Reducing Global Warming and Adapting to Climate Change: The Potential of Organic Agriculture

Climate change mitigation is urgent and adaptation to climate change is crucial, particularly in agriculture, where food security is at stake. Agriculture, currently responsible for 20-30% of global greenhouse gas emissions counting direct and indirect agricultural emissions), can however contribute to both climate change mitigation and adaptation. The main mitigation potential lies in the capacity of agricultural soils to sequester CO2 through building organic matter. This potential can be realized by employing sustainable agricultural practices, such as those commonly found within organic farming systems. Examples of these practices are the use of organic fertilizers and crop rotations including legumes leys and cover crops. Mitigation is also achieved in organic agriculture through the avoidance of open biomass burning and the avoidance of synthetic fertilizers and the related production emissions from fossil fuels. Common organic practices also contribute to adaptation. Building soil organic matter increases water retention capacity, and creates more stabile, fertile soils, thus reducing vulnerability to drought, extreme precipitation events, floods and water logging. Adaptation is further supported by increased agro-ecosystem diversity of organic farms, due to reduced nitrogen inputs and the absence of chemical pesticides. The high diversity together with the lower input costs of organic agriculture is key in reducing production risks associated with extreme weather events. All these advantageous practices are not exclusive to organic agriculture. However, they are core parts of the organic production system, in contrast to most non-organic agriculture, where they play a minor role only. Mitigation in agriculture cannot be restricted to the agricultural sector alone, though. Consumer behaviour strongly influences agricultural production systems, and thus their mitigation potential. Significant factors are meat consumption and food wastage. Any discussion on mitigation climate change in agriculture needs to address the entire food chain and needs to be linked to general sustainable development strategies. The main challenges to climate change mitigation and adaptation in organic agriculture and agriculture in general concern a)the understanding of some of the basic processes, such as the interaction of N2O emissions and soil carbon sequestration, contributions of roots to soil carbon sequestration and the life-cycle emissions of organic fertilizers such as compost; b) approaches for emissions accounting that adequately represent agricultural production systems with multiple and diverse outputs and that also encompass ecosystem services; c) the identification and implementation of most adequate policy frameworks for supporting mitigation and adaptation in agriculture, i.e: not putting systemic approaches at a disadvantage due to difficulties in the quantification of emissions, and in their allocation to single products; d) how to assure that the current focus on mitigation does not lead to neglect of the other sustainability aspects of agriculture, such as pesticide loads, eutrophication, acidification or soil erosion and e) the question how to address consumer behaviour and how to utilize the mitigation potential of changes in consumption patterns

Long-term follow-up and residual sequelae after treatment for intracerebral germ-cell tumour in children and adolescents

Background: Information on long-term follow-up of children and adolescents treated for intracerebral germ-cell tumour is scant. We report on the results of a small series of patients treated at a single institution. Patients and methods: Hospital records from 15 patients treated between 1980 and 1998 were reviewed. An attempt was made to correlate sequelae to tumour location and treatment modalities. Results: This cohort constitutes 5.5% of all brain tumours diagnosed at our institution. Histology: 10 germinomas, 2 benign teratomas, 2 malignant teratomas, and one mixed germ-cell tumour. Overall survival was 87%, with a mean follow-up time of 7 years and 8 months. The majority of patients have long-term sequelae involving one or several organ systems. In 66% endocrine, in 47% ophthalmologic, in 60% neuropsycho-logical defects were observed. Endocrine and ophthalmologic sequelae show a correlation to tumour location. Neuropsycho-logical long-term abnormalities are frequent and are associated with cranial irradiation in particular at young age, but less with tumour location, irradiation dose or surgery. Conclusions: Our preliminary data suggest that today intracerebral germinomas and mature teratomas have a good prognosis even when a relapse occurs. The outcome for mixed germ-cell tumours and malignant teratomas is less favourable. Although long-term sequelae are present in the majority of patients, there is some evidence that patients treated after 1990 suffer fewer severe long-term defects, thereby indicating that recent treatment protocols may result in a reduction of sequela

EHEC – kein spezifisches Problem nachhaltiger Landwirtschaft - [EHEC – A problem not specific to sustainable agriculture] [La EHEC – no es un problema específico de la agricultura sostenible] - [EHEC – Non è un problema specifi-co dell’agricoltura biologica] - [ECEH n’est pas un problème dû à l’agriculture durable] - [EHEC – nem speciálisan a fenntartható mezőgazdaság gondja] - [ECEH n’est pas un problème dû à l’agriculture durable]

