Reasons for irregular use of ferrous sulfate tablet in women referred to health centers in Bourojen city, 2005-2006

چکیده: زمینه و هدف: خانم های باردار و شیرده از جمله گروههای در معرض خطر ‌کم خونی فقر آهن می باشند. با وجود برنامه مدون در ارتباط با مصرف قرص آهن توسط مادران، آمار به دست آمده نشان میدهد حدود 67 درصد زنان باردار و شیرده قرص آهن را صحیح و منظم مصرف نمی کنند. لذا این مطالعه با هدف بررسی علل مصرف نامنظم قرص آهن در خانم های باردار و شیرده مراجعه کننده به مراکز بهداشتی درمانی شهر بروجن انجام شد. روش بررسی:در این مطالعه توصیفی – تحلیلی که در مراکز بهداشتی درمانی شهر بروجن در سال 85-1384 انجام گرفت، 270 نفر خانم که در دوره 16 هفتگی حاملگی الی 2 ماهگی پس از زایمان قرار داشتند به روش دردسترس انتخاب و طی مصاحبه حضوری به سؤالات پرسشنامه حاوی اطلاعات دموگرافیک، چگونگی مصرف قرص آهن، نگرش و عملکرد مادران در این خصوص پاسخ دادند. از آزمونهای کای دو، من ویتنی و ویلکاکسون و کروسکال والیس جهت تجزیه و تحلیل آْماری اطلاعات استفاده شد. یافته ها: نتایج نشان داد که 1/33 مادران قرص آهن را مرتب و منظم مصرف می کردند، 8/56 نامنظم و 2/10 اصلا مصرف نمی‌کردند. بین مصرف نامنظم قرص آهن و سطح اقتصادی - اجتماعی خانواده و تعداد زایمان ارتبــاط معنی داری وجود نداشت. از علل مصرف نامنظم قرص آهن 4/48 مادران فراموش کردن وعده های مصرف دارو، 4/12 تهوع و استفراغ حاملگی و 4/16 عدم آگاهی نسبت به لزوم مصرف آهن را ذکر کردند. بین تعداد زایمان و یا حاملگی، سن فرد و شاغل بودن با آگاهی، نگرش و عملکرد آنان ارتباط معنی دار وجود نداشت (05/0

SCALE DEPOSITS IN POROUS MEDIA AND THEIR REMOVAL BY EDTA INJECTION

Formation damage has been observed in several oil reservoirs and production equipment in Iranian oil fields. Laboratory and field testing confirmed that the primary cause of damage was the build-up of calcium carbonate, calcium sulfate and strontium sulfate scale either in the perforation tunnels or in the formation sandstone nears the wellbore. Conventional acid treatments could dissolve this scale, but scale precipitation from the spent acid caused rapid productivity decline. A scale removal treatment with Na2H2EDTA has been developed that can effectively dissolve scale and chelate the dissolved metal ions. Chelation of the dissolved scale prevents scale reprecipitation. This study describes the results of an experimental and theoretical study on the removal of formation damage resulting from scale formation in porous media. An experimental investigation was undertaken to look into the possible causes of the injectivity loss in a typical Iranian oilfield. Sets of experimental investigations were undertaken with different objectives in mind. Glass and sand bead packs were used to test the experimental set up and to observe the general behaviour of scale formation and removal by ethylene diamine tetra acetic acid (EDTA) to determine its possible effects on the permeability of the porous medium

Impedance Bandwidth Improvement of a Planar Antenna Based on Metamaterial-Inspired T-Matching Network

In this paper a metamaterial-inspired T-matching network is directly imbedded inside the feedline of a microstrip antenna to realize optimum power transfer between the front-end of an RF wireless transceiver and the antenna. The proposed T-matching network, which is composed of an arrangement of series capacitor, shunt inductor, series capacitor, exhibits left-handed metamaterial characteristics. The matching network is first theoretically modelled to gain insight of its limitations. It was then implemented directly in the 50-Omega feedline to a standard circular patch antenna, which is an unconventional methodology. The antenna's performance was verified through measurements. With the proposed technique there is 2.7 dBi improvement in the antenna's radiation gain and 12% increase in the efficiency at the center frequency, and this is achieved over a significantly wider frequency range by a factor of approximately twenty. Moreover, there is good correlation between the theoretical model, method of moments simulation, and the measurement results

