The Rowland Clark (41RR77) Site, Red River County, Texas : Editor\u27s Introduction

The Rowland Clark (41RR77) and Dan Holdeman (41RR11) archaeological sites were excavated in the late 1970s and early 1980s by Gregory Perino of the Museum of Red River in Idabel, Oklahoma. Manuscripts on those investigations were prepared by Perino shortly after the conclusion of the work, but these were never published, remaining instead on file at the Museum of the Red River

Theoretical Methods for Wave Propagation across Jointed Rock Masses

Different methods are presently available for the analysis of wave propagation across jointed rock masses with the consideration of multiple wave reflections between joints. These methods can be divided into two categories. One is based on the displacement discontinuity model for representing rock joints, where the displacements across a joint are discontinuous and the tractions are continuous, and the other is the equivalent medium method. For the first category, there are three methods, i.e., method of characteristics (MC), scattering matrix method (SMM) and virtual wave source method (VWS). MC solves the equation of motion by using the theory of characteristic curves. SMM is based on the definition of the scattering matrix in which the reflection and transmission coefficients of a set of joints are stored. VWS method replaces the joints in the rock mass with a virtual concept. For the second category, equivalent medium model treats the problem in the frame of continuum mechanics and simplifies it from an explicit wave propagation equation. The objective of this paper is to review and compare these theoretical methods. The comparison shows that the four solutions agree very well with each other. Some additional considerations about the advantages and disadvantages of these methods are also given in the pape

Sistema Fotovoltaico Autónomo para energizar la Planta Potabilizadora de Agua de la Universidad Nacional de San Luis (UNSL)

Se transita una crisis ambiental global donde el cambio climático es una de sus consecuencias primordiales. Frente a este nuevo escenario, el presente proyecto focaliza su objetivo en el diseño y dimensionado de la Planta Potabilizadora de Agua de la Universidad Nacional de San Luis (UNSL) y del Sistema Fotovoltaico Autónomo (SFA) que garantice el suministro anual y continuo de energía eléctrica a la misma. Para el dimensionado del Sistema Fotovoltaico Autónomo se tuvo en cuenta las normas y especificaciones para que el conjunto “SFA-Planta” opere satisfactoriamente con la mayor fiabilidad y al menor coste posible, velando por un equilibrio entre ambos. Dicho proyecto cumple todas las condiciones ingenieriles de calidad y fiabilidad para que la Planta Potabilizadora suministre agua sanitizada ininterrumpidamente, energizada por el Sistema Fotovoltaico Autónomo. La finalidad de incorporar un Sistema Fotovoltaico a la Planta y, por ende, al sistema energético de la Universidad insta armonizar el abastecimiento energético sustentable con una protección efectiva de la biosfera

Isolation of Pasteurella spp. from Sick and Healthy Feedlot Calves Using Four Different Sampling Techniques

Bovine respiratory disease is the most common disease complex of feedlot cattle. The peak incidence of the disease occurs within the first few weeks of arrival at the feedlot. Bovine respiratory disease is attributed to a complex interaction between bacteria, viruses, environment, stress, and managerial practices. Pasteurella hemolytica, and to a lesser extent Pasteurella multocida, are considered to be the most common bacterial isolates from cases of bovine respiratory disease. The purpose of this study was threefold: 1) compare the ability of four different sampling techniques to isolate Pasteurella spp. from the respiratory tract of calves, 2) compare the prevalence of Pasteurella spp. in the respiratory tract of sick calves and clinically normal cohorts, and 3) evaluate the feasibility and practicality of performing nonsurgical tracheal washes in a feedlot setting

Subconjunctival Injection of XG-102, a JNK Inhibitor Peptide, in Patients with Intraocular Inflammation: A Safety and Tolerability Study.