DEUTSCH Über den EHEC-Erreger, der in Deutschland zu über dreissig tragischen Todesfällen geführt hat, ist viel spekuliert worden. Unterdessen konnten die Verbreitungswege nahezu aufgeklärt werden, während die Entstehung des Krankheitserregers noch weitgehend unklar ist. Im Zusammenhang mit dem EHEC-Ausbruch wurde auch die Frage erörtert, ob bestimmte Landwirtschaftsmethoden (zum Beispiel gemischte Betriebe mit Tierhaltung und Pflanzenbau oder die organische Düngung von Gemüse) oder ob gewisse Hygienisierungsmethoden für frische, konsumfähige Produkte(wie zum Beispiel die Verwendung von schonenden, weniger Rückstände verursachenden organischen Säuren) das Risiko erhöhen könnten. Diese Dokumentation geht nicht auf die aktuellen Fälle von EHEC in Norddeutschland ein, sondern liefert an diesem Beispiel Hintergrundinformationen zur Frage, wie nachhaltige, in Kreisläufen arbeitende Landwirtschaftsmethoden mit vom Tier auf den Menschen übertragbare Krankheitserreger (Zoonosen) umgehen. ENGLISH There has been much speculation about the pathogenic EHEC bacterial strain that has tragically claimed the lives of more than 30 people so far in Germany. Meanwhile, the transmission pathways have for the most part been identified. The origin of the pathogen, however, is largely unclear. In the context of the EHEC outbreak there have been debates as to whether certain agriculturalmethods (e.g. mixed holdings including both livestock and crop production, or the use of organic fertilizers for vegetable production) or certain sanitization methods for fresh consumable products (such as the use of organic acids, a mild treatment that leaves fewer residues) may increase the risk of infection. This document does not address the current epidemiological situation of the outbreak in northern Germany. Its purpose is rather to provide background information on the question of how sustainable agricultural methods based on nutrient cycling deal with pathogens that can be transmitted from animals to humans (zoonoses). CASTELLANO Mucho se ha especulado sobre la bacteria patógena Escherichia coli enterohemorrágica (ECEH), que ha ocasionado más de treinta muertes trágicas en Alemania. Hasta ahora casi se ha podido esclarecer la via de su propagación, mientras que sigue estando poco claro como ha aparecido el agente patógeno. Con el brote de la ECEH se ha cuestionado si determinadas prácticas agrícolas (por ejemplo, mantener explotaciones mixtas con ganado y cultivos, o la fertilización orgánica de los vegetales) o si los métodos de higiene para productos frescos, listos para el consumo (como por ejemplo, el uso de ácidos orgánicos menos agresivos y con menor riesgo de dejar residudos), pudieran incrementar los riesgos. Esta documento no se refiere sólo a los casos actuales de ECEH en el norte de Alemania, sino que proporciona, información básica de fondo, aprovechando este ejemplo, sobre como los métodos de producción agraria de ciclos cerrados con animales evitan forma sostenible que los patógenos generadores de enfermedades contagiosas (zoonosis) trasmisibles al ser humano. ITALIANO A proposito dell’insorgenza di EHEC è stata sollevata la questione se determinati metodi agricoli (per esempio aziende miste con allevamento di animali e produzione vegetale o la concimazione organica di ortaggi) oppure se determinati metodi di igienizzazione per pro-dotti freschi adatti al consumo (come per esempio l’impiego di acidi organici che provocano meno residui) possano aumentare i rischi. La presente documentazione non entra nei particolari degli attuali casi di EHEC nella Ger-mania settentrionale bensì fornisce informazioni d’approfondimento su come i me-todi agri-coli sostenibili basati sui cicli degli elementi nutritivi trattano la questione degli agenti pato-geni trasmissibili dagli animali all’uomo (zoonosi). HUNGARIAN Sok a spekuláció az EHEC kórokozót illetően, amely Németországban harmincnál is több tragikus halálesethez vezetett. Időközben a terjedés útját már csaknem teljesen felderítették, míg a kórokozó létrejöttéről még szinte semmit sem tudunk. Az EHEC fertőzés kitörése kapcsán az a kérdés is felmerült, hogy bizonyos mezőgazdasági módszerek (pl. a vegyes üzemek, melyek egyaránt foglalkoznak növénytermesztéssel és állattenyésztéssel, vagy a zöldségek szerves trágyázása), ill. a friss, fogyasztásra kész termékek egyes fertőtlenítési módszerei (így pl. a kímélőbb, kevesebb hulladékot eredményező szerves savak alkalmazása) nem növelhetik-e a kockázatot. A jelen tanulmány nem a Németország északi részén kialakult aktuális EHEC esetekkel foglalkozik, hanem háttér-információval szolgál arról, hogy a körforgásos működésű, fenntartható mezőgazdasági módszerek milyen kapcsolatban lehetnek az állatról emberre terjedő betegségekkel, az ún. zoonózisokkal. FRANCAIS ECEH n’est pas un problème dû à l’agriculture durabl

DNA ploidy and proliferative activity (S-phase) in childhood soft-tissue sarcomas: their value as prognostic indicators.

