647 research outputs found
Quantum Frequency Translation of Single-Photon States in Photonic Crystal Fiber
We experimentally demonstrate frequency translation of a nonclassical optical
field via the Bragg scattering four-wave mixing process in a photonic crystal
fiber (PCF). The high nonlinearity and the ability to control dispersion in PCF
enable efficient translation between photon channels within the visible
to-near-infrared spectral range, useful in quantum networks. Heralded single
photons at 683 nm were translated to 659 nm with an efficiency of percent. Second-order correlation measurements on the 683-nm and 659-nm
fields yielded and respectively, showing the nonclassical nature of both fields.Comment: 5 pages, 3 figure
Photon pair-state preparation with tailored spectral properties by spontaneous four-wave mixing in photonic-crystal fiber
We study theoretically the generation of photon pairs by spontaneous
four-wave mixing (SFWM) in photonic crystal optical fiber. We show that it is
possible to engineer two-photon states with specific spectral correlation
(``entanglement'') properties suitable for quantum information processing
applications. We focus on the case exhibiting no spectral correlations in the
two-photon component of the state, which we call factorability, and which
allows heralding of single-photon pure-state wave packets without the need for
spectral post filtering. We show that spontaneous four wave mixing exhibits a
remarkable flexibility, permitting a wider class of two-photon states,
including ultra-broadband, highly-anticorrelated states.Comment: 17 pages, 7 figures, submitte
Unimpaired phase-sensitive amplification by vector four-wave mixing near the zero-dispersion frequency.
Phase-sensitive amplification (PSA), which is produced by degenerate four-wave mixing (FWM) in a randomly-birefringent fiber, has the potential to improve the performance of optical communication systems. Scalar FWM, which is driven by parallel pumps, is impaired by the generation of pump-pump and pump-signal harmonics, which limit the level, and modify the phase sensitivity, of the signal gain. In contrast, vector FWM, which is driven by perpendicular pumps, is not impaired by the generation of harmonics. Vector FWM produces PSA with the classical properties of a one-mode squeezing transformation
Efficient wavelength conversion and net parametric gain via four wave mixing in a high index doped silica waveguide
We demonstrate sub-picosecond wavelength conversion in the C-band via four wave mixing in a 45cm long high index doped silica spiral waveguide. We achieve an on/off conversion efficiency (signal to idler) of + 16.5dB as well as a parametric gain of + 15dB for a peak pump power of 38W over a wavelength range of 100nm. Furthermore, we demonstrated a minimum gain of + 5dB over a wavelength range as large as 200nm
Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity
Gene transfer of a human cocaine hydrolase (hCocH) derived from butyrylcholinesterase (BChE) by 5 mutations (A199S/F227A/S287G/A328W/Y332G) has shown promise in animal studies for treatment of cocaine addiction. To predict the physiological fate and immunogenicity of this enzyme in humans, a comparable enzyme was created and tested in a conspecific host. Thus, similar mutations (A199S/S227A/S287G/A328W/Y332G) were introduced into mouse BChE to obtain a mouse CocH (mCocH). The cDNA was incorporated into viral vectors based on: a) serotype-5 helper-dependent adenovirus (hdAD) with ApoE promoter, and b) serotype-8 adeno-associated virus with CMV promoter (AAV-CMV) or multiple promoter and enhancer elements (AAV-VIP). Experiments on substrate kinetics of purified mCocH expressed in HEK293T cells showed 30-fold higher activity (U/mg) with (3)H-cocaine and 25% lower activity with butyrylthiocholine, compared with wild type BChE. In mice given modest doses of AAV-CMV-mCocH vector (0.7 or 3 Ă— 10(11) particles) plasma hydrolase activity rose 10-fold above control for over one year with no observed immune response. Under the same conditions, transduction of the human counterpart continued less than 2 months and antibodies to hCocH were readily detected. The advanced AAV-VIP-mCocH vector generated a dose-dependent rise in plasma cocaine hydrolase activity from 20-fold (10(10) particles) to 20,000 fold (10(13) particles), while the hdAD vector (1.7 Ă— 10(12) particles) yielded a 300,000-fold increase. Neither vector caused adverse reactions such as motor weakness, elevated liver enzymes, or disturbance in spontaneous activity. Furthermore, treatment with high dose hdAD-ApoE-mCocH vector (1.7 Ă— 10(12) particles) prevented locomotor abnormalities, other behavioral signs, and release of hepatic alanine amino transferase after a cocaine dose fatal to most control mice (120 mg/kg). This outcome suggests that viral gene transfer can yield clinically effective cocaine hydrolase expression for lengthy periods without immune reactions or cholinergic dysfunction, while blocking toxicity from drug overdose
Mid-infrared optical parametric amplifier using silicon nanophotonic waveguides
All-optical signal processing is envisioned as an approach to dramatically
decrease power consumption and speed up performance of next-generation optical
telecommunications networks. Nonlinear optical effects, such as four-wave
mixing (FWM) and parametric gain, have long been explored to realize
all-optical functions in glass fibers. An alternative approach is to employ
nanoscale engineering of silicon waveguides to enhance the optical
nonlinearities by up to five orders of magnitude, enabling integrated
chip-scale all-optical signal processing. Previously, strong two-photon
absorption (TPA) of the telecom-band pump has been a fundamental and
unavoidable obstacle, limiting parametric gain to values on the order of a few
dB. Here we demonstrate a silicon nanophotonic optical parametric amplifier
exhibiting gain as large as 25.4 dB, by operating the pump in the mid-IR near
one-half the band-gap energy (E~0.55eV, lambda~2200nm), at which parasitic
TPA-related absorption vanishes. This gain is high enough to compensate all
insertion losses, resulting in 13 dB net off-chip amplification. Furthermore,
dispersion engineering dramatically increases the gain bandwidth to more than
220 nm, all realized using an ultra-compact 4 mm silicon chip. Beyond its
significant relevance to all-optical signal processing, the broadband
parametric gain also facilitates the simultaneous generation of multiple
on-chip mid-IR sources through cascaded FWM, covering a 500 nm spectral range.
Together, these results provide a foundation for the construction of
silicon-based room-temperature mid-IR light sources including tunable
chip-scale parametric oscillators, optical frequency combs, and supercontinuum
generators
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