1,086 research outputs found

    Development of Temperature and Humidity-Based Indicators for Diagnosing Problems in Low Tonnage, Split System Air Conditioners

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    This paper presents results of a survey of the literature and identifies the most common degraded conditions associated with low-tonnage air conditioners. Other laboratory studies as well as marketed diagnostic systems are also summarized. A procedure for identification of useful, low-cost temperature-based indicators of degraded conditions has been developed at the Energy Systems Laboratory, Texas A&M University in College Station, TX under contract to Honeywell. This paper presents the methodology used to identify the temperature-based indicators for the most common degraded conditions gleaned from the literature

    Hypoxic pre-conditioning increases the infiltration of endothelial cells into scaffolds for dermal regeneration pre-seeded with mesenchymal stem cells.

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    Many therapies using mesenchymal stem cells (MSC) rely on their ability to produce and release paracrine signals with chemotactic and pro-angiogenic activity. These characteristics, however, are mostly studied under standard in vitro culture conditions. In contrast, various novel cell-based therapies imply pre-seeding MSC into bio-artificial scaffolds. Here we describe human bone marrow-derived MSC seeded in Integra matrices, a common type of scaffold for dermal regeneration (SDR). We show and measured the distribution of MSC within the SDR, where cells clearly establish physical interactions with the scaffold, exhibiting constant metabolic activity for at least 15 days. In the SDR, MSC secrete VEGF and SDF-1α and induce transwell migration of CD34(+) hematopoietic/endothelial progenitor cells, which is inhibited in the presence of a CXCR4/SDF-1α antagonist. MSC in SDR respond to hypoxia by altering levels of angiogenic signals such as Angiogenin, Serpin-1, uPA, and IL-8. Finally, we show that MSC-containing SDR that have been pre-incubated in hypoxia show higher infiltration of endothelial cells after implantation into immune deficient mice. Our data show that MSC are fully functional ex vivo when implanted into SDR. In addition, our results strongly support the notion of hypoxic pre-conditioning MSC-containing SDR, in order to promote angiogenesis in the wounds

    Detecting Planets Around Very Low Mass Stars with the Radial Velocity Method

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    The detection of planets around very low-mass stars with the radial velocity method is hampered by the fact that these stars are very faint at optical wavelengths where the most high-precision spectrometers operate. We investigate the precision that can be achieved in radial velocity measurements of low mass stars in the near infrared (nIR) Y-, J-, and H-bands, and we compare it to the precision achievable in the optical. For early-M stars, radial velocity measurements in the nIR offer no or only marginal advantage in comparison to optical measurements. Although they emit more flux in the nIR, the richness of spectral features in the optical outweighs the flux difference. We find that nIR measurement can be as precise than optical measurements in stars of spectral type ~M4, and from there the nIR gains in precision towards cooler objects. We studied potential calibration strategies in the nIR finding that a stable spectrograph with a ThAr calibration can offer enough wavelength stability for m/s precision. Furthermore, we simulate the wavelength-dependent influence of activity (cool spots) on radial velocity measurements from optical to nIR wavelengths. Our spot simulations reveal that the radial velocity jitter does not decrease as dramatically towards longer wavelengths as often thought. The jitter strongly depends on the details of the spots, i.e., on spot temperature and the spectral appearance of the spot. Forthcoming nIR spectrographs will allow the search for planets with a particular advantage in mid- and late-M stars. Activity will remain an issue, but simultaneous observations at optical and nIR wavelengths can provide strong constraints on spot properties in active stars.Comment: accepted by ApJ, v2 accepted revision with new precision calculations, abstract abride

    A cool starspot or a second transiting planet in the TrES-1 system?

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    We investigate the origin of a flux increase found during a transit of TrES-1, observed with the HST. This feature in the HST light curve cannot be attributed to noise and is supposedly a dark area on the stellar surface of the host star eclipsed by TrES-1 during its transit. We investigate the likeliness of two possible hypothesis for its origin: A starspot or a second transiting planet. We made use of several transit observations of TrES-1 from space with the HST and from ground with the IAC-80 telescope. On the basis of these observations we did a statistical study of flux variations in each of the observed events, to investigate if similar flux increases are present in other parts of the data set. The HST observation presents a single clear flux rise during a transit whereas the ground observations led to the detection of two such events but with low significance. In the case of having observed a starspot in the HST data, assuming a central impact between the spot and TrES-1, we would obtain a lower limit for the spot radius of 42000 km. For this radius the spot temperature would be 4690 K, 560 K lower then the stellar surface of 5250 K. For a putative second transiting planet we can set a lower limit for its radius at 0.37 RJ_J and for periods of less than 10.5 days, we can set an upper limit at 0.72 RJ_J. Assuming a conventional interpretation, then this HST observation constitutes the detection of a starspot. Alternatively, this flux rise might also be caused by an additional transiting planet. The true nature of the origin can be revealed if a wavelength dependency of the flux rise can be shown or discarded with a higher certainty. Additionally, the presence of a second planet can also be detected by radial velocity measurements.Comment: 8 pages, 6 figures, accepted for publication in A&
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