The value of DNA ploidy as a prognostic indicator is well established in many cancers, but recent studies in childhood rhabdomyosarcoma (RMS) have been contradictory. In a retrospective study of 128 cases of soft-tissue sarcoma (STS) diagnosed since 1980, the prognostic value of clinical, histological and flow cytometric parameters was compared, using univariate and multivariate methods. Eighty-one RMSs, 18 extraosseous Ewing's (EOE)/peripheral neuroectodermal tumours (PNETs) and 29 other non-RMS STSs were histologically and clinically reviewed. Five year actuarial survival was 63.4% for all STSs and 69.4% for RMSs. Paraffin-embedded tissue blocks were available for flow cytometry in 90 cases. Of the RMSs, 65.5% were aneuploid [DNA index (DI) > 1.1] compared with 23% of the EOE/PNETs and 31% of non-RMS STSs. Median S-phase was also significantly higher in RMSs (17.0%) than in other STSs (10.8%) (P = 0.0023). Univariate analysis in RMSs showed that stage, ploidy status, S-phase, site and tumour size all had a significant impact on survival. In multivariate analysis of 59 cases of RMS, one clinical and two flow cytometric parameters were independently associated with poor prognosis. These were stage (IV), nonhyperdiploidy (DI < 1.10 and > 1.8) and a high rate of proliferative activity (S-phase > 14.0%). These results confirm that ploidy and S-phase are important new prognostic indicators in rhabdomyosarcoma

Priority themes for swiss sustainability research

With this report, the Swiss Academies of Arts and Sciences contribute to achieving the SDGs: With a view to meeting Switzerland‘s commitments under the 2030 Agenda as a whole, it identifies our country‘s most urgent research needs

Strategic Research and Innovation Agenda for Organic Food and Farming

TP Organics is the European Technology Platform for organic food and farming, and for low-input agriculture. Established in 2008, it brings together small and medium-sized enterprises, larger companies, farmers, researchers, consumers and civil society organisations involved in the organic value chain from production, input and supply, to food processing, marketing and consumption. It identifies research and innovation needs and communicates them to policy-makers. The aim is to leverage the organic sector’s contribution to sustainable farming and food production. Since 2013, TP Organics is officially recognised by the European Commission as one of 40 European Technology Platforms (ETPs). TP Organics published its first Strategic Research Agenda in 2009. This proved very successful, as about a third of the research questions identified gained funding through the 7th Framework Programme for Research and Development (FP7) of the EU, or through transnational research programmes (ERA-Nets) and national research projects. With the end of the 7th Framework Programme and the start of the new EU Framework Programme for Research and Innovation, Horizon 2020, TP Organics decided to revise its research agenda. This new Strategic Research and Innovation Agenda is the product of an intensive participatory process, which lasted for a year and a half and benefited from three consultations

Flotillins Interact with PSGL-1 in Neutrophils and, upon Stimulation, Rapidly Organize into Membrane Domains Subsequently Accumulating in the Uropod

BACKGROUND: Neutrophils polarize and migrate in response to chemokines. Different types of membrane microdomains (rafts) have been postulated to be present in rear and front of polarized leukocytes and disruption of rafts by cholesterol sequestration prevents leukocyte polarization. Reggie/flotillin-1 and -2 are two highly homologous proteins that are ubiquitously enriched in detergent resistant membranes and are thought to shape membrane microdomains by forming homo- and hetero-oligomers. It was the goal of this study to investigate dynamic membrane microdomain reorganization during neutrophil activation. METHODOLOGY/PRINCIPAL FINDINGS: We show now, using immunofluorescence staining and co-immunoprecipitation, that endogenous flotillin-1 and -2 colocalize and associate in resting spherical and polarized primary neutrophils. Flotillins redistribute very early after chemoattractant stimulation, and form distinct caps in more than 90% of the neutrophils. At later time points flotillins accumulate in the uropod of polarized cells. Chemotactic peptide-induced redistribution and capping of flotillins requires integrity and dynamics of the actin cytoskeleton, but does not involve Rho-kinase dependent signaling related to formation of the uropod. Both flotillin isoforms are involved in the formation of this membrane domain, as uropod location of exogenously expressed flotillins is dramatically enhanced by co-overexpression of tagged flotillin-1 and -2 in differentiated HL-60 cells as compared to cells expressing only one tagged isoform. Flotillin-1 and -2 associate with P-selectin glycoprotein ligand 1 (PSGL-1) in resting and in stimulated neutrophils as shown by colocalization and co-immunoprecipitation. Neutrophils isolated from PSGL-1-deficient mice exhibit flotillin caps to the same extent as cells isolated from wild type animals, implying that PSGL-1 is not required for the formation of the flotillin caps. Finally we show that stimulus-dependent redistribution of other uropod-located proteins, CD43 and ezrin/radixin/moesin, occurs much slower than that of flotillins and PSGL-1. CONCLUSIONS/SIGNIFICANCE: These results suggest that flotillin-rich actin-dependent membrane microdomains are importantly involved in neutrophil uropod formation and/or stabilization and organize uropod localization of PSGL-1