Postpartum Depression: Standardizing Motherhood?

Postpartum Depression: Standardizing Motherhood? by Pamela J. Regus Under the Direction of Wendy S. Simonds ABSTRACT An expansion of the medicalization of Postpartum Depression (PPD) is evident in increased screening for maternal depression that begins in pregnancy and continues in the postpartum period, and in the growing number of medical professionals alerted to watch for signs of maternal distress. Although a definitive etiology ofPPDremains elusive, the scientific and medical fields – highly imbued with authority to create knowledge in Western society – promote essentialist views of motherhood that espouse “natural” attributes such as maternal instincts and tendencies to nurture. Mothers who struggle with these standards of motherhood are then defined as being ill and become patients under the care of the medical profession until they can perform adequately in their motherhood roles, or they face social condemnation and legal repercussions for being “bad” mothers. Because characteristics of the “normal” postpartum period are said to be similar to symptoms of general depression, how do some women come to identify their postpartum experiences as depression while others do not? Does the choice of traditional obstetrics or an alternative, such as midwifery, make a difference in the incidence of postpartum depression? And what changes in the social support network occur in a woman’s life as a result of a diagnosis ofPPD? Using Foucault’s theory of docility, critical constructionism, and postmodern feminism as the theoretical focus, and in-depth interviews as the research method, I compare the postpartum experiences of mothers who have been diagnosed with postpartum depression with mothers who have not been diagnosed. The sample includes mothers who gave birth with the assistance of obstetrics and mothers who gave birth with the assistance of certified nurse-midwives. In order to examine the differences in approaches to and treatment of postpartum depression, I also interview a sample of obstetricians and certified nurse-midwives. Findings show that medical professionals use gender-normative assessments, such as physical appearance, language, and nurturing tendencies to determine whether the mother is performing as expected; if not, she is defined as ill and treated with antidepressant medication. Although the majority of mothers in the sample experienced feelings of depression in the postpartum period, many resisted diagnosis and medication. Mothers found the greatest support in their peers, rather than those closest to them, citing the ability to talk candidly about the struggles they face in their motherhood roles as the way to avert or heal from PPD. This finding highlights the enforcement of normative motherhood within the social institutions of the family and medicine; thus, cultural change from ideological representations of motherhood may come about through peer relationships. INDEX WORDS: Postpartum depression, Motherhood, Medicalization, Expansion of medical control, Maternal behavior, Childbearing years, Normative motherhoo

Policing the legume-Rhizobium symbiosis: a critical test of partner choice

In legume-Rhizobium symbioses, specialised soil bacteria fix atmospheric nitrogen in return for carbon. However, ineffective strains can arise, making discrimination essential. Discrimination can occur via partner choice, where legumes prevent ineffective strains from entering, or via sanctioning, where plants provide fewer resources. Several studies have inferred that legumes exercise partner choice, but the rhizobia compared were not otherwise isogenic. To test when and how plants discriminate ineffective strains we developed sets of fixing and non-fixing strains that differed only in the expression of nifH - essential for nitrogen fixation - and could be visualised using marker genes. We show that the plant is unable to select against the non-fixing strain at the point of entry, but that non-fixing nodules are sanctioned. We also used the technique to characterise mixed nodules (containing both a fixing and a non-fixing strain), whose frequency could be predicted using a simple diffusion model. We discuss that sanctioning is likely to evolve in preference to partner choice in any symbiosis where partner quality cannot be adequately assessed until goods or services are actively exchanged

Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system

Ribbon synapses transmit information in sensory systems, but their development is not well understood. To test the hypothesis that ribbon assembly stabilizes nascent synapses, we performed simultaneous time-lapse imaging of fluorescently-tagged ribbons in retinal cone bipolar cells (BCs) and postsynaptic densities (PSD95-FP) of retinal ganglion cells (RGCs). Ribbons and PSD95-FP clusters were more stable when these components colocalized at synapses. However, synapse density on ON-alpha RGCs was unchanged in mice lacking ribbons (ribeye knockout). Wildtype BCs make both ribbon-containing and ribbon-free synapses with these GCs even at maturity. Ribbon assembly and cone BC-RGC synapse maintenance are thus regulated independently. Despite the absence of synaptic ribbons, RGCs continued to respond robustly to light stimuli, although quantitative examination of the responses revealed reduced frequency and contrast sensitivity

