Pulsar Scintillation through Thick and Thin: Bow Shocks, Bubbles, and the Broader Interstellar Medium

Observations of pulsar scintillation are among the few astrophysical probes of very small-scale ($\lesssim$ au) phenomena in the interstellar medium (ISM). In particular, characterization of scintillation arcs, including their curvature and intensity distributions, can be related to interstellar turbulence and potentially over-pressurized plasma in local ISM inhomogeneities, such as supernova remnants, HII regions, and bow shocks. Here we present a survey of eight pulsars conducted at the Five-hundred-meter Aperture Spherical Telescope (FAST), revealing a diverse range of scintillation arc characteristics at high sensitivity. These observations reveal more arcs than measured previously for our sample. At least nine arcs are observed toward B1929$+$10 at screen distances spanning $\sim 90\%$ of the pulsar's $361$ pc path-length to the observer. Four arcs are observed toward B0355$+$54, with one arc yielding a screen distance as close as $\sim10^5$ au ($<1$ pc) from either the pulsar or the observer. Several pulsars show highly truncated, low-curvature arcs that may be attributable to scattering near the pulsar. The scattering screen constraints are synthesized with continuum maps of the local ISM and other well-characterized pulsar scintillation arcs, yielding a three-dimensional view of the scattering media in context.Comment: 20 pages, 14 figures. Submitted to MNRAS and comments welcome. Interactive version of Figure 12 available at https://stella-ocker.github.io/scattering_ism3d_ocker202

Acute liver toxicity with ifosfamide in the treatment of sarcoma: a case report

<p>Abstract</p> <p>Introduction</p> <p>Ifosfamide is a chemotherapy agent infrequently associated with liver toxicity. To the best of our knowledge, this report is the first to describe serious liver toxicity associated with ifosfamide used in combination with doxorubicin that caused acute but fully reversible liver failure and encephalopathy. This report reviews the possible mechanisms by which ifosfamide causes this adverse effect.</p> <p>Case report</p> <p>A 61-year-old Caucasian woman who presented with an inoperable right neck mass due to synovial sarcoma was treated with standard-dose ifosfamide and doxorubicin. Within 24 hours of completing the first cycle of chemotherapy, she developed significant derangements in liver function, with a 250-fold increase in transaminase and associated synthetic function impairment and encephalopathy. No other causes of liver failure were identified. Both biochemical tests and encephalopathy were reversed after supportive management and treatment with <it>N</it>-acetylcysteine. No liver toxicity was observed with subsequent cycles of chemotherapy with doxorubicin alone.</p> <p>Conclusion</p> <p>This case highlights the possibility that chemotherapy agents can cause rare and idiosyncratic toxicities, so physicians must be vigilant for drug reactions, especially when patients do not respond to usual treatment.</p

Acute liver toxicity with ifosfamide in the treatment of sarcoma: a case report

<p>Abstract</p> <p>Introduction</p> <p>Ifosfamide is a chemotherapy agent infrequently associated with liver toxicity. To the best of our knowledge, this report is the first to describe serious liver toxicity associated with ifosfamide used in combination with doxorubicin that caused acute but fully reversible liver failure and encephalopathy. This report reviews the possible mechanisms by which ifosfamide causes this adverse effect.</p> <p>Case report</p> <p>A 61-year-old Caucasian woman who presented with an inoperable right neck mass due to synovial sarcoma was treated with standard-dose ifosfamide and doxorubicin. Within 24 hours of completing the first cycle of chemotherapy, she developed significant derangements in liver function, with a 250-fold increase in transaminase and associated synthetic function impairment and encephalopathy. No other causes of liver failure were identified. Both biochemical tests and encephalopathy were reversed after supportive management and treatment with <it>N</it>-acetylcysteine. No liver toxicity was observed with subsequent cycles of chemotherapy with doxorubicin alone.</p> <p>Conclusion</p> <p>This case highlights the possibility that chemotherapy agents can cause rare and idiosyncratic toxicities, so physicians must be vigilant for drug reactions, especially when patients do not respond to usual treatment.</p

Pulsar scintillation through thick and thin: Bow shocks, bubbles, and the broader interstellar medium

Observations of pulsar scintillation are among the few astrophysical probes of very small-scale (≲ au) phenomena in the interstellar medium (ISM). In particular, characterization of scintillation arcs, including their curvature and intensity distributions, can be related to interstellar turbulence and potentially overpressurized plasma in local ISM inhomogeneities, such as supernova remnants, H II regions, and bow shocks. Here we present a survey of eight pulsars conducted at the Five-hundred-metre Aperture Spherical Telescope (FAST), revealing a diverse range of scintillation arc characteristics at high sensitivity. These observations reveal more arcs than measured previously for our sample. At least nine arcs are observed toward B1929+10 at screen distances spanning ~90 per cent of the pulsar’s 361 pc path length to the observer. Four arcs are observed toward B0355+54, with one arc yielding a screen distance as close as ∼105 au (<1 pc) from either the pulsar or the observer. Several pulsars show highly truncated, low-curvature arcs that may be attributable to scattering near the pulsar. The scattering screen constraints are synthesized with continuum maps of the local ISM and other well-characterized pulsar scintillation arcs, yielding a three-dimensional view of the scattering media in context

