inhibited mineralization on the surfaces of the specimens but promoted mineralization within the interiors. Pre-treatment with TPP enhanced overall mineralization of the pAsp group. However, when analysed via TEM, regions with little mineral were still present.ConclusionPoly(acrylic acid) was unable to remineralize demineralized dentin slices under the conditions employed, even when pre-treated with TPP. However, pre-treatment with TPP enhanced overall mineralization of specimens that were PILP-remineralized using pAsp

A Pilot Study on the Feasibility of Developing and Implementing a Mobile App for the Acquisition of Clinical Knowledge and Competencies by Medical Students Transitioning from Preclinical to Clinical Years

Due to the COVID-19 pandemic and the consequent restrictions, universities have had to adapt their curricula substantially to new schemes in which remote learning is of the essence. In this study, we assess the feasibility of developing a mobile app supplementary to the distant teaching paradigm for the “Cardiology” module of the “General Pathology” subject in undergraduate Medical Education, and we evaluate its impact and acceptability. A cohort of volunteer second-year medical students (n = 44) had access to the app, and their opinions on its utility (1–10) were collected. Additionally, the students were invited to refer their expected satisfaction (1–10) with a blended learning methodology overlapping this new tool with the traditional resources. The average expected satisfaction had been compared to the average satisfaction obtained by just the traditional methodology in other modules from the same subject. Through a qualitative approach, we defined the strengths and weaknesses of the tool. Seventy-seven percent of the participants rated at 8/10 or more the potential learning value of the application and, if used as a supplement to traditional teaching, it would also statistically improve the satisfaction of students (6.52 vs. 8.70, p < 0.001). Similarly, the qualitative data corroborated the benefits of such innovation. Multidisciplinary collaborations are encouraged to develop teaching innovations, although further research should aim to better define the effectiveness of learning with these resources

Monitoreo de la frecuencia cardiaca como indicador de la intensidad del entrenamiento en el futbolista profesional a 2 600 m sobre el nivel del mar

Resumen Introducción: Con el objetivo de analizar el comportamiento de la frecuencia cardiaca como indicador de la intensidad del entrenamiento en el futbolista profesional a 2 600 m sobre el nivel del mar. Materiales y métodos: Se realizó un estudio longitudinal, prospectivo de la temporada apertura 2017 y clausura 2018 del fútbol mexicano, con un análisis estadístico descriptivo con medidas de tendencia central y de dispersión, así como intervalos de confianza en un análisis de 2 328 monitoreos de la frecuencia cardiaca y distancia recorrida con el sistema de seguimiento por GPS Polar Team Pro y 111 monitoreos ambientales, con una duración aproximada de 120 minutos por sesión de entrenamiento. Resultados: Se llevaron a cabo 2 328 monitoreos con registros de frecuencia cardiaca en reposo, variabilidad de la frecuencia cardiaca (vfc), frecuencia cardiaca durante el entrenamiento y la recuperación; con 111 registros ambientales. Algunas de las variables propias del monitoreo de la frecuencia cardiaca durante el entrenamiento por la dinámica del mismo, como lo es, no seguir indicaciones o impuntualidad por el deportista; así como los tiempos propios marcados por el entrenador, falla del registro por desconexión del sensor, entre otras, hacen que algunos registros no sean valorables. Conclusiones: La frecuencia cardiaca de reposo permanece en los parámetros normales, la frecuencia cardiaca media de entrenamiento se encuentra en zona 2 de control de peso entre el 60-70% de la frecuencia cardiaca máxima, y la frecuencia cardiaca máxima de esfuerzo dentro de la zona 5 de alta intensidad, mientras que la frecuencia cardiaca mínima se ubica por debajo de la zona 1 de actividad regenerativa que va de un 50-60% de la frecuencia cardiaca máxima. Abstract Introduction: The purpose of this study is to analyze the behavior of the cardiac variability as an indicator of the training intensity in football players at 2600mts altitude above sea level. Methods: This was a longitudinal and prospective study of the 2017-2018 Mexican football seasons, with a descriptive analysis and central tendency on dispersion measurements as confidence intervals. These intervals consisted of 2328 heart rate cardiac monitorizations,traveled distance with the Polar Team Pro GPS tracking system and 111 environmental monitorizations, with each training session length of 120 minutes approximately. Results: After making 2328 monitorizations the following measures were obtained: resting heart rate, heart rate variability (hrv), heart rate during training and recovery sessions amongst 111 environmental registrations. Some variables of the heart rate monitorization records during the training session couldn´t be measured or valued such as not following instructions, football players running late, the coach training marked times, and the cardiac monitor connection errors. Conclusions: The resting heart rate is between the normal parameters. The medium heart rate is between 60-70% of the maximum heart rate of the second zone of weight control. The maximum heart rate posterior to the effort is in the fifth zone of high intensity, meanwhile the minimum heart rate is below the first zone of regenerative activity that corresponds from 50-60% of the maximum heart rate