Shining a Light on Exploitative Host Control in a Photosynthetic Endosymbiosis

Endosymbiosis allows hosts to acquire new functional traits such that the combined host and endosymbiont can exploit vacant ecological niches and occupy novel environments [1, 2]; consequently, endosymbiosis affects the structure and function of ecosystems [3, 4]. However, for many endosymbioses, it is unknown whether their evolutionary basis is mutualism or exploitation [5-9]. We estimated the fitness consequences of symbiosis using the interaction between the protist host Paramecium bursaria and the algal symbiont Chlorella sp. [10]. Host fitness was strongly context dependent: whereas hosts benefited from symbiosis at high light intensity, carrying endosymbionts was costly to hosts in the dark and conferred no benefit over growing autonomously at intermediate light levels. Autonomous Chlorella densities increased monotonically with light intensity, whereas per-host symbiont load and symbiont abundance peaked at intermediate light levels and were lowest at high light intensity. This suggests that hosts controlled the costs of symbiosis by manipulating symbiont load according to light intensity. Photosynthetic efficiency was consistently lower for symbiotic compared to autonomous algae, suggesting nutritional constraints upon algae in symbiosis. At intermediate light levels, we observed the establishment of small populations of free-living algae alongside the hosts with endosymbionts, suggesting that symbionts could escape symbiosis, but only under conditions where hosts didn't benefit from symbiosis. Together, these data suggest that hosts exerted strong control over endosymbionts and that there were no conditions where this nutritional symbiosis was mutually beneficial. Our findings support theoretical predictions (e.g., [5, 9]) that controlled exploitation is an important evolutionary pathway toward stable endosymbiosis

Absence of functional active zone protein Bassoon affects assembly and transport of ribbon precursors during early steps of photoreceptor synaptogenesis

The retinal photoreceptor ribbon synapse is a structurally and functionally unique type of chemical synapse, specialized for tonic release of neurotransmitter in the dark. It is characterized by the presynaptic ribbon, an electron-dense organelle at the active zone, which is covered by hundreds of synaptic vesicles. Recently we showed that photoreceptor ribbon complexes are assembled from non-membranous, spherical densities - the precursor spheres - during the first two postnatal weeks of photoreceptor synaptogenesis. A core component of the precursor spheres and a key player in attaching the ribbon to the active zone is the presynaptic cytomatrix protein Bassoon. In this study, we examined in a comprehensive light and electron microscopic analysis whether Bassoon plays a role in the formation of the precursor spheres using Bassoon mutant mice lacking functional Bassoon. We report that developing Bassoon mutant photoreceptors contain fewer and smaller precursor spheres and that transport of precursor spheres to nascent synapses is delayed compared to wild-type controls. Moreover, western blot analyses of homogenates from postnatal day 0 (P0) to P14 Bassoon mutant retinae exhibit lower RIBEYE and Piccolo protein levels compared to the wild type, indicating elevated protein degradation in the absence of Bassoon. Our findings reveal a novel function of Bassoon in the early formation and delivery of precursor spheres to nascent ribbon synaptic sites in addition to its known role in ribbon anchoring during later stages of photoreceptor ribbon synaptogenesis. (C) 2010 Elsevier GmbH. All rights reserved

Pola Pelesapan Unsur Bahasa Indonesia: Studi Kasus Opini Kompas

Dalam konstuksi sebuah wacana senantiasa terdapat unsur bahasa yang dilesapkan atau dihilangkan penulisnya. Unsur bahasa yang dilesapkan itu bisa berupa kata, frasa, atau klausa yang menduduki fungsi sintaksis tertentu. Kajian tentang pelesapan unsur bahasa Indonesia dianggap urgen mengingat hingga saat ini pola pelesapan bahasa Indonesia belum banyak diwacanakan di dalam kajian-kajian kebahasaan, juga belum dibakukan di dalam tata bahasa baku bahasa Indonesia. Penelitian ini bertujuan untuk mendeskripsikan pola pelesapan unsur bahasa Indonesia, sebuah studi kasus pada kolom opini Kompas. Pengumpulan data penelitian ini memanfaatkan metode simak yang diterapkan melalui teknik baca dan catat. Dalam analisis data digunakan metode analisis konten yang diterapkan melalui beberapa langkah, yakni inventarisasi, identifikasi, klasifikasi, dan deskripsi data. Hasil penelitian ini dideskripsikan sebagaimana berikut. Pertama, dalam kolom opini Kompas ditemukan pola pelesapan berupa kategori. Pada tataran kategori ditemukan pola pelesapan berupa nomina dan verba yang dilesapkan secara kataforis dan anaforis.  Kedua, dalam kolom opini Kompas ditemukan juga pola pelesapan pada kalimat koordinatif berupa (1) pelesapan subjek, (2) pelesapan subjek sekaligus predikat, dan (3) pelesapan objek.  Ketiga, dalam kolom opini Kompas disibak bahwa pola pelesapan unsur bahasa pada kalimat subordinatif berupa (1) pelesapan subjek pada klausa anak dan (2) pelesapan subjek pada klausa induk. Dalam kasus tertentu, pelesapan pada kalimat subordinatif bersifat lebih kompleks, yakni terjadinya pelesapan subjek pada induk dan anak kalimat, juga pelesapan subjek dan predikat pada anak-anak kalimat.&nbsp