Tuberculosi

Peer Reviewe

Biozonacion del Paleogeno continental de la zona oriental de la Cuenca del Ebro mediante carofitas: implicacions en la biozonacion general de carofitas de Europa occidental

A charophyte biozonation of the Paleogene (Thanetian-Chattian) sequences of the Eastern Ebro Basin (NE Spain) is proposed. This biozonation has been based on an intensive sampling carried out on well correlated sections which included, in some cases, fossil mammal localities. Bothfacts haveresultedin agood chronostratigraphic control of the biozonation. One of the most noticeable contributions from this local point of view is the characterization of the Ilerdian in the continental Ebro Basin sequences by the Maedleriella lavocati biozone. Although in afirst approach this biozonation is intended to be local the new data in the Eastern Ebro Basin have enlarged the ranges of some widespread charophyte index species. These changes in the charophyte sp&ies ranges has led to suggest some remarkable modifications of the preexistin~ Riveline' s (1986) charophyte biozonationfor western Europe: 1) TheN. (T. ) thaleri biozone siaried in the Ilerdian and not in the Cuisian. 2) The definition of new Late Eocene (S. labellata) and Late Oligocene (H. lagenalis) biozones. 3) The enlargement of the range of severa1 species which has resulted in suppressionof the Chara notata biozone and in redefinition of Chara microcera, St. pinguis, St. vectensis and Sr. berdotensis biozones. From apaleogeographic point of view the global percentages of pluricontinental, european and iberian species of the Paleogene Eastern Ebro Basin charophyte record suggest some kind of isolation of the charophyte populations in NE Iberia. This isolation could be enhanced by paleogeographic constraints during Bartonian and Latest Priabonian to Stampian transition.Peer Reviewe

Drainage basins evolution during the Neogene-Quaternary. Ebro Basin eastern margin

The monocline layout of the sedimentary pile of the Ebro Basin in its Eastern margin determines the generation and emptying of the adjacent erosive basins. It controls the drainage changes in the original sedimentary basin. A model of emptying erosive basins corresponding to a drainage architecture and sediment production is proposed. The emptying of erosive basins is achieved by two vectors: A) A drainage basin area growth due to anaclinal streams eroding into the resistant layers of the monocline stratigraphic succession. These streams empty and link small depressions generated at the expense of the lateral extension on the less resistant lithologic member. B) The drainage basin outlet point base level controls the drainage network entrenchment facilitated by the gradients created by Neogene extensional faults from the Valencia Trough. A model of the growth and entrenchment of erosive basins as well as the generated landforms and sediment production is described and analyze

Influence of structural and magnetic properties in the heating performance of multicore bioferrofluids

Under the terms of the Creative Commons Attribution License 3.0 (CC-BY).Biomedical applications of superparamagnetic iron oxide particles have been of interest for quite a number of years. Recent developments show that multifunctionality can be efficiently achieved using polymers to coat the particles and to provide anchoring elements to their surface. This leads to the formation of nanobeads with a reduced number of particles trapped by the polymeric structure. While the magnetothermic behavior of isolated nanoparticles has been a subject of interest over the past several years, multicore magnetic nanobeads have thus far not received the same attention. The influence of structural and magnetic properties in the hyperthermia performance of a series of magnetic fluids designed for biomedical purposes is studied here. The fluids are made of maghemite multicore polymeric beads, with variable nanoparticle size and hydrodynamic size, dispersed in a buffer solution. The specific loss power (SLP) was measured from 5 to 100 kHz with a field intensity of 21.8 kA/m. SLP increases with increasing magnetic core size, reaching 32 W/g Fe 2O3 at 100 kHz for 16.2 nm. Within the framework of the linear response theory, a graphical construction is proposed to describe the interplay of both size distributions and magnetic properties in the heating performance of such fluids in a given frequency range. Furthermore, a numerical model is developed to calculate the spare contribution of Néel and Brown relaxation mechanisms to SLP, which gives a fair reproduction of the experimental data. © 2013 American Physical Society.R.B. would like to thank ICMA-CSIC for the JAE predoc grant. Financial support from Grant No. MAT2011-25991 is gratefully acknowledged. We acknowledge Fundaçâo para a Ciência e Tecnologia (FCT, Portugal), COMPETE, and FEDER programs (Pest-C/CTM/LA0011/2013). N.J.O.S. acknowledges FCT for the Ciência 2008 program.Peer Reviewe

Studies with the Golgi method in central gangliogliomas and dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease)

The rapid Golgi method, combined with current optical and electronmicroscopica1 techniques, was used in three central gangliogliomas and in one dysplastic gangliocytoma of the cerebellum to study the morphology of ganglionic cells. Gangliogliomas were composed of bipolar, fusiform and radiate cells with dense core and clear vesicles in the perikaryon and cellular processes, the number of each cellular type varying from one case to another. These features, together with the fact that isodendritic neurons are considered to be phylogenetically old neurons, suggest that these tumours are composed of 'primitive' neurons that are not homogeneous with regard to their morphology. In contrast, ganglionic cells in dysplastic gangliocytoma are huge cells with long, stereotyped neurites that establish unique asymmetric contacts with neighbouring perikarya and neurites by means of claw-shaped processes covered with synaptic buttons. These morphological characteristics are different from those of any other neuron of the CNS

Catastrophic senescence and semelparity in the Penna aging model

The catastrophic senescence of the Pacific salmon is among the initial tests used to validate the Penna aging model. Based on the mutation accumulation theory, the sudden decrease in fitness following reproduction may be solely attributed to the semelparity of the species. In this work, we report other consequences of mutation accumulation. Contrary to earlier findings, such dramatic manifestation of aging depends not only on the choice of breeding strategy but also on the value of the reproduction age, R, and the mutation threshold, T. Senescence is catastrophic when $T \leq R$. As the organism's tolerance for harmful genetic mutations increases, the aging process becomes more gradual. We observe senescence that is threshold dependent whenever T>R. That is, the sudden drop in survival rate occurs at age equal to the mutation threshold value