Abstract Purpose: We aimed to investigate the safety, tolerability, and systemic diffusion of a single escalating dose of XG-102 (a 31-D-amino-acid peptide inhibiting JNK pathway activation), administered subconjunctivally in the treatment of post-surgery or post-trauma intraocular inflammation. Methods: This is a dose-escalating, tolerance Phase Ib study. Twenty patients with post-surgery or post-traumatic intraocular inflammation were assigned to 1 of the 4 dose escalating (45, 90, 450, or 900 μg XG-102) groups of 5 patients each. Patients were evaluated at 24, 48 h, 8, and 28 days following the administration of XG-102, including laboratory tests, standard eye examinations, vital signs, and occurrence of adverse events. A single plasma quantification of XG-102 was performed 30 min after administration, according to previous pharmacokinetics studies performed on volunteers. Results: A total of 17 non-serious adverse events, considered unrelated to the study treatment, were reported for 10 patients. The adverse event incidence was not related to the drug dose. All patients experienced a decrease in intraocular inflammation as of 24 h post-administration and this decrease was sustained up to 28 days thereafter. No patient required local injection or systemic administration of corticoids following the administration of XG-102. XG-102 was undetectable in the first 3 dose groups. In the fourth-dose group (900 μg) the XG-102 plasma levels were above the limit of detection for 3 patients and above the limit of quantification for 1 patient. Conclusions: In this first clinical trial using XG-102, administered as a single subconjunctival injection as adjunct therapy, in patients with recent post-surgery or post-trauma intraocular inflammation is safe and well tolerated. Further studies are required to evaluate its efficacy

Seismic response of a single and a set of filled joints of viscoelastic deformational behaviour

Rock joints are often filled with weak medium, for example, saturated clay or sand, of viscoelastic nature. Their effects on wave propagation can be modelled as displacement and stress discontinuity conditions. The viscoelastic behaviour of the filled joint can be described by either the Kelvin or the Maxwell models. The analytical solutions for wave propagation across a single joint are derived in this paper by accounting for the incident angle, the non-dimensional joint stiffness, the non-dimensional joint viscosity and the acoustic impedance ratio of the filled joint. It is shown that the viscoelastic behaviour results in dissipation of wave energy and frequency dependence of the reflection and transmission coefficients. Based on curve fitting of the experimental data of P-wave propagation across a single joint filled with saturated sand, both the Kelvin and Maxwell models are found to reproduce the behaviour of the filled joint, in terms of the amplitude and frequency contents. Then, wave transmission across a filled joint set is studied with the virtual wave source method and the scattering matrix method, where multiple wave reflections among joints are taken into account. It is shown that the non-dimensional joint spacing and the number of joints have significant effects on the transmission coefficient

Occupant-Centred Control strategies for Adaptive Facades: A preliminary study of the impact of shortwave solar radiation on thermal comfort

Adaptive facades have the potential to shape resource-efficient and occupant-centred spaces only when their control strategies are tailored to meet transient, local and personal demands. State-of-the-art control algorithms are currently failing to provide occupant thermal satisfaction because the data on occupant response to the thermal environment is not sufficiently granular. This paper presents a preliminary assessment of the use of the adjusted operative temperature, which accounts also for the additional effect of shortwave radiation on occupants, to dynamically devise learning control strategies that meet individual occupant comfort requirements. Shortwave effects of solar radiation on occupant comfort and operative temperature are compared to those considering only longwave radiation and two alternative occupant-centred control strategies are devised and assessed. Lastly, a combined occupant-centred control strategy is also proposed for an open space office

Neurofilament light plasma concentration positively associates with age and negatively associates with weight and height in the dog

Plasma neurofilament light chain (pNfL) concentration is a biomarker for neuroaxonal injury and degeneration and can be used to monitor response to treatment. Spontaneous canine neurodegenerative diseases are a valuable comparative resource for understanding similar human conditions and as large animal treatment models. The features of pNfL concentration in healthy dogs is not well established. We present data reporting basic pNfL concentration trends in the Labrador Retriever breed. Fifty-five Labrador Retrievers were enrolled. pNfL concentration was measured and correlated to age, sex, neuter status, height, weight, body mass index, and coat color. We found increased pNfL with age (P < 0.0001), shorter stature (P = 0.009) and decreased body weight (P < 0.001). These are similar to findings reported in humans. pNfL concentration did not correlate with sex, BMI or coat color. This data further supports findings that pNfL increase with age in a canine population but highlights a need to consider weight and height when determining normal pNfL concentration in canine populations