Hemispheric processing of memory is affected by sleep

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Sleep is known to affect learning and memory, but the extent to which it influences behavioural processing in the left and right hemispheres of the brain is as yet unknown. We tested two hypotheses about lateralised effects of sleep on recognition memory for words: whether sleep reactivated recent experiences of words promoting access to the long-term store in the left hemisphere (LH), and whether sleep enhanced spreading activation differentially in semantic networks in the hemispheres. In Experiment 1, participants viewed lists of semantically related words, then slept or stayed awake for 12 h before being tested on seen, unseen but related, or unrelated words presented to the left or the right hemisphere. Sleep was found to promote word recognition in the LH, and to spread activation equally within semantic networks in both hemispheres. Experiment 2 ensured that the results were not due to time of day effects influencing cognitive performance

Health assessment of elderly patients

BACKGROUND Comprehensive health assessment of the elderly in primary care will become a more important element of general practice as population aging proceeds and evidence of efficacy emerges. OBJECTIVE This article describes approaches to provision of health assessment in primary care based on the best available evidence. DISCUSSION Current best practice includes the use of structured health assessment protocols, an integrated multidisciplinary approach, targeting patient groups with intermediate levels of disability and handicap, in-home assessments and carefully structured follow up mechanisms.Len C Gray, Jonathan W Newbur

The determination of shock ramp width using the noncoplanar magnetic field component

We determine a simple expression for the ramp width of a collisionless fast shock, based upon the relationship between the noncoplanar and main magnetic field components. By comparing this predicted width with that measured during an observation of a shock, the shock velocity can be determined from a single spacecraft. For a range of low-Mach, low-beta bow shock observations made by the ISEE-1 and -2 spacecraft, ramp widths determined from two-spacecraft comparison and from this noncoplanar component relationship agree within 30%. When two-spacecraft measurements are not available or are inefficient, this technique provides a reasonable estimation of scale size for low-Mach shocks.Comment: 6 pages, LaTeX (aguplus + agutex); packages:amsmath,times,graphicx,float, psfrag,verbatim; 3 postscript figures called by the file; submitted to Geophys. Res. Let

Malnutrition in older people - screening and management strategies

Copyright © 2004 Royal Australian College of General Practitioners Copyright to Australian Family Physician. Reproduced with permission. Permission to reproduce must be sought from the publisher, The Royal Australian College of General Practitioners.Background: Malnutrition in older people is not only common, but frequently overlooked. It can result in multiple medical complications, hospitalisation and even death. Objective: This article focusses on the consequences, pathophysiology, diagnosis and management of this clinical syndrome. Discussion: Nonphysiological causes of malnutrition include social, psychological, medical and medication related factors. With vigilance, early screening and the institution of simple therapeutic measures of correcting nonphysiological causes and following dietary guidelines for older people, the adverse effects of malnutrition may be minimised.Renuka Visvanathan; Jonathan W Newbury; Ian Chapma

Full phase stabilization of a Yb:fiber femtosecond frequency comb via high-bandwidth transducers

We present full phase stabilization of an amplified Yb:fiber femtosecond frequency comb using an intra-cavity electro-optic modulator and an acousto-optic modulator. These transducers provide high servo bandwidths of 580 kHz and 250 kHz for frep and fceo, producing a robust and low phase noise fiber frequency comb. The comb was self-referenced with an f - 2f interferometer and phase locked to an ultra-stable optical reference used for the JILA Sr optical clock at 698 nm, exhibiting 0.21 rad and 0.47 rad of integrated phase errors (over 1 mHz - 1 MHz) respectively. Alternatively, the comb was locked to two optical references at 698 nm and 1064 nm, obtaining 0.43 rad and 0.14 rad of integrated phase errors respectively

Genetic, Morphometric, and Behavioral Factors Linked to the Midsagittal Area of the Corpus Callosum

The corpus callosum is the main commissure connecting left and right cerebral hemispheres, and varies widely in size. Differences in the midsagittal area of the corpus callosum (MSACC) have been associated with a number of cognitive and behavioral phenotypes, including obsessive-compulsive disorders, psychopathy, suicidal tendencies, bipolar disorder, schizophrenia, autism, and attention deficit hyperactivity disorder. Although there is evidence to suggest that MSACC is heritable in normal human populations, there is surprisingly little evidence concerning the genetic modulation of this variation. Mice provide a potentially ideal tool to dissect the genetic modulation of MSACC. Here, we use a large genetic reference panel – the BXD recombinant inbred line – to dissect the natural variation of the MSACC. We estimated the MSACC in over 300 individuals from nearly 80 strains. We found a 4-fold difference in MSACC between individual mice, and a 2.5-fold difference among strains. MSACC is a highly heritable trait (h2 = 0.60), and we mapped a suggestive QTL to the distal portion of Chr 14. Using sequence data and neocortical expression databases, we were able to identify eight positional and plausible biological candidate genes within this interval. Finally, we found that MSACC correlated with behavioral traits associated with anxiety and attention