Alignment in the orientation of LOFAR radio sources

©ESO 2020. The original publication is available at https://doi.org/10.1051/0004-6361/202037680Various studies have laid claim to finding an alignment of the polarization vectors or radio jets of active galactic nuclei (AGN) over large distances, but these results have proven controversial and so far, there is no clear explanation for this observed alignment. To investigate this case further, we tested the hypothesis that the position angles of radio galaxies are randomly oriented in the sky by using data from the Low-Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS). A sample of 7,555 double-lobed radio galaxies was extracted from the list of 318,520 radio sources in the first data release of LoTSS at 150 MHz. We performed statistical tests for uniformity of the two-dimensional (2D) orientations for the complete 7,555 source sample. We also tested the orientation uniformity in three dimensions (3D) for the 4,212 source sub-sample with photometric or spectroscopic redshifts. Our sample shows a significant deviation from uniformity (p-value <$10^{-5}$) in the 2D analysis at angular scales of about four degrees, mainly caused by sources with the largest flux densities. No significant alignment was found in the 3D analysis. Although the 3D analysis has access to fewer sources and suffers from uncertainties in the photometric redshift, the lack of alignment in 3D points towards the cause of the observed effect being unknown systematics or biases that predominantly affect the brightest sources, although this has yet to be demonstrated irrefutably and should be the subject of subsequent studies.Peer reviewe

WALOP-South: A Four Camera One Shot Imaging Polarimeter for PASIPHAE Survey. Paper I -- Optical Design

The WALOP-South instrument will be mounted on the 1 m SAAO telescope in South Africa as part of the PASIPHAE program to carry out a linear imaging polarization survey of the Galactic polar regions in the optical band. Designed to achieve polarimetric sensitivity of $0.05~\%$ across a $35\times35$ arcminute field of view, it will be capable of measuring the Stokes parameters I, q and u in a single exposure in the SDSS-r broadband and narrowband filters between $0.5~{\mu}m - 0.7~{\mu}m$. For each measurement, four images of the full field corresponding to linear polarization angles of 0 deg, 45 deg, 90 deg and 135 deg in the instrument coordinate system will be created on four detectors from which the Stokes parameters can be found using differential photometry. In designing the optical system, major challenges included correcting for the dispersion introduced by large split angle Wollaston Prisms used as analysers as well as other aberrations from the entire field to obtain imaging quality PSF at the detector. We present the optical design of the WALOP-South instrument which overcomes these challenges and delivers near seeing limited PSFs for the entire field of view.Comment: 31 pages, 18 Figures and 8 Tables. Accepted in the Journal of Astronomical Telescopes, Instruments, and System

Starlight-polarization-based tomography of the magnetized ISM: Pasiphae's line-of-sight inversion method

We present the first Bayesian method for tomographic decomposition of the plane-of-sky orientation of the magnetic field with the use of stellar polarimetry and distance. This standalone tomographic inversion method presents an important step forward in reconstructing the magnetized interstellar medium (ISM) in 3D within dusty regions. We develop a model in which the polarization signal from the magnetized and dusty ISM is described by thin layers at various distances. Our modeling makes it possible to infer the mean polarization (amplitude and orientation) induced by individual dusty clouds and to account for the turbulence-induced scatter in a generic way. We present a likelihood function that explicitly accounts for uncertainties in polarization and parallax. We develop a framework for reconstructing the magnetized ISM through the maximization of the log-likelihood using a nested sampling method. We test our Bayesian inversion method on mock data taking into account realistic uncertainties from $Gaia$ and as expected for the optical polarization survey PASIPHAE according to the currently planned observing strategy. We demonstrate that our method is effective in recovering the cloud properties as soon as the polarization induced by a cloud to its background stars is higher than $\sim 0.1\%$, for the adopted survey exposure time and level of systematic uncertainty. Our method makes it possible to recover not only the mean polarization properties but also to characterize the intrinsic scatter, thus opening ways to characterize ISM turbulence and the magnetic field strength. Finally, we apply our method to an existing dataset of starlight polarization with known line-of-sight decomposition, demonstrating agreement with previous results and an improved quantification of uncertainties in cloud properties.Comment: 28 pages, including 2 appendices, submitted to A&

Bright-Moon Sky as a Wide-Field Linear Polarimetric Flat Source for Calibration

Next-generation wide-field optical polarimeters like the Wide-Area Linear Optical Polarimeters (WALOPs) have a field of view (FoV) of tens of arcminutes. For efficient and accurate calibration of these instruments, wide-field polarimetric flat sources will be essential. Currently, no established wide-field polarimetric standard or flat sources exist. This paper tests the feasibility of using the polarized sky patches of the size of around ten-by-ten arcminutes, at a distance of up to 20 degrees from the Moon, on bright-Moon nights as a wide-field linear polarimetric flat source. We observed 19 patches of the sky adjacent to the bright-Moon with the RoboPol instrument in the SDSS-r broadband filter. These were observed on five nights within two days of the full-Moon across two RoboPol observing seasons. We find that for 18 of the 19 patches, the uniformity in the measured normalized Stokes parameters $q$ and $u$ is within 0.2 %, with 12 patches exhibiting uniformity within 0.07 % or better for both $q$ and $u$ simultaneously, making them reliable and stable wide-field linear polarization flats. We demonstrate that the sky on bright-Moon nights is an excellent wide-field linear polarization flat source. Various combinations of the normalized Stokes parameters $q$ and $u$ can be obtained by choosing suitable locations of the sky patch with respect to the MoonComment: 8 pages including appendix, 6 figures and 3 tables. Submitted to Astronomy and Astrophysics for review. Comments are welcom