Performance of BRCA1/2 mutation prediction models in male breast cancer patients

To establish whether existing mutation prediction models can identify which male breast cancer (MBC) patients should be offered BRCA1 and BRCA2 diagnostic DNA screening, we compared the performance of BOADICEA (Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm), BRCAPRO (BRCA probability) and the Myriad prevalence table ("Myriad"). These models were evaluated using the family data of 307 Dutch MBC probands tested for BRCA1/2, 58 (19%) of whom were carriers. We compared the numbers of observed vs predicted carriers and assessed the Area Under the Receiver Operating Characteristic (ROC) Curve (AUC) for each model. BOADICEA predicted the total number of BRCA1/2 mutation carriers quite accurately (observed/predicted ratio: 0.94). When a cut-off of 10% and 20% prior probability was used, BRCAPRO showed a non-significant better performance (observed/predicted ratio BOADICEA: 0.81, 95% confidence interval [CI]: [0.60-1.09] and 0.79, 95% CI: [0.57-1.09], vs. BRCAPRO: 1.02, 95% CI: [0.75-1.38] and 0.94, 95% CI: [0.68-1.31], respectively). Myriad underestimated the number of carriers in up to 69% of the cases. BRCAPRO showed a non-significant, higher AUC than BOADICEA (0.798 vs 0.776). Myriad showed a significantly lower AUC (0.671). BRCAPRO and BOADICEA can efficiently identify MBC patients as BRCA1/2 mutation carriers. Besides their general applicability, these tools will be of particular value in countries with limited healthcare resources

Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification

The multifactorial likelihood analysis method has demonstrated utility for quantitative assessment of variant pathogenicity for multiple cancer syndrome genes. Independent data types currently incorporated in the model for assessing BRCA1 and BRCA2 variants include clinically calibrated prior probability of pathogenicity based on variant location and bioinformatic prediction of variant effect, co-segregation, family cancer history profile, co-occurrence with a pathogenic variant in the same gene, breast tumor pathology, and case-control information. Research and clinical data for multifactorial likelihood analysis were collated for 1,395 BRCA1/2 predominantly intronic and missense variants, enabling classification based on posterior probability of pathogenicity for 734 variants: 447 variants were classified as (likely) benign, and 94 as (likely) pathogenic; and 248 classifications were new or considerably altered relative to ClinVar submissions. Classifications were compared with information not yet included in the likelihood model, and evidence strengths aligned to those recommended for ACMG/AMP classification codes. Altered mRNA splicing or function relative to known nonpathogenic variant controls were moderately to strongly predictive of variant pathogenicity. Variant absence in population datasets provided supporting evidence for variant pathogenicity. These findings have direct relevance for BRCA1 and BRCA2 variant evaluation, and justify the need for gene-specific calibration of evidence types used for variant classification

Global burden of chronic respiratory diseases and risk factors, 1990–2019: an update from the Global Burden of Disease Study 2019

Background: Updated data on chronic respiratory diseases (CRDs) are vital in their prevention, control, and treatment in the path to achieving the third UN Sustainable Development Goals (SDGs), a one-third reduction in premature mortality from non-communicable diseases by 2030. We provided global, regional, and national estimates of the burden of CRDs and their attributable risks from 1990 to 2019. Methods: Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we estimated mortality, years lived with disability, years of life lost, disability-adjusted life years (DALYs), prevalence, and incidence of CRDs, i.e. chronic obstructive pulmonary disease (COPD), asthma, pneumoconiosis, interstitial lung disease and pulmonary sarcoidosis, and other CRDs, from 1990 to 2019 by sex, age, region, and Socio-demographic Index (SDI) in 204 countries and territories. Deaths and DALYs from CRDs attributable to each risk factor were estimated according to relative risks, risk exposure, and the theoretical minimum risk exposure level input. Findings: In 2019, CRDs were the third leading cause of death responsible for 4.0 million deaths (95% uncertainty interval 3.6–4.3) with a prevalence of 454.6 million cases (417.4–499.1) globally. While the total deaths and prevalence of CRDs have increased by 28.5% and 39.8%, the age-standardised rates have dropped by 41.7% and 16.9% from 1990 to 2019, respectively. COPD, with 212.3 million (200.4–225.1) prevalent cases, was the primary cause of deaths from CRDs, accounting for 3.3 million (2.9–3.6) deaths. With 262.4 million (224.1–309.5) prevalent cases, asthma had the highest prevalence among CRDs. The age-standardised rates of all burden measures of COPD, asthma, and pneumoconiosis have reduced globally from 1990 to 2019. Nevertheless, the age-standardised rates of incidence and prevalence of interstitial lung disease and pulmonary sarcoidosis have increased throughout this period. Low- and low-middle SDI countries had the highest age-standardised death and DALYs rates while the high SDI quintile had the highest prevalence rate of CRDs. The highest deaths and DALYs from CRDs were attributed to smoking globally, followed by air pollution and occupational risks. Non-optimal temperature and high body-mass index were additional risk factors for COPD and asthma, respectively. Interpretation: Albeit the age-standardised prevalence, death, and DALYs rates of CRDs have decreased, they still cause a substantial burden and deaths worldwide. The high death and DALYs rates in low and low-middle SDI countries highlights the urgent need for improved preventive, diagnostic, and therapeutic measures. Global strategies for tobacco control, enhancing air quality, reducing occupational hazards, and fostering clean cooking fuels are crucial steps in reducing the burden of CRDs, especially in low- and lower-middle income countries