Phonological characteristics of the lexicon at 2;0 years predict language outcomes at 3;6 years

Poster session 3 - Early speech production: no. 7Toddlers’ first words are of higher mean phonological neighborhood density (ND) than words learned later. The words of children with delayed lexical development are of significantly higher mean ND than those of typically developing children. A relationship between a higher mean ND value at 2;0 years and expressive language skills at 3;6 years may indicate that early word processing difficulties inhibit ongoing development ...postprin

Fundamental noise limitations to supercontinuum generation in microstructure fiber

Broadband noise on supercontinuum spectra generated in microstructure fiber is shown to lead to amplitude fluctuations as large as 50 % for certain input laser pulse parameters. We study this noise using both experimental measurements and numerical simulations with a generalized stochastic nonlinear Schroedinger equation, finding good quantitative agreement over a range of input pulse energies and chirp values. This noise is shown to arise from nonlinear amplification of two quantum noise inputs: the input pulse shot noise and the spontaneous Raman scattering down the fiber.Comment: 16 pages with 6 figure

A mutation in amino acid permease AAP6 reduces the amino acid content of the Arabidopsis sieve elements but leaves aphid herbivores unaffected

The aim of this study was to investigate the role of the amino acid permease gene AAP6 in regulating phloem amino acid composition and then to determine the effects of this altered diet on aphid performance. A genotype of Arabidopsis thaliana (L.) was produced in which the function of the amino acid permease gene AAP6 (At5g49630) was abolished. Plants homozygous for the insertionally inactivated AAP6 gene had a significantly larger mean rosette width than the wild type and a greater number of cauline leaves. Seeds from the aap6 mutant were also significantly larger than those from the wild-type plants. Sieve element (SE) sap was collected by aphid stylectomy and the amino acids derivatized, separated, and quantified using Capillary Electrophoresis with Laser Induced Fluorescence (CE-LIF). In spite of the large variation across samples, the total amino acid concentration of SE sap of the aap6 mutant plants was significantly lower than that of the wild-type plants. The concentrations of lysine, phenylalanine, leucine, and aspartic acid were all significantly lower in concentration in the aap6 mutant plants compared with wild-type plants. This is the first direct demonstration of a physiological role for an amino acid transporter in regulating SE composition in vivo. The amino acid availability in sieve element sap is thought to be the major limiting factor for aphid growth and reproduction. Despite the changes in their diet, the aphid Myzus persicae (Sulzer) displayed only small changes in feeding behaviour on mutant plants when measured using the Electronic Penetration Graph (EPG) technique. Salivation by the aphid into the SE (E1 phase) was increased on mutant plants but there was no significant effect on other feeding EPG behaviours, or in the rate of honeydew production. Consistent with the small effect on aphid feeding behaviour, there was only a small effect of reduced sieve element amino acid concentration on aphid reproduction. The data are discussed in relation to the regulation of phloem composition and the role of phloem amino acids in regulating aphid performance

The effects of sodium bicarbonate ingestion on swimming interval performance in trained competitive swimmers

The use of sodium bicarbonate (NaHCO) supplementation to improve repeated high-intensity performance is recommended; however, most swimming performance studies examine time trial efforts rather than repeated swims with interspersed recovery that are more indicative of training sessions. The aim of this study, therefore, was to investigate the effects of 0.3 g.kg BM NaHCO supplementation on sprint interval swimming (8 × 50 m) in regionally trained swimmers. Fourteen regionally competitive male swimmers (body mass (BM): 73 ± 8 kg) volunteered for this double-blind, randomised, crossover designed study. Each participant was asked to swim 8 × 50 m (front crawl) at a maximum intensity from a diving block, interspersed with 50 m active recovery swimming. After one familiarisation trial, this was repeated on two separate occasions whereby participants ingested either 0.3 g.kg BM NaHCO or 0.05 g.kg BM sodium chloride (placebo) in solution 60 min prior to exercise. Whilst there were no differences in time to complete between sprints 1-4 (p > 0.05), improvements were observed in sprint 5 (p = 0.011; ES = 0.26), 6 (p = 0.014; ES = 0.39), 7 (p = 0.005; ES = 0.60), and 8 (p = 0.004; ES = 0.79). Following NaHCO supplementation, pH was greater at 60 min (p < 0.001; ES = 3.09), whilst HCO was greater at 60 min (p < 0.001; ES = 3.23) and post-exercise (p = 0.016; ES = 0.53) compared to placebo. These findings suggest NaHCO supplementation can improve the latter stages of sprint interval swimming performance, which is likely due to the augmentation of pH and HCO prior to exercise and the subsequent increase in buffering capacity during exercise