1,032 research outputs found

    The effects of a ten-week aerobic fitness program on depression

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    Minimal model for active nematics: quasi-long-range order and giant fluctuations

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    We propose a minimal microscopic model for active nematic particles similar in spirit to the Vicsek model for self-propelled polar particles. In two dimensions, we show that this model exhibits a Kosterlitz-Thouless-like transition to quasi-long-range orientational order and that in this non-equilibrium context, the ordered phase is characterized by giant density fluctuations, in agreement with the predictions of Ramaswamy {\it et al.} [Europhys. Lett. {\bf 62}, 196 (2003)].Comment: Submitted to Phys. Rev. Lett. 4 pages, 4 figure

    Hypersonic blunt body computations including real gas effects

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    The recently developed second-order explicit and implicit total variation diminishing (TVD) shock-capturing methods of the Harten and Yee, Yee, and van Leer types in conjunction with a generalized Roe's approximate Riemann solver of Vinokur and the generalized flux-vector splittings of Vinokur and Montagne for two-dimensional hypersonic real gas flows are studied. A previous study on one-dimensional unsteady problems indicated that these schemes produce good shock-capturing capability and that the state equation does not have a large effect on the general behavior of these methods for a wide range of flow conditions for equilibrium air. The objective of this paper is to investigate the applicability and shock resolution of these schemes for two-dimensional steady-state hypersonic blunt body flows. The main contribution of this paper is to identify some of the elements and parameters which can affect the convergence rate for high Mach numbers or real gases but have negligible effect for low Mach number cases for steady-state inviscid blunt body flows

    Stratégies d'évitement de collision en intersection

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    ACAPS 2015 - 16Ăšme CongrĂšs de l'Association des Chercheurs en ActivitĂ©s Physiques et Sportives, Nantes, FRANCE, 26-/10/2015 - 28/10/2015Dans la littĂ©rature, certaines Ă©tudes rĂ©vĂšlent un effet de la taille des vĂ©hicules croisĂ©s sur des tĂąches de jugement et de comportement de conduite des automobilistes Ă  une intersection. NĂ©anmoins, dans ces Ă©tudes, la taille et le type de vĂ©hicules croisĂ©s (e.g., voiture vs motocyclette) covariaient systĂ©matiquement. Cette Ă©tude examine sĂ©parĂ©ment l'incidence de la taille et du type de vĂ©hicules croisĂ©s sur une tĂąche de jugement et une tĂąche de franchissement rĂ©el d'intersection. Pour cela les voitures et les motocyclettes observĂ©es avaient les mĂȘmes dimensions. 14 participants ont rĂ©alisĂ© deux expĂ©riences dans un simulateur de conduite en rĂ©alitĂ© virtuelle. Les rĂ©sultats montrent que les automobilistes utilisaient la taille et type de vĂ©hicules croisĂ©s pour rĂ©aliser les deux tĂąches

    High- Resolution Shock-Capturing Schemes for Inviscid and Viscous Hypersonic Flows

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    A class of high-resolution implicit total variation diminishing (TVD) type algorithms suitable for transonic multidimensional Euler and Navier-Stokes equations has been extended to hypersonic computations. The improved conservative shock-capturing schemes are spatially second- and third-order and are fully implicit. They can be first- or second-order accurate in time and are suitable for either steady or unsteady calculations. Enhancement of stability and convergence rate for hypersonic flows is discussed. With the proper choice of the temporal discretization and implicit linearization, these schemes are fairly efficient and accurate for very complex two-dimensional hypersonic in viscid and viscous shock interactions. This study is complemented by a variety of steady and unsteady viscous and inviscid hypersonic blunt body flow computations. Due to the inherent stiffness of viscous flow problems, numerical experiments indicated that the convergence rate is in general slower for viscous flows than for inviscid steady flows

    Comprehensive study of phase transitions in relaxational systems with field-dependent coefficients

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    We present a comprehensive study of phase transitions in single-field systems that relax to a non-equilibrium global steady state. The mechanism we focus on is not the so-called Stratonovich drift combined with collective effects, but is instead similar to the one associated with noise-induced transitions a la Horsthemke-Lefever in zero-dimensional systems. As a consequence, the noise interpretation (e.g., Ito vs Stratonvich) merely shifts the phase boundaries. With the help of a mean-field approximation, we present a broad qualitative picture of the various phase diagrams that can be found in these systems. To complement the theoretical analysis we present numerical simulations that confirm the findings of the mean-field theory

    Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity

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    The receptor tyrosine kinase Met and its ligand, the hepatocyte growth factor, are essential to embryonic development, whereas the deregulation of Met signaling is associated with tumorigenesis. While ligand-activated Met promotes survival, caspase-dependent generation of the p40 Met fragment leads to apoptosis induction – hallmark of the dependence receptor. Although the survival signaling pathways induced by Met are well described, the pro-apoptotic signaling pathways are unknown. We show that, although p40 Met contains the entire kinase domain, it accelerates apoptosis independently of kinase activity. In cell cultures undergoing apoptosis, the fragment shows a mitochondrial localization, required for p40 Met-induced cell death. Fulminant hepatic failure induced in mice leads to the generation of p40 Met localized also in the mitochondria, demonstrating caspase cleavage of Met in vivo. According to its localization, the fragment induces mitochondrial permeabilization, which is inhibited by Bak silencing and Bcl-xL overexpression. Moreover, Met silencing delays mitochondrial permeabilization induced by an apoptotic treatment. Thus, the Met-dependence receptor in addition to its well-known role in survival signaling mediated by its kinase activity, also participates in the intrinsic apoptosis pathway through the generation of p40 Met – a caspase-dependent fragment of Met implicated in the mitochondrial permeabilization process

    Dynamics of Elastic Excitable Media

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    The Burridge-Knopoff model of earthquake faults with viscous friction is equivalent to a van der Pol-FitzHugh-Nagumo model for excitable media with elastic coupling. The lubricated creep-slip friction law we use in the Burridge-Knopoff model describes the frictional sliding dynamics of a range of real materials. Low-dimensional structures including synchronized oscillations and propagating fronts are dominant, in agreement with the results of laboratory friction experiments. Here we explore the dynamics of fronts in elastic excitable media.Comment: Int. J. Bifurcation and Chaos, to appear (1999
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